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Volumn 108, Issue 9, 2012, Pages 1532-1549

Molecular mechanisms of the cardiovascular protective effects of polyphenols

Author keywords

Antioxidants; Cardiovascular system; Endothelium; Free radicals; Nitric oxide; Polyphenols

Indexed keywords

CYCLOOXYGENASE 1; DELPHINIDIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTROGEN RECEPTOR ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NITRIC OXIDE; POLYPHENOL; QUERCETIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RESVERATROL; SIRTUIN 1;

EID: 84870054444     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512003406     Document Type: Review
Times cited : (168)

References (196)
  • 1
    • 79960490509 scopus 로고    scopus 로고
    • Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases
    • Chuang CC & McIntosh MK (2011) Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. Annu Rev Nutr 31, 155-176.
    • (2011) Annu Rev Nutr , vol.31 , pp. 155-176
    • Chuang, C.C.1    McIntosh, M.K.2
  • 2
    • 0033637140 scopus 로고    scopus 로고
    • The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer
    • Middleton EJ, Kandaswami C & Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol Rev 52, 673-751.
    • (2000) Pharmacol Rev , vol.52 , pp. 673-751
    • Middleton, E.J.1    Kandaswami, C.2    Theoharides, T.C.3
  • 3
    • 0016906546 scopus 로고
    • The flavonoids. A class of semi-essential food components: Their role in human nutrition
    • Kuhnau J (1976) The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 24, 117-191.
    • (1976) World Rev Nutr Diet , vol.24 , pp. 117-191
    • Kuhnau, J.1
  • 4
    • 0027291905 scopus 로고
    • Intake of potentially anticarcinogenic flavonoids and their determinants in adults in the Netherlands
    • Hertog MG, Hollman PC, Katan MB, et al. (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 20, 21-29.
    • (1993) Nutr Cancer , vol.20 , pp. 21-29
    • Hertog, M.G.1    Hollman, P.C.2    Katan, M.B.3
  • 5
    • 34447263552 scopus 로고    scopus 로고
    • Dietary intakes of flavonols and flavones and coronary heart disease in US women
    • Lin J, Rexrode KM, Hu F, et al. (2007) Dietary intakes of flavonols and flavones and coronary heart disease in US women. Am J Epidemiol 165, 1305-1313.
    • (2007) Am J Epidemiol , vol.165 , pp. 1305-1313
    • Lin, J.1    Rexrode, K.M.2    Hu, F.3
  • 6
    • 33745512076 scopus 로고    scopus 로고
    • Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption
    • Wu X, Beecher GR, Holden JM, et al. (2006) Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54, 4069-4075.
    • (2006) J Agric Food Chem , vol.54 , pp. 4069-4075
    • Wu, X.1    Beecher, G.R.2    Holden, J.M.3
  • 7
    • 2442430353 scopus 로고    scopus 로고
    • Polyphenols: Food sources and bioavailability
    • Manach C, Scalbert A, Morand C, et al. (2004) Polyphenols: food sources and bioavailability. Am J Clin Nutr 79, 727-747.
    • (2004) Am J Clin Nutr , vol.79 , pp. 727-747
    • Manach, C.1    Scalbert, A.2    Morand, C.3
  • 8
    • 9444296057 scopus 로고    scopus 로고
    • High absorption but very low bioavailability of oral resveratrol in humans
    • Walle T, Hsieh F, DeLegge MH, et al. (2004) High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32, 1377-1382.
    • (2004) Drug Metab Dispos , vol.32 , pp. 1377-1382
    • Walle, T.1    Hsieh, F.2    Delegge, M.H.3
  • 9
    • 77955285843 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the activation of eNOS
    • Fleming I (2010) Molecular mechanisms underlying the activation of eNOS. Pflugers Arch 459, 793-806.
    • (2010) Pflugers Arch , vol.459 , pp. 793-806
    • Fleming, I.1
  • 11
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: Role in cardiovascular biology and disease
    • Griendling KK, Sorescu D & Ushio-Fukai M (2000) NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86, 494-501.
    • (2000) Circ Res , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 12
    • 0142055950 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular injury: Part I: Basic mechanisms and in vivo monitoring of ROS
    • Griendling KK & FitzGerald GA (2003) Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation 108, 1912-1916.
    • (2003) Circulation , vol.108 , pp. 1912-1916
    • Griendling, K.K.1    Fitzgerald, G.A.2
  • 13
    • 0242349764 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascular injury: Part II: Animal and human studies
    • Griendling KK & FitzGerald GA (2003) Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation 108, 2034-2040.
    • (2003) Circulation , vol.108 , pp. 2034-2040
    • Griendling, K.K.1    Fitzgerald, G.A.2
  • 14
    • 77952889280 scopus 로고    scopus 로고
    • Human endothelial dysfunction: EDCFs
    • Virdis A, Ghiadoni L & Taddei S (2010) Human endothelial dysfunction: EDCFs. Pflugers Arch 459, 1015-1023.
    • (2010) Pflugers Arch , vol.459 , pp. 1015-1023
    • Virdis, A.1    Ghiadoni, L.2    Taddei, S.3
  • 15
    • 52649094446 scopus 로고    scopus 로고
    • Adherence to Mediterranean diet and health status: Meta-analysis
    • Sofi F, Cesari F, Abbate R, et al. (2008) Adherence to Mediterranean diet and health status: meta-analysis. BMJ 337, a1344.
    • (2008) BMJ , vol.337
    • Sofi, F.1    Cesari, F.2    Abbate, R.3
  • 16
    • 0026651085 scopus 로고
    • Wine, alcohol, platelets, and the French paradox for coronary heart disease
    • Renaud S & de Lorgeril M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523-1526.
    • (1992) Lancet , vol.339 , pp. 1523-1526
    • Renaud, S.1    De Lorgeril, M.2
  • 17
    • 77953673295 scopus 로고    scopus 로고
    • Berries: Emerging impact on cardiovascular health
    • Basu A, Rhone M & Lyons TJ (2010) Berries: emerging impact on cardiovascular health. Nutr Rev 68, 168-177.
    • (2010) Nutr Rev , vol.68 , pp. 168-177
    • Basu, A.1    Rhone, M.2    Lyons, T.J.3
  • 18
    • 0027319292 scopus 로고
    • Endothelium-dependent vasorelaxing activity of wine and other grape products
    • Fitzpatrick DF, Hirschfield SL & Coffey RG (1993) Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 265, H774-H778.
    • (1993) Am J Physiol , vol.265
    • Fitzpatrick, D.F.1    Hirschfield, S.L.2    Coffey, R.G.3
  • 19
    • 77955293389 scopus 로고    scopus 로고
    • Nutritional improvement of the endothelial control of vascular tone by polyphenols: Role of NO and EDHF
    • Schini-Kerth VB, Auger C, Kim JH, et al. (2010) Nutritional improvement of the endothelial control of vascular tone by polyphenols: role of NO and EDHF. Pflugers Arch 459, 853-862.
    • (2010) Pflugers Arch , vol.459 , pp. 853-862
    • Schini-Kerth, V.B.1    Auger, C.2    Kim, J.H.3
  • 20
    • 0030946696 scopus 로고    scopus 로고
    • Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta
    • Andriambeloson E, Kleschyov AL, Muller B, et al. (1997) Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Br J Pharmacol 120, 1053-1058.
    • (1997) Br J Pharmacol , vol.120 , pp. 1053-1058
    • Andriambeloson, E.1    Kleschyov, A.L.2    Muller, B.3
  • 21
    • 14644442257 scopus 로고    scopus 로고
    • Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery
    • Ndiaye M, Chataigneau M, Lobysheva I, et al. (2005) Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J 19, 455-457.
    • (2005) FASEB J , vol.19 , pp. 455-457
    • Ndiaye, M.1    Chataigneau, M.2    Lobysheva, I.3
  • 22
    • 0031751271 scopus 로고    scopus 로고
    • The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers
    • Duthie GG, Pedersen MW, Gardner PT, et al. (1998) The effect of whisky and wine consumption on total phenol content and antioxidant capacity of plasma from healthy volunteers. Eur J Clin Nutr 52, 733-736.
    • (1998) Eur J Clin Nutr , vol.52 , pp. 733-736
    • Duthie, G.G.1    Pedersen, M.W.2    Gardner, P.T.3
  • 23
    • 11244350975 scopus 로고    scopus 로고
    • Wine polyphenols stimulate superoxide anion production to promote calcium signaling and endothelial-dependent vasodilatation
    • Duarte J, Andriambeloson E, Diebolt M, et al. (2004) Wine polyphenols stimulate superoxide anion production to promote calcium signaling and endothelial-dependent vasodilatation. Physiol Res 53, 595-602.
    • (2004) Physiol Res , vol.53 , pp. 595-602
    • Duarte, J.1    Andriambeloson, E.2    Diebolt, M.3
  • 24
    • 58249126876 scopus 로고    scopus 로고
    • ENOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries
    • Madeira SV, Auger C, Anselm E, et al. (2009) eNOS activation induced by a polyphenol-rich grape skin extract in porcine coronary arteries. J Vasc Res 46, 406-416.
    • (2009) J Vasc Res , vol.46 , pp. 406-416
    • Madeira, S.V.1    Auger, C.2    Anselm, E.3
  • 25
    • 33845597319 scopus 로고    scopus 로고
    • Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src-and Akt-dependent activation of eNOS
    • Anselm E, Chataigneau M, Ndiaye M, et al. (2007) Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src-and Akt-dependent activation of eNOS. Cardiovasc Res 73, 404-413.
    • (2007) Cardiovasc Res , vol.73 , pp. 404-413
    • Anselm, E.1    Chataigneau, M.2    Ndiaye, M.3
  • 26
    • 77649123355 scopus 로고    scopus 로고
    • Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium
    • Chalopin M, Tesse A, Martinez MC, et al. (2010) Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium. PLoS One 5, e8554.
    • (2010) PLoS One , vol.5
    • Chalopin, M.1    Tesse, A.2    Martinez, M.C.3
  • 27
    • 23944432590 scopus 로고    scopus 로고
    • Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats
    • Peng N, Clark JT, Prasain J, et al. (2005) Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 289, R771-R775.
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.289
    • Peng, N.1    Clark, J.T.2    Prasain, J.3
  • 28
    • 21444437840 scopus 로고    scopus 로고
    • Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta
    • Machha A & Mustafa MR (2005) Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. J Cardiovasc Pharmacol 46, 36-40.
    • (2005) J Cardiovasc Pharmacol , vol.46 , pp. 36-40
    • MacHha, A.1    Mustafa, M.R.2
  • 29
    • 34250869653 scopus 로고    scopus 로고
    • Polyphenols restore endothelial function in DOCA-salt hypertension: Role of endothelin-1 and NADPH oxidase
    • Jimenez R, Lopez-Sepulveda R, Kadmiri M, et al. (2007) Polyphenols restore endothelial function in DOCA-salt hypertension: role of endothelin-1 and NADPH oxidase. Free Radic Biol Med 43, 462-473.
    • (2007) Free Radic Biol Med , vol.43 , pp. 462-473
    • Jimenez, R.1    Lopez-Sepulveda, R.2    Kadmiri, M.3
  • 30
    • 4344708332 scopus 로고    scopus 로고
    • Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine
    • de Moura RS, Miranda DZ, Pinto AC, et al. (2004) Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine. J Cardiovasc Pharmacol 44, 302-309.
    • (2004) J Cardiovasc Pharmacol , vol.44 , pp. 302-309
    • De Moura, R.S.1    Miranda, D.Z.2    Pinto, A.C.3
  • 31
    • 33845197949 scopus 로고    scopus 로고
    • Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase
    • Sarr M, Chataigneau M, Martins S, et al. (2006) Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc Res 71, 794-802.
    • (2006) Cardiovasc Res , vol.71 , pp. 794-802
    • Sarr, M.1    Chataigneau, M.2    Martins, S.3
  • 32
    • 0038150829 scopus 로고    scopus 로고
    • Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease
    • Harrison DG, Cai H, Landmesser U, et al. (2003) Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease. J Renin Angiotensin Aldosterone Syst 4, 51-61.
    • (2003) J Renin Angiotensin Aldosterone Syst , vol.4 , pp. 51-61
    • Harrison, D.G.1    Cai, H.2    Landmesser, U.3
  • 33
    • 46249095235 scopus 로고    scopus 로고
    • SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells
    • Miyazaki R, Ichiki T, Hashimoto T, et al. (2008) SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 28, 1263-1269.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1263-1269
    • Miyazaki, R.1    Ichiki, T.2    Hashimoto, T.3
  • 34
    • 37549011857 scopus 로고    scopus 로고
    • Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase
    • Steffen Y, Gruber C, Schewe T, et al. (2008) Mono-O-methylated flavanols and other flavonoids as inhibitors of endothelial NADPH oxidase. Arch Biochem Biophys 469, 209-219.
    • (2008) Arch Biochem Biophys , vol.469 , pp. 209-219
    • Steffen, Y.1    Gruber, C.2    Schewe, T.3
  • 35
    • 77950929066 scopus 로고    scopus 로고
    • Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: Preventive effect of red wine polyphenols
    • Kane MO, Etienne-Selloum N, Madeira SV, et al. (2010) Endothelium-derived contracting factors mediate the Ang II-induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols. Pflugers Arch 459, 671-679.
    • (2010) Pflugers Arch , vol.459 , pp. 671-679
    • Kane, M.O.1    Etienne-Selloum, N.2    Madeira, S.V.3
  • 36
    • 0033987705 scopus 로고    scopus 로고
    • Does a glass of red wine improve endothelial function?
    • Agewall S, Wright S, Doughty RN, et al. (2000) Does a glass of red wine improve endothelial function? Eur Heart J 21, 74-78.
    • (2000) Eur Heart J , vol.21 , pp. 74-78
    • Agewall, S.1    Wright, S.2    Doughty, R.N.3
  • 37
    • 2942516022 scopus 로고    scopus 로고
    • Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults
    • Engler MB, Engler MM, Chen CY, et al. (2004) Flavonoid-rich dark chocolate improves endothelial function and increases plasma epicatechin concentrations in healthy adults. J Am Coll Nutr 23, 197-204.
    • (2004) J Am Coll Nutr , vol.23 , pp. 197-204
    • Engler, M.B.1    Engler, M.M.2    Chen, C.Y.3
  • 38
    • 0035717941 scopus 로고    scopus 로고
    • Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease
    • Duffy SJ, Vita JA, Holbrook M, et al. (2001) Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arterioscler Thromb Vasc Biol 21, 1084-1089.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1084-1089
    • Duffy, S.J.1    Vita, J.A.2    Holbrook, M.3
  • 39
    • 34250362750 scopus 로고    scopus 로고
    • Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease
    • Widlansky ME, Hamburg NM, Anter E, et al. (2007) Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr 26, 95-102.
    • (2007) J Am Coll Nutr , vol.26 , pp. 95-102
    • Widlansky, M.E.1    Hamburg, N.M.2    Anter, E.3
  • 40
    • 33644878762 scopus 로고    scopus 로고
    • Polypheno-lic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease
    • Lekakis J, Rallidis LS, Andreadou I, et al. (2005) Polypheno-lic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil 12, 596-600.
    • (2005) Eur J Cardiovasc Prev Rehabil , vol.12 , pp. 596-600
    • Lekakis, J.1    Rallidis, L.S.2    Andreadou, I.3
  • 41
    • 34347404130 scopus 로고    scopus 로고
    • Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: A randomized controlled trial
    • Taubert D, Roesen R, Lehmann C, et al. (2007) Effects of low habitual cocoa intake on blood pressure and bioactive nitric oxide: a randomized controlled trial. JAMA 298, 49-60.
    • (2007) JAMA , vol.298 , pp. 49-60
    • Taubert, D.1    Roesen, R.2    Lehmann, C.3
  • 42
    • 16244423306 scopus 로고    scopus 로고
    • Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: Double-blind, placebo controlled intervention trial
    • Park YK, Kim JS & Kang MH (2004) Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: double-blind, placebo controlled intervention trial. Biofactors 22, 145-147.
    • (2004) Biofactors , vol.22 , pp. 145-147
    • Park, Y.K.1    Kim, J.S.2    Kang, M.H.3
  • 43
    • 0034907584 scopus 로고    scopus 로고
    • Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure
    • Aviram M & Dornfeld L (2001) Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158, 195-198.
    • (2001) Atherosclerosis , vol.158 , pp. 195-198
    • Aviram, M.1    Dornfeld, L.2
  • 44
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA & Sinclair DA (2006) Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5, 493-506.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 45
  • 46
    • 77649198149 scopus 로고    scopus 로고
    • Resveratrol: A multifunctional compound improving endothelial function. Editorial to: "resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats" by S. Soylemez et al
    • Li H & Forstermann U (2009) Resveratrol: a multifunctional compound improving endothelial function. Editorial to: "Resveratrol supplementation gender independently improves endothelial reactivity and suppresses superoxide production in healthy rats" by S. Soylemez et al. Cardiovasc Drugs Ther 23, 425-429.
    • (2009) Cardiovasc Drugs Ther , vol.23 , pp. 425-429
    • Li, H.1    Forstermann, U.2
  • 47
    • 84862777886 scopus 로고    scopus 로고
    • Cardiovascular effects and molecular targets of resveratrol
    • Li H, Xia N & Forstermann U (2012) Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide 26, 102-110.
    • (2012) Nitric Oxide , vol.26 , pp. 102-110
    • Li, H.1    Xia, N.2    Forstermann, U.3
  • 48
    • 1942484416 scopus 로고    scopus 로고
    • Potent induction of cellular anti-oxidants and phase 2 enzymes by resveratrol in cardiomyo-cytes: Protection against oxidative and electrophilic injury
    • Cao Z & Li Y (2004) Potent induction of cellular anti-oxidants and phase 2 enzymes by resveratrol in cardiomyo-cytes: protection against oxidative and electrophilic injury. Eur J Pharmacol 489, 39-48.
    • (2004) Eur J Pharmacol , vol.489 , pp. 39-48
    • Cao, Z.1    Li, Y.2
  • 49
    • 27744488160 scopus 로고    scopus 로고
    • Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress
    • Li Y, Cao Z & Zhu H (2006) Upregulation of endogenous antioxidants and phase 2 enzymes by the red wine polyphenol, resveratrol in cultured aortic smooth muscle cells leads to cytoprotection against oxidative and electrophilic stress. Pharmacol Res 53, 6-15.
    • (2006) Pharmacol Res , vol.53 , pp. 6-15
    • Li, Y.1    Cao, Z.2    Zhu, H.3
  • 50
  • 51
    • 77950901103 scopus 로고    scopus 로고
    • Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure
    • Tanno M, Kuno A, Yano T, et al. (2010) Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem 285, 8375-8382.
    • (2010) J Biol Chem , vol.285 , pp. 8375-8382
    • Tanno, M.1    Kuno, A.2    Yano, T.3
  • 52
    • 77957220423 scopus 로고    scopus 로고
    • Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein e knockout mice
    • Xia N, Daiber A, Habermeier A, et al. (2010) Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 335, 149-154.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 149-154
    • Xia, N.1    Daiber, A.2    Habermeier, A.3
  • 53
    • 77950469163 scopus 로고    scopus 로고
    • Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4)
    • Spanier G, Xu H, Xia N, et al. (2009) Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol 60, Suppl. 4, 111-116.
    • (2009) J Physiol Pharmacol , vol.60 , Issue.SUPPL. 4 , pp. 111-116
    • Spanier, G.1    Xu, H.2    Xia, N.3
  • 54
    • 77953734595 scopus 로고    scopus 로고
    • Endothelial Nrf2 activation: A new target for resveratrol?
    • Hasko G & Pacher P (2010) Endothelial Nrf2 activation: a new target for resveratrol? Am J Physiol Heart Circ Physiol 299, H10-H12.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Hasko, G.1    Pacher, P.2
  • 55
    • 77953741269 scopus 로고    scopus 로고
    • Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
    • Ungvari Z, Bagi Z, Feher A, et al. (2010) Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol 299, H18-H24.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299
    • Ungvari, Z.1    Bagi, Z.2    Feher, A.3
  • 56
    • 34547101726 scopus 로고    scopus 로고
    • Resveratrol alleviates cardiac dysfunction in strepto-zotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase
    • Thirunavukkarasu M, Penumathsa SV, Koneru S, et al. (2007) Resveratrol alleviates cardiac dysfunction in strepto-zotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med 43, 720-729.
    • (2007) Free Radic Biol Med , vol.43 , pp. 720-729
    • Thirunavukkarasu, M.1    Penumathsa, S.V.2    Koneru, S.3
  • 57
    • 11144338749 scopus 로고    scopus 로고
    • Vascular NADPH oxidases: Molecular mechanisms of activation
    • Brandes RP & Kreuzer J (2005) Vascular NADPH oxidases: molecular mechanisms of activation. Cardiovasc Res 65, 16-27.
    • (2005) Cardiovasc Res , vol.65 , pp. 16-27
    • Brandes, R.P.1    Kreuzer, J.2
  • 58
    • 1942468123 scopus 로고    scopus 로고
    • Novel NAD(P)H oxidases in the cardiovascular system
    • Griendling KK (2004) Novel NAD(P)H oxidases in the cardiovascular system. Heart 90, 491-493.
    • (2004) Heart , vol.90 , pp. 491-493
    • Griendling, K.K.1
  • 59
    • 68149150584 scopus 로고    scopus 로고
    • Resveratrol improves endothelial function: Role of TNF{alpha} and vascular oxidative stress
    • Zhang H, Zhang J, Ungvari Z, et al. (2009) Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol 29, 1164-1171.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1164-1171
    • Zhang, H.1    Zhang, J.2    Ungvari, Z.3
  • 60
    • 41149140205 scopus 로고    scopus 로고
    • Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells
    • Xu H, Goettsch C, Xia N, et al. (2008) Differential roles of PKCalpha and PKCepsilon in controlling the gene expression of Nox4 in human endothelial cells. Free Radic Biol Med 44, 1656-1667.
    • (2008) Free Radic Biol Med , vol.44 , pp. 1656-1667
    • Xu, H.1    Goettsch, C.2    Xia, N.3
  • 61
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann U & Munzel T (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113, 1708-1714.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 62
    • 70449431340 scopus 로고    scopus 로고
    • Prevention of atherosclerosis by interference with the vascular nitric oxide system
    • Li H & Forstermann U (2009) Prevention of atherosclerosis by interference with the vascular nitric oxide system. Curr Pharm Des 15, 3133-3145.
    • (2009) Curr Pharm des , vol.15 , pp. 3133-3145
    • Li, H.1    Forstermann, U.2
  • 63
    • 1542344000 scopus 로고    scopus 로고
    • Increased endo-thelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase i overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice
    • Alp NJ, McAteer MA, Khoo J, et al. (2004) Increased endo-thelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 24, 445-450.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 445-450
    • Alp, N.J.1    McAteer, M.A.2    Khoo, J.3
  • 64
    • 42449083767 scopus 로고    scopus 로고
    • Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling
    • Wohlfart P, Xu H, Endlich A, et al. (2008) Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (eNOS) expression and preventing eNOS uncoupling. J Pharmacol Exp Ther 325, 370-379.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 370-379
    • Wohlfart, P.1    Xu, H.2    Endlich, A.3
  • 65
    • 33646401101 scopus 로고    scopus 로고
    • Acute responses to phytoestrogens in small arteries from men with coronary heart disease
    • Cruz MN, Luksha L, Logman H, et al. (2006) Acute responses to phytoestrogens in small arteries from men with coronary heart disease. Am J Physiol Heart Circ Physiol 290, H1969-H1975.
    • (2006) Am J Physiol Heart Circ Physiol , vol.290
    • Cruz, M.N.1    Luksha, L.2    Logman, H.3
  • 66
    • 77953050012 scopus 로고    scopus 로고
    • Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health
    • Nicholson SK, Tucker GA & Brameld JM (2010) Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. Br J Nutr 103, 1398-1403.
    • (2010) Br J Nutr , vol.103 , pp. 1398-1403
    • Nicholson, S.K.1    Tucker, G.A.2    Brameld, J.M.3
  • 67
    • 69949116426 scopus 로고    scopus 로고
    • Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro
    • Appeldoorn MM, Venema DP, Peters TH, et al. (2009) Some phenolic compounds increase the nitric oxide level in endothelial cells in vitro. J Agric Food Chem 57, 7693-7699.
    • (2009) J Agric Food Chem , vol.57 , pp. 7693-7699
    • Appeldoorn, M.M.1    Venema, D.P.2    Peters, T.H.3
  • 68
    • 46749116365 scopus 로고    scopus 로고
    • Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells
    • Klinge CM, Wickramasinghe NS, Ivanova MM, et al. (2008) Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells. FASEB J 22, 2185-2197.
    • (2008) FASEB J , vol.22 , pp. 2185-2197
    • Klinge, C.M.1    Wickramasinghe, N.S.2    Ivanova, M.M.3
  • 69
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    • Pearson KJ, Baur JA, Lewis KN, et al. (2008) Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 8, 157-168.
    • (2008) Cell Metab , vol.8 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3
  • 70
    • 33750689471 scopus 로고    scopus 로고
    • Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development
    • Murad F (2006) Shattuck Lecture. Nitric oxide and cyclic GMP in cell signaling and drug development. N Engl J Med 355, 2003-2011.
    • (2006) N Engl J Med , vol.355 , pp. 2003-2011
    • Murad, F.1
  • 71
    • 52949145570 scopus 로고    scopus 로고
    • A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol
    • Gojkovic-Bukarica L, Novakovic A, Kanjuh V, et al. (2008) A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. J Pharmacol Sci 108, 124-130.
    • (2008) J Pharmacol Sci , vol.108 , pp. 124-130
    • Gojkovic-Bukarica, L.1    Novakovic, A.2    Kanjuh, V.3
  • 72
    • 0035695652 scopus 로고    scopus 로고
    • Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells
    • Ruef J, Moser M, Kubler W, et al. (2001) Induction of endothelin-1 expression by oxidative stress in vascular smooth muscle cells. Cardiovasc Pathol 10, 311-315.
    • (2001) Cardiovasc Pathol , vol.10 , pp. 311-315
    • Ruef, J.1    Moser, M.2    Kubler, W.3
  • 73
    • 39149137233 scopus 로고    scopus 로고
    • Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: The role of GLUT-4 and endothelin
    • Lekli I, Szabo G, Juhasz B, et al. (2008) Protective mechanisms of resveratrol against ischemia-reperfusion-induced damage in hearts obtained from Zucker obese rats: the role of GLUT-4 and endothelin. Am J Physiol Heart Circ Physiol 294, H859-H866.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Lekli, I.1    Szabo, G.2    Juhasz, B.3
  • 74
    • 0033635110 scopus 로고    scopus 로고
    • Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
    • Touyz RM & Schiffrin EL (2000) Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 52, 639-672.
    • (2000) Pharmacol Rev , vol.52 , pp. 639-672
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 75
    • 76149107498 scopus 로고    scopus 로고
    • A rapid assay for angio-tensin-converting enzyme activity using ultra-performance liquid chromatography-mass spectrometry
    • Geng F, He Y, Yang L, et al. (2010) A rapid assay for angio-tensin-converting enzyme activity using ultra-performance liquid chromatography-mass spectrometry. Biomed Chro-matogr 24, 312-317.
    • (2010) Biomed Chro-matogr , vol.24 , pp. 312-317
    • Geng, F.1    He, Y.2    Yang, L.3
  • 77
    • 78649896437 scopus 로고    scopus 로고
    • Trans-but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-kappaB activation and peroxisome proliferator-activated receptorgamma upregulation
    • Rius C, Abu-Taha M, Hermenegildo C, et al. (2010) Trans-but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-kappaB activation and peroxisome proliferator-activated receptorgamma upregulation. J Immunol 185, 3718-3727.
    • (2010) J Immunol , vol.185 , pp. 3718-3727
    • Rius, C.1    Abu-Taha, M.2    Hermenegildo, C.3
  • 78
    • 77957923658 scopus 로고    scopus 로고
    • Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants
    • Olholm J, Paulsen SK, Cullberg KB, et al. (2010) Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants. Int J Obes (Lond) 34, 1546-1553.
    • (2010) Int J Obes (Lond) , vol.34 , pp. 1546-1553
    • Olholm, J.1    Paulsen, S.K.2    Cullberg, K.B.3
  • 79
    • 77953536163 scopus 로고    scopus 로고
    • Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: Relative to inhibition of inflammatory responses
    • Kang L, Heng W, Yuan A, et al. (2010) Resveratrol modulates adipokine expression and improves insulin sensitivity in adipocytes: relative to inhibition of inflammatory responses. Biochimie 92, 789-796.
    • (2010) Biochimie , vol.92 , pp. 789-796
    • Kang, L.1    Heng, W.2    Yuan, A.3
  • 80
    • 77950189559 scopus 로고    scopus 로고
    • NF-kappaB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy
    • Kumar A & Sharma SS (2010) NF-kappaB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy. Biochem Biophys Res Commun 394, 360-365.
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 360-365
    • Kumar, A.1    Sharma, S.S.2
  • 81
    • 0036133998 scopus 로고    scopus 로고
    • Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro
    • Wang Z, Huang Y, Zou J, et al. (2002) Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Int J Mol Med 9, 77-79.
    • (2002) Int J Mol Med , vol.9 , pp. 77-79
    • Wang, Z.1    Huang, Y.2    Zou, J.3
  • 82
    • 7244234945 scopus 로고    scopus 로고
    • Resvera-trol and quercetin down-regulate tissue factor expression by human stimulated vascular cells
    • Di Santo A, Mezzetti A, Napoleone E, et al. (2003) Resvera-trol and quercetin down-regulate tissue factor expression by human stimulated vascular cells. J Thromb Haemost 1, 1089-1095.
    • (2003) J Thromb Haemost , vol.1 , pp. 1089-1095
    • Di Santo, A.1    Mezzetti, A.2    Napoleone, E.3
  • 83
    • 70349212203 scopus 로고    scopus 로고
    • Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level. Functional and modelling studies
    • Crescente M, Jessen G, Momi S, et al. (2009) Interactions of gallic acid, resveratrol, quercetin and aspirin at the platelet cyclooxygenase-1 level. Functional and modelling studies. Thromb Haemost 102, 336-346.
    • (2009) Thromb Haemost , vol.102 , pp. 336-346
    • Crescente, M.1    Jessen, G.2    Momi, S.3
  • 84
    • 2542445157 scopus 로고    scopus 로고
    • Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: A mechanistic approach to the design of COX-1 selective agents
    • Szewczuk LM, Forti L, Stivala LA, et al. (2004) Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. J Biol Chem 279, 22727-22737.
    • (2004) J Biol Chem , vol.279 , pp. 22727-22737
    • Szewczuk, L.M.1    Forti, L.2    Stivala, L.A.3
  • 86
    • 66949138823 scopus 로고    scopus 로고
    • Anti-hypertensive effects of the flavonoid quercetin
    • Perez-Vizcaino F, Duarte J, Jimenez R, et al. (2009) Anti-hypertensive effects of the flavonoid quercetin. Pharmacol Rep 61, 67-75.
    • (2009) Pharmacol Rep , vol.61 , pp. 67-75
    • Perez-Vizcaino, F.1    Duarte, J.2    Jimenez, R.3
  • 87
    • 0028318752 scopus 로고
    • The correlation between active oxygens scavenging and antioxidative effects of flavonoids
    • Hanasaki Y, Ogawa S & Fukui S (1994) The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Radic Biol Med 16, 845-850.
    • (1994) Free Radic Biol Med , vol.16 , pp. 845-850
    • Hanasaki, Y.1    Ogawa, S.2    Fukui, S.3
  • 88
    • 38549084243 scopus 로고    scopus 로고
    • Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro
    • Wilms LC, Kleinjans JC, Moonen EJ, et al. (2008) Discriminative protection against hydroxyl and superoxide anion radicals by quercetin in human leucocytes in vitro. Toxicol In vitro 22, 301-307.
    • (2008) Toxicol in Vitro , vol.22 , pp. 301-307
    • Wilms, L.C.1    Kleinjans, J.C.2    Moonen, E.J.3
  • 89
    • 70349667448 scopus 로고    scopus 로고
    • Clarification of the role of quercetin hydroxyl groups in superoxide generation and cell apoptosis by chemical modification
    • Sakao K, Fujii M & Hou DX (2009) Clarification of the role of quercetin hydroxyl groups in superoxide generation and cell apoptosis by chemical modification. Biosci Biotechnol Biochem 73, 2048-2053.
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 2048-2053
    • Sakao, K.1    Fujii, M.2    Hou, D.X.3
  • 90
    • 33749246068 scopus 로고    scopus 로고
    • Endothelial function and cardiovascular disease: Effects of quercetin and wine polyphenols
    • Perez-Vizcaino F, Duarte J & Andriantsitohaina R (2006) Endothelial function and cardiovascular disease: effects of quercetin and wine polyphenols. Free Radic Res 40, 1054-1065.
    • (2006) Free Radic Res , vol.40 , pp. 1054-1065
    • Perez-Vizcaino, F.1    Duarte, J.2    Andriantsitohaina, R.3
  • 91
    • 77954143619 scopus 로고    scopus 로고
    • Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels
    • Khoo NK, White CR, Pozzo-Miller L, et al. (2010) Dietary flavonoid quercetin stimulates vasorelaxation in aortic vessels. Free Radic Biol Med 49, 339-347.
    • (2010) Free Radic Biol Med , vol.49 , pp. 339-347
    • Khoo, N.K.1    White, C.R.2    Pozzo-Miller, L.3
  • 93
    • 76449115494 scopus 로고    scopus 로고
    • Quercetin and its major metabolites selectively modulate cyclic GMP-depen-dent relaxations and associated tolerance in pig isolated coronary artery
    • Suri S, Liu XH, Rayment S, et al. (2010) Quercetin and its major metabolites selectively modulate cyclic GMP-depen-dent relaxations and associated tolerance in pig isolated coronary artery. Br J Pharmacol 159, 566-575.
    • (2010) Br J Pharmacol , vol.159 , pp. 566-575
    • Suri, S.1    Liu, X.H.2    Rayment, S.3
  • 94
    • 33646392442 scopus 로고    scopus 로고
    • Quercetin inhibits e NOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells
    • Jackson SJ & Venema RC (2006) Quercetin inhibits e NOS, microtubule polymerization, and mitotic progression in bovine aortic endothelial cells. J Nutr 136, 1178-1184.
    • (2006) J Nutr , vol.136 , pp. 1178-1184
    • Jackson, S.J.1    Venema, R.C.2
  • 95
    • 33744499710 scopus 로고    scopus 로고
    • Divergent effects of quercetin conjugates on angiogenesis
    • Donnini S, Finetti F, Lusini L, et al. (2006) Divergent effects of quercetin conjugates on angiogenesis. Br J Nutr 95, 1016-1023.
    • (2006) Br J Nutr , vol.95 , pp. 1016-1023
    • Donnini, S.1    Finetti, F.2    Lusini, L.3
  • 96
    • 57649232223 scopus 로고    scopus 로고
    • Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC
    • Romero M, Jimenez R, Sanchez M, et al. (2009) Quercetin inhibits vascular superoxide production induced by endothelin-1: role of NADPH oxidase, uncoupled eNOS and PKC. Atherosclerosis 202, 58-67.
    • (2009) Atherosclerosis , vol.202 , pp. 58-67
    • Romero, M.1    Jimenez, R.2    Sanchez, M.3
  • 97
    • 41349100106 scopus 로고    scopus 로고
    • The antihyper-tensive effects of quercetin in a salt-sensitive model of hypertension
    • Mackraj I, Govender T & Ramesar S (2008) The antihyper-tensive effects of quercetin in a salt-sensitive model of hypertension. J Cardiovasc Pharmacol 51, 239-245.
    • (2008) J Cardiovasc Pharmacol , vol.51 , pp. 239-245
    • MacKraj, I.1    Govender, T.2    Ramesar, S.3
  • 98
    • 31044449456 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme activity by flavanol-rich foods
    • Actis-Goretta L, Ottaviani JI & Fraga CG (2006) Inhibition of angiotensin converting enzyme activity by flavanol-rich foods. J Agric Food Chem 54, 229-234.
    • (2006) J Agric Food Chem , vol.54 , pp. 229-234
    • Actis-Goretta, L.1    Ottaviani, J.I.2    Fraga, C.G.3
  • 99
    • 77956800515 scopus 로고    scopus 로고
    • Chronic treatment with quercetin does not inhibit angiotensin-converting enzyme in vivo or in vitro
    • Neto-Neves EM, Montenegro MF, Dias-Junior CA, et al. (2010) Chronic treatment with quercetin does not inhibit angiotensin-converting enzyme in vivo or in vitro. Basic Clin Pharmacol Toxicol 107, 825-829.
    • (2010) Basic Clin Pharmacol Toxicol , vol.107 , pp. 825-829
    • Neto-Neves, E.M.1    Montenegro, M.F.2    Dias-Junior, C.A.3
  • 100
    • 79951682474 scopus 로고    scopus 로고
    • Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: Role of miR-155
    • Boesch-Saadatmandi C, Loboda A, Wagner AE, et al. (2011) Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155. J Nutr Biochem 22, 293-299.
    • (2011) J Nutr Biochem , vol.22 , pp. 293-299
    • Boesch-Saadatmandi, C.1    Loboda, A.2    Wagner, A.E.3
  • 101
    • 77950902298 scopus 로고    scopus 로고
    • Specific dietary polyphenols attenuate atherosclerosis in apolipo-protein E-knockout mice by alleviating inflammation and endothelial dysfunction
    • Loke WM, Proudfoot JM, Hodgson JM, et al. (2010) Specific dietary polyphenols attenuate atherosclerosis in apolipo-protein E-knockout mice by alleviating inflammation and endothelial dysfunction. Arterioscler Thromb Vasc Biol 30, 749-757.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 749-757
    • Loke, W.M.1    Proudfoot, J.M.2    Hodgson, J.M.3
  • 102
    • 77954761550 scopus 로고    scopus 로고
    • Quercetin enhances adiponectin secretion by a PPAR-gamma independent mechanism
    • Wein S, Behm N, Petersen RK, et al. (2010) Quercetin enhances adiponectin secretion by a PPAR-gamma independent mechanism. Eur J Pharm Sci 41, 16-22.
    • (2010) Eur J Pharm Sci , vol.41 , pp. 16-22
    • Wein, S.1    Behm, N.2    Petersen, R.K.3
  • 103
    • 63049132131 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloprotei-nase-9: Its direct inhibition by quercetin
    • Hwang MK, Song NR, Kang NJ, et al. (2009) Activation of phosphatidylinositol 3-kinase is required for tumor necrosis factor-alpha-induced upregulation of matrix metalloprotei-nase-9: its direct inhibition by quercetin. Int J Biochem Cell Biol 41, 1592-1600.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1592-1600
    • Hwang, M.K.1    Song, N.R.2    Kang, N.J.3
  • 104
    • 77953631110 scopus 로고    scopus 로고
    • Immuno-suppressive effect of quercetin on dendritic cell activation and function
    • Huang RY, Yu YL, Cheng WC, et al. (2010) Immuno-suppressive effect of quercetin on dendritic cell activation and function. J Immunol 184, 6815-6821.
    • (2010) J Immunol , vol.184 , pp. 6815-6821
    • Huang, R.Y.1    Yu, Y.L.2    Cheng, W.C.3
  • 105
    • 77957252267 scopus 로고    scopus 로고
    • A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects
    • Heinz SA, Henson DA, Nieman DC, et al. (2010) A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects. Br J Nutr 104, 849-857.
    • (2010) Br J Nutr , vol.104 , pp. 849-857
    • Heinz, S.A.1    Henson, D.A.2    Nieman, D.C.3
  • 106
    • 69449096565 scopus 로고    scopus 로고
    • Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients
    • Bae SC, Jung WJ, Lee EJ, et al. (2009) Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients. J Am Coll Nutr 28, 56-62.
    • (2009) J Am Coll Nutr , vol.28 , pp. 56-62
    • Bae, S.C.1    Jung, W.J.2    Lee, E.J.3
  • 107
    • 70350532011 scopus 로고    scopus 로고
    • Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets
    • Navarro-Nunez L, Rivera J, Guerrero JA, et al. (2009) Differential effects of quercetin, apigenin and genistein on signalling pathways of protease-activated receptors PAR(1) and PAR(4) in platelets. Br J Pharmacol 158, 1548-1556.
    • (2009) Br J Pharmacol , vol.158 , pp. 1548-1556
    • Navarro-Nunez, L.1    Rivera, J.2    Guerrero, J.A.3
  • 108
    • 72249120209 scopus 로고    scopus 로고
    • Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases
    • Navarro-Nunez L, Lozano ML, Martinez C, et al. (2010) Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia 81, 75-80.
    • (2010) Fitoterapia , vol.81 , pp. 75-80
    • Navarro-Nunez, L.1    Lozano, M.L.2    Martinez, C.3
  • 109
    • 77949389166 scopus 로고    scopus 로고
    • A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids
    • Wright B, Moraes LA, Kemp CF, et al. (2010) A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. Br J Pharmacol 159, 1312-1325.
    • (2010) Br J Pharmacol , vol.159 , pp. 1312-1325
    • Wright, B.1    Moraes, L.A.2    Kemp, C.F.3
  • 110
    • 0032562766 scopus 로고    scopus 로고
    • Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
    • Manach C, Morand C, Crespy V, et al. (1998) Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties. FEBS Lett 426, 331-336.
    • (1998) FEBS Lett , vol.426 , pp. 331-336
    • Manach, C.1    Morand, C.2    Crespy, V.3
  • 111
    • 0031866899 scopus 로고    scopus 로고
    • Plasma metabolites of quercetin and their antioxidant properties
    • Morand C, Crespy V, Manach C, et al. (1998) Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol 275, R212-R219.
    • (1998) Am J Physiol , vol.275
    • Morand, C.1    Crespy, V.2    Manach, C.3
  • 112
    • 0345261543 scopus 로고    scopus 로고
    • Absorption and disposition kinetics of the dietary antioxi-dant quercetin in man
    • Hollman PC, vd Gaag M, Mengelers MJ, et al. (1996) Absorption and disposition kinetics of the dietary antioxi-dant quercetin in man. Free Radic Biol Med 21, 703-707.
    • (1996) Free Radic Biol Med , vol.21 , pp. 703-707
    • Hollman, P.C.1    Vd Gaag, M.2    Mengelers, M.J.3
  • 113
    • 84858052503 scopus 로고    scopus 로고
    • Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation
    • Galindo P, Rodriguez-Gomez I, Gonzalez-Manzano S, et al. (2012) Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PLoS One 7, e32673.
    • (2012) PLoS One , vol.7
    • Galindo, P.1    Rodriguez-Gomez, I.2    Gonzalez-Manzano, S.3
  • 114
    • 27144437234 scopus 로고    scopus 로고
    • Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans
    • Felgines C, Talavera S, Texier O, et al. (2005) Blackberry anthocyanins are mainly recovered from urine as methylated and glucuronidated conjugates in humans. J Agric Food Chem 53, 7721-7727.
    • (2005) J Agric Food Chem , vol.53 , pp. 7721-7727
    • Felgines, C.1    Talavera, S.2    Texier, O.3
  • 115
    • 0032430844 scopus 로고    scopus 로고
    • Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta
    • Andriambeloson E, Magnier C, Haan-Archipoff G, et al. (1998) Natural dietary polyphenolic compounds cause endothelium-dependent vasorelaxation in rat thoracic aorta. J Nutr 128, 2324-2333.
    • (1998) J Nutr , vol.128 , pp. 2324-2333
    • Andriambeloson, E.1    Magnier, C.2    Haan-Archipoff, G.3
  • 116
    • 58149337246 scopus 로고    scopus 로고
    • Structures and antioxidant activity of anthocyanins in many accessions of eggplant and its related species
    • Azuma K, Ohyama A, Ippoushi K, et al. (2008) Structures and antioxidant activity of anthocyanins in many accessions of eggplant and its related species. J Agric Food Chem 56, 10154-10159.
    • (2008) J Agric Food Chem , vol.56 , pp. 10154-10159
    • Azuma, K.1    Ohyama, A.2    Ippoushi, K.3
  • 117
    • 33749242813 scopus 로고    scopus 로고
    • Superoxide radical-and peroxynitrite-scavenging activity of anthocyanins; Structure-activity relationship and their synergism
    • Rahman MM, Ichiyanagi T, Komiyama T, et al. (2006) Superoxide radical-and peroxynitrite-scavenging activity of anthocyanins; structure-activity relationship and their synergism. Free Radic Res 40, 993-1002.
    • (2006) Free Radic Res , vol.40 , pp. 993-1002
    • Rahman, M.M.1    Ichiyanagi, T.2    Komiyama, T.3
  • 118
    • 71349085097 scopus 로고    scopus 로고
    • Delphinidin attenuates stress injury induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells
    • Chen CY, Yi L, Jin X, et al. (2010) Delphinidin attenuates stress injury induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells. Chem Biol Interact 183, 105-112.
    • (2010) Chem Biol Interact , vol.183 , pp. 105-112
    • Chen, C.Y.1    Yi, L.2    Jin, X.3
  • 119
    • 77952881787 scopus 로고    scopus 로고
    • Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice
    • Domitrovic R & Jakovac H (2010) Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice. Toxicology 272, 1-10.
    • (2010) Toxicology , vol.272 , pp. 1-10
    • Domitrovic, R.1    Jakovac, H.2
  • 120
    • 77956174228 scopus 로고    scopus 로고
    • Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells
    • Cvorovic J, Tramer F, Granzotto M, et al. (2010) Oxidative stress-based cytotoxicity of delphinidin and cyanidin in colon cancer cells. Arch Biochem Biophys 501, 151-157.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 151-157
    • Cvorovic, J.1    Tramer, F.2    Granzotto, M.3
  • 121
    • 0036217796 scopus 로고    scopus 로고
    • Red wine polyphenols increase calcium in bovine aortic endo-thelial cells: A basis to elucidate signalling pathways leading to nitric oxide production
    • Martin S, Andriambeloson E, Takeda K, et al. (2002) Red wine polyphenols increase calcium in bovine aortic endo-thelial cells: a basis to elucidate signalling pathways leading to nitric oxide production. Br J Pharmacol 135, 1579-1587.
    • (2002) Br J Pharmacol , vol.135 , pp. 1579-1587
    • Martin, S.1    Andriambeloson, E.2    Takeda, K.3
  • 122
    • 35948978104 scopus 로고    scopus 로고
    • Effects of red wine polyphenols on postischemic neovascu-larization model in rats: Low doses are proangiogenic, high doses anti-angiogenic
    • Baron-Menguy C, Bocquet A, Guihot AL, et al. (2007) Effects of red wine polyphenols on postischemic neovascu-larization model in rats: low doses are proangiogenic, high doses anti-angiogenic. FASEB J 21, 3511-3521.
    • (2007) FASEB J , vol.21 , pp. 3511-3521
    • Baron-Menguy, C.1    Bocquet, A.2    Guihot, A.L.3
  • 123
    • 58649117965 scopus 로고    scopus 로고
    • Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia-reperfusion-induced injury
    • Scarabelli TM, Mariotto S, Abdel-Azeim S, et al. (2009) Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia-reperfusion-induced injury. FEBS Lett 583, 531-541.
    • (2009) FEBS Lett , vol.583 , pp. 531-541
    • Scarabelli, T.M.1    Mariotto, S.2    Abdel-Azeim, S.3
  • 124
    • 31544483653 scopus 로고    scopus 로고
    • Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells
    • Lazze MC, Pizzala R, Perucca P, et al. (2006) Anthocyanidins decrease endothelin-1 production and increase endothelial nitric oxide synthase in human endothelial cells. Mol Nutr Food Res 50, 44-51.
    • (2006) Mol Nutr Food Res , vol.50 , pp. 44-51
    • Lazze, M.C.1    Pizzala, R.2    Perucca, P.3
  • 125
    • 0036672162 scopus 로고    scopus 로고
    • Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells
    • Khan NQ, Lees DM, Douthwaite JA, et al. (2002) Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells. Clin Sci (Lond) 103, Suppl. 48, 72S-75S.
    • (2002) Clin Sci (Lond) , vol.103 , Issue.SUPPL. 48
    • Khan, N.Q.1    Lees, D.M.2    Douthwaite, J.A.3
  • 126
    • 0346366814 scopus 로고    scopus 로고
    • Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins
    • Actis-Goretta L, Ottaviani JI, Keen CL, et al. (2003) Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins. FEBS Lett 555, 597-600.
    • (2003) FEBS Lett , vol.555 , pp. 597-600
    • Actis-Goretta, L.1    Ottaviani, J.I.2    Keen, C.L.3
  • 127
    • 72449151640 scopus 로고    scopus 로고
    • Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin-and cyanidin-3-O-sambubio-sides from Hibiscus sabdariffa
    • Ojeda D, Jimenez-Ferrer E, Zamilpa A, et al. (2010) Inhibition of angiotensin convertin enzyme (ACE) activity by the anthocyanins delphinidin-and cyanidin-3-O-sambubio-sides from Hibiscus sabdariffa. J Ethnopharmacol 127, 7-10.
    • (2010) J Ethnopharmacol , vol.127 , pp. 7-10
    • Ojeda, D.1    Jimenez-Ferrer, E.2    Zamilpa, A.3
  • 128
    • 70849132926 scopus 로고    scopus 로고
    • Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase
    • Kwon JY, Lee KW, Kim JE, et al. (2009) Delphinidin suppresses ultraviolet B-induced cyclooxygenases-2 expression through inhibition of MAPKK4 and PI-3 kinase. Carcino-genesis 30, 1932-1940.
    • (2009) Carcino-genesis , vol.30 , pp. 1932-1940
    • Kwon, J.Y.1    Lee, K.W.2    Kim, J.E.3
  • 129
    • 61449168794 scopus 로고    scopus 로고
    • Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha
    • Hwang MK, Kang NJ, Heo YS, et al. (2009) Fyn kinase is a direct molecular target of delphinidin for the inhibition of cyclooxygenase-2 expression induced by tumor necrosis factor-alpha. Biochem Pharmacol 77, 1213-1222.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1213-1222
    • Hwang, M.K.1    Kang, N.J.2    Heo, Y.S.3
  • 130
    • 70349869211 scopus 로고    scopus 로고
    • Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family
    • Teller N, Thiele W, Boettler U, et al. (2009) Delphinidin inhibits a broad spectrum of receptor tyrosine kinases of the ErbB and VEGFR family. Mol Nutr Food Res 53, 1075-1083.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 1075-1083
    • Teller, N.1    Thiele, W.2    Boettler, U.3
  • 131
    • 69549108123 scopus 로고    scopus 로고
    • SPhospholi-pase A(2) is inhibited by anthocyanidins
    • Dreiseitel A, Korte G, Schreier P, et al. (2009) sPhospholi-pase A(2) is inhibited by anthocyanidins. J Neural Transm 116, 1071-1077.
    • (2009) J Neural Transm , vol.116 , pp. 1071-1077
    • Dreiseitel, A.1    Korte, G.2    Schreier, P.3
  • 132
    • 44649181057 scopus 로고    scopus 로고
    • Inhibition of proteasome activity by anthocyanins and anthocyanidins
    • Dreiseitel A, Schreier P, Oehme A, et al. (2008) Inhibition of proteasome activity by anthocyanins and anthocyanidins. Biochem Biophys Res Commun 372, 57-61.
    • (2008) Biochem Biophys Res Commun , vol.372 , pp. 57-61
    • Dreiseitel, A.1    Schreier, P.2    Oehme, A.3
  • 133
    • 2542502931 scopus 로고    scopus 로고
    • Antioxidant and cellular activities of anthocyanins and their corresponding vitisins A-studies in platelets, monocytes, and human endothelial cells
    • Garcia-Alonso M, Rimbach G, Rivas-Gonzalo JC, et al. (2004) Antioxidant and cellular activities of anthocyanins and their corresponding vitisins A-studies in platelets, monocytes, and human endothelial cells. J Agric Food Chem 52, 3378-3384.
    • (2004) J Agric Food Chem , vol.52 , pp. 3378-3384
    • Garcia-Alonso, M.1    Rimbach, G.2    Rivas-Gonzalo, J.C.3
  • 134
    • 0035849516 scopus 로고    scopus 로고
    • Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release
    • Freedman JE, Parker Cr, Li L, et al. (2001) Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 103, 2792-2798.
    • (2001) Circulation , vol.103 , pp. 2792-2798
    • Freedman, J.E.1    Cr, P.2    Li, L.3
  • 135
    • 13844281685 scopus 로고    scopus 로고
    • Bioavail-ability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, et al. (2005) Bioavail-ability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81, 230S-242S.
    • (2005) Am J Clin Nutr , vol.81
    • Manach, C.1    Williamson, G.2    Morand, C.3
  • 136
    • 70249105060 scopus 로고    scopus 로고
    • The oral microbiota: Living with a permanent guest
    • Avila M, Ojcius DM & Yilmaz O (2009) The oral microbiota: living with a permanent guest. DNA Cell Biol 28, 405-411.
    • (2009) DNA Cell Biol , vol.28 , pp. 405-411
    • Avila, M.1    Ojcius, D.M.2    Yilmaz, O.3
  • 137
    • 71749100220 scopus 로고    scopus 로고
    • AMP-activated protein kinase: A potential target for the diseases prevention by natural occurring polyphenols
    • Hwang JT, Kwon DY & Yoon SH (2009) AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols. N Biotechnol 26, 17-22.
    • (2009) N Biotechnol , vol.26 , pp. 17-22
    • Hwang, J.T.1    Kwon, D.Y.2    Yoon, S.H.3
  • 138
    • 34249846128 scopus 로고    scopus 로고
    • Resveratrol stimulates AMP kinase activity in neurons
    • Dasgupta B & Milbrandt J (2007) Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci U S A. 104, 7217-7222.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , pp. 7217-7222
    • Dasgupta, B.1    Milbrandt, J.2
  • 139
    • 33749349202 scopus 로고    scopus 로고
    • Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    • Zang M, Xu S, Maitland-Toolan KA, et al. (2006) Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55, 2180-2191.
    • (2006) Diabetes , vol.55 , pp. 2180-2191
    • Zang, M.1    Xu, S.2    Maitland-Toolan, K.A.3
  • 140
    • 77950348878 scopus 로고    scopus 로고
    • AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
    • Um JH, Park SJ, Kang H, et al. (2010) AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 59, 554-563.
    • (2010) Diabetes , vol.59 , pp. 554-563
    • Um, J.H.1    Park, S.J.2    Kang, H.3
  • 141
    • 57149123016 scopus 로고    scopus 로고
    • Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium
    • Penumathsa SV, Thirunavukkarasu M, Zhan L, et al. (2008) Resveratrol enhances GLUT-4 translocation to the caveolar lipid raft fractions through AMPK/Akt/eNOS signalling pathway in diabetic myocardium. J Cell Mol Med 12, 2350-2361.
    • (2008) J Cell Mol Med , vol.12 , pp. 2350-2361
    • Penumathsa, S.V.1    Thirunavukkarasu, M.2    Zhan, L.3
  • 142
    • 77957933189 scopus 로고    scopus 로고
    • Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity
    • Lu J, Wu DM, Zheng YL, et al. (2010) Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity. J Pathol 222, 199-212.
    • (2010) J Pathol , vol.222 , pp. 199-212
    • Lu, J.1    Wu, D.M.2    Zheng, Y.L.3
  • 143
    • 48949115243 scopus 로고    scopus 로고
    • The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways
    • Ahn J, Lee H, Kim S, et al. (2008) The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochem Biophys Res Commun 373, 545-549.
    • (2008) Biochem Biophys Res Commun , vol.373 , pp. 545-549
    • Ahn, J.1    Lee, H.2    Kim, S.3
  • 144
    • 77249168728 scopus 로고    scopus 로고
    • Dietary antho-cyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice
    • Takikawa M, Inoue S, Horio F, et al. (2010) Dietary antho-cyanin-rich bilberry extract ameliorates hyperglycemia and insulin sensitivity via activation of AMP-activated protein kinase in diabetic mice. J Nutr 140, 527-533.
    • (2010) J Nutr , vol.140 , pp. 527-533
    • Takikawa, M.1    Inoue, S.2    Horio, F.3
  • 145
    • 36749087548 scopus 로고    scopus 로고
    • Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    • Milne JC, Lambert PD, Schenk S, et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 450, 712-716.
    • (2007) Nature , vol.450 , pp. 712-716
    • Milne, J.C.1    Lambert, P.D.2    Schenk, S.3
  • 146
    • 34249083199 scopus 로고    scopus 로고
    • Sirtuins in mammals: Insights into their biological function
    • Michan S & Sinclair D (2007) Sirtuins in mammals: insights into their biological function. Biochem J 404, 1-13.
    • (2007) Biochem J , vol.404 , pp. 1-13
    • Michan, S.1    Sinclair, D.2
  • 147
    • 40849135481 scopus 로고    scopus 로고
    • The Sirtuin family: Therapeutic targets to treat diseases of aging
    • Milne JC & Denu JM (2008) The Sirtuin family: therapeutic targets to treat diseases of aging. Curr Opin Chem Biol 12, 11-17.
    • (2008) Curr Opin Chem Biol , vol.12 , pp. 11-17
    • Milne, J.C.1    Denu, J.M.2
  • 148
    • 33845868198 scopus 로고    scopus 로고
    • Sirtuins as potential targets for metabolic syndrome
    • Guarente L (2006) Sirtuins as potential targets for metabolic syndrome. Nature 444, 868-874.
    • (2006) Nature , vol.444 , pp. 868-874
    • Guarente, L.1
  • 149
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127, 1109-1122.
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 150
    • 77950246109 scopus 로고    scopus 로고
    • SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
    • Pacholec M, Bleasdale JE, Chrunyk B, et al. (2010) SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem 285, 8340-8351.
    • (2010) J Biol Chem , vol.285 , pp. 8340-8351
    • Pacholec, M.1    Bleasdale, J.E.2    Chrunyk, B.3
  • 152
    • 3042681042 scopus 로고    scopus 로고
    • Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    • Picard F, Kurtev M, Chung N, et al. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429, 771-776.
    • (2004) Nature , vol.429 , pp. 771-776
    • Picard, F.1    Kurtev, M.2    Chung, N.3
  • 153
    • 33244486764 scopus 로고    scopus 로고
    • Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
    • Bordone L, Motta MC, Picard F, et al. (2006) Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol 4, e31.
    • (2006) PLoS Biol , vol.4
    • Bordone, L.1    Motta, M.C.2    Picard, F.3
  • 154
    • 35549008884 scopus 로고    scopus 로고
    • SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
    • Mattagajasingh I, Kim CS, Naqvi A, et al. (2007) SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 104, 14855-14860.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 14855-14860
    • Mattagajasingh, I.1    Kim, C.S.2    Naqvi, A.3
  • 156
    • 77953455149 scopus 로고    scopus 로고
    • Shear stress, SIRT1, and vascular homeostasis
    • Chen Z, Peng IC, Cui X, et al. (2010) Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A 107, 10268-10273.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 10268-10273
    • Chen, Z.1    Peng, I.C.2    Cui, X.3
  • 157
    • 65949090502 scopus 로고    scopus 로고
    • Querce-tin increases brain and muscle mitochondrial biogenesis and exercise tolerance
    • Davis JM, Murphy EA, Carmichael MD, et al. (2009) Querce-tin increases brain and muscle mitochondrial biogenesis and exercise tolerance. Am J Physiol Regul Integr Comp Physiol 296, R1071-R1077.
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.296
    • Davis, J.M.1    Murphy, E.A.2    Carmichael, M.D.3
  • 158
    • 0031444281 scopus 로고    scopus 로고
    • Resver-atrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor
    • Gehm BD, McAndrews JM, Chien PY, et al. (1997) Resver-atrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Proc Natl Acad Sci U S A 94, 14138-14143.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 14138-14143
    • Gehm, B.D.1    McAndrews, J.M.2    Chien, P.Y.3
  • 159
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta
    • Kuiper GG, Carlsson B, Grandien K, et al. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138, 863-870.
    • (1997) Endocrinology , vol.138 , pp. 863-870
    • Kuiper, G.G.1    Carlsson, B.2    Grandien, K.3
  • 160
    • 33947270312 scopus 로고    scopus 로고
    • Differential expression of genes induced by resveratrol in human breast cancer cell lines
    • Le Corre L, Chalabi N, Delort L, et al. (2006) Differential expression of genes induced by resveratrol in human breast cancer cell lines. Nutr Cancer 56, 193-203.
    • (2006) Nutr Cancer , vol.56 , pp. 193-203
    • Le Corre, L.1    Chalabi, N.2    Delort, L.3
  • 161
    • 48249092768 scopus 로고    scopus 로고
    • Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and-independent pathways
    • Deng JY, Hsieh PS, Huang JP, et al. (2008) Activation of estrogen receptor is crucial for resveratrol-stimulating muscular glucose uptake via both insulin-dependent and-independent pathways. Diabetes 57, 1814-1823.
    • (2008) Diabetes , vol.57 , pp. 1814-1823
    • Deng, J.Y.1    Hsieh, P.S.2    Huang, J.P.3
  • 162
    • 55149123939 scopus 로고    scopus 로고
    • Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model
    • Schlachterman A, Valle F, Wall KM, et al. (2008) Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Transl Oncol 1, 19-27.
    • (2008) Transl Oncol , vol.1 , pp. 19-27
    • Schlachterman, A.1    Valle, F.2    Wall, K.M.3
  • 163
    • 0033036785 scopus 로고    scopus 로고
    • The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function
    • Miodini P, Fioravanti L, Di Fronzo G, et al. (1999) The two phyto-oestrogens genistein and quercetin exert different effects on oestrogen receptor function. Br J Cancer 80, 1150-1155.
    • (1999) Br J Cancer , vol.80 , pp. 1150-1155
    • Miodini, P.1    Fioravanti, L.2    Di Fronzo, G.3
  • 164
    • 0031733298 scopus 로고    scopus 로고
    • Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta
    • Kuiper GG, Lemmen JG, Carlsson B, et al. (1998) Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139, 4252-4263.
    • (1998) Endocrinology , vol.139 , pp. 4252-4263
    • Kuiper, G.G.1    Lemmen, J.G.2    Carlsson, B.3
  • 165
    • 3042547161 scopus 로고    scopus 로고
    • The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells
    • Maggiolini M, Vivacqua A, Fasanella G, et al. (2004) The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem 279, 27008-27016.
    • (2004) J Biol Chem , vol.279 , pp. 27008-27016
    • Maggiolini, M.1    Vivacqua, A.2    Fasanella, G.3
  • 166
    • 76449110705 scopus 로고    scopus 로고
    • Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation
    • Lin JN, Lin VC, Rau KM, et al. (2010) Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation. J Agric Food Chem 58, 1584-1592.
    • (2010) J Agric Food Chem , vol.58 , pp. 1584-1592
    • Lin, J.N.1    Lin, V.C.2    Rau, K.M.3
  • 167
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 168
    • 50649112638 scopus 로고    scopus 로고
    • SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
    • Hou X, Xu S, Maitland-Toolan KA, et al. (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem 283, 20015-20026.
    • (2008) J Biol Chem , vol.283 , pp. 20015-20026
    • Hou, X.1    Xu, S.2    Maitland-Toolan, K.A.3
  • 169
    • 55549096745 scopus 로고    scopus 로고
    • SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
    • Lan F, Cacicedo JM, Ruderman N & Ido Y (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 283, 27628-27635.
    • (2008) J Biol Chem , vol.283 , pp. 27628-27635
    • Lan, F.1    Cacicedo, J.M.2    Ruderman, N.3    Ido, Y.4
  • 170
    • 33645702096 scopus 로고    scopus 로고
    • Polyphenols as potential therapeutical agents against cardiovascular diseases
    • Curin Y & Andriantsitohaina R (2005) Polyphenols as potential therapeutical agents against cardiovascular diseases. Pharmacol Rep 57, 97-107.
    • (2005) Pharmacol Rep , vol.57 , pp. 97-107
    • Curin, Y.1    Andriantsitohaina, R.2
  • 171
    • 33644986836 scopus 로고    scopus 로고
    • Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model
    • Liu Z, Song Y, Zhang X, et al. (2005) Effects of trans-resveratrol on hypertension-induced cardiac hypertrophy using the partially nephrectomized rat model. Clin Exp Pharmacol Physiol 32, 1049-1054.
    • (2005) Clin Exp Pharmacol Physiol , vol.32 , pp. 1049-1054
    • Liu, Z.1    Song, Y.2    Zhang, X.3
  • 172
    • 77952837883 scopus 로고    scopus 로고
    • Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes
    • Biala A, Tauriainen E, Siltanen A, et al. (2010) Resveratrol induces mitochondrial biogenesis and ameliorates Ang II-induced cardiac remodeling in transgenic rats harboring human renin and angiotensinogen genes. Blood Press 19, 196-205.
    • (2010) Blood Press , vol.19 , pp. 196-205
    • Biala, A.1    Tauriainen, E.2    Siltanen, A.3
  • 173
    • 34249720541 scopus 로고    scopus 로고
    • Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats
    • Rush JW, Quadrilatero J, Levy AS, et al. (2007) Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats. Exp Biol Med (Maywood) 232, 814-822.
    • (2007) Exp Biol Med (Maywood) , vol.232 , pp. 814-822
    • Rush, J.W.1    Quadrilatero, J.2    Levy, A.S.3
  • 174
    • 79952276355 scopus 로고    scopus 로고
    • Resver-atrol and small artery compliance and remodeling in the spontaneously hypertensive rat
    • Behbahani J, Thandapilly SJ, Louis XL, et al. (2010) Resver-atrol and small artery compliance and remodeling in the spontaneously hypertensive rat. Am J Hypertens 23, 1273-1278.
    • (2010) Am J Hypertens , vol.23 , pp. 1273-1278
    • Behbahani, J.1    Thandapilly, S.J.2    Louis, X.L.3
  • 175
    • 73449145596 scopus 로고    scopus 로고
    • Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats
    • Romero M, Jimenez R, Hurtado B, et al. (2010) Lack of beneficial metabolic effects of quercetin in adult spontaneously hypertensive rats. Eur J Pharmacol 627, 242-250.
    • (2010) Eur J Pharmacol , vol.627 , pp. 242-250
    • Romero, M.1    Jimenez, R.2    Hurtado, B.3
  • 176
    • 1942474582 scopus 로고    scopus 로고
    • Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats
    • Galisteo M, Garcia-Saura MF, Jimenez R, et al. (2004) Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats. Mol Cell Biochem 259, 91-99.
    • (2004) Mol Cell Biochem , vol.259 , pp. 91-99
    • Galisteo, M.1    Garcia-Saura, M.F.2    Jimenez, R.3
  • 177
    • 0035569012 scopus 로고    scopus 로고
    • Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression
    • Diebolt M, Bucher B & Andriantsitohaina R (2001) Wine polyphenols decrease blood pressure, improve NO vasodilatation, and induce gene expression. Hypertension 38, 159-165.
    • (2001) Hypertension , vol.38 , pp. 159-165
    • Diebolt, M.1    Bucher, B.2    Andriantsitohaina, R.3
  • 178
    • 0036081822 scopus 로고    scopus 로고
    • Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension
    • Bernatova I, Pechanova O, Babal P, et al. (2002) Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol 282, H942-H948.
    • (2002) Am J Physiol Heart Circ Physiol , vol.282
    • Bernatova, I.1    Pechanova, O.2    Babal, P.3
  • 179
    • 3843054610 scopus 로고    scopus 로고
    • Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension
    • Pechanova O, Bernatova I, Babal P, et al. (2004) Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens 22, 1551-1559.
    • (2004) J Hypertens , vol.22 , pp. 1551-1559
    • Pechanova, O.1    Bernatova, I.2    Babal, P.3
  • 180
    • 20344382855 scopus 로고    scopus 로고
    • Polyphenols in cerebral ischemia: Novel targets for neuroprotection
    • Simonyi A, Wang Q, Miller RL, et al. (2005) Polyphenols in cerebral ischemia: novel targets for neuroprotection. Mol Neurobiol 31, 135-147.
    • (2005) Mol Neurobiol , vol.31 , pp. 135-147
    • Simonyi, A.1    Wang, Q.2    Miller, R.L.3
  • 181
    • 58149279285 scopus 로고    scopus 로고
    • Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia
    • Yousuf S, Atif F, Ahmad M, et al. (2009) Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia. Brain Res 1250, 242-253.
    • (2009) Brain Res , vol.1250 , pp. 242-253
    • Yousuf, S.1    Atif, F.2    Ahmad, M.3
  • 182
    • 77049102824 scopus 로고    scopus 로고
    • Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats
    • Li C, Yan Z, Yang J, et al. (2010) Neuroprotective effects of resveratrol on ischemic injury mediated by modulating the release of neurotransmitter and neuromodulator in rats. Neurochem Int 56, 495-500.
    • (2010) Neurochem Int , vol.56 , pp. 495-500
    • Li, C.1    Yan, Z.2    Yang, J.3
  • 183
    • 77951895853 scopus 로고    scopus 로고
    • Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptors
    • Saleh MC, Connell BJ & Saleh TM (2010) Resveratrol preconditioning induces cellular stress proteins and is mediated via NMDA and estrogen receptors. Neuroscience 166, 445-454.
    • (2010) Neuroscience , vol.166 , pp. 445-454
    • Saleh, M.C.1    Connell, B.J.2    Saleh, T.M.3
  • 184
    • 62249110887 scopus 로고    scopus 로고
    • Resver-atrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway
    • Della-Morte D, Dave KR, DeFazio RA, et al. (2009) Resver-atrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1-uncoupling protein 2 pathway. Neuroscience 159, 993-1002.
    • (2009) Neuroscience , vol.159 , pp. 993-1002
    • Della-Morte, D.1    Dave, K.R.2    Defazio, R.A.3
  • 185
    • 49749094366 scopus 로고    scopus 로고
    • Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angio-genic factors
    • Dong W, Li N, Gao D, et al. (2008) Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angio-genic factors. J Vasc Surg 48, 709-714.
    • (2008) J Vasc Surg , vol.48 , pp. 709-714
    • Dong, W.1    Li, N.2    Gao, D.3
  • 186
    • 49849101939 scopus 로고    scopus 로고
    • Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats
    • Rivera F, Costa G, Abin A, et al. (2008) Reduction of ischemic brain damage and increase of glutathione by a liposomal preparation of quercetin in permanent focal ischemia in rats. Neurotox Res 13, 105-114.
    • (2008) Neurotox Res , vol.13 , pp. 105-114
    • Rivera, F.1    Costa, G.2    Abin, A.3
  • 187
    • 70350490786 scopus 로고    scopus 로고
    • Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus
    • Hwang IK, Lee CH, Yoo KY, et al. (2009) Neuroprotective effects of onion extract and quercetin against ischemic neuronal damage in the gerbil hippocampus. J Med Food 12, 990-995.
    • (2009) J Med Food , vol.12 , pp. 990-995
    • Hwang, I.K.1    Lee, C.H.2    Yoo, K.Y.3
  • 188
    • 0036902931 scopus 로고    scopus 로고
    • Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage
    • Sweeney MI, Kalt W, MacKinnon SL, et al. (2002) Feeding rats diets enriched in lowbush blueberries for six weeks decreases ischemia-induced brain damage. Nutr Neurosci 5, 427-431.
    • (2002) Nutr Neurosci , vol.5 , pp. 427-431
    • Sweeney, M.I.1    Kalt, W.2    MacKinnon, S.L.3
  • 189
    • 53949090789 scopus 로고    scopus 로고
    • Acute treatment with red wine polyphenols protects from ischemia-induced excitotoxicity, energy failure and oxidative stress in rats
    • Ritz MF, Curin Y, Mendelowitsch A, et al. (2008) Acute treatment with red wine polyphenols protects from ischemia-induced excitotoxicity, energy failure and oxidative stress in rats. Brain Res 1239, 226-234.
    • (2008) Brain Res , vol.1239 , pp. 226-234
    • Ritz, M.F.1    Curin, Y.2    Mendelowitsch, A.3
  • 190
    • 40449095777 scopus 로고    scopus 로고
    • Chronic treatment with red wine polyphenol compounds mediates neuroprotection in a rat model of ischemic cerebral stroke
    • Ritz MF, Ratajczak P, Curin Y, et al. (2008) Chronic treatment with red wine polyphenol compounds mediates neuroprotection in a rat model of ischemic cerebral stroke. J Nutr 138, 519-525.
    • (2008) J Nutr , vol.138 , pp. 519-525
    • Ritz, M.F.1    Ratajczak, P.2    Curin, Y.3
  • 191
    • 77955295236 scopus 로고    scopus 로고
    • Anti-angio-genic effect of high-dose resveratrol in a swine model of metabolic syndrome
    • Robich MP, Chu LM, Chaudray M, et al. (2010) Anti-angio-genic effect of high-dose resveratrol in a swine model of metabolic syndrome. Surgery 148, 453-462.
    • (2010) Surgery , vol.148 , pp. 453-462
    • Robich, M.P.1    Chu, L.M.2    Chaudray, M.3
  • 192
    • 60949087943 scopus 로고    scopus 로고
    • Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
    • Rivera L, Moron R, Zarzuelo A, et al. (2009) Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol 77, 1053-1063.
    • (2009) Biochem Pharmacol , vol.77 , pp. 1053-1063
    • Rivera, L.1    Moron, R.2    Zarzuelo, A.3
  • 193
    • 77954614584 scopus 로고    scopus 로고
    • Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner
    • Fischer-Posovszky P, Kukulus V, Tews D, et al. (2010) Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr 92, 5-15.
    • (2010) Am J Clin Nutr , vol.92 , pp. 5-15
    • Fischer-Posovszky, P.1    Kukulus, V.2    Tews, D.3
  • 194
    • 50649107938 scopus 로고    scopus 로고
    • Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
    • Rivera L, Moron R, Sanchez M, et al. (2008) Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring) 16, 2081-2087.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 2081-2087
    • Rivera, L.1    Moron, R.2    Sanchez, M.3
  • 195
    • 58849163229 scopus 로고    scopus 로고
    • Preventive effects of nutritional doses of polyphenolic molecules on cardiac fibrosis associated with metabolic syndrome: Involvement of osteopontin and oxidative stress
    • Sutra T, Oiry C, Azay-Milhau J, et al. (2008) Preventive effects of nutritional doses of polyphenolic molecules on cardiac fibrosis associated with metabolic syndrome: involvement of osteopontin and oxidative stress. J Agric Food Chem 56, 11683-11687.
    • (2008) J Agric Food Chem , vol.56 , pp. 11683-11687
    • Sutra, T.1    Oiry, C.2    Azay-Milhau, J.3
  • 196
    • 65949113140 scopus 로고    scopus 로고
    • Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa)
    • Agouni A, Lagrue-Lak-Hal AH, Mostefai HA, et al. (2009) Red wine polyphenols prevent metabolic and cardiovascular alterations associated with obesity in Zucker fatty rats (Fa/Fa). PLoS One 4, e5557.
    • (2009) PLoS One , vol.4
    • Agouni, A.1    Lagrue-Lak-Hal, A.H.2    Mostefai, H.A.3


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