Pharmacokinetic interaction between JBP485 and cephalexin in rats

Drug Metabolism and Disposition

Volumn 38, Issue 6, 2010, Pages 930-938

  Zhang, Jian ^a   Wang, Changyuan ^a   Liu, Qi ^a   Meng, Qiang ^a   Cang, Jian ^a   Sun, Huijun ^a   Gao, Ying ^a   Kaku, Taiichi ^b   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b Japan Bioproducts Industry Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CEFALEXIN; CYCLO 4 HYDROXYPROLYLSERINE; DIPEPTIDE; JBP 485; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; PEPTIDE TRANSPORTER 1; PEPTIDE TRANSPORTER 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG HALF LIFE; DRUG UPTAKE; HUMAN; HUMAN CELL; INTESTINE MUCOSA; JEJUNUM; KIDNEY CLEARANCE; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANS ISOMER; URINARY EXCRETION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CELLS, CULTURED; CEPHALEXIN; DRUG INTERACTIONS; HUMANS; KIDNEY; KIDNEY TUBULES; MALE; ORGANIC ANION TRANSPORTERS; PEPTIDES, CYCLIC; RATS; RATS, WISTAR;

AVENA; RATTUS;

EID: 77952297570     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.032060     Document Type: Article

References (32)

1. Amidon GL and Lee HJ (1994) Absorption of peptide and peptidomimetic drugs. Annu Rev Pharmacol Toxicol 34:321-341.
2. Anand BS, Dey S, and Mitra AK (2002) Current prodrug strategies via membrane transporters/receptors. Expert Opin Biol Ther 2:607-620.
3. Annaert PP and Brouwer KL (2005) Assessment of drug interactions in hepatobiliary transport using rhodamine123 in sandwich-cultured rat hepatocytes. Drug Metab Dispos 33:388-394.
4. Berggren S, Hoogstraate J, Fagerholm U, and Lennernäs H (2004) Characterization of jejunal absorption and apical efflux of ropivacaine, lidocaine and bupivacaine in the rat using in situ and in vitro absorption models. Eur J Pharmacol 21:553-560.
5. +/peptide symporter (PEPT1), and the uptake into Caco-2 cell monolayers and the transepithelial flux. Pharm Res 16:55-61.
6. Cummins CL, Salphati L, Reid MJ, and Benet LZ (2003) In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. J Pharmacol Exp Ther 305:306-314. (Pubitemid 36373865)
7. Daniel H and Kottra G (2004) The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Pflugers Arch 447:610-618.
8. Ganapathy ME, Huang W, Wang H, Ganapathy V, and Leibach FH (1998) Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Biochem Biophys Res Commun 246:470-475. (Pubitemid 28412626)
9. Ganapathy V, Brandsch M, and Leibach FH (1994) Intestinal transport of amino acids and peptides, in Physiology of the Gastrointestinal Tract (Johnson LR ed) 3rd ed, pp 1773-1794, Raven Press, New York.
10. Hedman A, Angelin B, Arvidsson A, Beck O, Dahlqvist R, Nilsson B, Olsson M, and Schenck-Gustafsson K (1991) Digoxin-verapamil interaction: reduction of biliary but not renal digoxin clearance in humans. Clin Pharmacol Ther 49:256-262.
11. Khamdang S, Teda M, Babu E, Marreli M, and Shafran SD (2003) Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol 465:l-7.
12. Kojima R, Sekine T, Kawachi M, Cha SH, Suzuki Y, and Endou H (2002) Immunolocalization of multispecific organic anion transporters, OAT1, OAT2, and OAT3, in rat kidney. J Am Soc Nephrol 13:848-857. (Pubitemid 34274080)
13. Kusuhara H and Sugiyama Y (2002) Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney. J Control Release 78:43-54. (Pubitemid 34081852)
14. Leibach FH and Ganapathy V (1996) Peptide transporters in the intestine and the kidney. Annu Rev Nutr 16:99-119.
15. Liu KX, Kato Y, Kaku T, and Sugiyama Y (1998) Human placental extract stimulates liver regeneration in rats. Biol Pharm Bull 21:44-49. (Pubitemid 28087816)
16. Liu KX, Kato Y, Kaku TI, Santa T, Imai K, Yagi A, Ishizu T, and Sugiyama Y (2000) Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats. J Pharmacol Exp Ther 294:510-515. (Pubitemid 30490823)
17. Liu KX, Kato Y, Narukawa M, Kim DC, Hanano M, Higuchi O, Nakamura T, and Sugiyama Y (1992) Importance of the liver in plasma clearance of hepatocyte growth factors in rats. Am J Physiol 263:G642-G649.
18. Manfredini S, Pavan B, Vertuani S, Scaglianti M, Compagnone D, Biondi C, Scatturin A, Tanganelli S, Ferraro L, Prasad P, et al. (2002) Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity. J Med Chem 45:559-562. (Pubitemid 34145702)
19. Matsushima S, Maeda K, Inoue K, Ohta KY, Yuasa H, Kondo T, Nakayama H, Horita S, Kusuhara H, and Sugiyama Y(2009) The inhibition of human multidrug and toxin extrusion 1 is involved in the drug-drug interaction caused by cimetidine. Drug Metab Dispos 37:555-559.
20. Nozaki Y, Kusuhara H, Kondo T, Hasegawa M, Shiroyanagi Y, Nakazawa H, Okano T, and Sugiyama Y (2007) Characterization of the uptake of organic anion transporter (OAT) 1 and OAT3 substrates by human kidney slices. J Pharmacol Exp Ther 321:362-369. (Pubitemid 46456974)
21. Ogawa M, Suzuki H, Sawada Y, Hanano M, and Sugiyama Y (1994) Kinetics of active efflux via choroid plexus of β-lactam antibiotics from the CSF into the circulation. Am J Physiol 266:R392-R399.
22. Rubio-Aliaga I and Daniel H (2002) Mammalian peptide transporters as targets for drug delivery. Trends Pharmacol Sci 23:434-440. (Pubitemid 35247773)
23. Sakaeda T, Tada Y, Sugawara T, Ryu T, Hirose F, Yoshikawa T, Hirano K, Kupczyk-Subotkowska L, Siahaan TJ, Audus KL, et al. (2001) Conjugation with L-glutamate for in vivo brain drug delivery. J Drug Target 9:23-37.
24. Shitara Y, Li AP, Kato Y, Lu C, Ito K, Itoh T, and Sugiyama Y (2003) Function of uptake transporters for taurocholate and estradiol 17 β-D-glucuronide in cryopreserved human hepatocytes. Drug Metab Pharmacokinet 18:33-41.
25. Sweet DH, Wolff NA, and Pritchard JB (1997) Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. J Biol Chem 272:30088-30095. (Pubitemid 27512205)
26. Takeda M, Babu E, Narikawa S, and Endou H (2002) Interaction of human organic anion transporters with various cephalosporin antibiotics. Eur J Pharmacol 438:137-142. (Pubitemid 34241501)
27. Takeda M, Tojo A, Sekine T, Hosoyamada M, Kanai Y, and Endou H (1999) Role of organic anion transporter 1 (OAT1) in cephaloridine (CER)-induced nephrotoxicity. Kidney Int 56: 2128-2136.
28. Wilson TH and Wiseman G (1954) The use of sacs of everted small intestine for the study of the transference of substances from the mucosal to the serosal surface. J Physiol 123:116-125.
29. Wu J, Wang C, Liu Q, Yang T, Zhang Q, Peng J, Gao Y, Sun H, Kaku T, and Liu K (2008) Protective effect of JBP485 on concanavalin A-induced hepatocyte toxicity in primary cultured rat hepatocytes. Eur J Pharmacol 589:299-305.
30. Yang T, Wu J, Wang C, Liu Q, Ma X, Peng J, Kaku T, and Liu K (2009) Protective effect of JBP485 on concanavalin A-induced liver injury in mice. J Pharm Pharmacol 61:767-774.
31. Yano I, Takayama A, Takano M, Inatani M, Tanihara H, Ogura Y, Honda Y, and Inui K (1998) Pharmacokinetics and pharmacodynamics of acetazolamide in patients with transient intraocular pressure elevation. Eur J Clin Pharmacol 54:63-68.
32. Zhang Q, Liu Q, Wu J, Wang C, Peng J, Ma X, and Liu K (2009) PEPT1 involved in the uptake and transepithelial transport of cefditoren in vivo and in vitro. Eur J Pharmacol 612:9-14.