Protein kinase a inhibits leukotriene synthesis by phosphorylation of 5-lipoxygenase on serine 523

Journal of Biological Chemistry

Volumn 279, Issue 40, 2004, Pages 41512-41520

  Luo, Ming ^a   Jones, Sandra M ^a   Phare, Susan M ^a   Coffey, Michael J ^a   Peters Golden, Marc ^a   Brock, Thomas G ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; INORGANIC ACIDS; PATIENT TREATMENT; SYNTHESIS (CHEMICAL);

ARACHIDONIC ACID; CELL FUNCTION; LEUKOTRIENES (LT);

ENZYMES;

ADENOSINE; ARACHIDONATE 5 LIPOXYGENASE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUTAMIC ACID; LEUKOTRIENE; PROSTAGLANDIN E2; RECOMBINANT ENZYME; SERINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; FATTY ACID SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WILD TYPE;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CALCIUM; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME ACTIVATION; HUMANS; LEUKOTRIENE B4; LEUKOTRIENES; MICE; MUTATION, MISSENSE; NIH 3T3 CELLS; PHOSPHORYLATION; SERINE; TRANSFECTION;

ANIMALIA; SIGANUS;

EID: 4744375385     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M312568200     Document Type: Article

References (50)

1. Funk, C. D. (2001) Science 294, 1871-1875
2. Bailie, M. B., Standiford, T. J., Laichalk, L. L., Coffey, M. J., Strieter, R., and Peters-Golden, M. (1996) J. Immunol. 157, 5221-5224
3. Drazen, J. M., Lilly, C. M., Sperling, R., Rubin, P., and Israel, E. (1994) Adv. Prostaglandin Thromboxane Leukotriene Res. 22, 251-262
4. Wilborn, J., Bailie, M., Coffey, M., Burdick, M., Strieter, R., and Peters-Golden, M. (1996) J. Clin. Invest. 97, 1827-1836
5. Dwyer, J. H., Allayee, H., Dwyer, K. M., Fan, J., Wu, H., Mar, R., Lusis, A. J., and Mehrabian, M. (2004) N. Engl. J. Med. 350, 29-37
6. Deleted in proof
7. Bonventre, J. V., Huang, Z., Taheri, M. R., O'Leary, E., Li, E., Moskowitz, M. A., and Sapirstein, A. (1997) Nature 390, 622-625
8. Kooman, W. J., Orange, R. P., and Austen, K. F. (1970) J. Immunol. 105, 1096-1102
9. Ham, E. A., Soderman, D. D., Zanetti, M. E., Dougherty, H. W., McCauley, E., and Kuehl, F. A., Jr. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 4349-4353
10. Krump, E., Picard, S., Mancini, J., and Borgeat, P. (1997) J. Exp. Med. 186, 1401-1406
11. Flamand, N., Boudreault, S., Picard, S., Austin, M., Surette, M. E., Plante, H., Krump, E., Vallee, M. J., Gilbert, C., Naccache, P., Laviolette, M., and Borgeat, P. (2000) Am. J. Respir. Crit. Care Med. 161, S88-S94
12. Marone, G., Columbo, M., Triggiani, M., Cirillo, R., Genovese, A., and Formisano, S. (1987) Biochem. Pharmacol. 36, 13-20
13. Undem, B. J., Torphy, T. J., Goldman, D., and Chilton, F. H. (1990) J. Biol. Chem. 265, 6750-6758
14. Flamand, N., Surette, M. E., Picard, S., Bourgoin, S., and Borgeat, P. (2002) Mol. Pharmacol. 62, 250-256
15. Tenor, H., Hatzelmann, A., Church, M. K., Schudt, C., and Shute, J. K. (1996) Br. J. Pharmacol. 118, 1727-1735
16. Denis, D., and Riendeau, D. (1999) Eur. J. Pharmacol. 367, 343-350
17. Surette, M. E., Krump, E., Picard, S., and Borgeat, P. (1999) Mol. Pharmacol. 56, 1055-1062
18. Shichijo, M., Inagaki, N., Kimata, M., Serizawa, I., Saito, H., and Nagai, H. (1999) J. Allergy Clin. Immunol. 103, S421-S428
19. Meliton, A. Y., Munoz, N. M., Liu, J., Lambertino, A. T., Boetticher, E., Myo, S., Myou, S., Zhu, X., Johnson, M., and Leff, A. R. (2003) J. Allergy Clin. Immunol. 112, 404-410
20. Wightman, P. D., and Dallob, A. (1990) J. Biol. Chem. 265, 9176-9180
21. Murthy, K. S., and Makhlouf, G. M. (1998) J. Biol. Chem. 273, 34519-34526
22. Takenawa, T., Ishitoya, J., and Nagai, Y. (1986) J. Biol. Chem. 261, 1092-1098
23. Fonteh, A. N., Winkler, J. D., Torphy, T. J., Heravi, J., Undem, B. J., and Chilton, F. H. (1993) J. Immunol. 151, 339-350
24. Strokin, M., Sergeeva, M., and Reiser, G. (2003) Br. J. Pharmacol. 139, 1014-1022
25. Sheu, J. N., Baum, M., Harkins, E. W., and Quigley, R. (1997) Kidney Int. 52, 71-79
26. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
27. Hemak, J., Gale, D., and Brock, T. G. (2002) J. Mol. Model. 8, 75-83
28. Healy, A. M., Peters-Golden, M., Yao, J. P., and Brock, T. G. (1999) J. Biol. Chem. 274, 29812-29818
29. Jones, S. M., Luo, M., Healy, A. M., Peters-Golden, M., and Brock, T. G. (2002) J. Biol. Chem. 277, 38550-38556
30. Luo, M., Jones, S. M., Peters-Golden, M., and Brock, T. G. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 12165-12170
31. Woods, J. W., Evans, J. F., Ethier, D., Scott, S., Vickers, P. J., Hearn, L., Charleson, S., Heibein, J. A., and Singer, I. I. (1993) J. Exp. Med. 178, 1935-1946
32. Coffey, M., Phare, S., Kazanjian, P., and Peters-Golden, M. (1996) J. Immunol. 157, 393-399
33. Rouzer, C. A., and Kargman, S. (1988) J. Biol. Chem. 263, 10980-10988
34. Brock, T. G., McNish, R. W., Coffey, M. J., Ojo, T. C., Phare, S. M., and Peters-Golden, M. (1996) J. Immunol. 156, 2522-2527
35. Sigrist, C. J., Cerutti, L., Hulo, N., Gattiker, A., Falquet, L., Pagni, M., Bairoch, A., and Bucher, P. (2002) Brief Bioinform. 3, 265-274
36. Evans, G. J., Wilkinson, M. C., Graham, M. E., Turner, K. M., Chamberlain, L. H., Burgoyne, R. D., and Morgan, A. (2001) J. Biol. Chem. 276, 47877-47885
37. Werz, O., Klemm, J., Samuelsson, B., and Radmark, O. (2001) Blood 97, 2487-2495
38. Gillmor, S., Villasenor, A., Fletterick, R., Sigal, E., and Browner, M. (1997) Nat. Struct. Biol. 4, 1003-1010
39. Borngraber, S., Browner, M., Gillmor, S., Gerth, C., Anton, M., Fletterick, R., and Kuhn, H. (1999) J. Biol. Chem. 274, 37345-37350
40. Gan, Q. F., Browner, M. F., Sloane, D. L., and Sigal, E. (1996) J. Biol. Chem. 271, 25412-25418
41. Sloane, D. L., Leung, T. S. C. C., and Sigal, E. (1991) Nature 354, 149-152
42. Orlic, T., Loomis, W. H., Shreve, A., Namiki, S., and Junger, W. G. (2002) Am. J. Physiol. 282, C1261-C1269
43. Munoz, N. M., Kim, Y. J., Meliton, A. Y., Kim, K. P., Han, S. K., Boetticher, E., O'Leary, E., Myou, S., Zhu, X., Bonventre, J. V., Leff, A. R., and Cho, W. (2003) J. Biol. Chem. 278, 38813-38820
44. Werz, O., Szellas, D., Steinhilber, D., and Radmark, O. (2002) J. Biol. Chem. 277, 14793-14800
45. Peters-Golden, M., Bailie, M., Marshall, T., Wilke, C., Phan, S. H., Toews, G. B., and Moore, B. B. (2002) Am. J. Respir. Crit. Care Med. 165, 229-235
46. Wardlaw, A., Hay, H., Cromwell, O., Collins, J., and Kay, A. (1989) J. Allergy Clin. Immunol. 84, 19-26
47. Ozaki, T., Moriguchi, H., Nakamura, Y., Kamei, T., Yasuoka, S., and Ogura, T. (1990) Am. Rev. Respir. Dis. 141, 965-969
48. Wilborn, J., Crofford, L. J., Burdick, M. D., Kunkel, S. L., Strieter, R. M., and Peters-Golden, M. (1995) J. Clin. Invest. 95, 1861-1868
49. Hackshaw, K. V., Voelkel, N. F., Thomas, R. B., and Westcott, J. Y. (1992) J. Rheumatol. 19, 252-258
50. Kammer, G. M. (2002) Ann. N. Y. Acad. Sci. 968, 96-105