Control of the cell death pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-related caspase activator

Molecular Cell

Volumn 4, Issue 5, 1999, Pages 757-769

  Kanuka, Hirotaka ^a   Sawamoto, Kazunobu ^a,b,c   Inohara, Naohiro ^d   Matsuno, Kenji ^a,b,e   Okano, Hideyuki ^a,b   Miura, Masayuki ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Sci and Technology Agency of Japan   (Japan)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APAF 1; CASPASE; CED 4 PROTEIN; CYTOCHROME C; DAFAF 1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING AFFINITY; DROSOPHILA; ENZYME ACTIVATION; GENE EXPRESSION; NONHUMAN; SEQUENCE HOMOLOGY;

EID: 0033231614     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80386-X     Document Type: Article

References (59)

1. Abrams, J.M., White, K., Fessler, L.I., and Steller, H. (1993). Programmed cell death during Drosophila embryogenesis. Development 117, 29-43.
2. Aravind, L., Dixit, V.M., and Koonin, E.V. (1999). The domains of death: evolution of the apoptosis machinery. Trends Biochem. Sci. 24, 47-53.
3. Ashkenazi, A., and Dixit, V.M. (1998). Death receptors: signaling and modulation. Science 281, 1305-1308.
4. + channels. Proc. Natl. Acad. Sci. USA 95, 11703-11708.
5. Boise, L.H., Gonzalez-Garcia, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nunez, G., Thompson, C.B. (1993). bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608.
6. Brand, A.M., and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
7. Cecconi, F., Alvarez, B.G., Meyer, B.I., Roth, K.A., and Gruss, P. (1998). Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727-737.
8. Chen, P., Nordstrom, W., Gish, B., and Abrams, J.M. (1996). grim, a novel cell death gene in Drosophila. Genes Dev. 10, 1773-1782.
9. Chen, P., Rodriguez, A., Erskine, R., Thach, T., and Abrams, J.M. (1998). Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila. Dev. Biol. 207, 202-216.
10. Chinnaiyan, A.M., Chaudhary, D., O'Rourke, K., Koonin, E.V., and Dixit, V.M. (1997a). Role of CED-4 in the activation of CED-3. Nature 388, 728-729.
11. Chinnaiyan, A.M., O'Rourke, K., Lane, B.R., and Dixit, V.M. (1997b). Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 275, 1122-1126.
12. Chou, J.J., Matsuo, H., Duan, H., and Wagner, G. (1998). Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 94, 171-180.
13. Conradt, B., and Horvitz, H.R. (1998). The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9. Cell 93, 519-529.
14. Dorstyn, L., Colussi, P.A., Quinn, L.M., Richardson, H., and Kumar, S. (1999). DRONC, an ecdysone-inducible Drosophila caspase. Proc. Natl. Acad. Sci. USA 96, 4307-4312.
15. Enari, M., Talanian, R.V., Wong, W.W., and Nagata, S. (1996). Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380, 723-726.
16. Fraser, A.G., and Evan, G.I. (1997a). Identification of a Drosophila melanogaster ICE/CED-3-related protease, drICE. EMBO J. 16, 2805-2813.
17. Fraser, A.G., McCarthy, N.J., and Evan, G.I. (1997b). drICE is an essential caspase required for apoptotic activity in Drosophila cells. EMBO J. 16, 6192-6199.
18. Grether, M.E., Abrams, J.M., Agapite, J., White, K., and Steller, H. (1995). The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 9, 1694-1708.
19. Hakem, R., Hakem, A., Duncan, G.S., Henderson, J.T., Woo, M., Soengas, M.S., Elia, A., De la Pompa, J.L., Kagi, D., Khoo, W., et al. (1998). Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94, 339-352.
20. Hay, B.A., Wolff, T., and Rubin, G.M. (1994). Expression of baculovirus P35 prevents cell death in Drosophila. Development 720, 2121-2129.
21. Hisahara, S., Kanuka, H., Shoji, S., Yoshikawa, S., Okano, H., and Miura, M. (1998). Caenorhabditis elegans anti-apoptotic gene ced-9 prevents ced-3-induced cell death in Drosophila cells. J. Cell Sci. 111, 667-673.
22. Hu, Y., Ding, L., Spencer, D.M., and Nunez, G. (1998a). WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation. J. Biol. Chem. 273, 33489-33494.
23. Hu, Y., Benedict, M.A., Wu, D., Inohara, N., and Nunez, G. (1998b). Bcl-xL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl. Acad. Sci. USA 95, 4386-4391.
24. Hu, Y., Benedict, M.A., Ding, L., and Nunez, G. (1999). Role of cytochrome c and dATP/ATP hydrolysis in apaf-1-mediated caspase-9 activation and apoptosis. EMBO J. 18, 3586-3595.
25. Imai, Y., Kimura, T., Murakami, A., Yajima, N., Sakamaki, K., and Yonehara, S. (1999). The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis. Nature 398, 777-785.
26. Inohara, N., Koseki, T., Hu, Y., Chen, S., and Nunez, G. (1997). CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. Proc. Natl. Acad. Sci. USA 94, 10717-10722.
27. Inohara, N., del Peso, L., Koseki, T., Chen, S., and Nunez, G. (1998). RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis. J. Biol. Chem. 273, 12296-12300.
28. Kanuka, H., Hisahara, S., Sawamoto, K., Shoji, S., Okano, H., and Miura, M. (1999). Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation. Proc. Natl. Acad. Sci. USA 96, 145-150.
29. Kondo, T., Yokokura, T., and Nagata, S. (1997). Activation of distinct caspase-like proteases by Fas and reaper in Drosophila cells. Proc. Natl. Acad. Sci. USA 94, 11951-11956.
30. Kramer, H., and Cagan, R.L. (1994). Determination of photoreceptor cell fate in the Drosophila retina. Curr. Opin. Neurobiol. 4, 14-20.
31. Kuida, K., Zheng, T.S., Na, S., Kuan, C., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R.A. (1996). Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384, 368-372.
32. Kuida, K., Haydar, T.F., Kuan, C.Y., Gu, Y., Taya, C., Karasuyama, H., Su, M.S., Rakic, P., and Flavell, R.A. (1998). Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94, 325-337.
33. Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., and Wang, X. (1997). Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489.
34. Matsuzaki, F., Koizumi, K., Hama, C., Yoshioka, T., and Nabeshima, Y. (1992). Cloning of the Drosophila prospero gene and its expression in ganglion mother cells. Biochem. Biophys. Res. Commun. 182, 1326-1332.
35. Matsuzaki, F., Ohshiro, T., Ikeshima, K.H., and Izumi, H. (1998). miranda localizes staufen and prospero asymmetrically in mitotic neuroblasts and epithelial cells in early Drosophila embryogenesis. Development 125, 4089-4098.
36. Miura, M., Zhu, H., Rotello, R., Hartwieg, E.A., and Yuan, J. (1993). Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75, 653-660.
37. Raff, M.C. (1992). Social controls on cell survival and cell death. Nature 356, 397-400.
38. Rodriguez, A., Oliver, H., Zou, H., Chen, P., Wang, X., and Abrams, J.M. (1999). Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat. Cell Biol. 1, 272-279.
39. Shaham, S., and Horvitz, H.R. (1996). An alternatively spliced C. elegans ced-4 RNA encodes a novel cell death inhibitor. Cell 86, 201-208.
40. Song, Z., McCall, K., and Steller, H. (1997). DCP-1, a Drosophila cell death protease essential for development. Science 275, 536-540.
41. Srinivasula, S.M., Ahmad, M., Fernandes, A.T., and Alnemri, E.S. (1998). Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol. Cell. 1, 949-957.
42. Thornberry, N.A., Rano, T.A., Peterson, E.P., Rasper, D.M., Timkey, T., Garcia, C.M., Houtzager, V.M., Nordstrom, P.A., Roy, S., Vaillancourt, J.P., et al. (1997). A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272, 17907-17911.
43. Thress, K., Henzel, W., Shillinglaw, W., and Kornbluth, S. (1998). Scythe: a novel reaper-binding apoptotic regulator. EMBO J. 17, 6135-6143.
44. Van der Biezen, E, and Jones, J.D. (1998). The NB-ARC domain: a novel signaling motif shared by plant resistance gene products and regulators of cell death in animals. Curr. Biol. 8, R226-R227.
45. Varkey, J., Chen, P., Jemmerson, R., and Abrams, J.M. (1999). Altered cytochrome c display precedes apoptotic cell death in Drosophila. J. Cell Biol. 144, 701-710.
46. Vaux, D.L., and Korsmeyer, S. (1999). Cell death in development. Cell 96, 245-254.
47. Wang, L., Miura, M., Bergeron, L., Zhu, H., and Yuan, J. (1994). Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 78, 739-750.
48. Wang, S., Miura, M., Jung, Y.k., Zhu, H., Gagliardini, V., Shi, L., Greenberg, A.M., and Yuan, J. (1996). Identification and characterization of Ich-3, a member of the interleukin-1β converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J. Biol. Chem. 271, 20580-20587.
49. Wang, S., Miura, M., Jung, Y.K., Zhu, H., Li, E., and Yuan, J. (1998). Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92, 501-509.
50. White, K., Grether, M.E., Abrams, J.M., Young, L., Farrell, K., and Steller, H. (1994). Genetic control of programmed cell death in Drosophila. Science 264, 677-683.
51. White, K., Tahaoglu, E., and Steller, H. (1996). Cell killing by the Drosophila gene reaper. Science 271, 805-807.
52. Wu, D., Wallen, H.D., Inohara, N., and Nunez, G. (1997). Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9. J. Biol. Chem. 272, 21449-21454.
53. Yang, X., Chang, H.Y., and Baltimore, D. (1998). Essential role of CED-4 oligomerization in CED-3 activation and apoptosis. Science 281, 1355-1357.
54. Yoshida, H., Kong, Y.Y., Yoshida, R., Elia, A.J., Hakem, A., Hakem, R., Penninger, J.M., and Mak, T.W. (1998). Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94, 739-750.
55. Yuan, J., and Horvitz, H.R. (1992). The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death. Development 116, 309-320.
56. Yuan, J., Shaham, S., Ledoux, S., Ellis, H.M., and Horvitz, H.R. (1993). The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75, 641-652.
57. Zhou, L., Schnitzler, A., Agapite, J., Schwartz, L.M., Steller, H., and Nambu, J.R. (1997). Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells. Proc. Natl. Acad. Sci. USA 94, 5131-5136.
58. Zhou, L., Song, Z., Tittel, J., and Steller, H. (1999). HAC-1, a Drosophila homolog of APAF-1 and CED-4, functions in developmental and radiation-induced apoptosis. Mol. Cell. 4, this issue, 745-755.
59. Zou, H., Henzel, W.J., Liu, X., Lutschg, A., and Wang, X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413.