메뉴 건너뛰기




Volumn 20, Issue 6, 2012, Pages 268-273

Hypoxia-inducible factor-1 alpha in the heart: A double agent?

Author keywords

heart; HIF 1 ; ischemia

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); BRAIN NATRIURETIC PEPTIDE; CASPASE 3; CASPASE 9; CYTOCHROME C; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; PROTEIN BAX; PROTEIN BNIP3; PROTEIN P53; TRANSCRIPTION FACTOR; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 1;

EID: 84867539657     PISSN: 10615377     EISSN: 15384683     Source Type: Journal    
DOI: 10.1097/CRD.0b013e31826287f6     Document Type: Review
Times cited : (25)

References (96)
  • 1
    • 0034006016 scopus 로고    scopus 로고
    • HIF-1: Mediator of physiological and pathophysiological responses to hypoxia
    • Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol. 2000;88:1474-1480.
    • (2000) J Appl Physiol. , vol.88 , pp. 1474-1480
    • Semenza, G.L.1
  • 2
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA. 1995;92:5510-5514.
    • (1995) Proc Natl Acad Sci USA. , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, B.H.2    Rue, E.A.3
  • 3
    • 43649093915 scopus 로고    scopus 로고
    • Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
    • Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell. 2008;30:393-402.
    • (2008) Mol Cell. , vol.30 , pp. 393-402
    • Kaelin, Jr.W.G.1    Ratcliffe, P.J.2
  • 4
    • 67650531089 scopus 로고    scopus 로고
    • Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profling of hypoxia-inducible transcripts
    • Mole DR, Blancher C, Copley RR, et al. Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profling of hypoxia-inducible transcripts. J Biol Chem. 2009;284:16767-16775.
    • (2009) J Biol Chem. , vol.284 , pp. 16767-16775
    • Mole, D.R.1    Blancher, C.2    Copley, R.R.3
  • 5
    • 0030583293 scopus 로고    scopus 로고
    • In vivo expression of mRNAs encoding hypoxia-inducible factor 1
    • Wiener CM, Booth G, Semenza GL. In vivo expression of mRNAs encoding hypoxia-inducible factor 1. Biochem Biophys Res Commun. 1996;225:485-488.
    • (1996) Biochem Biophys Res Commun. , vol.225 , pp. 485-488
    • Wiener, C.M.1    Booth, G.2    Semenza, G.L.3
  • 6
    • 0035917313 scopus 로고    scopus 로고
    • HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
    • Ivan M, Kondo K, Yang H, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science. 2001;292:464-468.
    • (2001) Science. , vol.292 , pp. 464-468
    • Ivan, M.1    Kondo, K.2    Yang, H.3
  • 7
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hip-pel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hip-pel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001;292:468-472.
    • (2001) Science. , vol.292 , pp. 468-472
    • Jaakkola, P.1    Mole, D.R.2    Tian, Y.M.3
  • 8
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271-275.
    • (1999) Nature. , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3
  • 9
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • Ohh M, Park CW, Ivan M, et al. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol. 2000;2:423-427.
    • (2000) Nat Cell Biol. , vol.2 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3
  • 10
    • 0035347260 scopus 로고    scopus 로고
    • Induction of HIF-1alpha in response to hypoxia is instantaneous
    • Jewell UR, Kvietikova I, Scheid A, et al. Induction of HIF-1alpha in response to hypoxia is instantaneous. FASEB J. 2001;15:1312-1314.
    • (2001) FASEB J. , vol.15 , pp. 1312-1314
    • Jewell, U.R.1    Kvietikova, I.2    Scheid, A.3
  • 12
    • 70449527373 scopus 로고    scopus 로고
    • Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing
    • Webb JD, Coleman ML, Pugh C W. Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing. Cell Mol Life Sci. 2009; 66:3539-3554.
    • (2009) Cell Mol Life Sci. , vol.66 , pp. 3539-3554
    • Webb, J.D.1    Coleman, M.L.2    Pugh, C.W.3
  • 13
    • 0035887011 scopus 로고    scopus 로고
    • FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
    • Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001;15:2675-2686.
    • (2001) Genes Dev. , vol.15 , pp. 2675-2686
    • Mahon, P.C.1    Hirota, K.2    Semenza, G.L.3
  • 14
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40:294-309.
    • (2010) Mol Cell. , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 15
    • 21344438419 scopus 로고    scopus 로고
    • Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1)
    • Greijer AE, van der Groep P, Kemming D, et al. Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol. 2005;206:291-304.
    • (2005) J Pathol. , vol.206 , pp. 291-304
    • Greijer, A.E.1    Van Der Groep, P.2    Kemming, D.3
  • 16
    • 0034594876 scopus 로고    scopus 로고
    • Early expression of angiogenesis factors in acute myocardial ischemia and infarction
    • Lee SH, Wolf PL, Escudero R, et al. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med. 2000;342:626-633.
    • (2000) N Engl J Med. , vol.342 , pp. 626-633
    • Lee, S.H.1    Wolf, P.L.2    Escudero, R.3
  • 17
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer N V, Kotch LE, Agani F, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998;12:149-162.
    • (1998) Genes Dev. , vol.12 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3
  • 18
    • 34247631690 scopus 로고    scopus 로고
    • The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
    • Lum JJ, Bui T, Gruber M, et al. The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 2007;21:1037-1049.
    • (2007) Genes Dev. , vol.21 , pp. 1037-1049
    • Lum, J.J.1    Bui, T.2    Gruber, M.3
  • 19
    • 0035027828 scopus 로고    scopus 로고
    • Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
    • Seagroves TN, Ryan HE, Lu H, et al. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells. Mol Cell Biol. 2001;21:3436-3444.
    • (2001) Mol Cell Biol. , vol.21 , pp. 3436-3444
    • Seagroves, T.N.1    Ryan, H.E.2    Lu, H.3
  • 20
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, et al. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab. 2006;3:177-185.
    • (2006) Cell Metab. , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3
  • 21
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, et al. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab. 2006;3:187-197.
    • (2006) Cell Metab. , vol.31 , pp. 87-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3
  • 22
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 regulates cytochrome oxi-dase subunits to optimize effciency of respiration in hypoxic cells
    • Fukuda R, Zhang H, Kim J W, et al. HIF-1 regulates cytochrome oxi-dase subunits to optimize effciency of respiration in hypoxic cells. Cell. 2007;129:111-122.
    • (2007) Cell. , vol.129 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.W.3
  • 23
    • 85047682984 scopus 로고    scopus 로고
    • Regulation of oxygen homeostasis by hypoxia-inducible factor 1
    • Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda). 2009;24:97-106.
    • (2009) Physiology (Bethesda). , vol.24 , pp. 97-106
    • Semenza, G.L.1
  • 24
    • 0037227316 scopus 로고    scopus 로고
    • Erythropoietin: Physiology and pharmacology update
    • Fisher J W. Erythropoietin: physiology and pharmacology update. Exp Biol Med (Maywood). 2003;228:1-14.
    • (2003) Exp Biol Med (Maywood). , vol.228 , pp. 1-14
    • Fisher, J.W.1
  • 25
    • 3142598688 scopus 로고    scopus 로고
    • An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection
    • Bogoyevitch MA. An update on the cardiac effects of erythropoietin cardioprotection by erythropoietin and the lessons learnt from studies in neuroprotection. Cardiovasc Res. 2004;63:208-216.
    • (2004) Cardiovasc Res. , vol.63 , pp. 208-216
    • Bogoyevitch, M.A.1
  • 26
    • 37349123107 scopus 로고    scopus 로고
    • Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent path-way
    • Kim KH, Oudit GY, Backx PH. Erythropoietin protects against doxorubicin-induced cardiomyopathy via a phosphatidylinositol 3-kinase-dependent path-w a y. J Pharmacol Exp Ther. 2008;324:160-169.
    • (2008) J Pharmacol Exp Ther. , vol.324 , pp. 160-169
    • Kim, K.H.1    Oudit, G.Y.2    Backx, P.H.3
  • 27
    • 0036275028 scopus 로고    scopus 로고
    • Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myo-cardial infarction model in the rat
    • Shyu KG, Wang MT, Wang BW, et al. Intramyocardial injection of naked DNA encoding HIF-1alpha/VP16 hybrid to enhance angiogenesis in an acute myo-cardial infarction model in the rat. Cardiovasc Res. 2002;54:576-583.
    • (2002) Cardiovasc Res. , vol.54 , pp. 576-583
    • Shyu, K.G.1    Wang, M.T.2    Wang, B.W.3
  • 28
    • 28244446238 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse
    • Kido M, Du L, Sullivan CC, et al. Hypoxia-inducible factor 1-alpha reduces infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse. J Am Coll Cardiol. 2005;46:2116-2124.
    • (2005) J Am Coll Cardiol. , vol.46 , pp. 2116-2124
    • Kido, M.1    Du, L.2    Sullivan, C.C.3
  • 29
    • 0038163900 scopus 로고    scopus 로고
    • Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury
    • Cai Z, Manalo DJ, Wei G, et al. Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury. Circulation. 2003;108:79-85.
    • (2003) Circulation. , vol.108 , pp. 79-85
    • Cai, Z.1    Manalo, D.J.2    Wei, G.3
  • 30
    • 39149108824 scopus 로고    scopus 로고
    • Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocar-dial hypoxic preconditioning in the rat
    • Belaidi E, Beguin PC, Levy P, et al. Prevention of HIF-1 activation and iNOS gene targeting by low-dose cadmium results in loss of myocar-dial hypoxic preconditioning in the rat. Am J Physiol Heart Circ Physiol. 2008;294:H901-H908.
    • (2008) Am J Physiol Heart Circ Physiol. , vol.294
    • Belaidi, E.1    Beguin, P.C.2    Levy, P.3
  • 31
    • 0036302622 scopus 로고    scopus 로고
    • Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia
    • Xi L, Tekin D, Gursoy E, et al. Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia. Am J Physiol Heart Circ Physiol. 2002;283:H5-H12.
    • (2002) Am J Physiol Heart Circ Physiol. , vol.283
    • Xi, L.1    Tekin, D.2    Gursoy, E.3
  • 32
    • 0035920256 scopus 로고    scopus 로고
    • Cardiac-specifc expression of heme oxygen-ase-1 protects against ischemia and reperfusion injury in transgenic mice
    • Ye t S F, Tian R, Layne MD, et al. Cardiac-specifc expression of heme oxygen-ase-1 protects against ischemia and reperfusion injury in transgenic mice. Circ Res. 2001;89:168-173.
    • (2001) Circ Res. , vol.89 , pp. 168-173
    • Yet, S.F.1    Tian, R.2    Layne, M.D.3
  • 33
    • 0035957249 scopus 로고    scopus 로고
    • H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene
    • Yoshida T, Maulik N, Ho YS, et al. H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene. Circulation. 2001;103:1695-1701.
    • (2001) Circulation. , vol.103 , pp. 1695-1701
    • Yoshida, T.1    Maulik, N.2    Ho, Y.S.3
  • 34
    • 23744443462 scopus 로고    scopus 로고
    • HIF-1 activation attenuates postischemic myocardial injury: Role for heme oxygenase-1 in modulating microvascular chemokine generation
    • Ockaili R, Natarajan R, Salloum F, et al. HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am J Physiol Heart Circ Physiol. 2005;289:H542-H548.
    • (2005) Am J Physiol Heart Circ Physiol. , vol.289
    • Ockaili, R.1    Natarajan, R.2    Salloum, F.3
  • 35
    • 80054120475 scopus 로고    scopus 로고
    • HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia
    • Robador PA, San José G, Rodríguez C, et al. HIF-1-mediated up-regulation of cardiotrophin-1 is involved in the survival response of cardiomyocytes to hypoxia. Cardiovasc Res. 2011;92:247-255.
    • (2011) Cardiovasc Res. , vol.92 , pp. 247-255
    • Robador, P.A.1    San José, G.2    Rodríguez, C.3
  • 36
    • 0036194881 scopus 로고    scopus 로고
    • Cardiotrophin-1 (CT-1) can protect the adult heart from injury when added both prior to ischaemia and at reperfusion
    • Liao Z, Brar BK, Cai Q, et al. Cardiotrophin-1 (CT-1) can protect the adult heart from injury when added both prior to ischaemia and at reperfusion. Car-diovasc Res. 2002;53:902-910.
    • (2002) Car-diovasc Res. , vol.53 , pp. 902-910
    • Liao, Z.1    Brar, B.K.2    Cai, Q.3
  • 37
    • 33645242669 scopus 로고    scopus 로고
    • Immunohisto-chemical expression of HIF-1alpha in response to early myocardial ischemia
    • Blanco Pampín J, García Rivero SA, Otero Cepeda XL, et al. Immunohisto-chemical expression of HIF-1alpha in response to early myocardial ischemia. J Forensic Sci. 2006;51:120-124.
    • (2006) J Forensic Sci. , vol.51 , pp. 120-124
    • Blanco Pampín, J.1    García Rivero, S.A.2    Otero Cepeda, X.L.3
  • 38
    • 12144257637 scopus 로고    scopus 로고
    • Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury
    • Date T, Mochizuki S, Belanger AJ, et al. Expression of constitutively stable hybrid hypoxia-inducible factor-1alpha protects cultured rat cardiomyocytes against simulated ischemia-reperfusion injury. Am J Physiol, Cell Physiol. 2005;288:C314-C320.
    • (2005) Am J Physiol, Cell Physiol. , vol.288
    • Date, T.1    Mochizuki, S.2    Belanger, A.J.3
  • 39
    • 0022970945 scopus 로고
    • Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
    • Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124-1136.
    • (1986) Circulation. , vol.74 , pp. 1124-1136
    • Murry, C.E.1    Jennings, R.B.2    Reimer, K.A.3
  • 40
    • 79957952535 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning
    • Semenza GL. Hypoxia-inducible factor 1: regulator of mitochondrial metabolism and mediator of ischemic preconditioning. Biochim Biophys Acta. 2011;1813:1263-1268.
    • (2011) Biochim Biophys Acta. , vol.1813 , pp. 1263-1268
    • Semenza, G.L.1
  • 41
    • 72449173802 scopus 로고    scopus 로고
    • Attenuation of myocardial injury by postconditioning: Role of hypoxia inducible factor-1alpha
    • Zhao HX, Wang XL, Wang YH, et al. Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha. Basic Res Cardiol. 2010;105:109-118.
    • (2010) Basic Res Cardiol. , vol.105 , pp. 109-118
    • Zhao, H.X.1    Wang, X.L.2    Wang, Y.H.3
  • 42
    • 42349109848 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha induces the coronary collaterals for coronary artery disease
    • Chen SM, Li YG, Zhang HX, et al. Hypoxia-inducible factor-1alpha induces the coronary collaterals for coronary artery disease. Coron Artery Dis. 2008;19:173-179.
    • (2008) Coron Artery Dis. , vol.19 , pp. 173-179
    • Chen, S.M.1    Li, Y.G.2    Zhang, H.X.3
  • 43
    • 23744461969 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease
    • Resar JR, Roguin A, Voner J, et al. Hypoxia-inducible factor 1alpha polymorphism and coronary collaterals in patients with ischemic heart disease. Chest. 2005;128:787-791.
    • (2005) Chest. , vol.128 , pp. 787-791
    • Resar, J.R.1    Roguin, A.2    Voner, J.3
  • 44
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 2001;294:1337-1340.
    • (2001) Science. , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 45
    • 79960920655 scopus 로고    scopus 로고
    • Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1a and VEGF production and improves functional recovery after acute ischemia/reperfusion
    • Poynter JA, Manukyan MC, Wang Y, et al. Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1a and VEGF production and improves functional recovery after acute ischemia/reperfusion. Surgery. 2011;150:278-283.
    • (2011) Surgery. , vol.150 , pp. 278-283
    • Poynter, J.A.1    Manukyan, M.C.2    Wang, Y.3
  • 46
    • 77955982949 scopus 로고    scopus 로고
    • Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat
    • Bao W, Qin P, Needle S, et al. Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat. J Cardiovasc Pharmacol. 2010;56:147-155.
    • (2010) J Cardiovasc Pharmacol. , vol.56 , pp. 147-155
    • Bao, W.1    Qin, P.2    Needle, S.3
  • 47
    • 79960060795 scopus 로고    scopus 로고
    • Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia
    • Huang M, Wu JC. Molecular imaging of RNA interference therapy targeting PHD2 for treatment of myocardial ischemia. Methods Mol Biol. 2011;709:211-221.
    • (2011) Methods Mol Biol. , vol.709 , pp. 211-221
    • Huang, M.1    Wu, J.C.2
  • 48
    • 79953179377 scopus 로고    scopus 로고
    • Cardiomyocyte-specifc prolyl-4-hydrox-ylase domain 2 knock out protects from acute myocardial ischemic injury
    • Hölscher M, Silter M, Krull S, et al. Cardiomyocyte-specifc prolyl-4-hydrox-ylase domain 2 knock out protects from acute myocardial ischemic injury. J Biol Chem. 2011;286:11185-11194.
    • (2011) J Biol Chem. , vol.286 , pp. 11185-11194
    • Hölscher, M.1    Silter, M.2    Krull, S.3
  • 49
    • 79952438784 scopus 로고    scopus 로고
    • Gene therapy with hypoxia-induc-ible factor 1 alpha in skeletal muscle is cardioprotective in vivo
    • Czibik G, Gravning J, Martinov V, et al. Gene therapy with hypoxia-induc-ible factor 1 alpha in skeletal muscle is cardioprotective in vivo. Life Sci. 2011;88:543-550.
    • (2011) Life Sci. , vol.88 , pp. 543-550
    • Czibik, G.1    Gravning, J.2    Martinov, V.3
  • 50
    • 77951738011 scopus 로고    scopus 로고
    • Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting-A multicenter phase i and safety study
    • Kilian EG, Sadoni S, Vicol C, et al. Myocardial transfection of hypoxia inducible factor-1alpha via an adenoviral vector during coronary artery bypass grafting-A multicenter phase I and safety study. Circ J. 2010;74:916-924.
    • (2010) Circ J. , vol.74 , pp. 916-924
    • Kilian, E.G.1    Sadoni, S.2    Vicol, C.3
  • 51
    • 77955416660 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 protects against nitrate tolerance and stunning in rabbit cardiac myocytes
    • Tan T, Weiss HR. Hypoxia inducible factor-1 protects against nitrate tolerance and stunning in rabbit cardiac myocytes. Cardiovasc Drugs Ther. 2010;24:95-106.
    • (2010) Cardiovasc Drugs Ther. , vol.24 , pp. 95-106
    • Tan, T.1    Weiss, H.R.2
  • 52
    • 77952512346 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity
    • Tan T, Marín-García J, Damle S, et al. Hypoxia-inducible factor-1 improves inotropic responses of cardiac myocytes in ageing heart without affecting mitochondrial activity. Exp Physiol. 2010;95:712-722.
    • (2010) Exp Physiol. , vol.95 , pp. 712-722
    • Tan, T.1    Marín-García, J.2    Damle, S.3
  • 53
    • 33746826853 scopus 로고    scopus 로고
    • Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia
    • Zampino M, Yuzhakova M, Hansen J, et al. Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006;291:H957-H964.
    • (2006) Am J Physiol Heart Circ Physiol. , vol.291
    • Zampino, M.1    Yuzhakova, M.2    Hansen, J.3
  • 54
    • 67049086583 scopus 로고    scopus 로고
    • Estrogen, aging and the cardiovascular system
    • Stice J P, Lee JS, Pechenino AS, et al. Estrogen, aging and the cardiovascular system. Future Cardiol. 2009;5:93-103.
    • (2009) Future Cardiol. , vol.5 , pp. 93-103
    • Stice, J.P.1    Lee, J.S.2    Pechenino, A.S.3
  • 55
    • 34447309302 scopus 로고    scopus 로고
    • Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease
    • Koledova V V, Khalil RA. Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease. Expert Rev Cardiovasc Ther. 2007;5:777-789.
    • (2007) Expert Rev Cardiovasc Ther. , vol.57 , pp. 77-789
    • Koledova, V.V.1    Khalil, R.A.2
  • 57
    • 75149186664 scopus 로고    scopus 로고
    • The unfolding stories of GPR30, a new membrane-bound estrogen receptor
    • Maggiolini M, Picard D. The unfolding stories of GPR30, a new membrane-bound estrogen receptor. J Endocrinol. 2010;204:105-114.
    • (2010) J Endocrinol. , vol.204 , pp. 105-114
    • Maggiolini, M.1    Picard, D.2
  • 58
    • 79953227087 scopus 로고    scopus 로고
    • The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes
    • Recchia AG, De Francesco EM, Vivacqua A, et al. The G protein-coupled receptor 30 is up-regulated by hypoxia-inducible factor-1alpha (HIF-1alpha) in breast cancer cells and cardiomyocytes. J Biol Chem. 2011;286:10773-10782.
    • (2011) J Biol Chem. , vol.286 , pp. 10773-10782
    • Recchia, A.G.1    De Francesco, E.M.2    Vivacqua, A.3
  • 59
    • 78149327208 scopus 로고    scopus 로고
    • Gene expression profling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia
    • Bohuslavová R, Kolár F, Kuthanová L, et al. Gene expression profling of sex differences in HIF1-dependent adaptive cardiac responses to chronic hypoxia. J Appl Physiol. 2010;109:1195-1202.
    • (2010) J Appl Physiol. , vol.109 , pp. 1195-1202
    • Bohuslavová, R.1    Kolár, F.2    Kuthanová, L.3
  • 60
    • 34447517169 scopus 로고    scopus 로고
    • Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury
    • Murphy E, Steenbergen C. Gender-based differences in mechanisms of protection in myocardial ischemia-reperfusion injury. Cardiovasc Res. 2007;75:478-486.
    • (2007) Cardiovasc Res. , vol.75 , pp. 478-486
    • Murphy, E.1    Steenbergen, C.2
  • 61
    • 70349159587 scopus 로고    scopus 로고
    • Gender differences in cardiac ischemic injury and protection-experimental aspects
    • Ostadal B, Netuka I, Maly J, et al. Gender differences in cardiac ischemic injury and protection-experimental aspects. Exp Biol Med (Maywood). 2009;234:1011-1019.
    • (2009) Exp Biol Med (Maywood). , vol.234 , pp. 1011-1019
    • Ostadal, B.1    Netuka, I.2    Maly, J.3
  • 62
    • 43649100536 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
    • Lei L, Mason S, Liu D, et al. Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein. Mol Cell Biol. 2008;28:3790-3803.
    • (2008) Mol Cell Biol. , vol.28 , pp. 3790-3803
    • Lei, L.1    Mason, S.2    Liu, D.3
  • 63
    • 77955408429 scopus 로고    scopus 로고
    • Conditional HIF-1alpha expression produces a reversible cardiomyopathy
    • Bekeredjian R, Walton CB, MacCannell KA, et al. Conditional HIF-1alpha expression produces a reversible cardiomyopathy. PLoS ONE. 2010; 5:e11693.
    • (2010) PLoS ONE. , vol.5
    • Bekeredjian, R.1    Walton, C.B.2    MacCannell, K.A.3
  • 64
    • 77957254118 scopus 로고    scopus 로고
    • Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardio-myopathy
    • Moslehi J, Minamishima YA, Shi J, et al. Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardio-myopathy. Circulation. 2010;122:1004-1016.
    • (2010) Circulation. , vol.122 , pp. 1004-1016
    • Moslehi, J.1    Minamishima, Y.A.2    Shi, J.3
  • 65
    • 77953959103 scopus 로고    scopus 로고
    • Hypoxia inducible factor-1 improves the negative functional effects of natriuretic peptide and nitric oxide signaling in hypertrophic cardiac myocytes
    • Tan T, Scholz PM, Weiss HR. Hypoxia inducible factor-1 improves the negative functional effects of natriuretic peptide and nitric oxide signaling in hypertrophic cardiac myocytes. Life Sci. 2010;87:9-16.
    • (2010) Life Sci , vol.87 , pp. 9-16
    • Tan, T.1    Scholz, P.M.2    Weiss, H.R.3
  • 66
    • 21244479992 scopus 로고    scopus 로고
    • Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart
    • Shyu KG, Liou JY, Wang B W, et al. Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart. J Biomed Sci. 2005;12:409-420.
    • (2005) J Biomed Sci. , vol.12 , pp. 409-420
    • Shyu, K.G.1    Liou, J.Y.2    Wang, B.W.3
  • 67
    • 47649097740 scopus 로고    scopus 로고
    • Regulation of gene expression by hypoxia: Integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element
    • Kaluz S, Kaluzová M, Stanbridge EJ. Regulation of gene expression by hypoxia: integration of the HIF-transduced hypoxic signal at the hypoxia-responsive element. Clin Chim Acta. 2008;395:6-13.
    • (2008) Clin Chim Acta , vol.395 , pp. 6-13
    • Kaluz, S.1    Kaluzová, M.2    Stanbridge, E.J.3
  • 68
    • 16644363476 scopus 로고    scopus 로고
    • HIF-1 and p53: Communication of transcription factors under hypoxia
    • Schmid T, Zhou J, Brüne B. HIF-1 and p53: communication of transcription factors under hypoxia. J Cell Mol Med. 2004;8:423-431.
    • (2004) J Cell Mol Med. , vol.8 , pp. 423-431
    • Schmid, T.1    Zhou, J.2    Brüne, B.3
  • 69
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci USA. 2000;97:9082-9087.
    • (2000) Proc Natl Acad Sci USA. , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 70
    • 0043091971 scopus 로고    scopus 로고
    • BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF
    • Kothari S, Cizeau J, McMillan-Ward E, et al. BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene. 2003;22:4734-4744.
    • (2003) Oncogene. , vol.22 , pp. 4734-4744
    • Kothari, S.1    Cizeau, J.2    McMillan-Ward, E.3
  • 71
    • 0346655211 scopus 로고    scopus 로고
    • BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
    • Kim JY, Ahn HJ, Ryu JH, et al. BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha. J Exp Med. 2004;199:113-124.
    • (2004) J Exp Med. , vol.199 , pp. 113-124
    • Kim, J.Y.1    Ahn, H.J.2    Ryu, J.H.3
  • 72
    • 33746078851 scopus 로고    scopus 로고
    • Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival
    • Wang J, Cao Y, Chen Y, et al. Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. Proc Natl Acad Sci USA. 2006;103:10636-10641.
    • (2006) Proc Natl Acad Sci USA. , vol.103 , pp. 10636-10641
    • Wang, J.1    Cao, Y.2    Chen, Y.3
  • 73
    • 82555164967 scopus 로고    scopus 로고
    • The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of cas-pase activation
    • An HJ, Shin H, Jo SG, et al. The survival effect of mitochondrial Higd-1a is associated with suppression of cytochrome C release and prevention of cas-pase activation. Biochim Biophys Acta. 2011;1813:2088-2098.
    • (2011) Biochim Biophys Acta. , vol.1813 , pp. 2088-2098
    • An, H.J.1    Shin, H.2    Jo, S.G.3
  • 74
    • 77649153953 scopus 로고    scopus 로고
    • The effect of hypoxia-inducible factor 1-alpha on hypoxia-induced apoptosis in primary neonatal rat ventricular myocytes
    • Zhou YF, Zheng X W, Zhang GH, et al. The effect of hypoxia-inducible factor 1-alpha on hypoxia-induced apoptosis in primary neonatal rat ventricular myocytes. Cardiovasc J Afr. 2010;21:37-41.
    • (2010) Cardiovasc J Afr. , vol.21 , pp. 37-41
    • Zhou, Y.F.1    Zheng, X.W.2    Zhang, G.H.3
  • 75
    • 33846990665 scopus 로고    scopus 로고
    • A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent
    • Kim HL, Ye o EJ, Chun YS, et al. A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent. Int J Oncol. 2006;29:255-260.
    • (2006) Int J Oncol. , vol.29 , pp. 255-260
    • Kim, H.L.1    Yeo, E.J.2    Chun, Y.S.3
  • 76
    • 0030751493 scopus 로고    scopus 로고
    • Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
    • Gerber H P, Condorelli F, Park J, et al. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J Biol Chem. 1997;272:23659- 23667.
    • (1997) J Biol Chem. , vol.272 , pp. 23659-23667
    • Gerber, H.P.1    Condorelli, F.2    Park, J.3
  • 77
    • 0032513043 scopus 로고    scopus 로고
    • Hypoxic stabilization of vascular endo-thelial growth factor mRNA by the RNA-binding protein HuR
    • Levy NS, Chung S, Furneaux H, et al. Hypoxic stabilization of vascular endo-thelial growth factor mRNA by the RNA-binding protein HuR. J Biol Chem. 1998;273:6417-6423.
    • (1998) J Biol Chem. , vol.273 , pp. 6417-6423
    • Levy, N.S.1    Chung, S.2    Furneaux, H.3
  • 78
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe JA, Jiang BH, Iyer N V, et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol. 1996;16:4604-4613.
    • (1996) Mol Cell Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3
  • 79
    • 0027421333 scopus 로고
    • Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor
    • Kendall RL, Thomas KA. Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor. Proc Natl Acad Sci USA. 1993;90:10705-10709.
    • (1993) Proc Natl Acad Sci USA. , vol.90 , pp. 10705-10709
    • Kendall, R.L.1    Thomas, K.A.2
  • 80
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber H P, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669-676.
    • (2003) Nat Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 81
    • 38349138807 scopus 로고    scopus 로고
    • Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation
    • May D, Gilon D, Djonov V, et al. Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation. Proc Natl Acad Sci USA. 2008;105:282-287.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 282-287
    • May, D.1    Gilon, D.2    Djonov, V.3
  • 82
    • 78651410622 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, soluble fms-like tyrosine kinase 1, and the severity of coronary artery disease
    • Kim SY, Lee SH, Park S, et al. Vascular endothelial growth factor, soluble fms-like tyrosine kinase 1, and the severity of coronary artery disease. Angiol-ogy. 2011;62:176-183.
    • (2011) Angiol-ogy. , vol.62 , pp. 176-183
    • Kim, S.Y.1    Lee, S.H.2    Park, S.3
  • 83
    • 33745234763 scopus 로고    scopus 로고
    • Atorvastatin increases plasma soluble Fms-like tyrosine kinase-1 and decreases vascular endothelial growth factor and placental growth factor in association with improvement of ventricular function in acute myocardial infarction
    • Kodama Y, Kitta Y, Nakamura T, et al. Atorvastatin increases plasma soluble Fms-like tyrosine kinase-1 and decreases vascular endothelial growth factor and placental growth factor in association with improvement of ventricular function in acute myocardial infarction. J Am Coll Cardiol. 2006;48:43-50.
    • (2006) J Am Coll Cardiol. , vol.48 , pp. 43-50
    • Kodama, Y.1    Kitta, Y.2    Nakamura, T.3
  • 84
    • 71649086215 scopus 로고    scopus 로고
    • Usefulness of soluble Fms-like tyrosine kinase-1 as a biomarker of acute severe heart failure in patients with acute myocardial infarction
    • Onoue K, Uemura S, Takeda Y, et al. Usefulness of soluble Fms-like tyrosine kinase-1 as a biomarker of acute severe heart failure in patients with acute myocardial infarction. Am J Cardiol. 2009;104:1478-1483.
    • (2009) Am J Cardiol. , vol.104 , pp. 1478-1483
    • Onoue, K.1    Uemura, S.2    Takeda, Y.3
  • 85
    • 79551716592 scopus 로고    scopus 로고
    • Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratifcation and early diagnosis in patients with suspected acute myocardial infarction
    • Hochholzer W, Reichlin T, Stelzig C, et al. Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratifcation and early diagnosis in patients with suspected acute myocardial infarction. Eur Heart J. 2011;32:326-335.
    • (2011) Eur Heart J. , vol.32 , pp. 326-335
    • Hochholzer, W.1    Reichlin, T.2    Stelzig, C.3
  • 86
    • 33749316052 scopus 로고    scopus 로고
    • Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1
    • Nevo O, Soleymanlou N, Wu Y, et al. Increased expression of sFlt-1 in in vivo and in vitro models of human placental hypoxia is mediated by HIF-1. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1085-R1093.
    • (2006) Am J Physiol Regul Integr Comp Physiol. , vol.291
    • Nevo, O.1    Soleymanlou, N.2    Wu, Y.3
  • 87
    • 84856603825 scopus 로고    scopus 로고
    • Protein modulation in mouse heart under acute and chronic hypoxia
    • Viganò A, Vasso M, Caretti A, et al. Protein modulation in mouse heart under acute and chronic hypoxia. Proteomics. 2011;11:4202-4217.
    • (2011) Proteomics. , vol.11 , pp. 4202-4217
    • Viganò, A.1    Vasso, M.2    Caretti, A.3
  • 88
    • 24144444133 scopus 로고    scopus 로고
    • Oxygen sensing requires mitochon-drial ROS but not oxidative phosphorylation
    • Brunelle JK, Bell EL, Quesada NM, et al. Oxygen sensing requires mitochon-drial ROS but not oxidative phosphorylation. Cell Metab. 2005;1:409-414.
    • (2005) Cell Metab. , vol.1 , pp. 409-414
    • Brunelle, J.K.1    Bell, E.L.2    Quesada, N.M.3
  • 89
    • 0034682786 scopus 로고    scopus 로고
    • Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
    • Chandel NS, McClintock DS, Feliciano CE, et al. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J Biol Chem. 2000;275:25130-25138.
    • (2000) J Biol Chem. , vol.275 , pp. 25130-25138
    • Chandel, N.S.1    McClintock, D.S.2    Feliciano, C.E.3
  • 90
    • 24144447915 scopus 로고    scopus 로고
    • Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation
    • Mansfeld KD, Guzy RD, Pan Y, et al. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metab. 2005;1:393-399.
    • (2005) Cell Metab. , vol.1 , pp. 393-399
    • Mansfeld, K.D.1    Guzy, R.D.2    Pan, Y.3
  • 91
    • 24144493814 scopus 로고    scopus 로고
    • Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
    • Guzy RD, Hoyos B, Robin E, et al. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 2005;1:401-408.
    • (2005) Cell Metab. , vol.1 , pp. 401-408
    • Guzy, R.D.1    Hoyos, B.2    Robin, E.3
  • 92
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser D, Agani F, Iyer N V, et al. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 1999;59:3915-3918.
    • (1999) Cancer Res. , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3
  • 93
    • 0035937715 scopus 로고    scopus 로고
    • Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia
    • Chen C, Pore N, Behrooz A, et al. Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J Biol Chem. 2001;276:9519-9525.
    • (2001) J Biol Chem. , vol.276 , pp. 9519-9525
    • Chen, C.1    Pore, N.2    Behrooz, A.3
  • 94
    • 0037044578 scopus 로고    scopus 로고
    • Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia
    • Karni R, Dor Y, Keshet E, et al. Activated pp60c-Src leads to elevated hypoxia-inducible factor (HIF)-1alpha expression under normoxia. J Biol Chem. 2002;277:42919-42925.
    • (2002) J Biol Chem. , vol.277 , pp. 42919-42925
    • Karni, R.1    Dor, Y.2    Keshet, E.3
  • 95
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylino-sitol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylino-sitol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 2000;60:1541-1545.
    • (2000) Cancer Res. , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3
  • 96
    • 0037070223 scopus 로고    scopus 로고
    • Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phospha-tidylinositol 3-kinase pathway
    • Stiehl D P, Jelkmann W, Wenger RH, et al. Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phospha-tidylinositol 3-kinase pathway. FEBS Lett. 2002;512:157-162.
    • (2002) FEBS Lett. , vol.512 , pp. 157-162
    • Stiehl, D.P.1    Jelkmann, W.2    Wenger, R.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.