The caspase-derived C-terminal fragment of βAPP induces caspase-independent toxicity and triggers selective increase of Aβ42 in mammalian cells

Journal of Neurochemistry

Volumn 78, Issue 5, 2001, Pages 1153-1161

  Dumanchin Njock, Cécile ^a   Alves Da Costa, Cristine ^a   Mercken, Luc ^b   Pradier, Laurent ^b   Checler, Frédéric ^a  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b SANOFI   (France)

Author keywords

amyloid precursor protein; Alzheimer's disease; Amyloid; Caspases; HEK293 cells TSM1 neurons

Indexed keywords

AMINO ACID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CASPASE; CYTOCHROME C; ENZYME PRECURSOR; GAMMA SECRETASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN P53; STAUROSPORINE;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HYDROLYSIS; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; RAT; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CASPASES; CELL LINE; CYTOCHROME C GROUP; GENE EXPRESSION; HUMANS; KIDNEY; MAMMALS; NEURONS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; TRANSFECTION;

ANIMALIA; MAMMALIA;

EID: 0034846164     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00513.x     Document Type: Article

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