Evidence that NOS2 acts as a trigger and mediator of late preconditioning induced by acute systemic hypoxia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 283, Issue 1 52-1, 2002, Pages

  Xi, Lei ^a   Tekin, Demet ^a   Gursoy, Erdal ^a   Salloum, Fadi ^a   Levasseur, Joseph E ^a   Kukreja, Rakesh C ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Adaptive cardioprotection; Cyclooxygenase 2; Inducible nitric oxide synthase; Ischemia; Myocardial infarction

Indexed keywords

CYCLOOXYGENASE 2; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE SYNTHASE; S METHYLPSEUDOTHIOUREA; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; HYPOXIA; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REPERFUSION INJURY;

EID: 0036302622     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00920.2001     Document Type: Article

References (47)

1. ATP channel
2. ATP channel
3. Adaptation of hearts to chronic hypoxia increases tolerance to subsequent ischemia by increased nitric oxide production
4. The late phase of preconditioning
5. Effects of acute and chronic hypoxia on rat lung cyclooxygenase
6. Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart
7. Cardioprotection in pigs by exogenous norepinephrine but not by cerebral ischemia-induced release of endogenous norepinephrine
8. ATP channel activity during chronic myocardial hypoxia: Is cardioprotection mediated by improved bioenergetics?
9. Influence of hypoxia on nitric oxide synthase activity and gene expression in children with congenital heart disease: A novel pathophysiological adaptive mechanism
10. Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas
11. Acute hypoxia upregulates NOS gene expression in rats
12. Nitric oxide mediates cerebral ischemic tolerance in a neonatal rat model of hypoxic preconditioning
13. Evidence for an essential role of cyclooxygenase-2 as a mediator of the late phase of ischemic preconditioning in mice
14. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
15. Some clinical aspects of life at high altitudes
16. Pharmacological evidence that inducible nitric oxide synthase is a mediator of delayed preconditioning
17. Hypoxic regulation of inducible nitric oxide synthase via hypoxia inducible factor-1 in cardiac myocytes
18. 3 receptors
19. Evidence against a role of inducible nitric oxide synthase in the endothelial protective effects of delayed preconditioning
20. NO-dependent mechanisms of adaptation to hypoxia
21. Altered myocardial performance in response to anoxia after high-altitude exposure
22. Adaptation to high altitude hypoxia as a factor preventing development of myocardial ischemic necrosis
23. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
24. Effects of hypobaric hypoxia on antioxidant enzymes in rats
25. Chronic exposure of rats to hypoxic environment alters the mechanism of energy transfer in myocardium
26. Development of cardiac sensitivity to oxygen deficiency: Comparative and ontogenetic aspects
27. Acclimation to simulated high altitude and acute cardiac necrosis
28. Activation of mitochondrial ATP-dependent potassium channels by nitric oxide
29. Chronic myocardial hypoxia increases nitric oxide synthase and decrease caveolin-3
30. Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits
31. Beneficial effects of and improved survival in rodent models of septic shock with S-methyl-isothiourea sulfate, a novel, potent and selective inhibitor of inducible nitric oxide synthase
32. Acute ischemic preconditioning and chronic hypoxia independently increase myocardial tolerance to ischemia
33. α-adrenergic receptor stimulation produces late preconditioning through inducible nitric oxide synthase in mouse heart
34. Mitogen-activated protein kinases mediate heat shock-induced delayed protection in mouse heart
35. Downregulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vivo
36. S-methylisothiourea inhibits inducible nitric oxide synthase and improves left ventricular performance after acute myocardial infarction
37. Ischemic preconditioning in isolated perfused mouse heart: Reduction in infarct size without improvement of postischemic ventricular function
38. Essential role of inducible nitric oxide synthase in monophosphoryl lipid A-induced late cardioprotection: Evidence from pharmacological inhibition and gene knockout mice
39. Myocardial ischemia/reperfusion injury in the inducible nitric oxide synthase knockout mice
40. Glycolipid RC552 induces delayed preconditioning-like effect via iNOS-dependent pathway in mice
41. Acute systemic hypoxia enhances myocardial ischemic tolerance via iNOS not COX-2
42. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
43. Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbits
44. 1 receptors: Evidence from gene-knockout mice
45. ATP channel
46. p38 triggers late preconditioning elicited by anisomycin in heart: Involvement of NF-kB and iNOS