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Volumn 116, Issue , 2012, Pages 51-92

The Leukotrienes: Immune-Modulating Lipid Mediators of Disease

Author keywords

Arachidonic acid; Cardiovascular diseases; Immune responses; Leukocytes; Leukotrienes

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; AM 103; AMELUBANT; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN INHIBITOR; BESTATIN; CAPTOPRIL; CYSTEINYL LEUKOTRIENE RECEPTOR 1; CYSTEINYL LEUKOTRIENE RECEPTOR 2; ETALOCIB; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 17; LEUKOTRIENE; LEUKOTRIENE A4 HYDROLASE; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE B4 RECEPTOR 1; LEUKOTRIENE B4 RECEPTOR 2; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE RECEPTOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; MONTELUKAST; MOXILUBANT; PRANLUKAST; PURINERGIC P2Y12 RECEPTOR; QUIFLAPON; SA 6541; SC 57461A; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZAFIRLUKAST; ZILEUTON;

EID: 84867341631     PISSN: 00652776     EISSN: 15578445     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394300-2.00002-8     Document Type: Chapter
Times cited : (109)

References (183)
  • 2
    • 34547631962 scopus 로고    scopus 로고
    • Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis
    • Ago H., Kanaoka Y., Irikura D., Lam B.K., Shimamura T., Austen K.F., et al. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature 2007, 448:609-612.
    • (2007) Nature , vol.448 , pp. 609-612
    • Ago, H.1    Kanaoka, Y.2    Irikura, D.3    Lam, B.K.4    Shimamura, T.5    Austen, K.F.6
  • 5
    • 0032560647 scopus 로고    scopus 로고
    • Differential leukotriene constrictor responses in human atherosclerotic coronary arteries
    • Allen S., Dashwood M., Morrison K., Yacoub M. Differential leukotriene constrictor responses in human atherosclerotic coronary arteries. Circulation 1998, 97:2406-2413.
    • (1998) Circulation , vol.97 , pp. 2406-2413
    • Allen, S.1    Dashwood, M.2    Morrison, K.3    Yacoub, M.4
  • 8
    • 84857743365 scopus 로고    scopus 로고
    • The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen-induced retinopathy
    • Barajas-Espinosa A., Ni N.C., Yan D., Zarini S., Murphy R.C., Funk C.D. The cysteinyl leukotriene 2 receptor mediates retinal edema and pathological neovascularization in a murine model of oxygen-induced retinopathy. FASEB Journal 2011, 26:1100-1109.
    • (2011) FASEB Journal , vol.26 , pp. 1100-1109
    • Barajas-Espinosa, A.1    Ni, N.C.2    Yan, D.3    Zarini, S.4    Murphy, R.C.5    Funk, C.D.6
  • 10
    • 60549110301 scopus 로고    scopus 로고
    • Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells
    • Barrett N.A., Maekawa A., Rahman O.M., Austen K.F., Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. Journal of Immunology 2009, 182:1119-1128.
    • (2009) Journal of Immunology , vol.182 , pp. 1119-1128
    • Barrett, N.A.1    Maekawa, A.2    Rahman, O.M.3    Austen, K.F.4    Kanaoka, Y.5
  • 15
    • 84855971147 scopus 로고    scopus 로고
    • The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms
    • Bisoendial R.J., Tanck M.W., Golledge J., Broekhuizen L.N., Legemate D.A., Stroes E.S., et al. The association between the gene encoding 5-lipoxygenase activating protein and abdominal aortic aneurysms. Atherosclerosis 2011, 220:425-428.
    • (2011) Atherosclerosis , vol.220 , pp. 425-428
    • Bisoendial, R.J.1    Tanck, M.W.2    Golledge, J.3    Broekhuizen, L.N.4    Legemate, D.A.5    Stroes, E.S.6
  • 17
    • 34248226331 scopus 로고    scopus 로고
    • Mast cells and eicosanoid mediators: A system of reciprocal paracrine and autocrine regulation
    • Boyce J.A. Mast cells and eicosanoid mediators: A system of reciprocal paracrine and autocrine regulation. Immunological Reviews 2007, 217:168-185.
    • (2007) Immunological Reviews , vol.217 , pp. 168-185
    • Boyce, J.A.1
  • 18
    • 84867384715 scopus 로고    scopus 로고
    • The biology of mast cells
    • Lippincott Williams & Wilkins, Philadelphia, K.F. Austen (Ed.)
    • Boyce J.A., Austen K.F. The biology of mast cells. Immunological diseases 2001, Lippincott Williams & Wilkins, Philadelphia. 6th ed. K.F. Austen (Ed.).
    • (2001) Immunological diseases
    • Boyce, J.A.1    Austen, K.F.2
  • 19
    • 62649157212 scopus 로고    scopus 로고
    • Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice
    • Cao R.Y., St Amand T., Grabner R., Habenicht A.J., Funk C.D. Genetic and pharmacological inhibition of the 5-lipoxygenase/leukotriene pathway in atherosclerotic lesion development in ApoE deficient mice. Atherosclerosis 2009, 203:395-400.
    • (2009) Atherosclerosis , vol.203 , pp. 395-400
    • Cao, R.Y.1    St Amand, T.2    Grabner, R.3    Habenicht, A.J.4    Funk, C.D.5
  • 20
    • 80053904558 scopus 로고    scopus 로고
    • Synthesis of cysteinyl leukotrienes in human endothelial cells: Subcellular localization and autocrine signaling through the CysLT2 receptor
    • Carnini C., Accomazzo M.R., Borroni E., Vitellaro-Zuccarello L., Durand T., Folco G., et al. Synthesis of cysteinyl leukotrienes in human endothelial cells: Subcellular localization and autocrine signaling through the CysLT2 receptor. FASEB Journal 2011, 25:3519-3528.
    • (2011) FASEB Journal , vol.25 , pp. 3519-3528
    • Carnini, C.1    Accomazzo, M.R.2    Borroni, E.3    Vitellaro-Zuccarello, L.4    Durand, T.5    Folco, G.6
  • 21
    • 80053605687 scopus 로고    scopus 로고
    • Antimicrobial peptides important in innate immunity
    • Cederlund A., Gudmundsson G.H., Agerberth B. Antimicrobial peptides important in innate immunity. FEBS Journal 2011, 278:3942-3951.
    • (2011) FEBS Journal , vol.278 , pp. 3942-3951
    • Cederlund, A.1    Gudmundsson, G.H.2    Agerberth, B.3
  • 22
    • 67749129263 scopus 로고    scopus 로고
    • The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury
    • Ceruti S., Villa G., Genovese T., Mazzon E., Longhi R., Rosa P., et al. The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. Brain 2009, 132:2206-2218.
    • (2009) Brain , vol.132 , pp. 2206-2218
    • Ceruti, S.1    Villa, G.2    Genovese, T.3    Mazzon, E.4    Longhi, R.5    Rosa, P.6
  • 24
    • 78650879821 scopus 로고    scopus 로고
    • Discovery of (2-fluoro-benzyl)-(2-methyl-2-phenethyl-2H-chromen-6-yl)-amine (KRH-102140) as an orally active 5-lipoxygenase inhibitor with activity in murine inflammation models
    • Cho Y.S., Song J.S., Huh J.Y., Kim C.H., Gong Y.D., Cheon H.G. Discovery of (2-fluoro-benzyl)-(2-methyl-2-phenethyl-2H-chromen-6-yl)-amine (KRH-102140) as an orally active 5-lipoxygenase inhibitor with activity in murine inflammation models. Pharmacology 2011, 87:49-55.
    • (2011) Pharmacology , vol.87 , pp. 49-55
    • Cho, Y.S.1    Song, J.S.2    Huh, J.Y.3    Kim, C.H.4    Gong, Y.D.5    Cheon, H.G.6
  • 25
    • 33749323854 scopus 로고    scopus 로고
    • The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor
    • Ciana P., Fumagalli M., Trincavelli M.L., Verderio C., Rosa P., Lecca D., et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. The EMBO Journal 2006, 25:4615-4627.
    • (2006) The EMBO Journal , vol.25 , pp. 4615-4627
    • Ciana, P.1    Fumagalli, M.2    Trincavelli, M.L.3    Verderio, C.4    Rosa, P.5    Lecca, D.6
  • 28
  • 32
    • 80054082654 scopus 로고    scopus 로고
    • 2 enzymes: Physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention
    • 2 enzymes: Physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chemical Reviews 2011, 111:6130-6185.
    • (2011) Chemical Reviews , vol.111 , pp. 6130-6185
    • Dennis, E.A.1    Cao, J.2    Hsu, Y.H.3    Magrioti, V.4    Kokotos, G.5
  • 34
    • 4544275829 scopus 로고    scopus 로고
    • Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: A role for transcellular biosynthesis of cysteinyl-leukotrienes
    • Di Gennaro A., Carnini C., Buccellati C., Ballerio R., Zarini S., Fumagalli F., et al. Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: A role for transcellular biosynthesis of cysteinyl-leukotrienes. FASEB Journal 2004, 18:842-844.
    • (2004) FASEB Journal , vol.18 , pp. 842-844
    • Di Gennaro, A.1    Carnini, C.2    Buccellati, C.3    Ballerio, R.4    Zarini, S.5    Fumagalli, F.6
  • 35
    • 67649373005 scopus 로고    scopus 로고
    • 4 -induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin)
    • 4 -induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin). FASEB Journal 2009, 23:1750-1757.
    • (2009) FASEB Journal , vol.23 , pp. 1750-1757
    • Di Gennaro, A.1    Kenne, E.2    Wan, M.3    Soehnlein, O.4    Lindbom, L.5    Haeggstrom, J.Z.6
  • 39
  • 40
    • 79954584873 scopus 로고    scopus 로고
    • Zymosan suppresses leukotriene C synthase activity in differentiating monocytes: Antagonism by aspirin and protein kinase inhibitors
    • Esser J., Gehrmann U., Salvado M.D., Wetterholm A., Haeggstrom J.Z., Samuelsson B., et al. Zymosan suppresses leukotriene C synthase activity in differentiating monocytes: Antagonism by aspirin and protein kinase inhibitors. FASEB Journal 2011, 25:1417-1427.
    • (2011) FASEB Journal , vol.25 , pp. 1417-1427
    • Esser, J.1    Gehrmann, U.2    Salvado, M.D.3    Wetterholm, A.4    Haeggstrom, J.Z.5    Samuelsson, B.6
  • 41
  • 42
    • 34547560098 scopus 로고    scopus 로고
    • Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein
    • Ferguson A.D., McKeever B.M., Xu S., Wisniewski D., Miller D.K., Yamin T.T., et al. Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein. Science 2007, 317:510-512.
    • (2007) Science , vol.317 , pp. 510-512
    • Ferguson, A.D.1    McKeever, B.M.2    Xu, S.3    Wisniewski, D.4    Miller, D.K.5    Yamin, T.T.6
  • 44
    • 34250177883 scopus 로고    scopus 로고
    • 4 triggers the in vitro and in vivo release of potent antimicrobial agents
    • 4 triggers the in vitro and in vivo release of potent antimicrobial agents. Journal of Immunology 2007, 178:8036-8045.
    • (2007) Journal of Immunology , vol.178 , pp. 8036-8045
    • Flamand, L.1    Tremblay, M.J.2    Borgeat, P.3
  • 45
    • 0025855366 scopus 로고
    • Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities
    • Flodgaard H., Ostergaard E., Bayne S., Svendsen A., Thomsen J., Engels M., et al. Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities. European Journal of Biochemistry 1991, 197:535-547.
    • (1991) European Journal of Biochemistry , vol.197 , pp. 535-547
    • Flodgaard, H.1    Ostergaard, E.2    Bayne, S.3    Svendsen, A.4    Thomsen, J.5    Engels, M.6
  • 48
    • 44449122937 scopus 로고    scopus 로고
    • 4 induces release of antimicrobial peptides in lungs of virally infected mice
    • 4 induces release of antimicrobial peptides in lungs of virally infected mice. Journal of Immunology 2008, 180:6211-6221.
    • (2008) Journal of Immunology , vol.180 , pp. 6211-6221
    • Gaudreault, E.1    Gosselin, J.2
  • 49
    • 0034780733 scopus 로고    scopus 로고
    • Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability
    • Gautam N., Olofsson A.M., Herwald H., Iversen L.F., Lundgren-Akerlund E., Hedqvist P., et al. Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability. Nature Medicine 2001, 7:1123-1127.
    • (2001) Nature Medicine , vol.7 , pp. 1123-1127
    • Gautam, N.1    Olofsson, A.M.2    Herwald, H.3    Iversen, L.F.4    Lundgren-Akerlund, E.5    Hedqvist, P.6
  • 51
    • 67349098843 scopus 로고    scopus 로고
    • Anti-atherogenic effects of montelukast associated with reduced MCP-1 expression in a rabbit carotid balloon injury model
    • Ge S., Zhou G., Cheng S., Liu D., Xu J., Xu G., et al. Anti-atherogenic effects of montelukast associated with reduced MCP-1 expression in a rabbit carotid balloon injury model. Atherosclerosis 2009, 205:74-79.
    • (2009) Atherosclerosis , vol.205 , pp. 74-79
    • Ge, S.1    Zhou, G.2    Cheng, S.3    Liu, D.4    Xu, J.5    Xu, G.6
  • 54
    • 12444253835 scopus 로고    scopus 로고
    • 4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation
    • 4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation. Journal of Immunology 2005, 174:1587-1593.
    • (2005) Journal of Immunology , vol.174 , pp. 1587-1593
    • Gosselin, J.1    Borgeat, P.2    Flamand, L.3
  • 55
    • 80052253240 scopus 로고    scopus 로고
    • 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)-A novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo
    • Greiner C., Hornig C., Rossi A., Pergola C., Zettl H., Schubert-Zsilavecz M., et al. 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)-A novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. British Journal of Pharmacology 2011, 164:781-793.
    • (2011) British Journal of Pharmacology , vol.164 , pp. 781-793
    • Greiner, C.1    Hornig, C.2    Rossi, A.3    Pergola, C.4    Zettl, H.5    Schubert-Zsilavecz, M.6
  • 56
    • 80054052917 scopus 로고    scopus 로고
    • Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease
    • Haeggstrom J.Z., Funk C.D. Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease. Chemical Reviews 2011, 111:5866-5898.
    • (2011) Chemical Reviews , vol.111 , pp. 5866-5898
    • Haeggstrom, J.Z.1    Funk, C.D.2
  • 58
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease. The New England Journal of Medicine 2005, 352:1685-1695.
    • (2005) The New England Journal of Medicine , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 59
    • 79959750245 scopus 로고    scopus 로고
    • Genetic contribution of the leukotriene pathway to coronary artery disease
    • Hartiala J., Li D., Conti D.V., Vikman S., Patel Y., Tang W.H., et al. Genetic contribution of the leukotriene pathway to coronary artery disease. Human Genetics 2011, 129:617-627.
    • (2011) Human Genetics , vol.129 , pp. 617-627
    • Hartiala, J.1    Li, D.2    Conti, D.V.3    Vikman, S.4    Patel, Y.5    Tang, W.H.6
  • 60
    • 59849121110 scopus 로고    scopus 로고
    • Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-κB pathways
    • Hashimoto K., Ichiyama T., Hasegawa M., Hasegawa S., Matsubara T., Furukawa S. Cysteinyl leukotrienes induce monocyte chemoattractant protein-1 in human monocyte/macrophages via mitogen-activated protein kinase and nuclear factor-κB pathways. International Archives of Allergy and Immunology 2009, 149:275-282.
    • (2009) International Archives of Allergy and Immunology , vol.149 , pp. 275-282
    • Hashimoto, K.1    Ichiyama, T.2    Hasegawa, M.3    Hasegawa, S.4    Matsubara, T.5    Furukawa, S.6
  • 61
    • 0025016872 scopus 로고
    • Beneficial effects of a new 5-lipoxygenase inhibitor on occlusion- and occlusion-reperfusion-induced myocardial injury
    • Hashimoto H., Miyazawa K., Hagiwara M., Miyasaka K., Nakashima M. Beneficial effects of a new 5-lipoxygenase inhibitor on occlusion- and occlusion-reperfusion-induced myocardial injury. Arzneimittel-Forschung 1990, 40:126-129.
    • (1990) Arzneimittel-Forschung , vol.40 , pp. 126-129
    • Hashimoto, H.1    Miyazawa, K.2    Hagiwara, M.3    Miyasaka, K.4    Nakashima, M.5
  • 67
    • 79952800679 scopus 로고    scopus 로고
    • A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors
    • Hofmann B., Barzen S., Rodl C.B., Kiehl A., Borig J., Zivkovic A., et al. A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors. Journal of Medicinal Chemistry 2011, 54:1943-1947.
    • (2011) Journal of Medicinal Chemistry , vol.54 , pp. 1943-1947
    • Hofmann, B.1    Barzen, S.2    Rodl, C.B.3    Kiehl, A.4    Borig, J.5    Zivkovic, A.6
  • 71
    • 0035861566 scopus 로고    scopus 로고
    • The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization
    • Hui Y., Yang G., Galczenski H., Figueroa D.J., Austin C.P., Copeland N.G., et al. The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. The Journal of Biological Chemistry 2001, 276:47489-47495.
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 47489-47495
    • Hui, Y.1    Yang, G.2    Galczenski, H.3    Figueroa, D.J.4    Austin, C.P.5    Copeland, N.G.6
  • 72
    • 70349648499 scopus 로고    scopus 로고
    • 5-lipoxygenase-activating protein inhibitors: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2 -ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103)
    • Hutchinson J.H., Li Y., Arruda J.M., Baccei C., Bain G., Chapman C., et al. 5-lipoxygenase-activating protein inhibitors: Development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2 -ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103). Journal of Medicinal Chemistry 2009, 52:5803-5815.
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 5803-5815
    • Hutchinson, J.H.1    Li, Y.2    Arruda, J.M.3    Baccei, C.4    Bain, G.5    Chapman, C.6
  • 74
  • 76
    • 0030835266 scopus 로고    scopus 로고
    • 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice
    • Irvin C.G., Tu Y.P., Sheller J.R., Funk C.D. 5-Lipoxygenase products are necessary for ovalbumin-induced airway responsiveness in mice. The American Journal of Physiology 1997, 272:L1053-L1058.
    • (1997) The American Journal of Physiology , vol.272
    • Irvin, C.G.1    Tu, Y.P.2    Sheller, J.R.3    Funk, C.D.4
  • 78
    • 0030923439 scopus 로고    scopus 로고
    • Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities
    • Jakobsson P.J., Mancini J.A., Riendeau D., Ford-Hutchinson A.W. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. The Journal of Biological Chemistry 1997, 272:22934-22939.
    • (1997) The Journal of Biological Chemistry , vol.272 , pp. 22934-22939
    • Jakobsson, P.J.1    Mancini, J.A.2    Riendeau, D.3    Ford-Hutchinson, A.W.4
  • 80
    • 40449090322 scopus 로고    scopus 로고
    • Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury
    • Jiang W., Hall S.R., Moos M.P., Cao R.Y., Ishii S., Ogunyankin K.O., et al. Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury. The American Journal of Pathology 2008, 172:592-602.
    • (2008) The American Journal of Pathology , vol.172 , pp. 592-602
    • Jiang, W.1    Hall, S.R.2    Moos, M.P.3    Cao, R.Y.4    Ishii, S.5    Ogunyankin, K.O.6
  • 82
    • 40149107407 scopus 로고    scopus 로고
    • 4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear cultures
    • 4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear cultures. Immunology Letters 2008, 116:174-177.
    • (2008) Immunology Letters , vol.116 , pp. 174-177
    • Klein, E.1    Liu, A.2    Claesson, H.E.3
  • 83
    • 33847072582 scopus 로고    scopus 로고
    • No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population
    • Koch W., Hoppmann P., Mueller J.C., Schomig A., Kastrati A. No association of polymorphisms in the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a large central European population. Genetics in Medicine 2007, 9:123-129.
    • (2007) Genetics in Medicine , vol.9 , pp. 123-129
    • Koch, W.1    Hoppmann, P.2    Mueller, J.C.3    Schomig, A.4    Kastrati, A.5
  • 87
    • 77952424069 scopus 로고    scopus 로고
    • Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation
    • Kristo F., Hardy G.J., Anderson T.J., Sinha S., Ahluwalia N., Lin A.Y., et al. Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation. Atherosclerosis 2010, 210:107-113.
    • (2010) Atherosclerosis , vol.210 , pp. 107-113
    • Kristo, F.1    Hardy, G.J.2    Anderson, T.J.3    Sinha, S.4    Ahluwalia, N.5    Lin, A.Y.6
  • 92
    • 40149111807 scopus 로고    scopus 로고
    • 4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures
    • 4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures. Blood 2008, 111:2693-2703.
    • (2008) Blood , vol.111 , pp. 2693-2703
    • Liu, A.1    Claesson, H.E.2    Mahshid, Y.3    Klein, G.4    Klein, E.5
  • 93
    • 77649195762 scopus 로고    scopus 로고
    • Montelukast inhibits matrix metalloproteinases expression in atherosclerotic rabbits
    • Liu D., Ge S., Zhou G., Xu G., Zhang R., Zhu W., et al. Montelukast inhibits matrix metalloproteinases expression in atherosclerotic rabbits. Cardiovascular Drugs and Therapy 2009, 23:431-437.
    • (2009) Cardiovascular Drugs and Therapy , vol.23 , pp. 431-437
    • Liu, D.1    Ge, S.2    Zhou, G.3    Xu, G.4    Zhang, R.5    Zhu, W.6
  • 95
    • 0033600291 scopus 로고    scopus 로고
    • Characterization of the human cysteinyl leukotriene CysLT1 receptor
    • Lynch K.R., O'Neill G.P., Liu Q., Im D.S., Sawyer N., Metters K.M., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999, 399:789-793.
    • (1999) Nature , vol.399 , pp. 789-793
    • Lynch, K.R.1    O'Neill, G.P.2    Liu, Q.3    Im, D.S.4    Sawyer, N.5    Metters, K.M.6
  • 96
    • 0142093583 scopus 로고    scopus 로고
    • α-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors
    • Mackewicz C.E., Yuan J., Tran P., Diaz L., Mack E., Selsted M.E., et al α-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors. AIDS 2003, 17:F23-F32.
    • (2003) AIDS , vol.17
    • Mackewicz, C.E.1    Yuan, J.2    Tran, P.3    Diaz, L.4    Mack, E.5    Selsted, M.E.6
  • 102
    • 0037178728 scopus 로고    scopus 로고
    • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    • Mehrabian M., Allayee H., Wong J., Shi W., Wang X.P., Shaposhnik Z., et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circulation Research 2002, 91:120-126.
    • (2002) Circulation Research , vol.91 , pp. 120-126
    • Mehrabian, M.1    Allayee, H.2    Wong, J.3    Shi, W.4    Wang, X.P.5    Shaposhnik, Z.6
  • 103
    • 0037018105 scopus 로고    scopus 로고
    • Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists
    • Mellor E.A., Austen K.F., Boyce J.A. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. The Journal of Experimental Medicine 2002, 195:583-592.
    • (2002) The Journal of Experimental Medicine , vol.195 , pp. 583-592
    • Mellor, E.A.1    Austen, K.F.2    Boyce, J.A.3
  • 106
    • 60149101968 scopus 로고    scopus 로고
    • Endothelial cysteinyl leukotriene 2 receptor expression and myocardial ischemia/reperfusion injury
    • Moos M.P., Funk C.D. Endothelial cysteinyl leukotriene 2 receptor expression and myocardial ischemia/reperfusion injury. Trends in Cardiovascular Medicine 2008, 18:268-273.
    • (2008) Trends in Cardiovascular Medicine , vol.18 , pp. 268-273
    • Moos, M.P.1    Funk, C.D.2
  • 107
    • 57349129651 scopus 로고    scopus 로고
    • Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport
    • Moos M.P., Mewburn J.D., Kan F.W., Ishii S., Abe M., Sakimura K., et al. Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport. FASEB Journal 2008, 22:4352-4362.
    • (2008) FASEB Journal , vol.22 , pp. 4352-4362
    • Moos, M.P.1    Mewburn, J.D.2    Kan, F.W.3    Ishii, S.4    Abe, M.5    Sakimura, K.6
  • 115
    • 33748521513 scopus 로고    scopus 로고
    • Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation
    • Nieves D., Moreno J.J. Role of 5-lipoxygenase pathway in the regulation of RAW 264.7 macrophage proliferation. Biochemical Pharmacology 2006, 72:1022-1030.
    • (2006) Biochemical Pharmacology , vol.72 , pp. 1022-1030
    • Nieves, D.1    Moreno, J.J.2
  • 119
    • 20544442905 scopus 로고    scopus 로고
    • Alarmins: Chemotactic activators of immune responses
    • Oppenheim J.J., Yang D. Alarmins: Chemotactic activators of immune responses. Current Opinion in Immunology 2005, 17:359-365.
    • (2005) Current Opinion in Immunology , vol.17 , pp. 359-365
    • Oppenheim, J.J.1    Yang, D.2
  • 124
    • 0034744491 scopus 로고    scopus 로고
    • 4 ) hydrolase as potential anti-inflammatory agents
    • 4 ) hydrolase as potential anti-inflammatory agents. Current Pharmaceutical Design 2001, 7:163-179.
    • (2001) Current Pharmaceutical Design , vol.7 , pp. 163-179
    • Penning, T.D.1
  • 125
    • 80053925891 scopus 로고    scopus 로고
    • Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes
    • Pergola C., Rogge A., Dodt G., Northoff H., Weinigel C., Barz D., et al. Testosterone suppresses phospholipase D, causing sex differences in leukotriene biosynthesis in human monocytes. The FASEB Journal 2011, 25:3377-3387.
    • (2011) The FASEB Journal , vol.25 , pp. 3377-3387
    • Pergola, C.1    Rogge, A.2    Dodt, G.3    Northoff, H.4    Weinigel, C.5    Barz, D.6
  • 127
    • 77949363808 scopus 로고    scopus 로고
    • The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease
    • Poeckel D., Funk C.D. The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease. Cardiovascular Research 2010, 86:243-253.
    • (2010) Cardiovascular Research , vol.86 , pp. 243-253
    • Poeckel, D.1    Funk, C.D.2
  • 128
    • 68949116297 scopus 로고    scopus 로고
    • Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice
    • Poeckel D., Zemski Berry K.A., Murphy R.C., Funk C.D. Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in ApoE knock-out mice. The Journal of Biological Chemistry 2009, 284:21077-21089.
    • (2009) The Journal of Biological Chemistry , vol.284 , pp. 21077-21089
    • Poeckel, D.1    Zemski Berry, K.A.2    Murphy, R.C.3    Funk, C.D.4
  • 133
    • 79960907537 scopus 로고    scopus 로고
    • A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm
    • Revermann M., Mieth A., Popescu L., Paulke A., Wurglics M., Pellowska M., et al. A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm. British Journal of Pharmacology 2011, 163:1721-1732.
    • (2011) British Journal of Pharmacology , vol.163 , pp. 1721-1732
    • Revermann, M.1    Mieth, A.2    Popescu, L.3    Paulke, A.4    Wurglics, M.5    Pellowska, M.6
  • 137
    • 65949088595 scopus 로고    scopus 로고
    • Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock
    • Rossi A., Cuzzocrea S., Sautebin L. Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. Current Vascular Pharmacology 2009, 7:185-197.
    • (2009) Current Vascular Pharmacology , vol.7 , pp. 185-197
    • Rossi, A.1    Cuzzocrea, S.2    Sautebin, L.3
  • 138
    • 0029876318 scopus 로고    scopus 로고
    • Myocardial protection by the leukotriene synthesis inhibitor BAY X1005: Importance of transcellular biosynthesis of cysteinyl-leukotrienes
    • Rossoni G., Sala A., Berti F., Testa T., Buccellati C., Molta C., et al. Myocardial protection by the leukotriene synthesis inhibitor BAY X1005: Importance of transcellular biosynthesis of cysteinyl-leukotrienes. The Journal of Pharmacology and Experimental Therapeutics 1996, 276:335-341.
    • (1996) The Journal of Pharmacology and Experimental Therapeutics , vol.276 , pp. 335-341
    • Rossoni, G.1    Sala, A.2    Berti, F.3    Testa, T.4    Buccellati, C.5    Molta, C.6
  • 139
    • 0037059334 scopus 로고    scopus 로고
    • Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms
    • Rudberg P.C., Tholander F., Thunnissen M.M., Haeggstrom J.Z. Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. The Journal of Biological Chemistry 2002, 277:1398-1404.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 1398-1404
    • Rudberg, P.C.1    Tholander, F.2    Thunnissen, M.M.3    Haeggstrom, J.Z.4
  • 142
    • 0034724434 scopus 로고    scopus 로고
    • Monoclonal anti-CD18 antibody prevents transcellular biosynthesis of cysteinyl leukotrienes in vitro and in vivo and protects against leukotriene-dependent increase in coronary vascular resistance and myocardial stiffness
    • Sala A., Rossoni G., Berti F., Buccellati C., Bonazzi A., Maclouf J., et al. Monoclonal anti-CD18 antibody prevents transcellular biosynthesis of cysteinyl leukotrienes in vitro and in vivo and protects against leukotriene-dependent increase in coronary vascular resistance and myocardial stiffness. Circulation 2000, 101:1436-1440.
    • (2000) Circulation , vol.101 , pp. 1436-1440
    • Sala, A.1    Rossoni, G.2    Berti, F.3    Buccellati, C.4    Bonazzi, A.5    Maclouf, J.6
  • 143
    • 0023177955 scopus 로고
    • Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects
    • Samuelsson B., Dahlen S.E., Lindgren J.A., Rouzer C.A., Serhan C.N. Leukotrienes and lipoxins: Structures, biosynthesis, and biological effects. Science 1987, 237:1171-1176.
    • (1987) Science , vol.237 , pp. 1171-1176
    • Samuelsson, B.1    Dahlen, S.E.2    Lindgren, J.A.3    Rouzer, C.A.4    Serhan, C.N.5
  • 147
    • 0021183247 scopus 로고
    • Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate
    • Shafer W.M., Martin L.E., Spitznagel J.K. Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate. Infection and Immunity 1984, 45:29-35.
    • (1984) Infection and Immunity , vol.45 , pp. 29-35
    • Shafer, W.M.1    Martin, L.E.2    Spitznagel, J.K.3
  • 151
    • 18644362931 scopus 로고    scopus 로고
    • Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions
    • Soehnlein O., Xie X., Ulbrich H., Kenne E., Rotzius P., Flodgaard H., et al. Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions. The Journal of Immunology 2005, 174:6399-63405.
    • (2005) The Journal of Immunology , vol.174 , pp. 6399-63405
    • Soehnlein, O.1    Xie, X.2    Ulbrich, H.3    Kenne, E.4    Rotzius, P.5    Flodgaard, H.6
  • 153
    • 82555168047 scopus 로고    scopus 로고
    • 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyri din-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor
    • Stock N.S., Bain G., Zunic J., Li Y., Ziff J., Roppe J., et al. 5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyri din-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor. Journal of Medicinal Chemistry 2011, 54:8013-8029.
    • (2011) Journal of Medicinal Chemistry , vol.54 , pp. 8013-8029
    • Stock, N.S.1    Bain, G.2    Zunic, J.3    Li, Y.4    Ziff, J.5    Roppe, J.6
  • 166
    • 1142309740 scopus 로고    scopus 로고
    • Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
    • Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovascular Research 2004, 61:481-497.
    • (2004) Cardiovascular Research , vol.61 , pp. 481-497
    • Vinten-Johansen, J.1
  • 168
    • 34548476951 scopus 로고    scopus 로고
    • 4 triggers release of the cathelicidin LL-37 from human neutrophils: Novel lipid-peptide interactions in innate immune responses
    • 4 triggers release of the cathelicidin LL-37 from human neutrophils: Novel lipid-peptide interactions in innate immune responses. FASEB Journal 2007, 21:2897-2905.
    • (2007) FASEB Journal , vol.21 , pp. 2897-2905
    • Wan, M.1    Sabirsh, A.2    Wetterholm, A.3    Agerberth, B.4    Haeggstrom, J.Z.5
  • 171
    • 0036464591 scopus 로고    scopus 로고
    • Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes
    • Werz O., Burkert E., Samuelsson B., Radmark O., Steinhilber D. Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood 2002, 99:1044-1052.
    • (2002) Blood , vol.99 , pp. 1044-1052
    • Werz, O.1    Burkert, E.2    Samuelsson, B.3    Radmark, O.4    Steinhilber, D.5
  • 173
    • 0037177904 scopus 로고    scopus 로고
    • Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2)
    • Werz O., Szellas D., Steinhilber D., Radmark O. Arachidonic acid promotes phosphorylation of 5-lipoxygenase at Ser-271 by MAPK-activated protein kinase 2 (MK2). The Journal of Biological Chemistry 2002, 277:14793-14800.
    • (2002) The Journal of Biological Chemistry , vol.277 , pp. 14793-14800
    • Werz, O.1    Szellas, D.2    Steinhilber, D.3    Radmark, O.4
  • 176
    • 83955163766 scopus 로고    scopus 로고
    • Molecular characterization of EP6-A novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor
    • Wisniewska J.M., Rodl C.B., Kahnt A.S., Buscato E., Ulrich S., Tanrikulu Y., et al. Molecular characterization of EP6-A novel imidazo[1,2-a]pyridine based direct 5-lipoxygenase inhibitor. Biochemical Pharmacology 2011, 83:228-240.
    • (2011) Biochemical Pharmacology , vol.83 , pp. 228-240
    • Wisniewska, J.M.1    Rodl, C.B.2    Kahnt, A.S.3    Buscato, E.4    Ulrich, S.5    Tanrikulu, Y.6
  • 177
    • 0028937635 scopus 로고
    • 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation
    • Woods J.W., Coffey M.J., Brock T.G., Singer I.I., Peters-Golden M. 5-Lipoxygenase is located in the euchromatin of the nucleus in resting human alveolar macrophages and translocates to the nuclear envelope upon cell activation. The Journal of Clinical Investigation 1995, 95:2035-2046.
    • (1995) The Journal of Clinical Investigation , vol.95 , pp. 2035-2046
    • Woods, J.W.1    Coffey, M.J.2    Brock, T.G.3    Singer, I.I.4    Peters-Golden, M.5
  • 178
    • 77951683063 scopus 로고    scopus 로고
    • Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptor
    • Wunder F., Tinel H., Kast R., Geerts A., Becker E.M., Kolkhof P., et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptor. British Journal of Pharmacology 2010, 160:399-409.
    • (2010) British Journal of Pharmacology , vol.160 , pp. 399-409
    • Wunder, F.1    Tinel, H.2    Kast, R.3    Geerts, A.4    Becker, E.M.5    Kolkhof, P.6
  • 183
    • 4644301666 scopus 로고    scopus 로고
    • The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
    • Zhao L., Moos M.P., Grabner R., Pedrono F., Fan J., Kaiser B., et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nature Medicine 2004, 10:966-973.
    • (2004) Nature Medicine , vol.10 , pp. 966-973
    • Zhao, L.1    Moos, M.P.2    Grabner, R.3    Pedrono, F.4    Fan, J.5    Kaiser, B.6


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