The transcription factor HIF-1 plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

Genes and Development

Volumn 21, Issue 9, 2007, Pages 1037-1049

  Lum, Julian J ^a,b   Bui, Thi ^a,b   Gruber, Michaela ^a   Gordan, John D ^a   DeBerardinis, Ralph J ^a,b,c   Covello, Kelly L ^a   Simon, M Celeste ^a,d   Thompson, Craig B ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Cell survival; Glucose metabolism; Growth factor signaling; HIF 1 ; Hypoxia

Indexed keywords

GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PHOSPHATIDYLINOSITIDE;

AEROBIC METABOLISM; ANAEROBIC GLYCOLYSIS; ARTICLE; CELL FATE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GLUCOSE METABOLISM; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

AEROBIOSIS; ANAEROBIOSIS; ANIMALS; BASE SEQUENCE; CELL HYPOXIA; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; GENE DELETION; GLUCOSE; GLYCOLYSIS; GROWTH SUBSTANCES; HEMATOPOIETIC SYSTEM; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERLEUKIN-3; MICE; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; NIH 3T3 CELLS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 34247631690     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1529107     Document Type: Article

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