Crystal structure of inhibitor-bound human 5-lipoxygenase-activating protein

Science

Volumn 317, Issue 5837, 2007, Pages 510-512

  Ferguson, Andrew D ^a   McKeever, Brian M ^a,b   Xu, Shihua ^a   Wisniewski, Douglas ^a   Miller, Douglas K ^a,c   Yamin, Ting Ting ^a   Spencer, Robert H ^a,d   Chu, Lin ^a   Ujjainwalla, Feroze ^a   Cunningham, Barry R ^a   Evans, Jilly F ^a,e   Becker, Joseph W ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Vitae Pharmaceuticals   (United States)

^c PFIZER INC   (United States)

^d Cara Therapeutics   (United States)

^e Amira Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 (2 QUINOLINYLMETHOXY) 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; ARACHIDONIC ACID; LEUKOTRIENE;

CARDIOVASCULAR DISEASE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; INHIBITOR; PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; HUMAN; IMAGE ANALYSIS; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; BINDING SITES; CARRIER PROTEINS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYTOSOL; HUMANS; HYDROPHOBICITY; INDOLES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MUTAGENESIS; NUCLEAR ENVELOPE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; QUINOLINES;

EID: 34547560098     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1144346     Document Type: Article

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29. We thank K. Bateman, T. LeRiche, and D. Zink for mass spectrometry data; J. Badger for assistance with Rigaku software; C. Vonrhein for useful discussions and assistance using Global Phasing software; and M. Abramovitz, J. A. Mancini, J. Menke, R. T. Mosley, M. Ouellet, and S. M. Soisson for useful discussions and critical review of the manuscript. Coordinates and structure factors have been deposited in the Protein Data Bank under the accession codes 2Q7M and 2Q7R.