-
1
-
-
0034641936
-
Apoptosis in the nervous system
-
Yuan J., et al. Apoptosis in the nervous system. Nature 2000, 407:802-809.
-
(2000)
Nature
, vol.407
, pp. 802-809
-
-
Yuan, J.1
-
2
-
-
0032862692
-
The role of cell death in regulating the size and shape of the mammalian forebrain
-
Haydar T.F., et al. The role of cell death in regulating the size and shape of the mammalian forebrain. Cereb. Cortex 1999, 9:621-626.
-
(1999)
Cereb. Cortex
, vol.9
, pp. 621-626
-
-
Haydar, T.F.1
-
3
-
-
0029956641
-
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
-
Kuida K., et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 1996, 384:368-372.
-
(1996)
Nature
, vol.384
, pp. 368-372
-
-
Kuida, K.1
-
4
-
-
15844393657
-
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
-
Rotonda J., et al. The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat. Struct. Biol. 1996, 3:619-625.
-
(1996)
Nat. Struct. Biol.
, vol.3
, pp. 619-625
-
-
Rotonda, J.1
-
5
-
-
84861653938
-
Non-apoptotic roles for death-related molecules: When mitochondria chose cell fate
-
Strappazzon F., et al. Non-apoptotic roles for death-related molecules: When mitochondria chose cell fate. Exp. Cell Res. 2012, 318:1309-1315.
-
(2012)
Exp. Cell Res.
, vol.318
, pp. 1309-1315
-
-
Strappazzon, F.1
-
6
-
-
0032526268
-
Apoptosis signaling by death receptors
-
Schulze-Osthoff K., et al. Apoptosis signaling by death receptors. Eur. J. Biochem. 1998, 254:439-459.
-
(1998)
Eur. J. Biochem.
, vol.254
, pp. 439-459
-
-
Schulze-Osthoff, K.1
-
7
-
-
3442886811
-
The pathophysiology of mitochondrial cell death
-
Green D.R., et al. The pathophysiology of mitochondrial cell death. Science 2004, 305:626-629.
-
(2004)
Science
, vol.305
, pp. 626-629
-
-
Green, D.R.1
-
8
-
-
33748961826
-
Mitochondria as the target of the pro-apoptotic protein Bax
-
Er E., et al. Mitochondria as the target of the pro-apoptotic protein Bax. Biochim. Biophys. Acta 2006, 1757:1301-1311.
-
(2006)
Biochim. Biophys. Acta
, vol.1757
, pp. 1301-1311
-
-
Er, E.1
-
9
-
-
33845977959
-
Mitochondrial membrane permeabilization in cell death
-
Kroemer G., et al. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 2007, 87:99-163.
-
(2007)
Physiol. Rev.
, vol.87
, pp. 99-163
-
-
Kroemer, G.1
-
10
-
-
33745962416
-
BH3-only proteins in cell death initiation, malignant disease and anticancer therapy
-
Labi V., et al. BH3-only proteins in cell death initiation, malignant disease and anticancer therapy. Cell Death Differ. 2006, 13:1325-1338.
-
(2006)
Cell Death Differ.
, vol.13
, pp. 1325-1338
-
-
Labi, V.1
-
11
-
-
0030954209
-
The CARD domain: a new apoptotic signalling motif
-
Hofmann K., Bucher P. The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 1997, 22:155-156.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 155-156
-
-
Hofmann, K.1
Bucher, P.2
-
12
-
-
0034105784
-
Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes
-
Cain K., et al. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J. Biol. Chem. 2000, 275:6067-6070.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 6067-6070
-
-
Cain, K.1
-
13
-
-
39749182234
-
Apoptosis: controlled demolition at the cellular level
-
Taylor R.C., et al. Apoptosis: controlled demolition at the cellular level. Nat. Rev. Mol. Cell Biol. 2008, 9:231-241.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 231-241
-
-
Taylor, R.C.1
-
14
-
-
17644378775
-
C-FLIPR, a new regulator of death receptor-induced apoptosis
-
Golks A., et al. c-FLIPR, a new regulator of death receptor-induced apoptosis. J. Biol. Chem. 2005, 280:14507-14513.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14507-14513
-
-
Golks, A.1
-
15
-
-
0030970013
-
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
-
Thome M., et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 1997, 386:517-521.
-
(1997)
Nature
, vol.386
, pp. 517-521
-
-
Thome, M.1
-
16
-
-
0037648485
-
Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis
-
Neumar R.W., et al. Cross-talk between calpain and caspase proteolytic systems during neuronal apoptosis. J. Biol. Chem. 2003, 278:14162-14167.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14162-14167
-
-
Neumar, R.W.1
-
17
-
-
0035831019
-
Structural basis for the inhibition of caspase-3 by XIAP
-
Riedl S.J. Structural basis for the inhibition of caspase-3 by XIAP. Cell 2001, 104:791-800.
-
(2001)
Cell
, vol.104
, pp. 791-800
-
-
Riedl, S.J.1
-
18
-
-
67649794805
-
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing
-
Choi Y.E., et al. The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J. Biol. Chem. 2009, 284:12772-12782.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 12772-12782
-
-
Choi, Y.E.1
-
19
-
-
0036544535
-
The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites
-
Silke J., et al. The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites. J. Cell Biol. 2002, 157:115-124.
-
(2002)
J. Cell Biol.
, vol.157
, pp. 115-124
-
-
Silke, J.1
-
20
-
-
50049110244
-
Regulation of apoptosis by XIAP ubiquitin-ligase activity
-
Schile A.J., et al. Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev. 2008, 22:2256-2266.
-
(2008)
Genes Dev.
, vol.22
, pp. 2256-2266
-
-
Schile, A.J.1
-
21
-
-
0031411431
-
Apoptosis in neural development and disease
-
Mazarakis N.D., et al. Apoptosis in neural development and disease. Arch. Dis. Child. 1997, 77:165-170.
-
(1997)
Arch. Dis. Child.
, vol.77
, pp. 165-170
-
-
Mazarakis, N.D.1
-
22
-
-
0030947095
-
Programmed cell death in animal development
-
Jacobson M.D., et al. Programmed cell death in animal development. Cell 1997, 88:347-354.
-
(1997)
Cell
, vol.88
, pp. 347-354
-
-
Jacobson, M.D.1
-
23
-
-
42549129931
-
Cell death in brain development and degeneration: control of caspase expression may be key!
-
Madden S.D., Cotter T.G. Cell death in brain development and degeneration: control of caspase expression may be key!. Mol. Neurobiol. 2008, 37:1-6.
-
(2008)
Mol. Neurobiol.
, vol.37
, pp. 1-6
-
-
Madden, S.D.1
Cotter, T.G.2
-
24
-
-
33747869352
-
Adaptive roles of programmed cell death during nervous system development
-
Buss R.R., et al. Adaptive roles of programmed cell death during nervous system development. Annu. Rev. Neurosci. 2006, 29:1-35.
-
(2006)
Annu. Rev. Neurosci.
, vol.29
, pp. 1-35
-
-
Buss, R.R.1
-
25
-
-
0029863114
-
Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex
-
Blaschke A.J., et al. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development 1996, 122:1165-1174.
-
(1996)
Development
, vol.122
, pp. 1165-1174
-
-
Blaschke, A.J.1
-
26
-
-
10644288480
-
Drosophila caspase DRONC is required for specific developmental cell death pathways and stress induced apoptosis
-
Daish T.J., et al. Drosophila caspase DRONC is required for specific developmental cell death pathways and stress induced apoptosis. Dev. Cell 2004, 7:909-915.
-
(2004)
Dev. Cell
, vol.7
, pp. 909-915
-
-
Daish, T.J.1
-
27
-
-
19444366944
-
The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila
-
Xu D., et al. The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 2005, 132:2125-2134.
-
(2005)
Development
, vol.132
, pp. 2125-2134
-
-
Xu, D.1
-
28
-
-
21844449428
-
The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals
-
Waldhuber M., et al. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech. Dev. 2005, 122:914-927.
-
(2005)
Mech. Dev.
, vol.122
, pp. 914-927
-
-
Waldhuber, M.1
-
29
-
-
10344258000
-
Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila
-
Perez-Garijo A., et al. Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila. Development 2004, 131:5591-5598.
-
(2004)
Development
, vol.131
, pp. 5591-5598
-
-
Perez-Garijo, A.1
-
30
-
-
0033231548
-
HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis
-
Zhou L., et al. HAC-1, a Drosophila homolog of APAF-1 and CED-4 functions in developmental and radiation-induced apoptosis. Mol. Cell 1999, 4:745-755.
-
(1999)
Mol. Cell
, vol.4
, pp. 745-755
-
-
Zhou, L.1
-
31
-
-
0033231614
-
Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator
-
Kanuka H., et al. Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator. Mol. Cell 1999, 4:757-769.
-
(1999)
Mol. Cell
, vol.4
, pp. 757-769
-
-
Kanuka, H.1
-
32
-
-
0036327243
-
Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice
-
Leonard J.R., et al. Strain-dependent neurodevelopmental abnormalities in caspase-3-deficient mice. J. Neuropathol. Exp. Neurol. 2002, 61:673-677.
-
(2002)
J. Neuropathol. Exp. Neurol.
, vol.61
, pp. 673-677
-
-
Leonard, J.R.1
-
33
-
-
0032493910
-
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
-
Kuida K., et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 1998, 94:325-337.
-
(1998)
Cell
, vol.94
, pp. 325-337
-
-
Kuida, K.1
-
34
-
-
0032544449
-
Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
-
Cecconi F., et al. Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 1998, 94:727-737.
-
(1998)
Cell
, vol.94
, pp. 727-737
-
-
Cecconi, F.1
-
35
-
-
4644370139
-
Early neural cell death: dying to become neurons
-
Yeo W., Gautier J. Early neural cell death: dying to become neurons. Dev. Biol. 2004, 274:233-244.
-
(2004)
Dev. Biol.
, vol.274
, pp. 233-244
-
-
Yeo, W.1
Gautier, J.2
-
36
-
-
69549103121
-
Physiological Purkinje cell death is spatiotemporally organized in the developing mouse cerebellum
-
Jankowski J., et al. Physiological Purkinje cell death is spatiotemporally organized in the developing mouse cerebellum. Cerebellum 2009, 8:277-290.
-
(2009)
Cerebellum
, vol.8
, pp. 277-290
-
-
Jankowski, J.1
-
37
-
-
0035399637
-
Programmed cell death of developing mammalian neurons after genetic deletion of caspases
-
Oppenheim R.W., et al. Programmed cell death of developing mammalian neurons after genetic deletion of caspases. J. Neurosci. 2001, 21:4752-4760.
-
(2001)
J. Neurosci.
, vol.21
, pp. 4752-4760
-
-
Oppenheim, R.W.1
-
38
-
-
0032520195
-
Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
-
White F.A., et al. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J. Neurosci. 1998, 18:1428-1439.
-
(1998)
J. Neurosci.
, vol.18
, pp. 1428-1439
-
-
White, F.A.1
-
39
-
-
40849120902
-
Misplacement of Purkinje cells during postnatal development in Bax knock-out mice: a novel role for programmed cell death in the nervous system?
-
Jung A.R., et al. Misplacement of Purkinje cells during postnatal development in Bax knock-out mice: a novel role for programmed cell death in the nervous system?. J. Neurosci. 2008, 28:2941-2948.
-
(2008)
J. Neurosci.
, vol.28
, pp. 2941-2948
-
-
Jung, A.R.1
-
40
-
-
26444537963
-
Neural stem cell differentiation is dependent upon endogenous caspase 3 activity
-
Fernando P., et al. Neural stem cell differentiation is dependent upon endogenous caspase 3 activity. FASEB J. 2005, 19:1671-1673.
-
(2005)
FASEB J.
, vol.19
, pp. 1671-1673
-
-
Fernando, P.1
-
41
-
-
0037143626
-
Caspase-3 activity is required for skeletal muscle differentiation
-
Fernando P., et al. Caspase-3 activity is required for skeletal muscle differentiation. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:11025-11030.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 11025-11030
-
-
Fernando, P.1
-
42
-
-
11144356373
-
High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase-3 regulatory mechanism
-
Okuyama R., et al. High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase-3 regulatory mechanism. Dev. Cell 2004, 6:551-562.
-
(2004)
Dev. Cell
, vol.6
, pp. 551-562
-
-
Okuyama, R.1
-
43
-
-
0037468853
-
Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones
-
Campbell D.S., et al. Apoptotic pathway and MAPKs differentially regulate chemotropic responses of retinal growth cones. Neuron 2003, 37:939-952.
-
(2003)
Neuron
, vol.37
, pp. 939-952
-
-
Campbell, D.S.1
-
44
-
-
44349111132
-
Caspase activity mediates the differentiation of embryonic stem cells
-
Fujita J., et al. Caspase activity mediates the differentiation of embryonic stem cells. Cell Stem Cell 2008, 2:595-601.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 595-601
-
-
Fujita, J.1
-
45
-
-
77956648430
-
Control of embryonic stem cell identity by nucleosome remodeling enzymes
-
Fazzio T.G., Panning B. Control of embryonic stem cell identity by nucleosome remodeling enzymes. Curr. Opin. Genet. Dev. 2010, 20:500-504.
-
(2010)
Curr. Opin. Genet. Dev.
, vol.20
, pp. 500-504
-
-
Fazzio, T.G.1
Panning, B.2
-
46
-
-
33845439096
-
Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation
-
Huesmann G.R., Clayton D.F. Dynamic role of postsynaptic caspase-3 and BIRC4 in zebra finch song-response habituation. Neuron 2006, 52:1061-1072.
-
(2006)
Neuron
, vol.52
, pp. 1061-1072
-
-
Huesmann, G.R.1
Clayton, D.F.2
-
47
-
-
77954927345
-
Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids
-
Kaplan Y., et al. Gradients of a ubiquitin E3 ligase inhibitor and a caspase inhibitor determine differentiation or death in spermatids. Dev. Cell 2010, 19:160-173.
-
(2010)
Dev. Cell
, vol.19
, pp. 160-173
-
-
Kaplan, Y.1
-
48
-
-
77955793357
-
Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity
-
Ohsawa S., et al. Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:13366-13371.
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 13366-13371
-
-
Ohsawa, S.1
-
49
-
-
0043033220
-
Semaphorin 7A promotes axon outgrowth through integrins and MAPKs
-
Pasterkamp R.J., et al. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature 2003, 424:398-405.
-
(2003)
Nature
, vol.424
, pp. 398-405
-
-
Pasterkamp, R.J.1
-
50
-
-
38149016966
-
The cell biology of synaptic plasticity: AMPA receptor trafficking
-
Shepherd J.D., Huganir R.L. The cell biology of synaptic plasticity: AMPA receptor trafficking. Annu. Rev. Cell Dev. Biol. 2007, 23:613-643.
-
(2007)
Annu. Rev. Cell Dev. Biol.
, vol.23
, pp. 613-643
-
-
Shepherd, J.D.1
Huganir, R.L.2
-
51
-
-
9644278075
-
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
-
Zhou Q., et al. Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses. Neuron 2004, 44:749-757.
-
(2004)
Neuron
, vol.44
, pp. 749-757
-
-
Zhou, Q.1
-
52
-
-
77953271477
-
Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
-
Li Z., et al. Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell 2010, 141:859-871.
-
(2010)
Cell
, vol.141
, pp. 859-871
-
-
Li, Z.1
-
53
-
-
79956210669
-
Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission
-
Jiao S., Li Z. Nonapoptotic function of BAD and BAX in long-term depression of synaptic transmission. Neuron 2011, 70:758-772.
-
(2011)
Neuron
, vol.70
, pp. 758-772
-
-
Jiao, S.1
Li, Z.2
-
54
-
-
0042831025
-
Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?
-
Gilman C.P., Mattson M.P. Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?. Neuromol. Med. 2002, 2:197-214.
-
(2002)
Neuromol. Med.
, vol.2
, pp. 197-214
-
-
Gilman, C.P.1
Mattson, M.P.2
-
55
-
-
33746363831
-
Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning
-
Kuo C.T., et al. Identification of E2/E3 ubiquitinating enzymes and caspase activity regulating Drosophila sensory neuron dendrite pruning. Neuron 2006, 51:283-290.
-
(2006)
Neuron
, vol.51
, pp. 283-290
-
-
Kuo, C.T.1
-
56
-
-
27744492906
-
Central administration of a caspase inhibitor impairs shuttle-box performance in rats
-
Stepanichev M.Y., et al. Central administration of a caspase inhibitor impairs shuttle-box performance in rats. Neuroscience 2005, 136:579-591.
-
(2005)
Neuroscience
, vol.136
, pp. 579-591
-
-
Stepanichev, M.Y.1
-
57
-
-
77956207696
-
Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury
-
Higgins G.C., et al. Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury. J. Alzheimers Dis. 2010, 20(Suppl. 2):S453-S473.
-
(2010)
J. Alzheimers Dis.
, vol.20
, Issue.SUPPL. 2
-
-
Higgins, G.C.1
-
58
-
-
67649460932
-
Mitochondrial membrane permeabilization in neuronal injury
-
Galluzzi L., et al. Mitochondrial membrane permeabilization in neuronal injury. Nat. Rev. Neurosci. 2009, 10:481-494.
-
(2009)
Nat. Rev. Neurosci.
, vol.10
, pp. 481-494
-
-
Galluzzi, L.1
-
59
-
-
70449536507
-
Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival
-
Naoi M., et al. Mitochondria in neurodegenerative disorders: regulation of the redox state and death signaling leading to neuronal death and survival. J. Neural Transm. 2009, 116:1371-1381.
-
(2009)
J. Neural Transm.
, vol.116
, pp. 1371-1381
-
-
Naoi, M.1
-
60
-
-
33644543761
-
Expanding insights of mitochondrial dysfunction in Parkinson's disease
-
Abou-Sleiman P.M., et al. Expanding insights of mitochondrial dysfunction in Parkinson's disease. Nat. Rev. Neurosci. 2006, 7:207-219.
-
(2006)
Nat. Rev. Neurosci.
, vol.7
, pp. 207-219
-
-
Abou-Sleiman, P.M.1
-
61
-
-
34250624810
-
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases
-
Mandemakers W., et al. A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. J. Cell Sci. 2007, 120:1707-1716.
-
(2007)
J. Cell Sci.
, vol.120
, pp. 1707-1716
-
-
Mandemakers, W.1
-
62
-
-
77958192164
-
Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease
-
Milnerwood A.J., et al. Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease. Trends Neurosci. 2010, 33:513-523.
-
(2010)
Trends Neurosci.
, vol.33
, pp. 513-523
-
-
Milnerwood, A.J.1
-
63
-
-
78751626397
-
Regulation of caspases in the nervous system: implications for functions in health and disease
-
Troy C.M., et al. Regulation of caspases in the nervous system: implications for functions in health and disease. Prog. Mol. Biol. Transl. Sci. 2011, 299:265-305.
-
(2011)
Prog. Mol. Biol. Transl. Sci.
, vol.299
, pp. 265-305
-
-
Troy, C.M.1
-
64
-
-
54049138387
-
Mechanisms of neuronal death in disease: defining the models and the players
-
Ribe E.M., et al. Mechanisms of neuronal death in disease: defining the models and the players. Biochem. J. 2008, 415:165-182.
-
(2008)
Biochem. J.
, vol.415
, pp. 165-182
-
-
Ribe, E.M.1
-
65
-
-
2442653111
-
Apoptosis in acute and chronic neurological disorders
-
Ekshyyan O., Aw T.Y. Apoptosis in acute and chronic neurological disorders. Front. Biosci. 2004, 9:1567-1576.
-
(2004)
Front. Biosci.
, vol.9
, pp. 1567-1576
-
-
Ekshyyan, O.1
Aw, T.Y.2
-
66
-
-
0037417220
-
Apoptosis and caspases in neurodegenerative diseases
-
Friedlander R.M. Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med. 2003, 348:1365-1375.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1365-1375
-
-
Friedlander, R.M.1
-
67
-
-
0029120647
-
Evidence for apoptotic cell death in Alzheimer's disease
-
Smale G., et al. Evidence for apoptotic cell death in Alzheimer's disease. Exp. Neurol. 1995, 133:225-230.
-
(1995)
Exp. Neurol.
, vol.133
, pp. 225-230
-
-
Smale, G.1
-
68
-
-
0029040355
-
In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
-
Dragunow M., et al. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport 1995, 6:1053-1057.
-
(1995)
Neuroreport
, vol.6
, pp. 1053-1057
-
-
Dragunow, M.1
-
69
-
-
0029086807
-
DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions
-
Thomas L.B., et al. DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions. Exp. Neurol. 1995, 133:265-272.
-
(1995)
Exp. Neurol.
, vol.133
, pp. 265-272
-
-
Thomas, L.B.1
-
70
-
-
0041846404
-
Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease
-
Colurso G.J., et al. Quantitative assessment of DNA fragmentation and beta-amyloid deposition in insular cortex and midfrontal gyrus from patients with Alzheimer's disease. Life Sci. 2003, 73:1795-1803.
-
(2003)
Life Sci.
, vol.73
, pp. 1795-1803
-
-
Colurso, G.J.1
-
71
-
-
79955978036
-
Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases
-
Cavallucci V., D'Amelio M. Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases. Curr. Pharm. Des. 2011, 17:215-229.
-
(2011)
Curr. Pharm. Des.
, vol.17
, pp. 215-229
-
-
Cavallucci, V.1
D'Amelio, M.2
-
72
-
-
79958199462
-
Antiapoptotic drugs: a therapeutic strategy for the prevention of neurodegenerative diseases
-
Sureda F.X., et al. Antiapoptotic drugs: a therapeutic strategy for the prevention of neurodegenerative diseases. Curr. Pharm. Des. 2011, 17:230-234.
-
(2011)
Curr. Pharm. Des.
, vol.17
, pp. 230-234
-
-
Sureda, F.X.1
-
73
-
-
78649287483
-
Organelle stress sensors and cell death mechanisms in neurodegenerative diseases
-
Viana R.J., et al. Organelle stress sensors and cell death mechanisms in neurodegenerative diseases. CNS Neurol. Disord. Drug Targets 2010, 9:679-692.
-
(2010)
CNS Neurol. Disord. Drug Targets
, vol.9
, pp. 679-692
-
-
Viana, R.J.1
-
74
-
-
81055125652
-
Programmed cell death in animal development and disease
-
Fuchs Y., Steller H. Programmed cell death in animal development and disease. Cell 2011, 147:742-758.
-
(2011)
Cell
, vol.147
, pp. 742-758
-
-
Fuchs, Y.1
Steller, H.2
-
75
-
-
79959923467
-
Protein aggregate spreading in neurodegenerative diseases: problems and perspectives
-
Lee S.J., et al. Protein aggregate spreading in neurodegenerative diseases: problems and perspectives. Neurosci. Res. 2011, 70:339-348.
-
(2011)
Neurosci. Res.
, vol.70
, pp. 339-348
-
-
Lee, S.J.1
-
76
-
-
9344227302
-
Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract
-
Goldberg Y.P., et al. Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract. Nat. Genet. 1996, 13:442-449.
-
(1996)
Nat. Genet.
, vol.13
, pp. 442-449
-
-
Goldberg, Y.P.1
-
77
-
-
0032502715
-
Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract
-
Wellington C.L., et al. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. J. Biol. Chem. 1998, 273:9158-9167.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9158-9167
-
-
Wellington, C.L.1
-
78
-
-
0030791305
-
Of molecular interactions, mice and mechanisms: new insights into Huntington's disease
-
Wellington C.L., Hayden M.R. Of molecular interactions, mice and mechanisms: new insights into Huntington's disease. Curr. Opin. Neurol. 1997, 10:291-298.
-
(1997)
Curr. Opin. Neurol.
, vol.10
, pp. 291-298
-
-
Wellington, C.L.1
Hayden, M.R.2
-
79
-
-
0034733607
-
Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells
-
Wellington C.L., et al. Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells. J. Biol. Chem. 2000, 275:19831-19838.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 19831-19838
-
-
Wellington, C.L.1
-
80
-
-
79959886270
-
Amyloid precursor protein processing and Alzheimer's disease
-
O'Brien R.J., Wong P.C. Amyloid precursor protein processing and Alzheimer's disease. Annu. Rev. Neurosci. 2011, 34:185-204.
-
(2011)
Annu. Rev. Neurosci.
, vol.34
, pp. 185-204
-
-
O'Brien, R.J.1
Wong, P.C.2
-
81
-
-
0033617402
-
Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation
-
Gervais F.G., et al. Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-β precursor protein and amyloidogenic Aβ peptide formation. Cell 1999, 97:395-406.
-
(1999)
Cell
, vol.97
, pp. 395-406
-
-
Gervais, F.G.1
-
82
-
-
0032510834
-
The X11a protein slows cellular amyloid precursor protein processing and reduces Aβ40 and Aβ42 secretion
-
Borg J.P., et al. The X11a protein slows cellular amyloid precursor protein processing and reduces Aβ40 and Aβ42 secretion. J. Biol. Chem. 1998, 273:14761-14766.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14761-14766
-
-
Borg, J.P.1
-
83
-
-
0034846164
-
The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells
-
Dumanchin-Njock C., et al. The caspase-derived C-terminal fragment of betaAPP induces caspase-independent toxicity and triggers selective increase of Abeta42 in mammalian cells. J. Neurochem. 2001, 8:1153-1161.
-
(2001)
J. Neurochem.
, vol.8
, pp. 1153-1161
-
-
Dumanchin-Njock, C.1
-
84
-
-
0030868903
-
Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease
-
Kim T.W., et al. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 1997, 277:373-376.
-
(1997)
Science
, vol.277
, pp. 373-376
-
-
Kim, T.W.1
-
85
-
-
0030873546
-
Presenilins are processed by caspase-type proteases
-
Loetscher H., et al. Presenilins are processed by caspase-type proteases. J. Biol. Chem. 1997, 272:20655-20659.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 20655-20659
-
-
Loetscher, H.1
-
86
-
-
33745197557
-
2+ homeostasis and accelerates apoptosis
-
2+ homeostasis and accelerates apoptosis. J. Biol. Chem. 2006, 281:16649-16655.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 16649-16655
-
-
Cai, C.1
-
87
-
-
0037809240
-
The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart
-
Alves da Costa C., et al. The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. J. Biol. Chem. 2003, 278:12064-12069.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12064-12069
-
-
Alves da Costa, C.1
-
88
-
-
0030680151
-
Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage
-
Vito P., et al. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. J. Biol. Chem. 1997, 272:28315-28320.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28315-28320
-
-
Vito, P.1
-
89
-
-
0029856850
-
Requirement of the familial Alzheimer's disease PS2 for apoptosis: opposing effect of ALG-3
-
Vito P., et al. Requirement of the familial Alzheimer's disease PS2 for apoptosis: opposing effect of ALG-3. J. Biol. Chem. 1996, 271:31025-31028.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 31025-31028
-
-
Vito, P.1
-
90
-
-
0344301890
-
Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in TiTo by distinct cellular mechanisms
-
Walter J., et al. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in TiTo by distinct cellular mechanisms. Biochemistry 1998, 37:5961-5967.
-
(1998)
Biochemistry
, vol.37
, pp. 5961-5967
-
-
Walter, J.1
-
91
-
-
0033573936
-
Phosphorylation of presenilin-2 regulates its cleavage by caspases and retard progression of apoptosis
-
Walter J., et al. Phosphorylation of presenilin-2 regulates its cleavage by caspases and retard progression of apoptosis. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:1391-1396.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 1391-1396
-
-
Walter, J.1
-
92
-
-
34249734831
-
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity
-
Tesco G., et al. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 2007, 54:721-737.
-
(2007)
Neuron
, vol.54
, pp. 721-737
-
-
Tesco, G.1
-
93
-
-
49349104833
-
Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease
-
Rohn T.T. Caspase-cleaved TAR DNA-binding protein-43 is a major pathological finding in Alzheimer's disease. Brain Res. 2009, 1228:189-198.
-
(2009)
Brain Res.
, vol.1228
, pp. 189-198
-
-
Rohn, T.T.1
-
94
-
-
77951540816
-
Caspase activation precedes and leads to tangles
-
de Calignon A., et al. Caspase activation precedes and leads to tangles. Nature 2010, 464:1201-1214.
-
(2010)
Nature
, vol.464
, pp. 1201-1214
-
-
de Calignon, A.1
-
95
-
-
34247611481
-
Synaptic alterations in CA1 in mild Alzheimer's disease and mild cognitive impairment
-
Scheff S.W., et al. Synaptic alterations in CA1 in mild Alzheimer's disease and mild cognitive impairment. Neurology 2007, 68:1501-1508.
-
(2007)
Neurology
, vol.68
, pp. 1501-1508
-
-
Scheff, S.W.1
-
96
-
-
78650659370
-
Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
-
D'Amelio M., et al. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat. Neurosci. 2011, 14:69-76.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 69-76
-
-
D'Amelio, M.1
-
97
-
-
79955484857
-
1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β
-
1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β. Nat. Neurosci. 2011, 14:545-547.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 545-547
-
-
Jo, J.1
-
98
-
-
84863063951
-
A pivotal role of GSK-3 in synaptic plasticity
-
Bradley C.A., et al. A pivotal role of GSK-3 in synaptic plasticity. Front. Mol. Neurosci. 2012, 5:13.
-
(2012)
Front. Mol. Neurosci.
, vol.5
, pp. 13
-
-
Bradley, C.A.1
-
99
-
-
77952546195
-
GSK3: a possible link between beta amyloid peptide and tau protein
-
Hernández F., et al. GSK3: a possible link between beta amyloid peptide and tau protein. Exp. Neurol. 2010, 223:322-325.
-
(2010)
Exp. Neurol.
, vol.223
, pp. 322-325
-
-
Hernández, F.1
-
100
-
-
55349115428
-
Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease
-
Louneva N., et al. Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease. Am. J. Pathol. 2008, 173:1488-1495.
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 1488-1495
-
-
Louneva, N.1
-
101
-
-
73949103706
-
Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease
-
Sultana R., et al. Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease. J. Neurosci. Res. 2010, 88:469-477.
-
(2010)
J. Neurosci. Res.
, vol.88
, pp. 469-477
-
-
Sultana, R.1
-
102
-
-
0029942337
-
Histochemical detection of apoptosis in Parkinson's disease
-
Mochizuki H., et al. Histochemical detection of apoptosis in Parkinson's disease. J. Neurol. Sci. 1996, 137:120-123.
-
(1996)
J. Neurol. Sci.
, vol.137
, pp. 120-123
-
-
Mochizuki, H.1
-
103
-
-
79952701436
-
Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?
-
Alves da Costa C., Checler F. Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?. Cell. Signal. 2011, 23:963-968.
-
(2011)
Cell. Signal.
, vol.23
, pp. 963-968
-
-
Alves da Costa, C.1
Checler, F.2
-
104
-
-
67649331705
-
Programmed cell death in Parkinson's disease
-
Burke R.E. Programmed cell death in Parkinson's disease. Handb. Clin. Neurol. 2007, 83:591-605.
-
(2007)
Handb. Clin. Neurol.
, vol.83
, pp. 591-605
-
-
Burke, R.E.1
-
105
-
-
33744963539
-
Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway
-
Giaime E., et al. Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway. J. Biol. Chem. 2006, 281:11515-11522.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 11515-11522
-
-
Giaime, E.1
-
106
-
-
0032952414
-
Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions
-
Engelender S., et al. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nat. Genet. 1999, 22:110-114.
-
(1999)
Nat. Genet.
, vol.22
, pp. 110-114
-
-
Engelender, S.1
-
107
-
-
79955485064
-
Caspase signalling controls microglia activation and neurotoxicity
-
Burguillos M.A., et al. Caspase signalling controls microglia activation and neurotoxicity. Nature 2011, 472:319-324.
-
(2011)
Nature
, vol.472
, pp. 319-324
-
-
Burguillos, M.A.1
-
108
-
-
7744246367
-
Life's smile, death's grin: vital functions of apoptosis-executing proteins
-
Garrido C., Kroemer G. Life's smile, death's grin: vital functions of apoptosis-executing proteins. Curr. Opin. Cell Biol. 2004, 16:639-646.
-
(2004)
Curr. Opin. Cell Biol.
, vol.16
, pp. 639-646
-
-
Garrido, C.1
Kroemer, G.2
-
109
-
-
77954626704
-
Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis
-
Wang W.L., et al. Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol. Biol. Cell 2010, 21:2453-2468.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 2453-2468
-
-
Wang, W.L.1
-
110
-
-
79952624787
-
Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling
-
Gabet A.S., et al. Caspase-activated ROCK-1 allows erythroblast terminal maturation independently of cytokine-induced Rho signaling. Cell Death Differ. 2011, 18:678-6789.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 678-6789
-
-
Gabet, A.S.1
-
111
-
-
0037654554
-
Caspase activity and a specific cytochrome c are required for sperm differentiation in Drosophila
-
Arama E., et al. Caspase activity and a specific cytochrome c are required for sperm differentiation in Drosophila. Dev. Cell 2003, 4:687-697.
-
(2003)
Dev. Cell
, vol.4
, pp. 687-697
-
-
Arama, E.1
-
112
-
-
36248975661
-
Nonapoptotic role for Apaf-1 in the DNA damage checkpoint
-
Zermati Y., et al. Nonapoptotic role for Apaf-1 in the DNA damage checkpoint. Mol. Cell 2007, 28:624-637.
-
(2007)
Mol. Cell
, vol.28
, pp. 624-637
-
-
Zermati, Y.1
-
113
-
-
84857222717
-
Apaf1 plays a pro-survival role by regulating centrosome morphology and function
-
Ferraro E., et al. Apaf1 plays a pro-survival role by regulating centrosome morphology and function. J. Cell Sci. 2011, 124:3450-3463.
-
(2011)
J. Cell Sci.
, vol.124
, pp. 3450-3463
-
-
Ferraro, E.1
|