The catalytic architecture of leukotriene C4 synthase with two arginine residues

Journal of Biological Chemistry

Volumn 286, Issue 18, 2011, Pages 16392-16401

  Saino, Hiromichi ^a   Ukita, Yoko ^a   Ago, Hideo ^a   Irikura, Daisuke ^a   Nisawa, Atsushi ^a   Ueno, Go ^a   Yamamoto, Masaki ^a   Kanaoka, Yoshihide ^b   Lam, Bing K ^b   Austen, K Frank ^b   Miyano, Masashi ^a  

^a RIKEN SPring 8 Center   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING FUNCTION; AMPHIPATHIC; ARACHIDONIC ACIDS; ARGININE RESIDUE; BINDING MODELS; BRONCHIAL ASTHMA; ENZYMATIC ASSAY; EPOXIDE GROUPS; GLUTATHIONES; MUTANT ENZYMES; NUCLEAR MEMBRANES; PATHOBIOLOGY; SYNTHASES; WATER SOLUBILITIES;

AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; CELL MEMBRANES; CHEMICAL ACTIVATION; ENZYMES;

CRYSTAL STRUCTURE;

ARACHIDONIC ACID DERIVATIVE; ARGININE; EPOXIDE; GLUTATHIONE; LEUKOTRIENE A4; LEUKOTRIENE C4; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE D4; LEUKOTRIENE E4; MUTANT PROTEIN;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYMATIC ASSAY; ENZYME SUBSTRATE; PRIORITY JOURNAL; PROTEIN BINDING; SOLUBILITY;

ARGININE; ASTHMA; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; LEUKOTRIENE C4; MUTATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955528808     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.150177     Document Type: Article

References (55)

1. Rouzer, C. A., Scott, W. A., Cohn, Z. A., Blackburn, P., and Manning, J. M. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 4928-4932
2. MacGlashan, D. W., Jr., Peters, S. P., Warner, J., and Lichtenstein, L. M. (1986) J. Immunol. 136, 2231-2239
3. MacGlashan, D. W., Jr., Schleimer, R. P., Peters, S. P., Schulman, E. S., Adams, G. K., 3rd, Newball, H. H., and Lichtenstein, L. M. (1982) J. Clin. Invest. 70, 747-751
4. Weller, P. F., Lee, C. W., Foster, D. W., Corey, E. J., Austen, K. F., and Lewis, R. A. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 7626-7630
5. Barrett, N. A., Maekawa, A., Rahman, O. M., Austen, K. F., and Kanaoka, Y. (2009) J. Immunol. 182, 1119-1128
6. Dahlén, S. E., Hedqvist, P., Hammarström, S., and Samuelsson, B. (1980) Nature 288, 484-486
7. Weiss, J. W., Drazen, J. M., Coles, N., McFadden, E. R., Jr., Weller, P. F., Corey, E. J., Lewis, R. A., and Austen, K. F. (1982) Science 216, 196-198
8. Dahlén, S. E., Björk, J., Hedqvist, P., Arfors, K. E., Hammarström, S., Lindgren, J. Å., and Samuelsson, B. (1981) Proc. Natl. Acad. Sci. U.S.A. 78, 3887-3891
9. Soter, N. A., Lewis, R. A., Corey, E. J., and Austen, K. F. (1983) J. Invest. Dermatol. 80, 115-119
10. Wardlaw, A. J., Hay, H., Cromwell, O., Collins, J. V., and Kay, A. B. (1989) J. Allergy Clin. Immunol. 84, 19-26
11. Smith, C. M., Christie, P. E., Hawksworth, R. J., Thien, F., and Lee, T. H. (1991) Am. Rev. Respir. Dis. 144, 1411-1413
12. Israel, E., Dermarkarian, R., Rosenberg, M., Sperling, R., Taylor, G., Rubin, P., and Drazen, J. M. (1990) N. Engl. J. Med. 323, 1740-1744
13. Manning, P. J., Watson, R. M., Margolskee, D. J., Williams, V. C., Schwartz, J. I., and O'Byrne, P. M. (1990) N. Engl. J. Med. 323, 1736-1739
14. Knapp, H. R. (1990) N. Engl. J. Med. 323, 1745-1748
15. Donnelly, A. L., Glass, M., Minkwitz, M. C., and Casale, T. B. (1995) Am. J. Respir. Crit. Care Med. 151, 1734-1739
16. Pacor, M. L., Di Lorenzo, G., and Corrocher, R. (2001) Clin. Exp. Allergy 31, 1607-1614
17. Clark, J. D., Milona, N., and Knopf, J. L. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 7708-7712
18. Rouzer, C. A. F., and Samuelsson, B. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 6040-6044
19. Dixon, R. A., Diehl, R. E., Opas, E., Rands, E., Vickers, P. J., Evans, J. F., Gillard, J. W., and Miller, D. K. (1990) Nature 343, 282-284
20. Woods, J. W., Evans, J. F., Ethier, D., Scott, S., Vickers, P. J., Hearn, L., Heibein, J. A., Charleson, S., and Singer, I. I. (1993) J. Exp. Med. 178, 1935-1946
21. Yoshimoto, T., Soberman, R. J., Spur, B., and Austen, K. F. (1988) J. Clin. Invest. 81, 866-871
22. Jakobsson, P. J., Morgenstern, R., Mancini, J., Ford-Hutchinson, A., and Persson, B. (1999) Protein Sci. 8, 689-692
23. Bresell, A., Weinander, R., Lundqvist, G., Raza, H., Shimoji, M., Sun, T. H., Balk, L., Wiklund, R., Eriksson, J., Jansson, C., Persson, B., Jakobsson, P. J., and Morgenstern, R. (2005) FEBS J. 272, 1688-1703
24. Shi, Z. Z., Han, B., Habib, G. M., Matzuk, M. M., and Lieberman, M. W. (2001) Mol. Cell. Biol. 21, 5389-5395
25. Habib, G. M., Shi, Z. Z., Cuevas, A. A., and Lieberman, M. W. (2003) FASEB J. 17, 1313-1315
26. Krilis, S., Lewis, R. A., Corey, E. J., and Austen, K. F. (1983) J. Clin. Invest. 71, 909-915
27. Sala, A., Voelkel, N., Maclouf, J., and Murphy, R. C. (1990) J. Biol. Chem. 265, 21771-21778
28. Lynch, K. R., O'Neill, G. P., Liu, Q., Im, D. S., Sawyer, N., Metters, K. M., Coulombe, N., Abramovitz, M., Figueroa, D. J., Zeng, Z., Connolly, B. M., Bai, C., Austin, C. P., Chateauneuf, A., Stocco, R., Greig, G. M., Kargman, S., Hooks, S. B., Hosfield, E., Williams, D. L., Jr., Ford-Hutchinson, A. W., Caskey, C. T., and Evans, J. F. (1999) Nature 399, 789-793
29. Heise, C. E., O'Dowd, B. F., Figueroa, D. J., Sawyer, N., Nguyen, T., Im, D. S., Stocco, R., Bellefeuille, J. N., Abramovitz, M., Cheng, R., Williams, D. L., Jr., Zeng, Z., Liu, Q., Ma, L., Clements, M. K., Coulombe, N., Liu, Y., Austin, C. P., George, S. R., O'Neill, G. P., Metters, K. M., Lynch, K. R., and Evans, J. F. (2000) J. Biol. Chem. 275, 30531-30536
30. Kim, D. C., Hsu, F. I., Barrett, N. A., Friend, D. S., Grenningloh, R., Ho, I. C., Al-Garawi, A., Lora, J. M., Lam, B. K., Austen, K. F., and Kanaoka, Y. (2006) J. Immunol. 176, 4440-4448
31. Beller, T. C., Friend, D. S., Maekawa, A., Lam, B. K., Austen, K. F., and Kanaoka, Y. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 3047-3052
32. Paruchuri, S., Tashimo, H., Feng, C., Maekawa, A., Xing, W., Jiang, Y., Kanaoka, Y., Conley, P., and Boyce, J. A. (2009) J. Exp. Med. 206, 2543-2555
33. Paruchuri, S., Jiang, Y., Feng, C., Francis, S. A., Plutzky, J., and Boyce, J. A. (2008) J. Biol. Chem. 283, 16477-16487
34. Maekawa, A., Kanaoka, Y., Xing, W., and Austen, K. F. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 16695-16700
35. Ago, H., Kanaoka, Y., Irikura, D., Lam, B. K., Shimamura, T., Austen, K. F., and Miyano, M. (2007) Nature 448, 609-612
36. Martinez Molina, D., Wetterholm, A., Kohl, A., McCarthy, A. A., Niegowski, D., Ohlson, E., Hammarberg, T., Eshaghi, S., Haeggström, J. Z., and Nordlund, P. (2007) Nature 448, 613-616
37. Lam, B. K., Penrose, J. F., Xu, K., Baldasaro, M. H., and Austen, K. F. (1997) J. Biol. Chem. 272, 13923-13928
38. Rådmark, O., Malmsten, C., Samuelsson, B., Goto, G., Marfat, A., and Corey, E. J. (1980) J. Biol. Chem. 255, 11828-11831
39. Carrier, D. J., Bogri, T., Cosentino, G. P., Guse, I., Rakhit, S., and Singh, K. (1988) Prostaglandins Leukot. Essent. Fatty Acids 34, 27-30
40. Schmidt-Krey, I., Kanaoka, Y., Mills, D. J., Irikura, D., Haase, W., Lam, B. K., Austen, K. F., and Kühlbrandt, W. (2004) Structure 12, 2009-2014
41. Okazaki, K., Okazaki, N., Kume, K., Jinno, S., Tanaka, K., and Okayama, H. (1990) Nucleic Acids Res. 18, 6485-6489
42. Ueno, G., Kanda, H., Hirose, R., Ida, K., Kumasaka, T., and Yamamoto, M. (2006) J. Struct. Funct. Genomics 7, 15-22
43. Adachi, S., Oguchi, T., Tanida, H., Park, S. Y., Shimizu, H., Miyatake, H., Kamiya, N., Shiro, Y., Inoue, Y., Ueki, T., and Iizuka, T. (2001) Nucl. Instrum. Methods Phys. Res. A 467, 711-714
44. Collaborative Computational Project Number 4 (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
45. Lewis, R. A., Austen, K. F., Drazen, J. M., Clark, D. A., Marfat, A., and Corey, E. J. (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 3710-3714
46. Maycock, A. L., Anderson, M. S., DeSousa, D. M., and Kuehl, F. A., Jr. (1982) J. Biol. Chem. 257, 13911-13914
47. Lam, B. K., Penrose, J. F., Freeman, G. J., and Austen, K. F. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 7663-7667
48. Andrade, M. A., Chacón, P., Merelo, J. J., and Morán, F. (1993) Protein Eng. 6, 383-390
49. Chen, W. J., Graminski, G. F., and Armstrong, R. N. (1988) Biochemistry 27, 647-654
50. Gu, Y., Singh, S. V., and Ji, X. (2000) Biochemistry 39, 12552-12557
51. Hoff, R. H., Hengge, A. C., Wu, L., Keng, Y. F., and Zhang, Z. Y. (2000) Biochemistry 39, 46-54
52. Silva, P. J., and Ramos, M. J. (2005) J. Phys. Chem. B. 109, 18195-18200
53. Silva, P. J., Schulz, C., Jahn, D., Jahn, M., and Ramos, M. J. (2010) J. Phys. Chem. B. 114, 8994-9001
54. Steiner, E. C., and Gilbert, J. M. (1963) J. Am. Chem. Soc. 85, 3054-3055
55. Lovell, S. C., Word, J. M., Richardson, J. S., and Richardson, D. C. (2000) Proteins 40, 389-408