Cysteinyl leukotriene 2 receptor-mediated vascular permeability via transendothelial vesicle transport

FASEB Journal

Volumn 22, Issue 12, 2008, Pages 4352-4362

  Moos, Michael P W ^a   Mewburn, Jeffrey D ^a   Kan, Frederick W K ^b   Ishii, Satoshi ^c,d   Abe, Manabu ^e   Sakimura, Kenji ^e   Noguchi, Kyoko ^c   Shimizu, Takao ^c   Funk, Colin D ^a,b  

^a QUEEN S UNIVERSITY   (Canada)

^b QUEEN S UNIVERSITY   (Canada)

^c UNIVERSITY OF TOKYO   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e NIIGATA UNIVERSITY   (Japan)

Author keywords

Caveolae; Inflammation; Intravital microscopy; Transgenic mice

Indexed keywords

6 (4 CARBOXYPHENYLTHIO) 5 HYDROXY 7,9,11,14 ICOSATETRAENOIC ACID; ALBUMIN; BAYU 9733; CYSTEINYL LEUKOTRIENE RECEPTOR 2; LEUKOTRIENE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CALCIUM SIGNALING; CONTROLLED STUDY; DRUG ANTAGONISM; EMBRYO; ENDOTHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM SIGNALING; CAPILLARY PERMEABILITY; ENDOTHELIUM, VASCULAR; FLUORESCEIN-5-ISOTHIOCYANATE; GENE EXPRESSION; HUMANS; MEMBRANE MICRODOMAINS; MICE; MICE, TRANSGENIC; RECEPTORS, LEUKOTRIENE; SERUM ALBUMIN; SRS-A;

MUS; MUS MUSCULUS;

EID: 57349129651     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.08-113274     Document Type: Article

References (39)

1. Aller, M. A., Arias, J. L., Sánchez-Patán, F., and Arias, J. (2006) The inflammatory response: an efficient way of life. Med. Sci. Monit. 12, RA225-234
2. Choileain, N. N., and Redmond, H. P. (2006) Cell response to surgery. Arch. Surg. 141, 1132-1140
3. Shiels, I. A., Taylor, S. M., and Fairlie, D. P. (2000) Cell phenotype as a target of drug therapy in chronic inflammatory diseases. Med. Hypotheses 54, 193-197
4. Funk, C. D. (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294, 1871-1875
5. Ciana, P., Fumagalli, M., Trincavelli, M. L., Verderio, C., Rosa, P., Lecca, D., Ferrario, S., Parravicini, C., Capra, V., Gelosa, P., Guerrini, U., Belcredito, S., Cimino, M., Sironi, L., Tremoli, E., Rovati, G. E., Martini, C., and Abbracchio, M. P. (2006) The orphan receptor GPR17 identified as a new dual uracil nucleotides/ cysteinyl-leukotrienes receptor. EMBO J. 25, 4615-4627
6. Funk, C. D. (2005) Leukotriene modifiers as potential therapeutics for cardiovascular disease. Nat. Rev. Drug Discov. 4, 664-672
7. Lötzer, K., Funk, C. D., and Habenicht, A. J. (2005) The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis. Biochim. Biophys. Acta 1736, 30-37
8. Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N. J., Gudmundsson, G., Grant, S. F., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E. M., Matthiasson, S. E., Johannsson, H., Gudmundsdottir, O., Gurney, M. E., Sainz, J., Thorhallsdottir, M., Andresdottir, M., Frigge, M. L., Topol, E. J., Kong, A., Gudnason, V., Hakonarson, H., Gulcher, J. R., and Stefansson, K. (2004) The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat. Genet. 36, 233-239
9. Dwyer, J. H., Allayee, H., Dwyer, K. M., Fan, J., Wu, H., Mar, R., Lusis, A. J., and Mehrabian, M. (2004) Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N. Engl. J. Med. 350, 29-37
10. Hui, Y., Cheng, Y., Smalera, I., Jian, W., Goldhahn, L., Fitzgerald, G. A., and Funk, C. D. (2004) Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure. Circulation 110, 3360-3366
11. 2R) expression mediates myocardial ischemia-reperfusion injury. Am. J. Pathol. 172, 592-602
12. Beller, T. C., Maekawa, A., Friend, D. S., Austen, K. F., and Kanaoka, Y. (2004) Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J. Biol. Chem. 279, 46129-46134
13. Hui, Y., Yang, G., Galczenski, H., Figueroa, D. J., Austin, C. P., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., and Funk, C. D. (2001) The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization. J. Biol. Chem. 276, 47489-47495
14. Mehta, D., and Malik, A. B. (2006) Signaling mechanisms regulating endothelial permeability. Physiol. Rev. 86, 279-367
15. McCafferty, D. M., Craig, A. W., Senis, Y. A., and Greer, P. A. (2002) Absence of Fer protein-tyrosine kinase exacerbates leukocyte recruitment in response to endotoxin. J. Immunol. 168, 4930-4935
16. Warren, M., Huizar, J. F., Shvedko, A. G., and Zaitsev, A. V. (2007). Spatiotemporal relationship between intracellular Ca2+ dynamics and wave fragmentation during ventricular fibrillation in isolated blood-perfused pig hearts. Circ. Res. 101, e90-e101
17. Fleming, I., Fisslthaler, B., and Busse, R. (1995) Calcium signaling in endothelial cells involves activation of tyrosine kinases and leads to activation of mitogen-activated protein kinases. Circ. Res. 76, 522-529
18. Gericke, M., Droogmans, G., and Nilius, B. (1993) Thapsigargin discharges intracellular calcium stores and induces transmembrane currents in human endothelial cells. Pflügers Arch. 422, 552-557
19. El-Mestrah, M., and Kan, F. W. (1999) Ultrastructural and ultracytochemical features of secretory granules in the ampullary epithelium of the hamster oviduct. Anat. Rec. 255, 227-239
20. Huang, Q., Xu, W., Ustinova, E., Wu, M., Childs, E., Hunter, F., and Yuan, S. (2003) Myosin light chain kinase-dependent microvascular hyperpermeability in thermal injury. Shock 20, 363-368
21. Lötzer, K., Spanbroek, R., Hildner, M., Urbach, A., Heller, R., Bretschneider, E., Galczenski, H., Evans, J. F., and Habenicht, A. J. (2003) Differential leukotriene receptor expression and calcium responses in endothelial cells and macrophages indicate 5-lipoxygenase-dependent circuits of inflammation and atherogenesis. Arterioscler. Thromb. Vasc. Biol. 23, e32-36
22. Koopman, W. J., Scheenen, W. J., Schoolderman, L. F., Cruijsen, P. M., Roubos, E. W., and Jenks, B. G. (2001) Intracellular calcium buffering shapes calcium oscillations in Xenopus melanotropes. Pflügers Arch. 443, 250-256
23. Predescu, D., Vogel, S. M., and Malik, A. B. (2004) Functional and morphological studies of protein transcytosis in continuous endothelia. Am. J. Physiol. Lung Cell. Mol. Physiol. 287, L895-L901
24. Fredholm, B. B., Hökfelt, T., and Milligan, G. (2007) G-protein-coupled receptors: an update. Acta Physiol. 190, 3-7
25. Casillan, A. J., Gonzalez, N. C., Johnson, J. S., Steiner, D. R., and Wood, J. G. (2003) Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. J. Appl. Physiol. 94, 2313-2322
26. Laemmel, E., Genet, M., Le Goualher, G., Perchant, A., Le Gargasson, J. F., and Vicaut, E. (2004) Fibered confocal fluorescence microscopy (Cell-viZio) facilitates extended imaging in the field of microcirculation. A comparison with intravital microscopy. J. Vasc. Res. 41, 400-411
27. Ferri, L. E., Pascual, J., Seely, A. J., Chaudhury, P., and Christou, N. V. (2002) Soluble L-selectin attenuates tumor necrosis factor-alpha-mediated leukocyte adherence and vascular permeability: a protective role for elevated soluble L-selectin in sepsis. Crit. Care Med. 30, 1842-1847
28. Lominadze, D., Roberts, A. M., Tyagi, N., Moshal, K. S., and Tyagi, S. C. (2006) Homocysteine causes cerebrovascular leakage in mice. Am. J. Physiol. Heart Circ. Physiol. 290, H1206-1213
29. Ghitescu, L., Fixman, A., Simionescu, M., and Simionescu, N. (1986) Specific binding sites for albumin restricted to plasma-lemmal vesicles of continuous capillary endothelium: receptor-mediated transcytosis. J. Cell Biol. 102, 1304-11
30. Hashizume, K., and Black, K. L. (2002) Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4. J. Neuropathol. Exp. Neurol. 61, 725-735
31. Nothacker, H. P., Wang, Z., Zhu, Y., Reinscheid, R. K., Lin, S. H., and Civelli, O. (2000) Molecular cloning and characterization of a second human cysteinyl leukotriene receptor: discovery of a subtype selective agonist. Mol. Pharmacol. 58, 1601-1608
32. Van Nieuw Amerongen, G. P., Draijer, R., Vermeer, M. A., and van Hinsbergh, V. W. (1998) Transient and prolonged increase in endothelial permeability induced by histamine and thrombin: role of protein kinases, calcium, and RhoA. Circ. Res. 83, 1115-1123
33. Bates, D. O., Hillman, N. J., Williams, B., Neal, C. R., and Pocock, T. M. (2002) Regulation of microvascular permeability by vascular endothelial growth factors. J. Anat. 200, 581-597
34. Rusakov, D. A. (2006) Ca2+-dependent mechanisms of presynaptic control at central synapses. Neuroscientist 12, 317-326
35. Chen, X. K., Xiong, Y. F., and Zhou, Z. (2006) "Kiss-and-run" exocytosis in astrocytes. Neuroscientist 12, 375-378
36. García, A. G., García-De-Diego, A. M., Gandía, L., Borges, R., and García-Sancho, J. (2006) Calcium signaling and exocytosis in adrenal chromaffin cells. Physiol. Rev. 86, 1093-1131
37. Oheim, M., Kirchhoff, F., and Stühmer, W. (2006) Calcium microdomains in regulated exocytosis. Cell Calcium 40, 423-439
38. Heise, C. E., O'Dowd, B. F., Figueroa, D. J., Sawyer, N., Nguyen, T., Im, D. S., Stocco, R., Bellefeuille, J. N., Abramovitz, M., Cheng, R., Williams, D. L. Jr., Zeng, Z., Liu, Q., Ma, L., Clements, M. K., Coulombe, N., Liu, Y., Austin, C. P., George, S. R., O'Neill, G.P., Metters, K. M., Lynch, K. R., and Evans, J. F. (2000) Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536
39. Ogasawara, H., Ishii, S., Yokomizo, T., Kakinuma, T., Komine, M., Tamaki, K., Shimizu, T., and Izumi, T. (2002) Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. J. Biol. Chem. 277, 18763-18768