Selective toxicity of aristolochic acids I and II

Drug Metabolism and Disposition

Volumn 35, Issue 7, 2007, Pages 1217-1222

  Shibutani, Shinya ^a,d   Dong, Huan ^a   Suzuki, Naomi ^a   Ueda, Shiro ^c   Miller, Frederick ^b   Grollman, Arthur P ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c CHIBA UNIVERSITY   (Japan)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARISTOLOCHIC ACID I; ARISTOLOCHIC ACID II; ARISTOLOLACTAM; PLANT MEDICINAL PRODUCT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLADDER; C3H MOUSE; CELL DEATH; CONTROLLED STUDY; DNA ADDUCT; DRUG STRUCTURE; FIBROSING ALVEOLITIS; GENOTOXICITY; HISTOPATHOLOGY; KIDNEY CORTEX; KIDNEY MEDULLA; MALE; MOUSE; NEPHROTOXICITY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; STANDARD; TARGET ORGAN;

ANIMALS; ARISTOLOCHIC ACIDS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; DNA ADDUCTS; FIBROSIS; KIDNEY CORTEX; KIDNEY DISEASES; KIDNEY MEDULLA; MALE; MICE; MICE, INBRED C3H; MUTAGENS; PLANT PREPARATIONS; URINARY BLADDER;

MUS;

EID: 34250785643     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.014688     Document Type: Article

References (40)

1. Arlt VM, Stiborova M, and Schmeiser HH (2002) Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. Mutagenesis 17:265-277.
2. Arlt VM, Alunni-Perret V, Quatrehomme G, Ohayon P, Albano L, Gaid H, Michiels JF, Meyrier A, Cassuto E, Wiessler M, et al. (2004) Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancer. Int J Cancer 111:977-980.
3. Balachandran P, Wei F, Lin RC, Khan IA, and Pasco DS (2005) Structure activity relationships of aristolochic acid analogues; toxicity in culture renal epithelial cells. Kidney Int 67:1797-1805.
4. 32P-Post-labelling analysis of DNA adducts formed by aristolochic acid in tissues from patients with Chinese herbs nephropathy. Carcinogenesis 18:1063-1067.
5. Conger JD, Schultz MF, Miller F, and Robinette JB (1994) Responses to hemorrhagic arterial pressure reduction in different ischemic renal failure models. Kidney Int 46:318-323.
6. Cosyns JP, Jadoul M, Squifflet JP, De Plaen JF, Ferluga D, and van Ypersele de Strihou C (1994) Chinese herbs nephropathy: a clue to Balkan endemic nephropathy? Kidney Int 45:1680-1688.
7. Cosyns J-P (2003) Aristolochic acid and 'Chinese herb nephropathy': a review of the evidence to date. Drug Saf 26:33-48.
8. Cosyns JP, Dehoux JP, Guiot Y, Goebbels RM, Robert A, Bernard AM, and van Ypersele de Strihou C (2001) Chronic aristolochic acid toxicity in rabbits: a model of Chinese herbs nephropathy? Kidney Int 59:2164-2173.
9. Cosyns JP, Jadoul M, Squifflet JP, Wese FX, and van Ypersele DS (1999) Urothelial lesions in Chinese-herb nephropathy. Am J Kidney Dis 33:1011-1017.
10. Cui M, Liu ZH, Qiu Q, Li H, and Li LS (2005) Tumour induction in rats following exposure to short-term high dose aristolochic acid I. Mutagenesis 20:45-49.
11. Debelle FD, Nortier JL, De Prez EG, Garbar CH, Vienne AR, Salmon IJ, Deschodt-Lanckman MM, and Vanherweghem JL (2002) Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J Am Soc Nephrol 13:431-436.
12. Depierreux M, Van Damme B, Vanden Houte K, and Vanherweghem JL (1994) Pathologic aspects of a newly described nephropathy related to the prolonged use of Chinese herbs. Am J Kidney Dis 24:172-180.
13. 32P-postlabeling/PAGE analysis. Drug Metab Dispos 34:1122-1127.
14. 32P-postlabelling in target and non-target organs of rats treated with aristolochic acid I. IARC Sci Publ 124:167-171.
15. Groopman JD and Kensler TW (2005) The light at the end of the tunnel for chemical-specific biomarkers: daylight or headlight? Carcinogenesis 20:1-11.
16. Kohara A, Suzuki T, Honma M, Oomori T, Ohwada T, and Hayashi M (2002) Mutagenicity of aristolochic acid in the lambda1lacZ transgenic mouse (Muta™Mouse). Mutat Res 515:63-72.
17. Krumbiegel G, Hallensleben J, Mennicke WH, Rittmann N, and Roth HJ (1987) Studies on the metabolism of aristolochic acids I and II. Xenobiotica 17:981-991.
18. Kumar V, Poonam, Prasad AK, and Parmar VS (2003) Naturally occurring aristolactams, aristolochic acids and dioxoaporphines and their biological activities. Nat Prod Rep 20:565-583.
19. Li Y, Liu Z, Guo X, Shu J, Chen Z, and Li L (2006) Aristolochic acid I-induced DNA damage and cell cycle arrest in renal tubular epithelial cells in vitro. Arch Toxicol 80:524-532.
20. Lord GM, Hollstein M, Arlt VM, Roufosse C, Pusey CD, Cook T, and Schmeiser HH (2004) DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy. Am J Kidney Dis 43:e11-e17.
21. Mei N, Arlt VM, Phillips DH, Heflich RH, and Chen T (2006) DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver. Mutat Res 602:83-91.
22. Mengs U (1983) On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Arch Toxicol 52:209-220.
23. Mengs U (1988) Tumour induction in mice following exposure to aristolochic acid. Arch Toxicol 61:504-505.
24. Mengs U and Stotzem CD (1993) Renal toxicity of aristolochic acid in rats as an example of nephrotoxicity testing in routine toxicology. Arch Toxicol 67:307-311.
25. Nortier JL, Martinez MC, Schmeiser HH, Arlt VM, Bieler CA, Petein M, Depierreux MF, De Pauw L, Abramowicz D, Vereerstraeten P, et al. (2000) Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). N Engl J Med 342:1686-1692.
26. Nortier JL and Vanherweghem JL (2002) Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). Toxicology 181-182:577-580.
27. Pfau W, Schmeiser HH, and Wiessler M (1990a) Aristolochic acid binds covalently to the exo-cyclic amino group of purine nucleotides in DNA. Carcinogenesis 11:313-319.
28. 32P-Postlabelling analysis of the DNA adducts formed by aristolochic acid I and II. Carcinogenesis 11:1627-1633.
29. 6-adenyl arylation of DNA by aristolochic acid II and a synthetic model for the putative proximate carcinogen. Chem Res Toxicol 4:581-586.
30. Sato N, Takahashi D, Chen SM, Tsuchiya R, Mukoyama T, Yamagata S, Ogawa M, Yoshida M, Kondo S, Satoh N, et al. (2004) Acute nephrotoxicity of aristolochic acids in mice. J Pharm Pharmacol 56:221-229.
31. Schmeiser HH, Pool BL, and Wiessler M (1986) Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver. Carcinogenesis 7:59-63.
32. Schmeiser HH, Schoepe KB, and Wiessler M (1988) DNA adduct formation of aristolochic acid I and II in vitro and in vivo. Carcinogenesis 9:297-303.
33. Schmeiser HH, Scherf HR, and Wiessler M (1991) Activating mutations at codon 61 of the c-Ha-ras gene in thin-tissue sections of tumors induced by aristolochic acid in rats and mice. Cancer Lett 59:139-143.
34. Schmeiser HH, Bieler CA, Wiessler M, van Ypersele de Strihou C, and Cosyns JP (1996) Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy. Cancer Res 56:2025-2028.
35. Stiborová M, Frei E, Sopko B, Wiessler M, and Schmeiser HH (2002): Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy. Carcinogenesis 23:617-625.
36. Stiborová M, Frei E, Hodek P, Wiessler M, and Schmeiser HH (2005) Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer. Int J Cancer 113:189-197.
37. Stiborová M, Hajek M, Frei E, and Schmeiser HH (2001) Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by NADPH:cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy. Gen Physiol Biophys 20:375-392.
38. 32P- Postlabeling/polyacrylamide gel electrophoresis analysis: application to the detection of DNA adducts. Chem Res Toxicol 15:305-311.
39. Vanherweghem JL, Depierreux M, Teilmans C, Abramowicz D, Dratwa M, Jadoul M, Richard C, Vandervelde D, Verbeelen D, and Vanhaelen-Fastre R (1993) Rapidly progressive interstitial renal fibrosis in young women; association with slimming regimen including Chinese herbs. Lancet 341:387-391.
40. Wen Y-J, Su T, Tang J-W, Zhang CY, Wang X, Cai SQ, and Li XM (2006) Cytotoxicity of phenanthrenes extracted from Aristolochia contorta in human proximal tubular cell line. Nephron Exp Nephrol 103:e95-e102.