pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4a tumor suppressor gene

Genes and Development

Volumn 21, Issue 1, 2007, Pages 49-54

  Kotake, Yojiro ^a   Cao, Ru ^a,b   Viatour, Patrick ^c   Sage, Julien ^c   Zhang, Yi ^a,b   Xiong, Yue ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BMI1; p16; pRB; PRC1; PRC2; transcriptional regulation

Indexed keywords

BINDING PROTEIN; NUCLEAR PROTEIN; POLYCOMB GROUP PROTEIN BMI1; POLYCOMB GROUP PROTEIN EZH2; PROTEIN P16INK4A; PROTEIN PRB; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL RENEWAL; CONTROLLED STUDY; GENE EXPRESSION; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRIMETHYLATION; TUMOR SUPPRESSOR GENE;

ANIMALS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA-BINDING PROTEINS; GENE SILENCING; HISTONE-LYSINE N-METHYLTRANSFERASE; HISTONES; HUMANS; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; REPRESSOR PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN THIOLESTERASE;

EID: 33846148370     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1499407     Document Type: Article

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