Arginine 104 is a key catalytic residue in leukotriene C4 synthase

Journal of Biological Chemistry

Volumn 285, Issue 52, 2010, Pages 40771-40776

  Rinaldo Matthis, Agnes ^a   Wetterholm, Anders ^a   Molina, Daniel Martinez ^a   Holm, Johanna ^a   Niegowski, Damian ^a   Ohlson, Eva ^a   Nordlund, Pär ^a   Morgenstern, Ralf ^a   Haeggström, Jesper Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BRONCHIAL ASTHMA; CATALYTIC ACTIVITY; CATALYTIC MECHANISMS; CATALYTIC RESIDUE; CATALYTIC ROLE; CONSERVED RESIDUES; GLUTATHIONES; INTEGRAL MEMBRANE; MEMBRANE PROTEINS; NUCLEOPHILIC ATTACK; SIDE CHAINS; SITE DIRECTED MUTAGENESIS; SPECIFIC ACTIVITY; STEADY-STATE KINETICS; SYNTHASES; THIOL GROUPS; THIOLATES; UV SPECTROSCOPY;

AMINO ACIDS; BIOLOGICAL MEMBRANES; CATALYST ACTIVITY; ENZYMES; THERMOANALYSIS; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

CRYSTAL STRUCTURE;

ALANINE; ARGININE; GLUTATHIONE TRANSFERASE; LEUKOTRIENE C4 SYNTHASE; LYSINE; SERINE; THREONINE;

AFFINITY CHROMATOGRAPHY; ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STEADY STATE; ULTRAVIOLET SPECTROSCOPY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; ARGININE; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; GLUTATHIONE TRANSFERASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; OXIDATION-REDUCTION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 78650346629     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.105940     Document Type: Article

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