Characterization of the human cysteinyl leukotriene CysLT1 receptor

Nature

Volumn 399, Issue 6738, 1999, Pages 789-793

  Lynch, Kevin R ^a   O'Neill, Gary P ^b   Liu, Qingyun ^c   Im, Dong Soon ^a   Sawyer, Nicole ^b   Metters, Kathleen M ^b   Coulombe, Nathalle ^b   Abramovitz, Mark ^b   Figueroa, David J ^c   Zeng, Zhizhen ^c   Connolly, Brett M ^c   Bai, Chang ^c   Austin, Christopher P ^c   Chateauneuf, Anne ^b   Stocco, Rino ^b   Greig, Gillian M ^b   Kargman, Stacia ^b   Hooks, Shelley B ^a   Hosfield, Elizabeth ^a   Williams Jr , David L ^c   Ford Hutchinson, Anthony W ^c   Caskey, C Thomas ^c   Evans, Jilly F ^c   more..

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CALCIUM; LEUKOTRIENE C4; LEUKOTRIENE D4; LEUKOTRIENE E4; LEUKOTRIENE RECEPTOR; MESSENGER RNA; MONTELUKAST; NUCLEOTIDE; PEPTIDOLEUKOTRIENE; PRANLUKAST; VERLUKAST; ZAFIRLUKAST;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CERCOPITHECIDAE; CONTROLLED STUDY; DOSE RESPONSE; GENE; GENE MAPPING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; X CHROMOSOME; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; CHROMOSOME MAPPING; CLONING, MOLECULAR; COS CELLS; HUMANS; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENE D4; LUNG; MACROPHAGES, ALVEOLAR; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH; RECEPTORS, LEUKOTRIENE; TISSUE DISTRIBUTION; TRANSFECTION; X CHROMOSOME; XENOPUS LAEVIS;

ANIMALIA; CERCOPITHECIDAE; XENOPUS LAEVIS;

EID: 0033600291     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/21658     Document Type: Article

References (28)

1. Dahlen, S. E., Hedqvist, P., Hammarstrom, S. & Samuelsson, B. Leukotrienes are potent constrictors of human bronchi. Nature 288, 484-486 (1980).
2. Piper, P. J. Formation and actions of leukotrienes. Physiol. Rev. 64, 744-761 (1984).
3. Lewis, R. A., Austen, K. F. & Soberman, R. J. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N. Engl. J. Med. 323, 645-655 (1990).
4. . Coleman, R. A. et al. Prostanoid and leukotriene receptors. A progress report from the IUPHAR working parties on classification and nomenclature. Adv. Prosteglandins Thromboxane Leukotriene Res. 23, 283-285 (1995).
5. 4-induced contractions of guinea pig trachea. Br. J. Pharmacol. 91, 179-188 (1987).
6. Labat, C. et at. A second cysteinyl leukotriene receptor in human lung. J. Pharmacol. Exp. Ther. 263, 800-805 (1992).
7. 4 receptor antagonist. Can. J. Physiol. Pharmacol. 73, 191-201 (1995).
8. Reiss, T. F. et al. Montelukast, a once-daily leukotriene receptor antagonist, in the treatment of chronic asthma: a multicenter, randomized, double-blind trial. Montelukast Clinical Research Study Group. Arch. Intern. Med. 158, 1213-1220 (1998).
9. Knorr, B. et al. Montelukast for chronic asthma in 6-to 14-year-old children: a randomized, double-blind trial. Pediatric Montelukast Study Group. J. Am. Med. Assoc. 279, 1181-1186 (1998).
10. Leff, J. A. et al. Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction. N. Eagl. J. Med. 339, 147-152 (1998).
11. Suissa, S. et al. Effectiveness of the leukotriene receptor antagonist zafirlukast for mild-moderate asthma. Ann. Int. Med. 126, 177-183 (1997).
12. Grossman, J. et al. Results of the first U.S. double-blind, placebo-controlled multicenter clinical study in asthma with pranlukast, a novel leukotriene receptor antagonist. J. Asthma 34, 321-328 (1997).
13. 4 receptor in guinea pig lung. J. Biol. Chem. 268, 6487-6495 (1993).
14. 4 that mediates chemotaxis. Nature 387, 620-624 (1997).
15. Martin, V. et al. Leukotriene binding, signaling and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor transfected cells J. Biol. Chem. 274, 8597-9603 (1999).
16. Pearson, W. R. & Lipman, D. J. Improved tools for biological sequence comparison. Proc. Natl Acad. Sci. USA 85, 2444-2448 (1988).
17. Ellis, C. et al. EP874047A2: cDNA clone HMTMF81 that encodes a novel human 7-transmembrane receptor. Eur. Patent Applic. EP0874047A2 (1998).
18. 4 receptor antagonists. J. Pharmacol. Exp. Ther. 269, 891-896 (1994).
19. Jones, T. R. et al. Pharmacology of L-460,711 (MK-371): a novel, receptor antagonist. Can. J. Physiol. Pharmacol. 67, 17-28 (1999).
20. McClintock, T. S., Rising. J. P. & Lerner, M. R. Metasopher pignant dispersion responses to agonists show two patterns of sensitivity to inhibitant of cAMP-dependent protein kinase and protein kinase C. J. Cell. Physiol. 167, 1-7 (1996).
21. Potenza, M. N., Graminiski, G. F., Schaose, C. & Lerner, M. R. Fractional expression and characterization of human D2 an dD3 despamine receptors. J. Neurosci. 14, 1463-1476 (1994).
22. 4 receptor in human lung and guinea-pig lung. Eur. J. Pharmacol. 244, 239-250 (1993).
23. Metters, K. M. Leuketriese receptors. J. Lipid Mediat. 12, 413-427 (1995).
24. Durieux, M. E., Cadial, S.J., Salafrases, M. N. & Lynch, K. R. Endogenous responses to sphingosine-1-phosphate in X. with lysophosphatidis acid signaling. Am. J. Physiol. 264, C1360-C1364 (1993).
25. Hooks, S. B. et al. Characterization of a receptors subtype selective lysophosphatidic acid mimetic. Mol. Pharmacol. 53, 188-194 (1998).
26. Kolakowski, L. F. Jr et al. Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3 J. Narsci. 71, 2239-2251 (1995).
27. Ungrin, M. D. et al. An automoted exproxin luminescence-based function calcium assay for G-protein coupled receptors. Anal. Biochem. (in the press).
28. Wright, D. H., Metters, K. M., Abaramovitz, M. & Ford-Hutchinson, A. W. Characterization of the recombinant prostanoid DP receptor and identification of L-644,698, a novel DP agonist Br. J. Pharmacol. 123, 1317-1324 (1998).