The great unravelling: Chromatin as a modulator of the aging process

Trends in Biochemical Sciences

Volumn 37, Issue 11, 2012, Pages 466-476

  O'Sullivan, Roderick J ^a   Karlseder, Jan ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Chromatin; Epigenetics; Heterochromatin; Histone; Senescence

Indexed keywords

ATM PROTEIN; ATR PROTEIN; BMI1 PROTEIN; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; HETEROCHROMATIN PROTEIN 1; HIGH MOBILITY GROUP A PROTEIN; HISTONE H1; HISTONE H2A; HISTONE H2B; HISTONE H3; HISTONE H4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; KU ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; NONHISTONE PROTEIN; NOTCH RECEPTOR; POLYCOMB GROUP PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROMYELOCYTIC LEUKEMIA PROTEIN; RETINOBLASTOMA PROTEIN; SIRTUIN 1; SIRTUIN 6; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR FOXO; WNT PROTEIN;

AGING; CELL CYCLE ARREST; CELL PROLIFERATION; CELL REGENERATION; CELL STRESS; CELL STRUCTURE; CELL SURVIVAL; CHROMATIN; CHROMATIN IMMUNOPRECIPITATION; DEACETYLATION; DNA METHYLATION; DNA REPAIR; DNA REPLICATION; DNA SEQUENCE; EPIGENETICS; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HISTONE ACETYLATION; HOMEOSTASIS; HUMAN; LIFESPAN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOSOME; PRIORITY JOURNAL; PROGERIA; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; REVIEW; SENESCENCE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

AGING; ANIMALS; CHROMATIN; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA REPAIR; EPIGENESIS, GENETIC; HETEROCHROMATIN; HISTONES; HUMANS;

MAMMALIA;

EID: 84867907645     PISSN: 09680004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tibs.2012.08.001     Document Type: Review

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