메뉴 건너뛰기




Volumn 132, Issue 8, 2009, Pages 2206-2218

The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury

Author keywords

Antisense oligonucleotides; Ependymal cells; GPR17; Precursor cells; Spinal cord injury

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BIOLOGICAL MARKER; BROXURIDINE; CELL MARKER; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR GPR 17; GLIAL FIBRILLARY ACIDIC PROTEIN; LEUKOTRIENE C4; LEUKOTRIENE D4; NESTIN; PURINERGIC P2Y12 RECEPTOR; PYRIMIDINE NUCLEOTIDE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCOSE;

EID: 67749129263     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awp147     Document Type: Article
Times cited : (107)

References (46)
  • 1
    • 33745742679 scopus 로고    scopus 로고
    • International Union of Pharmacology LVIII: Update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy
    • Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, et al. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev 2006; 58: 281-341.
    • (2006) Pharmacol Rev , vol.58 , pp. 281-341
    • Abbracchio, M.P.1    Burnstock, G.2    Boeynaems, J.M.3    Barnard, E.A.4    Boyer, J.L.5    Kennedy, C.6
  • 2
    • 33845204867 scopus 로고    scopus 로고
    • Roles of P2 receptors in glial cells: Focus on astrocytes
    • Abbracchio MP, Ceruti S. Roles of P2 receptors in glial cells: focus on astrocytes. Purinergic Signal 2006; 2: 595-604.
    • (2006) Purinergic Signal , vol.2 , pp. 595-604
    • Abbracchio, M.P.1    Ceruti, S.2
  • 3
    • 12244312473 scopus 로고    scopus 로고
    • Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: Reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin
    • Bao F, DeWitt DS, Prough DS, Liu D. Peroxynitrite generated in the rat spinal cord induces oxidation and nitration of proteins: reduction by Mn (III) tetrakis (4-benzoic acid) porphyrin. J Neurosci Res 2003; 71: 220-7.
    • (2003) J Neurosci Res , vol.71 , pp. 220-227
    • Bao, F.1    DeWitt, D.S.2    Prough, D.S.3    Liu, D.4
  • 4
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21.
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 5
    • 2642640416 scopus 로고    scopus 로고
    • A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21
    • Blasius R, Weber RG, Lichter P, Ogilvie A. A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. J Neurochem 1998; 70: 1357-65.
    • (1998) J Neurochem , vol.70 , pp. 1357-1365
    • Blasius, R.1    Weber, R.G.2    Lichter, P.3    Ogilvie, A.4
  • 6
    • 0020572269 scopus 로고
    • Cellular morphology of chronic spinal cord injury in the cat: Analysis of myelinated axons by line-sampling
    • Blight AR. Cellular morphology of chronic spinal cord injury in the cat: analysis of myelinated axons by line-sampling. Neuroscience 1983; 10: 521-43.
    • (1983) Neuroscience , vol.10 , pp. 521-543
    • Blight, A.R.1
  • 7
    • 17144468967 scopus 로고    scopus 로고
    • Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial
    • Bracken MB, Shepard MJ, Holford TR, Leo-Summers L, Aldrich EF, Fazl M, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg 1998; 89: 699-706.
    • (1998) J Neurosurg , vol.89 , pp. 699-706
    • Bracken, M.B.1    Shepard, M.J.2    Holford, T.R.3    Leo-Summers, L.4    Aldrich, E.F.5    Fazl, M.6
  • 8
    • 42149152075 scopus 로고    scopus 로고
    • Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
    • Buffo A, Rite I, Tripathi P, Lepier A, Colak D, Horn AP, et al. Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain. Proc Natl Acad Sci USA 2008; 105: 3581-6.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3581-3586
    • Buffo, A.1    Rite, I.2    Tripathi, P.3    Lepier, A.4    Colak, D.5    Horn, A.P.6
  • 9
    • 9144269934 scopus 로고    scopus 로고
    • Cellular distribution and functions of P2 receptor subtypes in different systems
    • Burnstock G, Knight GE. Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol 2004; 240: 31-304.
    • (2004) Int Rev Cytol , vol.240 , pp. 31-304
    • Burnstock, G.1    Knight, G.E.2
  • 10
    • 60749099023 scopus 로고    scopus 로고
    • Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
    • Carlén M, Meletis K, Gö ritz C, Darsalia V, Evergren E, Tanigaki K, et al. Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke. Nat Neurosci 2009; 12: 259-67.
    • (2009) Nat Neurosci , vol.12 , pp. 259-267
    • Carlén, M.1    Meletis, K.2    Gö ritz, C.3    Darsalia, V.4    Evergren, E.5    Tanigaki, K.6
  • 11
    • 33749323854 scopus 로고    scopus 로고
    • The orphan receptor GPR17 identified as a new dual uracil nucleotides/ cysteinyl-leukotrienes receptor
    • Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D, et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/ cysteinyl-leukotrienes receptor. EMBO J 2006; 25: 4615-27.
    • (2006) EMBO J , vol.25 , pp. 4615-4627
    • Ciana, P.1    Fumagalli, M.2    Trincavelli, M.L.3    Verderio, C.4    Rosa, P.5    Lecca, D.6
  • 12
    • 0034866203 scopus 로고    scopus 로고
    • Production of leukotrienes in a model of focal cerebral ischaemia in the rat
    • Ciceri P, Rabuffetti M, Monopoli A, Nicosia S. Production of leukotrienes in a model of focal cerebral ischaemia in the rat. Br J Pharmacol 2001; 133: 1323-9.
    • (2001) Br J Pharmacol , vol.133 , pp. 1323-1329
    • Ciceri, P.1    Rabuffetti, M.2    Monopoli, A.3    Nicosia, S.4
  • 13
    • 33745241901 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma
    • Cuzzocrea S, Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muia C, et al. Glycogen synthase kinase-3 beta inhibition reduces secondary damage in experimental spinal cord trauma. J Pharmacol Exp Ther 2006; 318: 79-89.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 79-89
    • Cuzzocrea, S.1    Genovese, T.2    Mazzon, E.3    Crisafulli, C.4    Di Paola, R.5    Muia, C.6
  • 14
  • 15
    • 23844458963 scopus 로고    scopus 로고
    • The molecular orchestra of the migration of oligodendrocyte precursors during development
    • de Castro F, Bribian A. The molecular orchestra of the migration of oligodendrocyte precursors during development. Brain Res Brain Res Rev 2005; 49: 227-41.
    • (2005) Brain Res Brain Res Rev , vol.49 , pp. 227-241
    • de Castro, F.1    Bribian, A.2
  • 20
    • 36749055911 scopus 로고    scopus 로고
    • Combination of dexamethasone and etanercept reduces secondary damage in experimental spinal cord trauma
    • Genovese T, Mazzon E, Crisafulli C, Esposito E, Di Paola R, Muia C, et al. Combination of dexamethasone and etanercept reduces secondary damage in experimental spinal cord trauma. Neuroscience 2007; 150: 168-81.
    • (2007) Neuroscience , vol.150 , pp. 168-181
    • Genovese, T.1    Mazzon, E.2    Crisafulli, C.3    Esposito, E.4    Di Paola, R.5    Muia, C.6
  • 21
    • 41149087320 scopus 로고    scopus 로고
    • Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury
    • Genovese T, Esposito E, Mazzon E, Muia C, Di Paola R, Meli R, et al. Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury. J Pharmacol Exp Ther 2008a; 325: 100-14.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 100-114
    • Genovese, T.1    Esposito, E.2    Mazzon, E.3    Muia, C.4    Di Paola, R.5    Meli, R.6
  • 22
    • 37549029154 scopus 로고    scopus 로고
    • TNF-alpha blockage in a mouse model of SCI: Evidence for improved outcome
    • Genovese T, Mazzon E, Crisafulli C, Di Paola R, Muia C, Esposito E, et al. TNF-alpha blockage in a mouse model of SCI: evidence for improved outcome. Shock 2008b; 29: 32-41.
    • (2008) Shock , vol.29 , pp. 32-41
    • Genovese, T.1    Mazzon, E.2    Crisafulli, C.3    Di Paola, R.4    Muia, C.5    Esposito, E.6
  • 23
    • 38849121453 scopus 로고    scopus 로고
    • Effects of zileuton and montelukast in mouse experimental spinal cord injury
    • Genovese T, Rossi A, Mazzon E, Di Paola R, Muia C, Caminiti R, et al. Effects of zileuton and montelukast in mouse experimental spinal cord injury. Br J Pharmacol 2008c; 153: 568-82.
    • (2008) Br J Pharmacol , vol.153 , pp. 568-582
    • Genovese, T.1    Rossi, A.2    Mazzon, E.3    Di Paola, R.4    Muia, C.5    Caminiti, R.6
  • 24
    • 33748564678 scopus 로고    scopus 로고
    • Neutralization of the chemokine CXCL10 reduces apoptosis and increases axon sprouting after spinal cord injury
    • Glaser J, Gonzalez R, Sadr E, Keirstead HS. Neutralization of the chemokine CXCL10 reduces apoptosis and increases axon sprouting after spinal cord injury. J Neurosci Res 2006; 84: 724-34.
    • (2006) J Neurosci Res , vol.84 , pp. 724-734
    • Glaser, J.1    Gonzalez, R.2    Sadr, E.3    Keirstead, H.S.4
  • 25
  • 26
    • 33646844063 scopus 로고    scopus 로고
    • Omega-3 fatty acids improve recovery, whereas Omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat
    • King VR, Huang WL, Dyall SC, Curran OE, Priestley JV, Michael-Titus AT. Omega-3 fatty acids improve recovery, whereas Omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci 2006; 26: 4672-80.
    • (2006) J Neurosci , vol.26 , pp. 4672-4680
    • King, V.R.1    Huang, W.L.2    Dyall, S.C.3    Curran, O.E.4    Priestley, J.V.5    Michael-Titus, A.T.6
  • 28
    • 0037294124 scopus 로고    scopus 로고
    • Differentiation and migration of astrocytes in the spinal cord following dorsal root injury in the adult rat
    • Kozlova EN. Differentiation and migration of astrocytes in the spinal cord following dorsal root injury in the adult rat. Eur J Neurosci 2003; 17: 782-90.
    • (2003) Eur J Neurosci , vol.17 , pp. 782-790
    • Kozlova, E.N.1
  • 29
    • 15544382576 scopus 로고    scopus 로고
    • Endogenous and exogenous CNS derived stem/progenitor cell approaches for neurotrauma
    • Kulbatski I, Mothe AJ, Nomura H, Tator CH. Endogenous and exogenous CNS derived stem/progenitor cell approaches for neurotrauma. Curr Drug Targets 2005; 6: 111-26.
    • (2005) Curr Drug Targets , vol.6 , pp. 111-126
    • Kulbatski, I.1    Mothe, A.J.2    Nomura, H.3    Tator, C.H.4
  • 30
    • 3342967871 scopus 로고    scopus 로고
    • Pathophysiology and pharmacologic treatment of acute spinal cord injury
    • Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR. Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J 2004; 4: 451-64.
    • (2004) Spine J , vol.4 , pp. 451-464
    • Kwon, B.K.1    Tetzlaff, W.2    Grauer, J.N.3    Beiner, J.4    Vaccaro, A.R.5
  • 31
    • 42649145405 scopus 로고    scopus 로고
    • Uracil nucleotides: From metabolic intermediates to neuroprotection and neuroinflammation
    • Lecca D, Ceruti S. Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation. Biochem Pharmacol 2008; 75: 1869-81.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1869-1881
    • Lecca, D.1    Ceruti, S.2
  • 32
    • 56349145808 scopus 로고    scopus 로고
    • The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair
    • Lecca D, Trincavelli ML, Gelosa P, Sironi L, Ciana P, Fumagalli M, et al. The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One 2008; 3: e3579.
    • (2008) PLoS One , vol.3
    • Lecca, D.1    Trincavelli, M.L.2    Gelosa, P.3    Sironi, L.4    Ciana, P.5    Fumagalli, M.6
  • 33
    • 0036089438 scopus 로고    scopus 로고
    • Cerebral ischemia and trauma-different etiologies yet similar mechanisms: Neuroprotective opportunities
    • Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Brain Res Rev 2002; 39: 55-73.
    • (2002) Brain Res Brain Res Rev , vol.39 , pp. 55-73
    • Leker, R.R.1    Shohami, E.2
  • 34
    • 34247566508 scopus 로고    scopus 로고
    • Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state
    • Maisel M, Herr A, Milosevic J, Hermann A, Habisch HJ, Schwarz S, et al. Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state. Stem Cells 2007; 25: 1231-40.
    • (2007) Stem Cells , vol.25 , pp. 1231-1240
    • Maisel, M.1    Herr, A.2    Milosevic, J.3    Hermann, A.4    Habisch, H.J.5    Schwarz, S.6
  • 35
    • 25144468525 scopus 로고    scopus 로고
    • To be or not to be (inflamed) - is that the question in anti-inflammatory drug therapy of neurodegenerative disorders?
    • Marchetti B, Abbracchio MP. To be or not to be (inflamed) - is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? Trends Pharmacol Sci 2005; 26: 517-25.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 517-525
    • Marchetti, B.1    Abbracchio, M.P.2
  • 37
    • 12844282237 scopus 로고    scopus 로고
    • Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat
    • Mothe AJ, Tator CH. Proliferation, migration, and differentiation of endogenous ependymal region stem/progenitor cells following minimal spinal cord injury in the adult rat. Neuroscience 2005; 131: 177-87.
    • (2005) Neuroscience , vol.131 , pp. 177-187
    • Mothe, A.J.1    Tator, C.H.2
  • 38
    • 0029851591 scopus 로고    scopus 로고
    • Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury
    • discussion 956-7
    • Nishisho T, Tonai T, Tamura Y, Ikata T. Experimental and clinical studies of eicosanoids in cerebrospinal fluid after spinal cord injury. Neurosurgery 1996; 39: 950-6; discussion 956-7.
    • (1996) Neurosurgery , vol.39 , pp. 950-956
    • Nishisho, T.1    Tonai, T.2    Tamura, Y.3    Ikata, T.4
  • 39
    • 47149104523 scopus 로고    scopus 로고
    • GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors
    • Parravicini C, Ranghino G, Abbracchio MP, Fantucci P. GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. BMC Bioinformatics 2008; 9: 263.
    • (2008) BMC Bioinformatics , vol.9 , pp. 263
    • Parravicini, C.1    Ranghino, G.2    Abbracchio, M.P.3    Fantucci, P.4
  • 41
    • 34249290749 scopus 로고    scopus 로고
    • An overview of tissue engineering approaches for management of spinal cord injuries
    • Samadikuchaksaraei A. An overview of tissue engineering approaches for management of spinal cord injuries. J Neuroeng Rehabil 2007; 4: 15.
    • (2007) J Neuroeng Rehabil , vol.4 , pp. 15
    • Samadikuchaksaraei, A.1
  • 43
    • 48249146633 scopus 로고    scopus 로고
    • Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry
    • Stirling DP, Yong VW. Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry. J Neurosci Res 2008; 86: 1944-58.
    • (2008) J Neurosci Res , vol.86 , pp. 1944-1958
    • Stirling, D.P.1    Yong, V.W.2
  • 44
    • 4043079197 scopus 로고    scopus 로고
    • P2X7 receptor inhibition improves recovery after spinal cord injury
    • Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, et al. P2X7 receptor inhibition improves recovery after spinal cord injury. Nat Med 2004; 10: 821-7.
    • (2004) Nat Med , vol.10 , pp. 821-827
    • Wang, X.1    Arcuino, G.2    Takano, T.3    Lin, J.4    Peng, W.G.5    Wan, P.6
  • 45
    • 33748358811 scopus 로고    scopus 로고
    • Incidence, prevalence and epidemiology of spinal cord injury: What learns a worldwide literature survey?
    • Wyndaele M, Wyndaele JJ. Incidence, prevalence and epidemiology of spinal cord injury: what learns a worldwide literature survey? Spinal Cord 2006; 44: 523-9.
    • (2006) Spinal Cord , vol.44 , pp. 523-529
    • Wyndaele, M.1    Wyndaele, J.J.2
  • 46
    • 20044362061 scopus 로고    scopus 로고
    • Cell proliferation and replacement following contusive spinal cord injury
    • Zai LJ, Wrathall JR. Cell proliferation and replacement following contusive spinal cord injury. Glia 2005; 50: 247-57.
    • (2005) Glia , vol.50 , pp. 247-257
    • Zai, L.J.1    Wrathall, J.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.