Quercetin enhances adiponectin secretion by a PPAR-γ independent mechanism

European Journal of Pharmaceutical Sciences

Volumn 41, Issue 1, 2010, Pages 16-22

  Wein, Silvia ^a   Behm, Norma ^a   Petersen, Rasmus K ^b   Kristiansen, Karsten ^b,c   Wolffram, Siegfried ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Adiponectin; Flavonoids; Oxidative stress; Peroxisome proliferator activated receptor; Quercetin

Indexed keywords

ADIPONECTIN; GLUCOSE; INSULIN; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; QUERCETIN; TRIACYLGLYCEROL; CHOLESTEROL; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; LIPID DIET; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WEIGHT GAIN; ANALYSIS; ANIMAL; BLOOD; CELL CULTURE; GENETICS; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOUSE; SECRETION (PROCESS); WISTAR RAT;

ADIPONECTIN; ANIMALS; BLOOD GLUCOSE; CELLS, CULTURED; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INSULIN; LEPTIN; MALE; MICE; OXIDATIVE STRESS; PPAR GAMMA; QUERCETIN; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRIGLYCERIDES;

EID: 77954761550     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.05.004     Document Type: Article

References (55)

1. Ader P., Block M., Pietzsch S., Wolffram S. Interaction of quercetin glucosides with the intestinal sodium/glucose co-transporter (SGLT-1). Cancer Lett. 2001, 162:175-180.
2. Ader P., Wessmann A., Wolffram S. Bioavailability and metabolism of the flavonol quercetin in the pig. Free Radic. Biol. Med. 2000, 28:1056-1067.
3. Auger C., Teissedre P.L., Gerain P., Lequeux N., Bornet A., Serisier S., Besancon P., Caporiccio B., Cristol J.P., Rouanet J.M. Dietary wine phenolics catechin, quercetin, and resveratrol efficiently protect hypercholesterolemic hamsters against aortic fatty streak accumulation. J. Agric. Food Chem. 2005, 53:2015-2021.
4. Bagi Z., Koller A., Kaley G. PPAR{gamma} activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes. Am. J. Physiol. Heart Circ. Physiol. 2004, 286:H742-H748.
5. Benton C.R., Holloway G.P., Campbell S.E., Yoshida Y., Tandon N.N., Glatz J.F.C., Luiken J.J.J.F., Spriet L.L., Bonen A. Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria. J. Physiol.-Lond. 2008, 586:1755-1766.
6. Boots A.W., Wilms L.C., Swennen E.L.R., Kleinjans J.C.S., Bast A., Haenen G.R.M.M. In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers. Nutrition 2008, 24:703-710.
7. Cacho J., Sevillano J., de Castro J., Herrera E., Ramos M.P. Validation of simple indexes to assess insulin sensitivity during pregnancy in Wistar and Sprague-Dawley rats. Am. J. Physiol.-Endocrinol. Metab. 2008, 295:E1269-E1276.
8. Chien P.J., Chen Y.C., Lu S.C., Sheu F. Dietary flavonoids suppress adipogenesis in 3T3-L1 preadipocytes. J. Food Drug Anal. 2005, 13:168-175.
9. Cho S.Y., Park S.J., Kwon M.J., Jeong T.S., Bok S.H., Choi W.Y., Jeong W.I., Ryu S.Y., Do S.H., Lee C.S., Song J.C., Jeong K.S. Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Mol. Cell. Biochem. 2003, 243:153-160.
10. Chopra M., Fitzsimons P.E., Strain J.J., Thurnham D.I., Howard A.N. Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clin. Chem. 2000, 46:1162-1170.
11. Cnop M. Fatty acids and glucolipotoxicity in the pathogenesis of Type 2 diabetes. Biochem. Soc. Trans. 2008, 36:348-352.
12. Coskun O., Kanter M., Korkmaz A., Oter S. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and beta-cell damage in rat pancreas. Pharmacol. Res. 2005, 51:117-123.
13. da Silva W.S., Harney J.W., Kim B.W., Li J., Bianco S.D.C., Crescenzi A., Christoffolete M.A., Huang S.A., Bianco A.C. The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation. Diabetes 2007, 56:767-776.
14. de Boer V.C.J., Dihal A.A., van der Woude H., Arts I.C.W., Wolffram S., Alink G.M., Rietjens I.M.C.M., Keijer J., Hollman P.C.H. Tissue distribution of quercetin in rats and pigs. J. Nutr. 2005, 135:1718-1725.
15. Evans J.L., Goldfine I.D., Maddux B.A., Grodsky G.M. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 2002, 23:599-622.
16. Formica J.V., Regelson W. Review of the biology of quercetin and related bioflavonoids. Food Chem. Toxicol. 1995, 33:1061-1080.
17. Gabler N.K., Ostrowska E., Sterling S.J., Jones R.B., Tatham B.G., Eagling D.R., Jois M., Dunshea F.R. Consumption of raw brown onions variably modulate plasma lipid profile and lipoprotein oxidation in pigs fed a high-fat diet. J. Sci. Food Agric. 2005, 85:154-160.
18. Gonzalez-Segovia R., Quintanar J.L., Salinas E., Ceballos-Salazar R., Aviles-Jimenez F., Torres-Lopez J. Effect of the flavonoid quercetin on inflammation and lipid peroxidation induced by Helicobacter pylori in gastric mucosa of guinea pig. J. Gastroenterol. 2008, 43:441-447.
19. Gopaul N.K., Anggard E.E., Mallet A.I., Betteridge D.J., Wolff S.P., Nourooz-Zadeh J. Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Lett. 1995, 368:225-229.
20. Guerre-Millo M. Adiponectin: an update. Diabetes Metab. 2008, 34:12-18.
21. Hamalainen M., Nieminen R., Vuorela P., Heinonen M., Moilanen E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappa B activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappa B activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediat. Inflamm. 2007, 45673.
22. Hansen M.K., Connolly T.M. Nuclear receptors as drug targets in obesity, dyslipidemia and atherosclerosis. Curr. Opin. Invest. Drugs 2008, 9:247-255.
23. Hertog M.G.L., Hollman P.C.H., Katan M.B. Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J. Agric. Food Chem. 1992, 40:2379-2383.
24. Kadowaki T., Yamauchi T. Adiponectin and adiponectin receptors. Endocr. Rev. 2005, 26:439-451.
25. Kaku S., Yunoki S., Mori M., Ohkura K., Nonaka M., Sugano M., Yamada K. Effect of dietary antioxidants on serum lipid contents and immunoglobulin productivity of lymphocytes in Sprague-Dawley rats. Biosci. Biotechnol. Biochem. 1999, 63:575-576.
26. Kamada C., Da Silva E.L., Ohnishi-Kameyama M., Moon J.H., Terao J. Attenuation of lipid peroxidation and hyperlipidemia by quercetin glucoside in the aorta of high cholesterol-fed rabbit. Free Radic. Res. 2005, 39:185-194.
27. Kuppusamy U.R., Das N.P. Effects of flavonoids on cyclic-amp phosphodiesterase and lipid mobilization in rat adipocytes. Biochem. Pharmacol. 1992, 44:1307-1315.
28. Larson-Meyer D.E., Heilbronn L.K., Redman L.M., Newcomer B.R., Frisard M.I., Anton S., Smith S.R., Alfonso A., Ravussin E. Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 2006, 29:1337-1344.
29. Lesser S., Wolffram S. Oral bioavailability of the flavonol quercetin-a review. Curr. Top. Nutr. Res. 2006, 4:239-256.
30. Mahesh T., Menon V.P. Quercetin alleviates oxidative stress in streptozotocin-induced diabetic rats. Phytother. Res. 2004, 18:123-127.
31. Manach C., Williamson G., Morand C., Scalbert A., Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr. 2005, 81:230S-242.
32. Marinic M., Piantanida I., Rusak G., Zinic M. Interactions of quercetin and its lanthane complex with double stranded DNA/RNA and single stranded RNA: spectrophotometric sensing of poly G. J. Inorg. Biochem. 2006, 100:288-298.
33. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28:412-419.
34. Montuschi P., Barnes P.J., Roberts L.J. Isoprostanes: markers and mediators of oxidative stress. FASEB J. 2004, 18:1791-1800.
35. Morand C., Crespy V., Manach C., Besson C., Demigne C., Remesy C. Plasma metabolites of quercetin and their antioxidant properties. Am. J. Physiol. 1998, 275:R212-R219.
36. Moskaug J.O., Carlsen H., Myhrstad M.C., Blomhoff R. Polyphenols and glutathione synthesis regulation. Am. J. Clin. Nutr. 2005, 81:277S-283.
37. Naumann C., Bassler R., Seibold R.B.C. Die chemische Untersuchung von Futtermitteln. Methodenbuch Band III, Verband Deutscher Landwirtschaftlicher Untersuchungs und Forschungsanstalten (VDLUFA) 1997, VDLUFA Verlag, Darmstadt. 3rd ed.
38. Perseghin G. Muscle lipid metabolism in the metabolic syndrome. Curr. Opin. Lipidol. 2005, 16:416-420.
39. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucl. Acids Res. 2001, 29:e45.
40. Rivera L., Moron R., Sanchez M., Zarzuelo A., Galisteo M. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity 2008, 16:2081-2087.
41. Robertson R.P., Harmon J., Tran P.O.T., Poitout V. beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004, 53:S119-S124.
42. Sanders R.A., Rauscher F.M., Watkins J.B. Effects of quercetin on antioxidant defense in streptozotocin-induced diabetic rats. J. Biochem. Mol. Toxicol. 2001, 15:143-149.
43. Sharabi Y., Oron-Herman M., Kamari Y., Avni I., Peleg E., Shabtay Z., Grossman E., Shamiss A. Effect of PPAR-gamma agonist on adiponectin levels in the metabolic syndrome: lessons from the high fructose fed rat model. Am. J. Hypertens. 2007, 20:206-210.
44. Shetty A.K., Rashmi R., Rajan M.G.R., Sambaiah K., Salimath P.V. Antidiabetic influence of quercetin in streptozotocin-induced diabetic rats. Nutr. Res. 2004, 24:373-381.
45. Soobrattee M.A., Neergheen V.S., Luximon-Ramma A., Aruoma O.I., Bahorun T. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutat. Res. 2005, 579:200-213.
46. Thuillier P., Brash A.R., Kehrer J.P., Stimmel J.B., Leesnitzer L.M., Yang P., Newman R.A., Fischer S.M. Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. Biochem. J. 2002, 366:901-910.
47. Tilg H., Moschen A.R. Inflammatory mechanisms in the regulation of insulin resistance. Mol. Med. 2008, 14:222-231.
48. Ulich T.R., Guo K., Remick D., Delcastillo J., Yin S.M. Endotoxin-induced cytokine gene-expression in vivo. 3. Il-6 messenger-RNA and serum-protein expression and the in vivo hematologic effects of Il-6. J. Immunol. 1991, 146:2316-2323.
49. Urakawa H., Katsuki A., Sumida Y., Gabazza E.C., Murashima S., Morioka K., Maruyama N., Kitagawa N., Tanaka T., Hori Y., Nakatani K., Yano Y., Adachi Y. Oxidative stress is associated with adiposity and insulin resistance in men. J. Clin. Endocrinol. Metab. 2003, 88:4673-4676.
50. Vessal M., Hemmati M., Vasei M. Antidiabetic effects of quercetin in streptozocin-induced diabetic rats. Comp. Biochem. Physiol. C: Toxicol. Pharmacol. 2003, 135C:357-364.
51. Wein S., Wolffram S., Schrezenmeir J., Gasperikova D., Klimes I., Sebokova E. Medium-chain fatty acids ameliorate insulin resistance caused by high-fat diets in rats. Diabetes Metab. Res. Rev. 2009, 25:185-194.
52. Weldin J., Jack R., Dugaw K., Kapur R.P. Quercetin, an over the-counter supplement, causes neuroblastoma-like elevation of plasma homovanillic acid. Pediatr. Dev. Pathol. 2003, 6:547-551.
53. Wilding J. Thiazolidinediones, insulin resistance and obesity: finding a balance. Int. J. Clin. Pract. 2006, 60:1272-1280.
54. Yugarani T., Tan B.K., Teh M., Das N.P. Effects of polyphenolic natural products on the lipid profiles of rats fed high fat diets. Lipids 1992, 27:181-186.
55. Zern T.L., West K.L., Fernandez M.L. Grape polyphenols decrease plasma triglycerides and cholesterol accumulation in the aorta of ovariectomized guinea pigs. J. Nutr. 2003, 133:2268-2272.