메뉴 건너뛰기




Volumn 116, Issue 11, 2009, Pages 1371-1381

Mitochondria in neurodegenerative disorders: Regulation of the redox state and death signaling leading to neuronal death and survival

Author keywords

Apoptosis; MAO inhibitor; Mitochondria; Neuroprotection; Oxidative stress; Redox state

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); DOPAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N PROPARGYLAMINE; NEUROMELANIN; NEUROPROTECTIVE AGENT; NEUROTOXIN; NEUROTROPHIC FACTOR; PROTEIN BCL 2; QUINONE DERIVATIVE; RASAGILINE; REACTIVE OXYGEN METABOLITE; SELEGILINE; UNCLASSIFIED DRUG;

EID: 70449536507     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-009-0309-7     Document Type: Review
Times cited : (66)

References (97)
  • 1
    • 33644543761 scopus 로고    scopus 로고
    • Expanding insights of mitochondrial dysfunction in Parkinson's disease
    • DOI 10.1038/nrn1868, PII N1868
    • PM Abou-Sleiman MM Muqit NW Wood 2006 Expanding insights of mitochondrial dysfunction in Parkinson's disease Nature Rev Neurosci 7 207 219 10.1038/nrn1868 1:CAS:528:DC%2BD28Xhs1Gqt70%3D (Pubitemid 43292466)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.3 , pp. 207-219
    • Abou-Sleiman, P.M.1    Muqit, M.M.K.2    Wood, N.W.3
  • 2
    • 33645076775 scopus 로고    scopus 로고
    • S-Glutathiolation in redox-sensitive signaling
    • 10.1016/j.ddmec.2005.05.022 1:CAS:528:DC%2BD2MXpvFOmu7Y%3D
    • T Adachi C Schöneich RA Cohen 2005 S-Glutathiolation in redox-sensitive signaling Drug Discov Today Dise Mechan 2 39 46 10.1016/j.ddmec.2005.05.022 1:CAS:528:DC%2BD2MXpvFOmu7Y%3D
    • (2005) Drug Discov Today Dise Mechan , vol.2 , pp. 39-46
    • Adachi, T.1    Schöneich, C.2    Cohen, R.A.3
  • 3
    • 0036677312 scopus 로고    scopus 로고
    • Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan
    • DOI 10.1046/j.1471-4159.2002.01047.x
    • Y Akao W Maruyama S Shimizu H Yi Y Nakagawa M Shamoto-Nagai MBH Youdim Y Tsujimoto M Naoi 2002 Mitochondrial permeability transition mediates apoptosis induced by N-methyl(R)salsolinol, an endogenous neurotoxin, and is inhibited by Bcl-2 and rasagiline, N-propargyl-1(R)-aminoindan J Neurochem 82 913 923 10.1046/j.1471-4159.2002.01047.x 1:CAS:528:DC%2BD38XmsF2hurc%3D 12358797 (Pubitemid 34898843)
    • (2002) Journal of Neurochemistry , vol.82 , Issue.4 , pp. 913-923
    • Akao, Y.1    Maruyama, W.2    Shimizu, S.3    Yi, H.4    Nakagawa, Y.5    Shamoto-Nagai, M.6    Youdim, M.B.H.7    Tsujimoto, Y.8    Naoi, M.9
  • 4
    • 0037189081 scopus 로고    scopus 로고
    • An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in human dopaminergic SH-SY5Y cells
    • DOI 10.1016/S0304-3940(02)00332-4, PII S0304394002003324
    • Y Akao W Maruyama H Yi M Shamoto-Nagai MBH Youdim M Naoi 2002 An anti-Parkinson's disease drug, N-propargyl-1(R)-aminoindan (rasagiline), enhances expression of anti-apoptotic Bcl-2 in dopaminergic SH-SY5Y cells Neurosci Lett 326 105 108 10.1016/S0304-3940(02)00332-4 1:CAS:528: DC%2BD38XktFKgt7o%3D 12057839 (Pubitemid 34607570)
    • (2002) Neuroscience Letters , vol.326 , Issue.2 , pp. 105-108
    • Akao, Y.1    Maruyama, W.2    Yi, H.3    Shamoto-Nagai, M.4    Youdim, M.B.H.5    Naoi, M.6
  • 5
    • 1842562333 scopus 로고    scopus 로고
    • Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development
    • 10.1111/j.1471-4159.2004.02323.x 1:CAS:528:DC%2BD2cXjtValt7o%3D 15030409
    • M Alonso M Melani D Converso A Jaitovich C Paz MC Carreras JH Medina JJ Poderoso 2004 Mitochondrial extracellular signal-regulated kinases 1/2 (ERK1/2) are modulated during brain development J Neurochem 89 248 256 10.1111/j.1471-4159.2004.02323.x 1:CAS:528:DC%2BD2cXjtValt7o%3D 15030409
    • (2004) J Neurochem , vol.89 , pp. 248-256
    • Alonso, M.1    Melani, M.2    Converso, D.3    Jaitovich, A.4    Paz, C.5    Carreras, M.C.6    Medina, J.H.7    Poderoso, J.J.8
  • 7
    • 37849043898 scopus 로고    scopus 로고
    • Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: Glutathionylation and protection of lipoic acid
    • 10.1021/bi7017464 1:CAS:528:DC%2BD2sXhsVehtbbN 18081316
    • MA Applegate KM Humphries LI Szweda 2008 Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid Biochemistry 47 473 478 10.1021/bi7017464 1:CAS:528:DC%2BD2sXhsVehtbbN 18081316
    • (2008) Biochemistry , vol.47 , pp. 473-478
    • Applegate, M.A.1    Humphries, K.M.2    Szweda, L.I.3
  • 8
    • 34848906324 scopus 로고    scopus 로고
    • Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostigil, respectively, exert neuroprotective properties in vitro
    • DOI 10.1111/j.1471-4159.2007.04777.x
    • O Bar-Am T Amit MBH Youdim 2007 Aminoindan and hydroxyaminoindan, metabolites of rasagiline and ladostignol, respectively, exert neuroprotective properties in vitro J Neurochem 103 500 508 10.1111/j.1471-4159.2007.04777.x 1:CAS:528:DC%2BD2sXht1KqsLzP 17635668 (Pubitemid 47498024)
    • (2007) Journal of Neurochemistry , vol.103 , Issue.2 , pp. 500-508
    • Bar-Am, O.1    Amit, T.2    Youdim, M.B.H.3
  • 9
    • 0034691507 scopus 로고    scopus 로고
    • Nonviral glial cell-derived neurotrophic factor gene transfer enhances survival of cultured dopaminergic neurons and improves their function after transplantation in a rat model of Parkinson's disease
    • DOI 10.1089/10430340050083261
    • M Bauer M Meyer L Grimm T Meitinger J Zimmer T Gasser M Ueffing HR Widmer 2000 Nonviral glial cell-derived neurotrophic factor gene transfer enhances survival of cultured dopaminergic neurons and improves their function after transplantation in a rat model of Parkinson's disease Hum Gene Ther 11 1529 1541 10.1089/10430340050083261 1:CAS:528:DC%2BD3cXlt1Gjsbw%3D 10945767 (Pubitemid 30670605)
    • (2000) Human Gene Therapy , vol.11 , Issue.11 , pp. 1529-1541
    • Bauer, M.1    Meyer, M.2    Grimm, L.3    Meitinger, T.4    Zimmer, J.5    Gasser, T.6    Ueffing, M.7    Widmer, H.R.8
  • 10
    • 2342573633 scopus 로고    scopus 로고
    • Dopamine toxicity involves mitochondrial complex I inhibition: Implications to dopamine-related neuropsychiatric disorders
    • DOI 10.1016/j.bcp.2004.02.015, PII S0006295204001303
    • D Ben-Shachar R Zuk H Gazawi P Ljubuncic 2004 Dopamine toxicity involves mitochondrial complex I inhibition: implications to dopamine-related neuropsychiatric disorders Biochem Pharmacol 67 1965 1974 10.1016/j.bcp.2004.02. 015 1:CAS:528:DC%2BD2cXjvVCju7s%3D 15130772 (Pubitemid 38591384)
    • (2004) Biochemical Pharmacology , vol.67 , Issue.10 , pp. 1965-1974
    • Ben-Shachar, D.1    Zuk, R.2    Gazawi, H.3    Ljubuncic, P.4
  • 11
    • 33846501598 scopus 로고    scopus 로고
    • GDNF family receptor complexes are emerging drug targets
    • DOI 10.1016/j.tips.2006.12.005, PII S0165614706002884
    • MM Bespalov M Saarma 2007 GDNF family receptor complexes are emerging drug targets Trends Pharmacol Sci 28 68 74 10.1016/j.tips.2006.12.005 1:CAS:528:DC%2BD2sXhtlCmu7g%3D 17218019 (Pubitemid 46161837)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.2 , pp. 68-74
    • Bespalov, M.M.1    Saarma, M.2
  • 12
    • 2342547676 scopus 로고    scopus 로고
    • Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease
    • DOI 10.1016/j.expneurol.2004.03.005, PII S0014488604000949
    • F Blandini MT Armentero T Fancellu E Blaugrund G Nappi 2004 Neuroprotective effect of rasagiline in a rodent model of Parkinson's disease Exp Neurol 187 455 459 10.1016/j.expneurol.2004.03.005 1:CAS:528: DC%2BD2cXktV2lsL0%3D 15144871 (Pubitemid 38610291)
    • (2004) Experimental Neurology , vol.187 , Issue.2 , pp. 455-459
    • Blandini, F.1    Armentero, M.T.2    Fancellu, R.3    Blaugrund, E.4    Nappi, G.5
  • 13
    • 40349085926 scopus 로고    scopus 로고
    • Genetic findings in Parkinson's disease and translation into treatment: A leading role for mitochondria?
    • DOI 10.1111/j.1601-183X.2007.00342.x
    • V Bogaerts J Theuns C van Broeckhoven 2008 Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? Genes Brain Behav 7 129 151 10.1111/j.1601-183X.2007.00342.x 1:CAS:528:DC%2BD1cXks1Sqtrg%3D 17680806 (Pubitemid 351342198)
    • (2008) Genes, Brain and Behavior , vol.7 , Issue.2 , pp. 129-151
    • Bogaerts, V.1    Theuns, J.2    Van Broeckhoven, C.3
  • 14
    • 33846675520 scopus 로고    scopus 로고
    • NF-ΚB as a therapeutic target in neurodegenerative diseases
    • DOI 10.1517/14728222.11.2.123
    • S Camandola MP Mattson 2007 NF-kB as a therapeutic target in neurodegenerative diseases Expert Opin Ther Targets 11 123 132 10.1517/14728222.11.2.123 1:CAS:528:DC%2BD2sXlt12rtA%3D%3D 17227229 (Pubitemid 46188809)
    • (2007) Expert Opinion on Therapeutic Targets , vol.11 , Issue.2 , pp. 123-132
    • Camandola, S.1    Mattson, M.P.2
  • 15
    • 0034705512 scopus 로고    scopus 로고
    • Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat
    • DOI 10.1016/S0024-3205(00)00643-3, PII S0024320500006433
    • MC Carrillo C Minami K Kitani W Maruyama K Ohashi T Yamamoto M Naoi K Kanai MBH Youdim 2000 Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat Life Sci 67 577 585 10.1016/S0024-3205(00)00643-3 1:CAS:528:DC%2BD3cXksVKjurg%3D 10993123 (Pubitemid 30431547)
    • (2000) Life Sciences , vol.67 , Issue.5 , pp. 577-585
    • Carrillo, M.C.1    Minami, C.2    Kitani, K.3    Maruyama, W.4    Ohashi, K.5    Yamamoto, T.6    Naoi, M.7    Kanai, S.8    Youdim, M.B.H.9
  • 16
    • 34248569415 scopus 로고    scopus 로고
    • Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase
    • DOI 10.1021/bi602580c
    • CL Chen L Zhang A Yeh CA Chen KB Green-Church JL Zweier YR Chen 2007 Site-specific S-glutathiolation of mitochondrial NADH ubiquinone reductase Biochemistry 46 5754 5765 10.1021/bi602580c 1:CAS:528:DC%2BD2sXksVSmt7c%3D 17444656 (Pubitemid 46764124)
    • (2007) Biochemistry , vol.46 , Issue.19 , pp. 5754-5765
    • Chen, C.-L.1    Zhang, L.2    Yeh, A.3    Chen, C.-A.4    Green-Church, K.B.5    Zweier, J.L.6    Chen, Y.-R.7
  • 17
    • 15744398884 scopus 로고    scopus 로고
    • Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with alzheimer and Parkinson diseases
    • DOI 10.1074/jbc.M414327200
    • J Choi HD Rees ST Weintraub AI Levey LS Chin L Li 2005 Oxidative modifications and aggregation of Cu, Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases J Biol Chem 280 11648 11655 10.1074/jbc.M414327200 1:CAS:528:DC%2BD2MXisVyjt7Y%3D 15659387 (Pubitemid 40418479)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.12 , pp. 11648-11655
    • Choi, J.1    Rees, H.D.2    Weintraub, S.T.3    Levey, A.I.4    Chin, L.-S.5    Li, L.6
  • 18
    • 16644387391 scopus 로고    scopus 로고
    • Thiol oxidation of cell signaling proteins: Controlling an apoptotic equilibrium
    • 10.1002/jcb.20202 1:CAS:528:DC%2BD2cXns1Siur0%3D 15352167
    • JV Cross DJ Templeton 2004 Thiol oxidation of cell signaling proteins: controlling an apoptotic equilibrium J Cell Biochem 93 104 111 10.1002/jcb.20202 1:CAS:528:DC%2BD2cXns1Siur0%3D 15352167
    • (2004) J Cell Biochem , vol.93 , pp. 104-111
    • Cross, J.V.1    Templeton, D.J.2
  • 19
    • 0036829946 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative strategies for Parkinson's disease
    • DOI 10.1038/nn941
    • TM Dawson VL Dawson 2002 Neuroprotective and neurorestorative strategies for Parkinson's disease Nature Neurosci Supp 5 1058 1061 10.1038/nn941 1:CAS:528:DC%2BD38Xpt1entb0%3D (Pubitemid 35247199)
    • (2002) Nature Neuroscience , vol.5 , Issue.SUPPL. , pp. 1058-1061
    • Dawson, T.M.1    Dawson, V.L.2
  • 20
    • 34249937901 scopus 로고    scopus 로고
    • Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease
    • MW Dodson M Guo 2008 Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease Curr Opin Neurobiol 17 1 7
    • (2008) Curr Opin Neurobiol , vol.17 , pp. 1-7
    • Dodson, M.W.1    Guo, M.2
  • 21
    • 0036719084 scopus 로고    scopus 로고
    • Influence of neuromelanin on oxidative pathways within the human substantia nigra
    • DOI 10.1016/S0892-0362(02)00218-0, PII S0892036202002180
    • KL Double D Ben-Shachar MB Youdim L Zecca P Riederer M Gerlach 2002 Influence of neuromelanin on oxidative pathways within the human substantia nigra Neurotoxicol Teratol 24 621 628 10.1016/S0892-0362(02)00218-0 1:CAS:528:DC%2BD38XmsVCit7o%3D 12200193 (Pubitemid 35013523)
    • (2002) Neurotoxicology and Teratology , vol.24 , Issue.5 , pp. 621-628
    • Double, K.L.1    Ben-Shachar, D.2    Youdim, M.B.H.3    Zecca, L.4    Riederer, P.5    Gerlach, M.6
  • 22
    • 1842429937 scopus 로고    scopus 로고
    • Ancient Invasions: From Endosymbionts to Organelles
    • DOI 10.1126/science.1094884
    • SD Dyall MT Brown PJ Johnson 2004 Ancient invasions: from endosymbionts to organelles Science 304 253 257 10.1126/science.1094884 1:CAS:528: DC%2BD2cXivV2isbc%3D 15073369 (Pubitemid 38452171)
    • (2004) Science , vol.304 , Issue.5668 , pp. 253-257
    • Dyall, S.D.1    Brown, M.T.2    Johnson, P.J.3
  • 23
    • 3242781888 scopus 로고    scopus 로고
    • Structure and mechanism of monoamine oxidase
    • 1:CAS:528:DC%2BD2cXlslWmu7s%3D 15279562
    • DE Edmondson A Mattevi C Binda M Li F Hubalek 2004 Structure and mechanism of monoamine oxidase Curr Med Chem 11 1983 1993 1:CAS:528: DC%2BD2cXlslWmu7s%3D 15279562
    • (2004) Curr Med Chem , vol.11 , pp. 1983-1993
    • Edmondson, D.E.1    Mattevi, A.2    Binda, C.3    Li, M.4    Hubalek, F.5
  • 24
    • 34250365299 scopus 로고    scopus 로고
    • Death in the substantia nigra: A motor tragedy
    • DOI 10.1586/14737175.7.6.677
    • E Esposito V Di Matteo G Di Giovanni 2007 Death in the substantia nigra: a motor tragedy Expert Rev Neurother 7 677 697 10.1586/14737175.7.6.677 1:CAS:528:DC%2BD2sXmsFWqsr8%3D 17563251 (Pubitemid 46911617)
    • (2007) Expert Review of Neurotherapeutics , vol.7 , Issue.6 , pp. 677-697
    • Esposito, E.1    Di Matteo, V.2    Di Giovanni, G.3
  • 25
    • 28244442462 scopus 로고    scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in human disease
    • DOI 10.1111/j.1365-2796.2005.01570.x
    • B Fadeel S Orrenius 2005 Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease J Int Med 258 479 517 10.1111/j.1365-2796.2005.01570.x 1:CAS:528:DC%2BD2MXhtlClurfE (Pubitemid 41705391)
    • (2005) Journal of Internal Medicine , vol.258 , Issue.6 , pp. 479-517
    • Fadeel, B.1    Orrenius, S.2
  • 27
    • 24644469955 scopus 로고    scopus 로고
    • Sites and mechanisms of aconitase inactivation by peroxynitrite: Modulation by citrate and glutathione
    • DOI 10.1021/bi0509393
    • D Han R Canali J Garcia R Aguilera TK Gallaher E Cadenas 2005 Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione Biochemistry 44 11986 11996 10.1021/bi0509393 1:CAS:528: DC%2BD2MXotVSltrk%3D 16142896 (Pubitemid 41285696)
    • (2005) Biochemistry , vol.44 , Issue.36 , pp. 11986-11996
    • Han, D.1    Canali, R.2    Garcia, J.3    Aguilera, R.4    Gallaher, T.K.5    Cadenas, E.6
  • 28
    • 55849122639 scopus 로고    scopus 로고
    • Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
    • 10.1038/ncpneuro0924 1:CAS:528:DC%2BD1cXhtlWktbnM 18978800
    • C Henchcliffe MF Beal 2008 Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis Nat Clin Pract Neurol 4 600 609 10.1038/ncpneuro0924 1:CAS:528:DC%2BD1cXhtlWktbnM 18978800
    • (2008) Nat Clin Pract Neurol , vol.4 , pp. 600-609
    • Henchcliffe, C.1    Beal, M.F.2
  • 30
    • 0142105387 scopus 로고    scopus 로고
    • Genetic analysis of NF-κB/Rel transcription factors defines functional specificities
    • DOI 10.1093/emboj/cdg534
    • A Hoffmann TH Leung S Baltimore 2003 Genetic analysis of NF-κB/Rel transcription factors defines functional specificities EMBO J 22 5530 5539 10.1093/emboj/cdg534 1:CAS:528:DC%2BD3sXot1Crurk%3D 14532125 (Pubitemid 37279962)
    • (2003) EMBO Journal , vol.22 , Issue.20 , pp. 5530-5539
    • Hoffmann, A.1    Leung, T.H.2    Baltimore, D.3
  • 31
    • 46949110191 scopus 로고    scopus 로고
    • GDNF therapy for Parkinson's disease
    • DOI 10.1586/14737175.8.7.1125
    • M Hong K Mukhida I Medez 2008 GDNF therapy for Parkinson's disease Expert Rev Neurother 8 1125 1139 10.1586/14737175.8.7.1125 1:CAS:528: DC%2BD1cXnvFShs7s%3D 18590482 (Pubitemid 351962079)
    • (2008) Expert Review of Neurotherapeutics , vol.8 , Issue.7 , pp. 1125-1139
    • Hong, M.1    Mukhida, K.2    Mendez, I.3
  • 33
    • 4644239177 scopus 로고    scopus 로고
    • Bcl-2 attenuation of oxidative cell death is associated with up-regulation of γ-glutamylcysteine ligase via constitutive NF-κB activation
    • DOI 10.1074/jbc.M406371200
    • JH Jang YJ Surh 2004 Bcl-2 attenuation of oxidative cell death is associated with up-regulation of gamma-glutamylcysteine ligase via constitutive NF-κB activation J Biol Chem 279 38779 38786 10.1074/jbc.M406371200 1:CAS:528:DC%2BD2cXnt1yjsrs%3D 15208316 (Pubitemid 39296036)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.37 , pp. 38779-38786
    • Jang, J.-H.1    Surh, Y.-J.2
  • 34
    • 0026662141 scopus 로고
    • Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content?
    • 10.1111/j.1471-4159.1992.tb08350.x 1:CAS:528:DyaK38XlsVyms7Y%3D 1494900
    • A Kastner EC Hirsch O Lejeune F Javoy-Agid O Rascol Y Agid 1992 Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? J Neurochem 59 1080 1089 10.1111/j.1471-4159.1992.tb08350.x 1:CAS:528:DyaK38XlsVyms7Y%3D 1494900
    • (1992) J Neurochem , vol.59 , pp. 1080-1089
    • Kastner, A.1    Hirsch, E.C.2    Lejeune, O.3    Javoy-Agid, F.4    Rascol, O.5    Agid, Y.6
  • 35
    • 0028874203 scopus 로고
    • GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo
    • 10.1016/0006-8993(94)01366-P 1:CAS:528:DyaK2MXjs1Ckur0%3D 7749731
    • CM Kearns DM Gash 1995 GDNF protects nigral dopamine neurons against 6-hydroxydopamine in vivo Brain Res 672 104 111 10.1016/0006-8993(94)01366-P 1:CAS:528:DyaK2MXjs1Ckur0%3D 7749731
    • (1995) Brain Res , vol.672 , pp. 104-111
    • Kearns, C.M.1    Gash, D.M.2
  • 36
    • 33646948530 scopus 로고    scopus 로고
    • Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
    • DOI 10.1523/JNEUROSCI.0984-06.2006
    • PM Keeney J Xie RA Capaldi JP Benett Jr 2006 Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled J Neurosci 26 5256 5264 10.1523/JNEUROSCI.0984-06.2006 1:CAS:528:DC%2BD28Xlt1Cisrk%3D 16687518 (Pubitemid 44315308)
    • (2006) Journal of Neuroscience , vol.26 , Issue.19 , pp. 5256-5264
    • Keeney, P.M.1    Xie, J.2    Capaldi, R.A.3    Bennett Jr., J.P.4
  • 37
    • 34247506768 scopus 로고    scopus 로고
    • A tale of two mitochondrial channels, MAC and PTP, in apoptosis
    • DOI 10.1007/s10495-007-0722-z, Special Issue on Mitochondria in Apoptosis
    • KW Kinnally B Antonsson 2007 A tale of two mitochondrial channels, MAC and PTP, in apoptosis Apoptosis 12 857 868 10.1007/s10495-007-0722-z 1:CAS:528:DC%2BD2sXksFamsb8%3D 17294079 (Pubitemid 46653291)
    • (2007) Apoptosis , vol.12 , Issue.5 , pp. 857-868
    • Kinnally, K.W.1    Antonsson, B.2
  • 38
    • 0034522588 scopus 로고    scopus 로고
    • Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: Implications for the life prolonging effect of (-)deprenyl
    • 11205136
    • K Kitani C Minami W Maruyama S Kanai GO Ivy MC Carrillo 2000 Common properties for propargylamines of enhancing superoxide dismutase and catalase activities in the dopaminergic system in the rat: implications for the life prolonging effect of (-)deprenyl J Neural Transm Suppl 60 139 156 11205136
    • (2000) J Neural Transm Suppl , vol.60 , pp. 139-156
    • Kitani, K.1    Minami, C.2    Maruyama, W.3    Kanai, S.4    Ivy, G.O.5    Carrillo, M.C.6
  • 39
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • DOI 10.1152/physrev.00013.2006
    • G Kroemer L Galluzzi C Brenner 2007 Mitochondrial membrane permeabilization in cell death Physiol Rev 87 99 163 10.1152/physrev.00013.2006 1:CAS:528:DC%2BD2sXitVahu7k%3D 17237344 (Pubitemid 46209992)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 40
    • 0034871806 scopus 로고    scopus 로고
    • Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: Comparison of rasagiline (TVP 1012) with selegiline
    • 10.1007/s007020170018 1:CAS:528:DC%2BD3MXotlGjs7o%3D 11716151
    • A Kupsch J Sautter ME Gotz, et al. 2001 Monoamine oxidase-inhibition and MPTP-induced neurotoxicity in the non-human primate: comparison of rasagiline (TVP 1012) with selegiline J Neural Transm 108 985 1009 10.1007/s007020170018 1:CAS:528:DC%2BD3MXotlGjs7o%3D 11716151
    • (2001) J Neural Transm , vol.108 , pp. 985-1009
    • Kupsch, A.1    Sautter, J.2    Gotz, M.E.3
  • 41
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
    • 10.1126/science.6823561 1:STN:280:DyaL3s7hvF2mtg%3D%3D 6823561
    • JW Langston P Ballard JW Tetrud I Irwin 1983 Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis Science 219 979 980 10.1126/science.6823561 1:STN:280:DyaL3s7hvF2mtg%3D%3D 6823561
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 42
    • 58049195155 scopus 로고    scopus 로고
    • Formation of dopamine adducts derived from brain polyunsaturated fatty acids. Mechanism for Parkinson's disease
    • 10.1074/jbc.M805682200 1:CAS:528:DC%2BD1cXhsVGqtrfF 18922792
    • X Liu N Yamada W Maruyama T Osawa 2008 Formation of dopamine adducts derived from brain polyunsaturated fatty acids. Mechanism for Parkinson's disease J Biol Chem 283 34887 34895 10.1074/jbc.M805682200 1:CAS:528: DC%2BD1cXhsVGqtrfF 18922792
    • (2008) J Biol Chem , vol.283 , pp. 34887-34895
    • Liu, X.1    Yamada, N.2    Maruyama, W.3    Osawa, T.4
  • 43
    • 33947612587 scopus 로고    scopus 로고
    • Redox control of neural function: Background, mechanisms, and significance
    • 10.1089/ars.2006.8.1941 1:CAS:528:DC%2BD28XhtVKntb%2FP
    • P Maher 2006 Redox control of neural function: Background, mechanisms, and significance Antioxidants Redox Signal 8 1941 1970 10.1089/ars.2006.8.1941 1:CAS:528:DC%2BD28XhtVKntb%2FP
    • (2006) Antioxidants Redox Signal , vol.8 , pp. 1941-1970
    • Maher, P.1
  • 44
    • 0041731997 scopus 로고    scopus 로고
    • Neuroprotective strategies in Parkinson's disease: An update on progress
    • DOI 10.2165/00023210-200317100-00004
    • S Mandel E Grünblatt P Riederer M Gerlach Y Levites MB Youdim 2003 Neuroprotective strategies in Parkinson's disease: an update on progress CNS Drugs 17 729 762 10.2165/00023210-200317100-00004 1:CAS:528:DC%2BD3sXntl2nsLk%3D 12873156 (Pubitemid 37000010)
    • (2003) CNS Drugs , vol.17 , Issue.10 , pp. 729-762
    • Mandel, S.1    Grunblatt, E.2    Riederer, P.3    Gerlach, M.4    Levites, Y.5    Youdim, M.B.H.6
  • 45
    • 17844406615 scopus 로고    scopus 로고
    • Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives
    • DOI 10.1016/j.brainresrev.2004.12.027, Glial-Neuron Crosstalk in Neuroinflamation, Neurodegeneration and Neuroprotection
    • S Mandel O Weinreb T Amit MB Youdim 2005 Mechanism of neuroprotective action of the anti-Parkinson drug rasagiline and its derivatives Brain Res Brain Res Rev 48 379 387 10.1016/j.brainresrev.2004.12.027 1:CAS:528: DC%2BD2MXjs1Clsr0%3D 15850677 (Pubitemid 40590050)
    • (2005) Brain Research Reviews , vol.48 , Issue.2 , pp. 379-387
    • Mandel, S.1    Weinreb, O.2    Amit, T.3    Youdim, M.B.H.4
  • 46
    • 34250624810 scopus 로고    scopus 로고
    • A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases
    • DOI 10.1242/jcs.03443
    • W Mandemakers VA Morais B De Strooper 2007 A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases J Cell Sci 120 1707 1716 10.1242/jcs.03443 1:CAS:528: DC%2BD2sXmvFWrsro%3D 17502481 (Pubitemid 46930408)
    • (2007) Journal of Cell Science , vol.120 , Issue.10 , pp. 1707-1716
    • Mandemakers, W.1    Morais, V.A.2    De Strooper, B.3
  • 47
    • 0034928655 scopus 로고    scopus 로고
    • Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: Suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine
    • DOI 10.1007/s007020170093
    • W Maruyama AA Boulton BA Davis P Dostert M Naoi 2001 Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: suppression of apoptosis by N-(2-heptyl)-N- methylpropargylamine J Neural Transm 108 11 24 10.1007/s007020170093 1:CAS:528:DC%2BD3MXivVKku7o%3D 11261742 (Pubitemid 32692610)
    • (2001) Journal of Neural Transmission , vol.108 , Issue.1 , pp. 11-24
    • Maruyama, W.1    Boulton, A.A.2    Davis, B.A.3    Dostert, P.4    Naoi, M.5
  • 48
    • 0034939146 scopus 로고    scopus 로고
    • Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022
    • 1:CAS:528:DC%2BD3MXlsV2ksL0%3D 11462787
    • W Maruyama MB Youdim M Naoi 2001 Antiapoptotic properties of rasagiline, N-propargylamine-1(R)-aminoindan, and its optical (S)-isomer, TV1022 Ann NY Acad Sci 939 320 329 1:CAS:528:DC%2BD3MXlsV2ksL0%3D 11462787
    • (2001) Ann NY Acad Sci , vol.939 , pp. 320-329
    • Maruyama, W.1    Youdim, M.B.2    Naoi, M.3
  • 49
    • 0034884148 scopus 로고    scopus 로고
    • Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol
    • DOI 10.1046/j.1471-4159.2001.00448.x
    • W Maruyama Y Akao MB Youdim BA Davis M Naoi 2001 Transfection- enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol J Neurochem 78 727 735 10.1046/j.1471-4159.2001.00448.x 1:CAS:528:DC%2BD3MXmt1egs70%3D 11520893 (Pubitemid 32777974)
    • (2001) Journal of Neurochemistry , vol.78 , Issue.4 , pp. 727-735
    • Maruyama, W.1    Akao, Y.2    Youdim, M.B.H.3    Davis, B.A.4    Naoi, M.5
  • 50
    • 0036719861 scopus 로고    scopus 로고
    • Neuroprotection by propargylamines in Parkinson's disease: Suppression of apoptosis and induction of prosurvival genes
    • DOI 10.1016/S0892-0362(02)00221-0, PII S0892036202002210
    • W Maruyama Y Akao MC Carrillo K Kitani MB Youdim M Naoi 2002 Neuroprotection by propargylamines in Parkinson's disease. Suppression of apoptosis and induction of prosurvival genes Neurotoxicol Teratol 24 675 682 10.1016/S0892-0362(02)00221-0 1:CAS:528:DC%2BD38XmsVCit7c%3D 12200198 (Pubitemid 35013527)
    • (2002) Neurotoxicology and Teratology , vol.24 , Issue.5 , pp. 675-682
    • Maruyama, W.1    Akao, Y.2    Carrillo, M.C.3    Kitani, K.-I.4    Youdium, M.B.H.5    Naoi, M.6
  • 51
    • 0036206323 scopus 로고    scopus 로고
    • The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells
    • DOI 10.1007/s007020200038
    • W Maruyama T Takahashi M Youdim M Naoi 2002 The anti-Parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human dopaminergic neuroblastoma SH-SY5Y cells J Neural Transm 109 467 481 10.1007/s007020200038 1:CAS:528:DC%2BD38XltFagurs%3D 11956966 (Pubitemid 34280405)
    • (2002) Journal of Neural Transmission , vol.109 , Issue.4 , pp. 467-481
    • Maruyama, W.1    Takahashi, T.2    Youdim, M.3    Naoi, M.4
  • 52
    • 0345237921 scopus 로고    scopus 로고
    • Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)- aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor
    • DOI 10.1016/S0304-3940(03)00211-8
    • W Maruyama M Weinstock MB Youdim M Nagai M Naoi 2003 Anti-apoptotic action of anti-Alzheimer drug, TV3326 [(N-propargyl)-(3R)-aminoindan-5-yl]-ethyl methyl carbamate, a novel cholinesterase-monoamine oxidase inhibitor Neurosci Lett 341 233 236 10.1016/S0304-3940(03)00211-8 1:CAS:528:DC%2BD3sXivFCqt7Y%3D 12697291 (Pubitemid 36403771)
    • (2003) Neuroscience Letters , vol.341 , Issue.3 , pp. 233-236
    • Maruyama, W.1    Weinstock, M.2    Youdim, M.B.H.3    Nagai, M.4    Naoi, M.5
  • 53
    • 0346848857 scopus 로고    scopus 로고
    • N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-κB transcription factor
    • DOI 10.1016/j.neuint.2003.08.005
    • W Maruyama A Nitta M Shamoto-Nagai Y Hirata Y Akao M Youdim S Furukawa T Nabeshima M Naoi 2004 N-Propargyl-1(R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kB transcription factor Neurochem Int 44 393 400 10.1016/j.neuint.2003.08.005 1:CAS:528:DC%2BD3sXpvVWnsLk%3D 14687604 (Pubitemid 37548404)
    • (2004) Neurochemistry International , vol.44 , Issue.6 , pp. 393-400
    • Maruyama, W.1    Nitta, A.2    Shamoto-Nagai, M.3    Hirata, Y.4    Akao, Y.5    Yodim, M.6    Furukawa, S.7    Nabeshima, T.8    Naoi, M.9
  • 54
    • 0037109064 scopus 로고    scopus 로고
    • Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore
    • DOI 10.1042/BJ20011672
    • GP McStay SJ Clarke AP Halestrap 2002 Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore Biochem J 367 541 548 10.1042/BJ20011672 1:CAS:528:DC%2BD38XotVWlt7k%3D 12149099 (Pubitemid 35216831)
    • (2002) Biochemical Journal , vol.367 , Issue.2 , pp. 541-548
    • McStay, G.P.1    Clarke, S.J.2    Halestrap, A.P.3
  • 55
    • 0029033862 scopus 로고
    • Mitochondrial changes associated with glutathione deficiency
    • 7599223
    • A Meister 1995 Mitochondrial changes associated with glutathione deficiency Biochim Biophys Acta 1271 35 42 7599223
    • (1995) Biochim Biophys Acta , vol.1271 , pp. 35-42
    • Meister, A.1
  • 56
    • 0034731367 scopus 로고    scopus 로고
    • Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes
    • DOI 10.1006/bbrc.2000.4037
    • I Mizuta N Ohta K Ohta M Nishimura E Mizuta K Hayashi S Kuno 2000 Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes Biochem Biophys Res Commun 279 751 755 10.1006/bbrc.2000.4037 1:CAS:528:DC%2BD3MXivValug%3D%3D 11162424 (Pubitemid 32042852)
    • (2000) Biochemical and Biophysical Research Communications , vol.279 , Issue.3 , pp. 751-755
    • Mizuta, I.1    Ohta, M.2    Ohta, K.3    Nishimura, M.4    Mizuta, E.5    Hayashi, K.6    Kuno, S.7
  • 57
    • 70349314934 scopus 로고    scopus 로고
    • Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease
    • 10.1586/ern.09.68 1:CAS:528:DC%2BD1MXpvF2ku70%3D 19673610
    • M Naoi W Maruyama 2009 Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease Expert Rev Neurother 9 1233 1250 10.1586/ern.09.68 1:CAS:528:DC%2BD1MXpvF2ku70%3D 19673610
    • (2009) Expert Rev Neurother , vol.9 , pp. 1233-1250
    • Naoi, M.1    Maruyama, W.2
  • 58
    • 0036717067 scopus 로고    scopus 로고
    • Dopamine-derived endogenous N-methyl-(R)-salsolinol: Its role in Parkinson's disease
    • DOI 10.1016/S0892-0362(02)00211-8, PII S0892036202002118
    • M Naoi W Maruyama Y Akao H Yi 2002 Dopamine-derived endogenous N-methyl-(R)-salsolinol. Its role in Parkinson's disease Neurotoxicol Teratol 24 579 591 10.1016/S0892-0362(02)00211-8 1:CAS:528:DC%2BD38XmsVCit74%3D 12200189 (Pubitemid 35013519)
    • (2002) Neurotoxicology and Teratology , vol.24 , Issue.5 , pp. 579-591
    • Naoi, M.1    Maruyama, W.2    Akao, Y.3    Yi, H.4
  • 59
    • 0036329996 scopus 로고    scopus 로고
    • Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines
    • DOI 10.1007/s007020200050
    • M Naoi W Maruyama Y Akao H Yi 2002 Mitochondria determine the survival and death in apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, and neuroprotection by propargylamines J Neural Transm 109 607 621 10.1007/s007020200050 1:CAS:528:DC%2BD38XmtVCqsrs%3D 12111453 (Pubitemid 34810759)
    • (2002) Journal of Neural Transmission , vol.109 , Issue.5-6 , pp. 607-621
    • Naoi, M.1    Maruyama, W.2    Akao, Y.3    Yi, H.4
  • 60
    • 34248549035 scopus 로고    scopus 로고
    • Involvement of type A monoamine oxidase in neurodegeneration: Regulation of mitochondrial signaling leading to cell death or neuroprotection
    • 10.1007/978-3-211-33328-0-8 1:CAS:528:DC%2BD28Xht1OltLjE 17447417
    • M Naoi W Maruyama Y Akao H Yi Y Yamaoka 2006 Involvement of type A monoamine oxidase in neurodegeneration: regulation of mitochondrial signaling leading to cell death or neuroprotection J Neural Transm Suppl 71 67 77 10.1007/978-3-211-33328-0-8 1:CAS:528:DC%2BD28Xht1OltLjE 17447417
    • (2006) J Neural Transm Suppl , vol.71 , pp. 67-77
    • Naoi, M.1    Maruyama, W.2    Akao, Y.3    Yi, H.4    Yamaoka, Y.5
  • 61
    • 38449116644 scopus 로고    scopus 로고
    • Neuroprotection by propargylamines in Parkinson's disease: Intracellular mechanism underlying the anti-apoptotic function and search for clinical markers
    • 10.1007/978-3-211-73574-9-15 1:CAS:528:DC%2BD2sXhsVKns7nM
    • M Naoi W Maruyama H Yi Y Akao Y Yamaoka M Shamoto-Nagai 2007 Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers J Neural Transm Supp 72 121 131 10.1007/978-3-211-73574-9-15 1:CAS:528:DC%2BD2sXhsVKns7nM
    • (2007) J Neural Transm Supp , vol.72 , pp. 121-131
    • Naoi, M.1    Maruyama, W.2    Yi, H.3    Akao, Y.4    Yamaoka, Y.5    Shamoto-Nagai, M.6
  • 62
    • 44649136091 scopus 로고    scopus 로고
    • Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: Involvement of the protein and melanin component
    • DOI 10.1111/j.1471-4159.2008.05329.x
    • M Naoi W Maruyama H Yi, et al. 2008 Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of protein and melanin component J Neurochem 105 2489 2500 10.1111/j.1471-4159.2008.05329.x 1:CAS:528:DC%2BD1cXnvVWiu7w%3D (Pubitemid 351782270)
    • (2008) Journal of Neurochemistry , vol.105 , Issue.6 , pp. 2489-2500
    • Naoi, M.1    Maruyama, W.2    Yi, H.3    Yamaoka, Y.4    Shamoto-Nagai, M.5    Akao, Y.6    Gerlach, M.7    Tanaka, M.8    Riederer, P.9
  • 63
    • 70449518337 scopus 로고    scopus 로고
    • Glycerldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan
    • 10.1007/s12640-009-9064-7 1:CAS:528:DC%2BD1MXptFCrtrc%3D
    • XM Ou D Lu C Johnson K Chen MBH Youdim G Rajkowska JC Shih 2009 Glycerldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan Neurotoxicol Res 16 148 159 10.1007/s12640-009-9064-7 1:CAS:528: DC%2BD1MXptFCrtrc%3D
    • (2009) Neurotoxicol Res , vol.16 , pp. 148-159
    • Ou, X.M.1    Lu, D.2    Johnson, C.3    Chen, K.4    Youdim, M.B.H.5    Rajkowska, G.6    Shih, J.C.7
  • 64
    • 29644447278 scopus 로고    scopus 로고
    • Rotenone model of Parkinson disease: Multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication
    • DOI 10.1074/jbc.M508628200
    • A Panov S Dikalov N Shalbuyeva G Taylor T Shererr JT Greenamyre 2005 Rotenone model of Parkinson's disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication J Biol Chem 280 42026 42035 10.1074/jbc.M508628200 1:CAS:528:DC%2BD2MXhtlajsrbM 16243845 (Pubitemid 43023171)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.51 , pp. 42026-42035
    • Panov, A.1    Dikalov, S.2    Shalbuyeva, N.3    Taylor, G.4    Sherer, T.5    Greenamyre, J.T.6
  • 65
    • 0025967971 scopus 로고
    • Specific detection of quinoproteins by redox-cycling staining
    • 1:CAS:528:DyaK3MXpslWhsw%3D%3D 1702437
    • MA Paz R Flückinger A Boak M Kagan PM Gallop 1991 Specific detection of quinoproteins by redox-cycling staining J Biol Chem 266 689 692 1:CAS:528:DyaK3MXpslWhsw%3D%3D 1702437
    • (1991) J Biol Chem , vol.266 , pp. 689-692
    • Paz, M.A.1    Flückinger, R.2    Boak, A.3    Kagan, M.4    Gallop, P.M.5
  • 67
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-κB and IKK function
    • DOI 10.1038/nrm2083, PII NRM2083
    • ND Perkins 2007 Integrating cell-signalling pathways with NF-κB and IKK function Nat Rev Mol Cell Biol 8 49 62 10.1038/nrm2083 1:CAS:528: DC%2BD28XhtlCjt7bK 17183360 (Pubitemid 46012014)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.1 , pp. 49-62
    • Perkins, N.D.1
  • 68
    • 10244222286 scopus 로고    scopus 로고
    • MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    • DOI 10.1023/B:JOBB.0000041771.66775.d5
    • S Przedborski K Tieu C Perier N Vila 2004 MPTP as a mitochondrial neurotoxic model of Parkinson's disease J Bioenerg Biomembr 36 375 379 10.1023/B:JOBB.0000041771.66775.d5 1:CAS:528:DC%2BD2cXnsFyjtbc%3D 15377875 (Pubitemid 39619844)
    • (2004) Journal of Bioenergetics and Biomembranes , vol.36 , Issue.4 SPEC.ISS. , pp. 375-379
    • Przedborski, S.1    Tieu, K.2    Perier, C.3    Vila, M.4
  • 69
    • 34547128886 scopus 로고    scopus 로고
    • Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFκB
    • DOI 10.1074/jbc.M610934200
    • S Qanungo DW Starke HV Pai JJ Mieyal A-L Nieminen 2007 Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFκB J Biol Chem 282 18427 18436 10.1074/jbc.M610934200 1:CAS:528:DC%2BD2sXmsVOks70%3D 17468103 (Pubitemid 47100260)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.25 , pp. 18427-18436
    • Qanungo, S.1    Starke, D.W.2    Pai, H.V.3    Mieyal, J.J.4    Nieminen, A.-L.5
  • 70
    • 0028807095 scopus 로고
    • Imidazoline/guanidinium binding domains on monoamine oxidases
    • 10.1074/jbc.270.46.27961 1:CAS:528:DyaK2MXpsFShu70%3D 7499273
    • R Raddatz A Parini SM Lanier 1995 Imidazoline/guanidinium binding domains on monoamine oxidases J Biol Chem 270 27961 27968 10.1074/jbc.270.46.27961 1:CAS:528:DyaK2MXpsFShu70%3D 7499273
    • (1995) J Biol Chem , vol.270 , pp. 27961-27968
    • Raddatz, R.1    Parini, A.2    Lanier, S.M.3
  • 72
    • 13944260852 scopus 로고    scopus 로고
    • Views on neurodegeneration as a basis for neuroprotective strategies
    • 1:CAS:528:DC%2BD2MXls1Ckug%3D%3D
    • PF Riederer 2004 Views on neurodegeneration as a basis for neuroprotective strategies Med Sci Monit 10 RA287 RA290 1:CAS:528: DC%2BD2MXls1Ckug%3D%3D
    • (2004) Med Sci Monit , vol.10
    • Riederer, P.F.1
  • 73
    • 0024557734 scopus 로고
    • Transition metals, ferritin, glutathione, and ascorbic acid in parkinsonian brains
    • DOI 10.1111/j.1471-4159.1989.tb09150.x
    • P Riederer E Sofic W-D Rausch B Schmidt GP Reynolds K Jellinger MB Youdim 1989 Transition metals, ferritin, glutathione, and ascorbic acid in Parkinsonian brains J Neurochem 52 515 520 10.1111/j.1471-4159.1989.tb09150.x 1:CAS:528:DyaL1MXhtFals78%3D 2911028 (Pubitemid 19037617)
    • (1989) Journal of Neurochemistry , vol.52 , Issue.2 , pp. 515-520
    • Riederer, P.1    Sofic, E.2    Rausch, W.-D.3    Schmidt, B.4    Reynolds, G.P.5    Jellinger, K.6    Youdim, M.B.H.7
  • 74
    • 33751078859 scopus 로고    scopus 로고
    • Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism
    • DOI 10.1016/j.nbd.2006.07.020, PII S0969996106002063
    • Y Sagi S Mandel T Amit MB Youdim 2007 Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP induced parkinsonism Neurobiol Dis 25 35 44 10.1016/j.nbd.2006.07.020 1:CAS:528:DC%2BD28Xht1Cls73L 17055733 (Pubitemid 44765215)
    • (2007) Neurobiology of Disease , vol.25 , Issue.1 , pp. 35-44
    • Sagi, Y.1    Mandel, S.2    Amit, T.3    Youdim, M.B.H.4
  • 75
    • 0035371184 scopus 로고    scopus 로고
    • Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
    • DOI 10.1016/S0891-5849(01)00480-4, PII S0891584901004804
    • FQ Schafer GR Beutner 2001 Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple Free Rad Biol Med 30 1191 1212 10.1016/S0891-5849(01)00480-4 1:CAS:528: DC%2BD3MXjsFegt78%3D 11368918 (Pubitemid 32463931)
    • (2001) Free Radical Biology and Medicine , vol.30 , Issue.11 , pp. 1191-1212
    • Schafer, F.Q.1    Buettner, G.R.2
  • 76
    • 0025254401 scopus 로고
    • Mitochondrial complex i deficiency in Parkinson's disease
    • 10.1111/j.1471-4159.1990.tb02325.x 1:CAS:528:DyaK3cXhsFKiur4%3D 2154550
    • AH Schapira JM Cooper D Dexter JB Clark P Jenner CD Marsden 1990 Mitochondrial complex I deficiency in Parkinson's disease J Neurochem 54 823 827 10.1111/j.1471-4159.1990.tb02325.x 1:CAS:528:DyaK3cXhsFKiur4%3D 2154550
    • (1990) J Neurochem , vol.54 , pp. 823-827
    • Schapira, A.H.1    Cooper, J.M.2    Dexter, D.3    Clark, J.B.4    Jenner, P.5    Marsden, C.D.6
  • 77
    • 33745936902 scopus 로고    scopus 로고
    • Bcl-2-related survival proteins
    • DOI 10.1038/sj.cdd.4401982, PII 4401982
    • PS Schwartz DM Hockenbery 2006 Bcl-2-related survival proteins Cell Death Differ 13 1250 1255 10.1038/sj.cdd.4401982 1:CAS:528:DC%2BD28XmvFaitbs%3D 16763619 (Pubitemid 44057453)
    • (2006) Cell Death and Differentiation , vol.13 , Issue.8 , pp. 1250-1255
    • Schwartz, P.S.1    Hockenbery, D.M.2
  • 78
    • 0030574241 scopus 로고    scopus 로고
    • Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage
    • DOI 10.1016/S0014-2999(96)00593-6, PII S0014299996005936
    • I Semkova P Woilz M Schilling J Krieglstein 1996 Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage Eur J Pharmacol 315 19 30 10.1016/S0014-2999(96)00593-6 1:CAS:528:DyaK28XntFWqu7Y%3D 8960860 (Pubitemid 26390945)
    • (1996) European Journal of Pharmacology , vol.315 , Issue.1 , pp. 19-30
    • Semkova, I.1    Wolz, P.2    Schilling, M.3    Krieglstein, J.4
  • 79
    • 0028121120 scopus 로고
    • Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by R(-)-deprenyl
    • 10.1002/jnr.490370213 1:CAS:528:DyaK2cXhvVart7k%3D 8060389
    • NA Seniuk JT Henderson WG Tatton JC Roder 1994 Increased CNTF gene expression in process-bearing astrocytes following injury is augmented by R(-)-deprenyl J Neurosci Res 37 278 286 10.1002/jnr.490370213 1:CAS:528:DyaK2cXhvVart7k%3D 8060389
    • (1994) J Neurosci Res , vol.37 , pp. 278-286
    • Seniuk, N.A.1    Henderson, J.T.2    Tatton, W.G.3    Roder, J.C.4
  • 80
    • 20844463252 scopus 로고    scopus 로고
    • Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: Therapeutic implications
    • DOI 10.2174/1568007053005127
    • JJ Shacka KA Roth 2005 Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications Curr Drug Targets CNS Neurol Dis 4 25 39 10.2174/1568007053005127 1:CAS:528:DC%2BD2MXhsVKmsbg%3D (Pubitemid 41408406)
    • (2005) Current Drug Targets: CNS and Neurological Disorders , vol.4 , Issue.1 , pp. 25-39
    • Shacka, J.J.1    Roth, K.A.2
  • 82
    • 33646378453 scopus 로고    scopus 로고
    • Neuromelanin induces oxidative stress in mitochondria through release of iron: Mechanism behind the inhibition of 26S proteasome
    • DOI 10.1007/s00702-005-0410-5
    • M Shamoto-Nagai W Maruyama H Yi Y Akao F Tribl M Gerlach T Osawa P Riederer M Naoi 2006 Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome J Neural Transm 113 633 644 10.1007/s00702-005-0410-5 1:CAS:528: DC%2BD28XjvFGhurs%3D 16362626 (Pubitemid 43673603)
    • (2006) Journal of Neural Transmission , vol.113 , Issue.5 , pp. 633-644
    • Shamoto-Nagai, M.1    Maruyama, W.2    Yi, H.3    Akao, Y.4    Tribl, F.5    Gerlach, M.6    Osawa, T.7    Riederer, P.8    Naoi, M.9
  • 83
    • 26444532918 scopus 로고    scopus 로고
    • Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins
    • DOI 10.1007/s10863-005-6590-8
    • L Soane G Fiskum 2005 Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family protein J Bioerg Biomembr 37 179 190 10.1007/s10863-005-6590-8 1:CAS:528:DC%2BD2MXhtVWiu7%2FM (Pubitemid 41420473)
    • (2005) Journal of Bioenergetics and Biomembranes , vol.37 , Issue.3 , pp. 179-190
    • Soane, L.1    Fiskum, G.2
  • 84
    • 0001155209 scopus 로고    scopus 로고
    • Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments
    • DOI 10.1002/(SICI)1097-4547(19980901)53:5<593::AID-JNR9>3.0.CO;2-4
    • YP Tang YL Ma CC Chao KY Chen EHY Lee 1998 Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments J Neurosci Res 53 593 604 10.1002/(SICI)1097-4547(19980901)53: 5<593::AID-JNR9>3.0.CO;2-4 1:STN:280:DyaK1czptlSgsw%3D%3D 9726430 (Pubitemid 28380800)
    • (1998) Journal of Neuroscience Research , vol.53 , Issue.5 , pp. 593-604
    • Tang, Y.P.1    Ma, Y.L.2    Chao, C.C.3    Chen, K.Y.4    Lee, E.H.Y.5
  • 85
    • 0027941312 scopus 로고
    • (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
    • 1:CAS:528:DyaK2cXmt1WrsLg%3D 7931312
    • WG Tatton WYL Ju DP Holland C Tai M Kwan 1994 (-)-Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis J Neurochem 63 1572 1575 1:CAS:528:DyaK2cXmt1WrsLg%3D 7931312
    • (1994) J Neurochem , vol.63 , pp. 1572-1575
    • Tatton, W.G.1    Ju, W.Y.L.2    Holland, D.P.3    Tai, C.4    Kwan, M.5
  • 87
    • 0037490142 scopus 로고    scopus 로고
    • Reversible glutathionylation of complex I increases mitochondrial superoxide formation
    • DOI 10.1074/jbc.M209359200
    • ER Taylor F Hurrell RJ Shannon TK Lin J Hirst MP Murphy 2003 Reversible glutathionylation of complex I increases mitochondrial superoxide formation J Biol Chem 278 19603 19610 10.1074/jbc.M209359200 1:CAS:528:DC%2BD3sXktVaqsLY%3D 12649289 (Pubitemid 36799143)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.22 , pp. 19603-19610
    • Taylor, E.R.1    Hurrell, F.2    Shannon, R.J.3    Lin, T.-K.4    Hirst, J.5    Murphy, M.P.6
  • 88
    • 38349049487 scopus 로고    scopus 로고
    • S-Glutathionylation Indicator of cell stress and regulator of the unfolded protein response
    • 10.1124/mi.7.6.7 1:CAS:528:DC%2BD1cXitVWisbw%3D 18199853
    • DM Townsend 2007 S-Glutathionylation Indicator of cell stress and regulator of the unfolded protein response Mol Interv 7 313 324 10.1124/mi.7.6.7 1:CAS:528:DC%2BD1cXitVWisbw%3D 18199853
    • (2007) Mol Interv , vol.7 , pp. 313-324
    • Townsend, D.M.1
  • 89
    • 3142523288 scopus 로고    scopus 로고
    • Genetic clues to the pathogenesis of Parkinson's disease
    • DOI 10.1038/nm1068
    • M Vila S Przedborski 2004 Genetic clues to the pathogenesis of Parkinson's disease Nat Med 10 S58 S62 10.1038/nm1068 15272270 (Pubitemid 38901868)
    • (2004) Nature Medicine , vol.10 , Issue.SUPPL.
    • Vila, M.1    Przedborski, S.2
  • 90
    • 53149087460 scopus 로고    scopus 로고
    • Mitochondrial alterations in Parkinson's disease: New clues
    • 10.1111/j.1471-4159.2008.05604.x 1:CAS:528:DC%2BD1cXhtlajtb3J 18680555
    • M Vila D Ramonet C Perier 2008 Mitochondrial alterations in Parkinson's disease: new clues J Neurochem 107 317 328 10.1111/j.1471-4159.2008.05604.x 1:CAS:528:DC%2BD1cXhtlajtb3J 18680555
    • (2008) J Neurochem , vol.107 , pp. 317-328
    • Vila, M.1    Ramonet, D.2    Perier, C.3
  • 91
    • 6944242126 scopus 로고    scopus 로고
    • Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members
    • 1:CAS:528:DC%2BD2cXntlKkuro%3D 15247150
    • O Weinreb O Bar-Am T Amit O Chillag-Talmor MB Youdim 2004 Neuroprotection via pro-survival protein kinase C isoforms associated with Bcl-2 family members FASEB J 18 1471 1473 1:CAS:528:DC%2BD2cXntlKkuro%3D 15247150
    • (2004) FASEB J , vol.18 , pp. 1471-1473
    • Weinreb, O.1    Bar-Am, O.2    Amit, T.3    Chillag-Talmor, O.4    Youdim, M.B.5
  • 93
    • 33644874108 scopus 로고    scopus 로고
    • Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl-(R)salsolinol, leading to apoptosis in SH-SY5Y cells
    • 10.1111/j.1471-4159.2005.03573.x 1:CAS:528:DC%2BD28XntVShsQ%3D%3D 16336631
    • H Yi Y Akao W Maruyama K Chen J Shih M Naoi 2006 Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl-(R)salsolinol, leading to apoptosis in SH-SY5Y cells J Neurochem 96 541 549 10.1111/j.1471-4159.2005.03573.x 1:CAS:528:DC%2BD28XntVShsQ%3D%3D 16336631
    • (2006) J Neurochem , vol.96 , pp. 541-549
    • Yi, H.1    Akao, Y.2    Maruyama, W.3    Chen, K.4    Shih, J.5    Naoi, M.6
  • 94
    • 29244431681 scopus 로고    scopus 로고
    • N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2
    • DOI 10.1007/s00702-005-0299-z
    • H Yi W Maruyama Y Akao T Takahashi K Iwasa MBH Youdim M Naoi 2006 N-Propargylamine protects SH-SY5Y cells from apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, through stabilization of mitochondrial membrane and induction of anti-apoptotic Bcl-2 J Neural Transm 113 21 32 10.1007/s00702-005-0299-z 1:CAS:528:DC%2BD2MXhtlCksrfN 15843867 (Pubitemid 41828953)
    • (2006) Journal of Neural Transmission , vol.113 , Issue.1 , pp. 21-32
    • Yi, H.1    Maruyama, W.2    Akao, Y.3    Takahashi, T.4    Iwasa, K.5    Youdim, M.B.H.6    Naoi, M.7
  • 95
    • 0642345197 scopus 로고    scopus 로고
    • The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline
    • DOI 10.1016/S0006-2952(03)00535-5, PII S0006295203005355
    • MB Youdim T Amit M Falach-Vogev OB Am W Maruyama M Naoi 2003 The essentiality of Bcl-2, PKC and proteasome-ubiquitin complex activations in the neuroprotective-antiapoptotic action of the anti-Parkinson drug, rasagiline Biochem Pharmacol 66 1635 1641 10.1016/S0006-2952(03)00535-5 1:CAS:528:DC%2BD3sXnvVeqsLk%3D 14555244 (Pubitemid 38373356)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.8 , pp. 1635-1641
    • Youdim, M.B.H.1    Amit, T.2    Falach-Yogev, M.3    Am, O.B.4    Maruyama, W.5    Naoi, M.6
  • 96
    • 33645307953 scopus 로고    scopus 로고
    • The therapeutic potential of monoamine oxidase inhibitors
    • 10.1038/nrn1883 1:CAS:528:DC%2BD28Xis1Gksrs%3D
    • MBH Youdim D Edmondson KF Tipton 2006 The therapeutic potential of monoamine oxidase inhibitors Nat Rev Neurosi 7 295 309 10.1038/nrn1883 1:CAS:528:DC%2BD28Xis1Gksrs%3D
    • (2006) Nat Rev Neurosi , vol.7 , pp. 295-309
    • Youdim, M.B.H.1    Edmondson, D.2    Tipton, K.F.3
  • 97
    • 47749110631 scopus 로고    scopus 로고
    • Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra; Implications for Parkinson's disease
    • 10.1007/s00401-008-0361-7 1:CAS:528:DC%2BD1cXosVOjtLg%3D 18343932
    • L Zecca H Wilms S Geick, et al. 2008 Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra; implications for Parkinson's disease Acta Neuropathol 116 47 55 10.1007/s00401-008-0361-7 1:CAS:528:DC%2BD1cXosVOjtLg%3D 18343932
    • (2008) Acta Neuropathol , vol.116 , pp. 47-55
    • Zecca, L.1    Wilms, H.2    Geick, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.