Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta

Journal of Cardiovascular Pharmacology

Volumn 46, Issue 1, 2005, Pages 36-40

  Machha, Ajay ^a   Mustafa, Mohd Rais ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

Blood pressure; Flavonoids; Hypertension; Nitric oxide; Vascular endothelium

Indexed keywords

ACETYLCHOLINE; BAICALEIN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FLAVONE; FLAVONOID; NITRIC OXIDE; NITROPRUSSIDE SODIUM; QUERCETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BLOOD PRESSURE REGULATION; CARDIOVASCULAR DISEASE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DISEASE MARKER; DRUG EFFECT; HEART PROTECTION; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; VASCULAR RING; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FLAVONOIDS; MALE; NITROPRUSSIDE; PHENYLEPHRINE; POTASSIUM; RATS; RATS, INBRED SHR; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 21444437840     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000162769.83324.c1     Document Type: Article

References (31)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;299: 373-376.
2. Rodrigo E, Maeso R, Garcia RM, et al. Endothelial dysfunction in spontaneously hypertensive rats: consequences of chronic treatment with losartan or captopril. J Hypertens. 1997;15:613-618.
3. Rubanyi GM. The role of endothelium in cardiovascular homeostasis and diseases. J Cardiovasc Pharmacol. 1993;22:S1-S14.
4. Luscher TF, Noll G. Endothelium dysfunction in the coronary circulation. J Cardiovasc Pharmacol. 1994;24:S16-S26.
5. Novosel D, Lang MG, Noll G, et al. Endothelial dysfunction in aorta of the spontaneously hypertensive, stroke-prone rat: effect of therapy with verapamil and trandolapril alone and in combination. J Cardiovasc Pharmacol. 1994;24:979-985.
6. Ulker S, McKeown PP, Bayraktutan U. Vitamins reverse endothelial dysfunction through regulation of eNOS and NAD(P)H oxidase activities. Hypertension. 2003;41:534-539.
7. Levine GN, Frie B, Koulouris SN, et al. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary heart disease. Circulation. 1996;93:1107-1113.
8. Hertog MGL, Feskens EJM, Hollman PCH, et al. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly study. Lancet. 1993b;342:1007-1011.
9. Knekt P, Jarvinen R, Reunanen A, et al. Flavonoid intake and coronary mortality in Finland: a cohort study. BMJ. 1996;312:478-481.
10. Zenebe W, Pechanova O, Bernatova I. Protective effects of red wine polyphenolic compounds on the cardiovascular system. Exp Clin Cardiol. 2001;6:153-158.
11. Duffy SJ, Keaney JF Jr, Holbrook M, et al. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation. 2001;104:151-156.
12. Stein JH, Keevil JG, Wiebe DA, et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation. 1999;100: 1050-1055.
13. Duarte J, Perez-Palencia R, Vargas F, et al. Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol. 2001;133:117-124.
14. Sagar S, Kallo IJ, Kaul N, et al. Oxygen free radicals in essential hypertension. Mol Cell Biochem. 1992;111:103-108.
15. Suzuki H, Swei A, Zweifach BW, et al. In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats: Hydroethidine microfluorography. Hypertension. 1995;25:1083-1089.
16. Lyons D. Impairment and restoration of nitric oxide-dependent vasodilation in cardiovascular disease. Int J Cardiol. 1997;62:S101-S109.
17. Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. 1986;320:454-456.
18. Yang B, Kotani A, Arai K, et al. Estimation of antioxidant activities of flavonoids from their oxidation potentials. Anal Sci. 2001;17:599-604.
19. Dragan A, Dusanka DA, Drago B, et al. Structure-radical scavenging activity relationships of flavonoids. Croat Chem Acta. 2003;76: 55-61.
20. Yuting C, Rongliang Z, Zhongjian J, et al. Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med. 1990;9:19-21.
21. Shieh DE, Liu LT, Lin CC. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000;20:2861-2865.
22. Ajay M, Gilani AH, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life Sci. 2003;74:603-612.
23. Duarte J, Perez Vizcaino F, Utrilla P, et al. Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships. Gen Pharmacol. 1993;24:857-862.
24. Chan ECH, Pannangpetch P, Woodman OL. Relaxation of flavones and flavonols in rat isolated thoracic aorta: mechanism of action and structure activity relationships. J Cardiovasc Pharmacol. 2000;35:326-333.
25. Ding Y, Vaziri ND. Calcium channel blockade enhances nitric oxide synthase expression by cultured endothelial cells. Hypertension. 1998;32:718-723.
26. Tojo A, Kobayashi N, Kimura K, et al. Effects of antihypertensive drugs on nitric oxide synthase activity in rat kidney. Kidney Int Suppl. 1996;55: S138-S140.
27. Gray GA, Clozel M, Clozel JP, et al. Effects of calcium channel blockade on the aortic intima in spontaneously hypertensive rats. Hypertension. 1993;22:569-576.
28. Kitiyakara C, Wilcox CS. Antioxidants for hypertension. Curr Opin Nephrol Hypertens. 1998;7:531-538.
29. Kim MK, Sasaki S, Sasazuki S, et al. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension. 2002;40: 797-803.
30. Uluoglu C, Korkusuz P, Uluoglu O, et al. Tween 80 and endothelium: functional reduction due to tissue damage. Res Commun Mol Pathol Pharmacol. 1996;91:173-183.
31. Bennett MA, Millier C, Thurston H. Endothelium-dependent relaxation in resistance arteries from spontaneously hypertensive rats: effect of long-term treatment with perindopril, quinapril, hydralazine or amlodipine. J Hypertens. 1996;14:389-397.