Organic anion transporter 1 (OAT1) involved in renal cell transport of aristolochic acid i

Human and Experimental Toxicology

Volumn 31, Issue 8, 2012, Pages 759-770

  Zeng, Y ^a   Zhang, R ^a   Wu, J ^a   Liu, M ^a   Peng, W ^a   Yu, X ^a   Yang, X ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

aristolochic acids; basolateral membrane; HEK293 cells; para aminohippuric acid; rat organic anion transporter 1

Indexed keywords

4 AMINOHIPPURIC ACID; ARISTOLOCHIC ACID; ARISTOLOCHIC ACID 1; ORGANIC ANION TRANSPORTER 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASOLATERAL MEMBRANE; BIOACCUMULATION; CELL DEATH; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO CELL; FLOW CYTOMETRY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; KIDNEY CELL; KIDNEY CLEARANCE; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ANIMALS; ARISTOLOCHIC ACIDS; BIOLOGICAL TRANSPORT; HEK293 CELLS; HUMANS; KIDNEY; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; RATS; RATS, WISTAR;

EID: 84865269067     PISSN: 09603271     EISSN: 14770903     Source Type: Journal    
DOI: 10.1177/0960327111424302     Document Type: Article

References (38)

1. Rizwan AN, Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm Res. 2007 ; 24: 450-470
2. Launay-Vacher V, Izzedine H, Karie S, Hulot JS, Baumelou A, Deray G. Renal tubular drug transporters. Nephron Physiol. 2006 ; 103: 97-106
3. Inui KI, Masuda S, Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int. 2000 ; 58: 944-958
4. Dantzler WH. Renal organic anion transport: a comparative and cellular perspective. Biochim Biophys Acta. 2002 ; 1566: 169-181
5. Anzai N, Kanai Y, Endou H. Organic anion transporter family: current knowledge. J Pharmacol Sci. 2006 ; 100: 411-426
6. Lee W, Kim RB. Transporters and renal drug elimination. Annu Rev Pharmacol Toxicol. 2004 ; 44: 137-166
7. Matsumoto S, Yoshida K, Ishiguro N, Maeda T, Tamai I. Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride]. J Pharmacol Exp Ther. 2007 ; 322: 1246-1252
8. Miyazaki H, Sekine T, Endou H. The multispecific organic anion transporter family: properties and pharmacological significance. Trends Pharmacol Sci. 2004 ; 25: 654-662
9. Sweet DH, Bush KT, Nigam SK. The organic anion transporter family: from physiology to ontogeny and the clinic. Am J Physiol Renal Physiol. 2001 ; 281: F197 - F205
10. Sekine T, Miyazaki H, Endou H. Molecular physiology of renal organic anion transporters. Am J Physiol Renal Physiol. 2006 ; 290: F251 - F261
11. Villar SR, Brandoni A, Anzai N, Endou H, Torres AM. Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction. Kidney Int. 2005 ; 68: 2704-2713
12. Hosoyamada M, Sekine T, Kanai Y, Endou H. Molecular cloning and functional expression of a multispecific organic anion transporter from human kidney. Am J Physiol. 1999 ; 276: F122 - F128
13. Di Giusto G, Anzai N, Ruiz ML, Endou H, Torres AM. Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride. Arch Toxicol. 2009 ; 83: 887-897
14. Zlender V, Zlender V, Breljak D, Ljubojevi M, Flajs D, Balen D, et al. Low doses of ochratoxin A upregulate the protein expression of organic anion transporters Oat1, Oat2, Oat3 and Oat5 in rat kidney cortex. Toxicol Appl Pharmacol. 2009 ; 239: 284-296
15. Ioset JR, Raoelison GE, Hostettmann K. Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens. Food Chem Toxicol. 2003 ; 41: 29-36
16. Vanherweghem JL, Depierreux M, Tielemans C, Abramowicz D, Dratwa M, Jadoul M.. Rapidly progressive interstitial renal fibrosis in young women: association with slimming regimen including Chinese herbs. Lancet. 1993 ; 341: 387-391
17. Zhu YP. Toxicity of the Chinese herb mu tong (Aristolochia manshuriensis). What history tells us. Adverse Drug React Toxicol Rev. 2002 ; 21: 171-177
18. Abt AB, Oh JY, Huntington RA, Burkhart KK. Chinese herbal medicine induced acute renal failure. Arch Intern Med. 1995 ; 155: 211-212
19. Nortier JL, Vanherweghem JL. Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi). Toxicology. 2002 ; 181-182: 577-580
20. Chen SM, Fan MY, Tseng CC, Ho Y, Hsu KY. Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits. Toxicon. 2007 ; 50: 180-188
21. Nortier JL, Vanherweghem JL. For patients taking herbal therapy-lessons from aristolochic acid nephropathy. Nephrol Dial Transplant. 2007 ; 22: 1512-1517
22. Bakhiya N, Arlt VM, Bahn A, Burckhardt G, Phillips DH, Glatt H. Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy. Toxicology. 2009 ; 264: 74-79
23. Enomoto A, Takeda M, Tojo A, Sekine T, Cha SH, Khamdang S, et al. Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J Am Soc Nephrol. 2002 ; 13: 1711-1720
24. Yeh YH, Lee YT, Hsieh HS, Hwang DF, et al. Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats. Food Chem Toxicol. 2008 ; 46: 1157-1163
25. Ladwig PM, Bergert JH, Larson TS. Capillary electrophoresis method to measure p-aminohippuric acid in urine and plasma for the assessment of renal plasma flow. Clin Chem. 2003 ; 49: 664-666
26. Yuan J, Liu Q, Zhu W, Ding L, Tang F, Yao S. Simultaneous analysis of six aristolochic acids and five aristolactams in herbal plants and their preparations by high-performance liquid chromatography-diode array detection-fluorescence detection. J Chromatogr A. 2008 ; 1182: 85-92
27. Debelle FD, Nortier JL, De Prez EG, Garbar CH, Vienne AR, Salmon IJ, et al. Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J Am Soc Nephrol. 2002 ; 13: 431-436
28. He Z, Lu L, Altmann C, Hoke TS, Ljubanovic D, Jani A, et al. Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury. Am J Physiol Renal Physiol. 2008 ; 295: F1414 - F1421
29. Villar SR, Villar SR, Brandoni A, Quaglia NB, Torres AM, et al. Renal elimination of organic anions in rats with bilateral ureteral obstruction. Biochim Biophys Acta. 2004 ; 1688: 204-209
30. Jensen RE, Berndt WO. Epinephrine and norepinephrine enhance p-aminohippurate transport into basolateral membrane vesicles. J Pharmacol Exp Ther. 1988 ; 244: 543-549
31. Burckhardt G. Bahn Andrew, Bakhiya Nadiya, Wolff Natascha A.. Physiology and pathophysiology of renal organic anion transporters OAT1 and OAT3. Nova Acta Leopoldina. 2004 ; 89: 131-137
32. Yang L, Li X, Wang H. Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis. Nephrol Dial Transplant. 2007 ; 22: 445-456
33. Pozdzik AA, Salmon IJ, Debelle FD, Decaestecker C, Van den Branden C, Verbeelen D, et al. Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation. Kidney Int. 2008 ; 73: 595-607
34. Wang W, Zhang J. Protective effect of erythropoietin against aristolochic acid-induced apoptosis in renal tubular epithelial cells. Eur J Pharmacol. 2008 ; 588: 135-140
35. Kwon O, Wang WW, Miller S. Renal organic anion transporter 1 is maldistributed and diminishes in proximal tubule cells but increases in vasculature after ischemia and reperfusion. Am J Physiol Renal Physiol. 2008 ; 295: F1807 - F1816
36. Zhang R, Yang X, Li J, Wu J, Peng WX, Dong XQ, et al. Upregulation of rat renal cortical organic anion transporter (OAT1 and OAT3) expression in response to ischemia/reperfusion injury. Am J Nephrol. 2008 ; 28: 772-783
37. Tanigawara Y, Saito Y, Aiba T, Ohoka K, Kamiya A, Hori R. Moment analysis of drug disposition in kidney. III: Transport of p-aminohippurate and tetraethylammonium in the perfused kidney isolated from uranyl nitrate-induced acute renal failure rats. J Pharm Sci. 1990 ; 79: 249-256
38. Matsuzaki T, Morisaki T, Sugimoto W, Yokoo K, Sato D, Nonoguchi H, et al. Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat multidrug and toxin extrusion 1 (Slc47a1) in ischemia/reperfusion-induced acute kidney injury. Drug Metab Dispos. 2008 ; 36: 649-654