Histochemical detection of apoptosis in Parkinson's disease

Journal of the Neurological Sciences

Volumn 137, Issue 2, 1996, Pages 120-123

  Mochizuki, Hideki ^a   Goto, Keigo ^a   Mori, Hideo ^a   Mizuno, Yoshikuni ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; In situ DNA nick end labeling; Parkinson's disease

Indexed keywords

DNA FRAGMENT;

ADULT; AGED; APOPTOSIS; ARTICLE; CELL DEATH; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

EID: 0029942337     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-510X(95)00336-Z     Document Type: Article

References (20)

1. Burns, R.S., Chiueh, C.C., Markey, S.P., Ebert, M.H., Jacobowitz, D, and Kopin, I.J. (1983) A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc Natl Acad Sci USA, 80: 4546-4550.
2. Carson, A.D. and Riberio, J.M. (1993) Apoptosis and disease. Lancet, 341:1251-1254.
3. Chiba, K., Trevor, A.J. and Castagnoli, N. Jr. (1984) Metabolism of the neurotoxic teritially amine, MPTP, by brain monoamine oxidase. Biochem Biophys Res Commun., 120: 574-578.
4. +, metabolite of MPTP, by brain synaptosomes. Biochem Biophys Res Commun., 129: 1228-1232.
5. Dragunow, M., Faull, L.M., Lawlor, P., Beilharz, E.J., Singleton, K., Walker, E.B. and Mee, E. (1995) In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobe. Neuro Report 6, 1053-1057.
6. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol., 119: 493-501.
7. Gold, R., Schmied, M., Rocthe, G., Breitschpf, H., Wekerle, H., and Lassmann, H., (1993) Detection of DNA fragmentation in apoptosis: Application of in situ nick translation to cell culture systems and tissue sections. J. Histochem. Cytochem. 41: 1023-1030.
8. Gold, R., Schmied, M., Giegerich, G., Breitschpf, H., Hartung, H.P., Toyka, K. V. and Lassmann, H., (1994) Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques. Lab. Invest., 71: 219-225.
9. Hattori, N., Tanaka, M., Ozawa, T. and Mizuno, Y., (1991) Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease. Ann. Neurol., 130: 563-571.
10. Ikebe, S., Tanaka, M., Ohno, K., Sato, W., Hattori, K., Kondo, T., Mizuno, Y. and Ozawa, T. (1990) Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence. Biochem Biophys Res Commum., 170: 1044-1048.
11. Ikebe, S., Tanaka, M. and Ozawa, T. (1995) Point mutations of mitochondrial genome in Parkinson's disease. Mol. Brain Res, 28: 281-295.
12. +): identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci Lett., 48: 87-92.
13. Lassmann, H., Bancher, C., Breitschopf, H., Wegiel, J., Bobinski, M., Jellinger, K. and Wisniewski, H.M., (1995) Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ, Acta. Neuropathol., 89: 35-41.
14. Mizuno, Y., Sone, N. and Saitoh, T. (1987) Effects of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain, J Neurochem., 48: 1787-1793.
15. Mochizuki, H., Nishi, K. and Mizuno, Y. (1993) Iron-melanin complex is toxic to dopaminergic neurons in a nigrostriatal co-culture. Neurodegeneration, 2: 2-7.
16. +) in a ventral mesencephalic-striatal co-culture in rat. Neurosci Lett., 170: 191-194.
17. +) and tetrahydroisoquinoline derivates on dopaminergic neurons in ventral mesencephalic-striatal co-culture. Neurodegeneration, 3: 33-42.
18. Schapira, A.V., Cooper, J.M., Dexter, D., Jenner, P., Clark, J.B. and Marsden, C.D. (1989) Mitochondrial complex I deficiency in Parkinson's disese. Lancet, i: 1269.
19. Wolvetang, E.J., Johnson, K.L., Krauer, K., Ralph, S.J. and Linnane, A.W. (1994) Mitochondrial respiraory chain inhibitors induce apoptosis. FEBS Lett., 339: 40-44.
20. Ziv, I., Melamed, E., Nardi, N., Luria, D., Achiron, A., Offen, D. and Barzilai, A. (1994) Dopamine induces apoptosis-like cell death in cultured chick sympathetic neurons - a possible novel pathogetic mechanism in Parkinson's disease, Neurosci. Lett., 170:136-140.