메뉴 건너뛰기




Volumn 36, Issue 3, 2004, Pages 233-239

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

(26)  Helgadottir, Anna a   Manolescu, Andrei a   Thorleifsson, Gudmar a   Gretarsdottir, Solveig a   Jonsdottir, Helga a   Thorsteinsdottir, Unnur a   Samani, Nilesh J b   Gudmundsson, Gudmundur a   Grant, Struan F A a   Thorgeirsson, Gudmundur c   Sveinbjornsdottir, Sigurlaug c   Valdimarsson, Einar M c   Matthiasson, Stefan E c   Johannsson, Halldor c   Gudmundsdottir, Olof a   Gurney, Mark E a   Sainz, Jesus a   Thorhallsdottir, Margret a   Andresdottir, Margret a   Frigge, Michael L a   more..


Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; LEUKOTRIENE B4;

EID: 10744220794     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1311     Document Type: Article
Times cited : (843)

References (50)
  • 1
    • 0037167664 scopus 로고    scopus 로고
    • World Heart Day 2002: The international burden of cardiovascular disease: Responding to the emerging global epidemic
    • Bonow, R.O., Smaha, L.A., Smith, S.C. Jr., Mensah, G.A. & Lenfant, C. World Heart Day 2002: the international burden of cardiovascular disease: responding to the emerging global epidemic. Circulation 106, 1602-1605 (2002).
    • (2002) Circulation , vol.106 , pp. 1602-1605
    • Bonow, R.O.1    Smaha, L.A.2    Smith Jr., S.C.3    Mensah, G.A.4    Lenfant, C.5
  • 3
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • Lusis, A.J. Atherosclerosis. Nature 407, 233-241 (2000).
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 4
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby, P. Inflammation in atherosclerosis. Nature 420, 868-874 (2002).
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 5
    • 0022635680 scopus 로고
    • Inflammatory infiltrates in human coronary atherosclerosis
    • Stratford, N., Britten, K. & Gallagher, P. Inflammatory infiltrates in human coronary atherosclerosis. Atherosclerosis 59, 271-276 (1986).
    • (1986) Atherosclerosis , vol.59 , pp. 271-276
    • Stratford, N.1    Britten, K.2    Gallagher, P.3
  • 6
    • 84961048900 scopus 로고
    • Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits
    • Poole, J.C. & Florey, H.W. Changes in the endothelium of the aorta and the behaviour of macrophages in experimental atheroma of rabbits. J. Pathol. Bacteriol. 75, 245-251 (1958).
    • (1958) J. Pathol. Bacteriol. , vol.75 , pp. 245-251
    • Poole, J.C.1    Florey, H.W.2
  • 7
    • 0035960593 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction
    • Topol, E.J. et al. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation 104, 2641-2644 (2001).
    • (2001) Circulation , vol.104 , pp. 2641-2644
    • Topol, E.J.1
  • 8
    • 18744407845 scopus 로고    scopus 로고
    • Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
    • Ozaki, K. et al. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat. Genet. 32, 650-654 (2002).
    • (2002) Nat. Genet. , vol.32 , pp. 650-654
    • Ozaki, K.1
  • 9
    • 0037069779 scopus 로고    scopus 로고
    • Prediction of the risk of myocardial infarction from polymorphisms in candidate genes
    • Yamada, Y. et al. Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N. Engl. J. Med. 347, 1916-1923 (2002).
    • (2002) N. Engl. J. Med. , vol.347 , pp. 1916-1923
    • Yamada, Y.1
  • 10
    • 18544372620 scopus 로고    scopus 로고
    • A comprehensive linkage analysis for myocardial infarction and its related risk factors
    • Broeckel, U. et al. A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat. Genet. 30, 210-214 (2002).
    • (2002) Nat. Genet. , vol.30 , pp. 210-214
    • Broeckel, U.1
  • 11
    • 18244398717 scopus 로고    scopus 로고
    • A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27
    • Francke, S. et al. A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27. Hum. Mol. Genet. 10, 2751-2765 (2001).
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2751-2765
    • Francke, S.1
  • 12
    • 0036094165 scopus 로고    scopus 로고
    • Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2
    • Harrap, S.B. et al. Genome-wide linkage analysis of the acute coronary syndrome suggests a locus on chromosome 2. Arterioscler. Thromb. Vasc. Biol. 22, 874-878 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 874-878
    • Harrap, S.B.1
  • 13
    • 0033658950 scopus 로고    scopus 로고
    • Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland
    • Pajukanta, P. et al. Two loci on chromosomes 2 and X for premature coronary heart disease identified in early- and late-settlement populations of Finland. Am. J. Hum. Genet. 67, 1481-1493 (2000).
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 1481-1493
    • Pajukanta, P.1
  • 14
    • 0344827206 scopus 로고    scopus 로고
    • Mutation of MEF2A in an inherited disorder with features of coronary artery disease
    • Wang, L., Fan, C., Topol, S.E., Topol, E.J. & Wang, Q. Mutation of MEF2A in an inherited disorder with features of coronary artery disease. Science 302, 1578-1581 (2003).
    • (2003) Science , vol.302 , pp. 1578-1581
    • Wang, L.1    Fan, C.2    Topol, S.E.3    Topol, E.J.4    Wang, Q.5
  • 15
    • 0025022489 scopus 로고
    • Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis
    • Dixon, R.A. et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343, 282-284 (1990).
    • (1990) Nature , vol.343 , pp. 282-284
    • Dixon, R.A.1
  • 16
    • 0037178728 scopus 로고    scopus 로고
    • Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice
    • Mehrabian, M. et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ. Res. 91, 120-126 (2002).
    • (2002) Circ. Res. , vol.91 , pp. 120-126
    • Mehrabian, M.1
  • 17
    • 0026680341 scopus 로고
    • Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy
    • Brezinski, D.A., Nesto, R.W. & Serhan, C.N. Angioplasty triggers intracoronary leukotrienes and lipoxin A4. Impact of aspirin therapy. Circulation 86, 56-63 (1992).
    • (1992) Circulation , vol.86 , pp. 56-63
    • Brezinski, D.A.1    Nesto, R.W.2    Serhan, C.N.3
  • 18
    • 0037417973 scopus 로고    scopus 로고
    • Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis
    • Spanbroek, R. et al. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc. Natl. Acad. Sci. USA 100, 1238-1243 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1238-1243
    • Spanbroek, R.1
  • 19
    • 0023866516 scopus 로고
    • The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): A major international collaboration
    • WHO MONICA Project Principal Investigators
    • The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators. J. Clin. Epidemiol. 41, 105-14 (1988).
    • (1988) J. Clin. Epidemiol. , vol.41 , pp. 105-114
  • 20
    • 0033156390 scopus 로고    scopus 로고
    • Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma
    • Koshino, T. et al. Novel polymorphism of the 5-lipoxygenase activating protein (FLAP) promoter gene associated with asthma. Mol. Cell. Biol. Res. Commun. 2, 32-35 (1999).
    • (1999) Mol. Cell. Biol. Res. Commun. , vol.2 , pp. 32-35
    • Koshino, T.1
  • 21
    • 0029666285 scopus 로고    scopus 로고
    • Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes
    • Sala, A., Bolla, M., Zarini, S., Muller-Peddinghaus, R. & Folco, G. Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes. J. Biol. Chem. 271, 17944-17948 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 17944-17948
    • Sala, A.1    Bolla, M.2    Zarini, S.3    Muller-Peddinghaus, R.4    Folco, G.5
  • 22
    • 0022137949 scopus 로고
    • Leukotriene C4 production by murine mast cells: Evidence of a role for extracellular leukotriene A4
    • Dahinden, C.A., Clancy, R.M., Gross, M., Chiller, J.M. & Hugli, T.E. Leukotriene C4 production by murine mast cells: evidence of a role for extracellular leukotriene A4. Proc. Natl. Acad. Sci. USA 82, 6632-6636 (1985).
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 6632-6636
    • Dahinden, C.A.1    Clancy, R.M.2    Gross, M.3    Chiller, J.M.4    Hugli, T.E.5
  • 23
    • 0025008523 scopus 로고
    • Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils
    • Fiore, S. & Serhan, C.N. Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils. J. Exp. Med. 172, 1451-1457 (1990).
    • (1990) J. Exp. Med. , vol.172 , pp. 1451-1457
    • Fiore, S.1    Serhan, C.N.2
  • 25
    • 0020597565 scopus 로고
    • Leukotrienes: Mediators of immediate hypersensitivity reactions and inflammation
    • Samuelsson, B. Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220, 568-575 (1983).
    • (1983) Science , vol.220 , pp. 568-575
    • Samuelsson, B.1
  • 26
    • 0020003783 scopus 로고
    • Leukotrienes C4, D4 and E4: Effects on human and guinea-pig cardiac preparations in vitro
    • Burke, J.A., Levi, R., Guo, Z.G. & Corey, E.J. Leukotrienes C4, D4 and E4: effects on human and guinea-pig cardiac preparations in vitro. J. Pharmacol. Exp. Ther. 221, 235-241 (1982).
    • (1982) J. Pharmacol. Exp. Ther. , vol.221 , pp. 235-241
    • Burke, J.A.1    Levi, R.2    Guo, Z.G.3    Corey, E.J.4
  • 27
    • 0021071125 scopus 로고
    • Studies on the mechanism of leukotriene induced coronary artery constriction
    • Roth, D.M. & Lefer, A.M. Studies on the mechanism of leukotriene induced coronary artery constriction. Prostaglandins 26, 573-581 (1983).
    • (1983) Prostaglandins , vol.26 , pp. 573-581
    • Roth, D.M.1    Lefer, A.M.2
  • 28
    • 0022373582 scopus 로고
    • Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene C4
    • Wargovich, T., Mehta, J., Nichols, W.W., Pepine, C.J. & Conti, C.R. Reduction in blood flow in normal and narrowed coronary arteries of dogs by leukotriene C4. J. Am. Coll. Cardiol. 6, 1047-1051 (1985).
    • (1985) J. Am. Coll. Cardiol. , vol.6 , pp. 1047-1051
    • Wargovich, T.1    Mehta, J.2    Nichols, W.W.3    Pepine, C.J.4    Conti, C.R.5
  • 29
    • 0029090411 scopus 로고
    • Coronary plaque disruption
    • Falk, E., Shah, P.K. & Fuster, V. Coronary plaque disruption. Circulation 92, 657-671 (1995).
    • (1995) Circulation , vol.92 , pp. 657-671
    • Falk, E.1    Shah, P.K.2    Fuster, V.3
  • 30
    • 0347418277 scopus 로고    scopus 로고
    • Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis
    • Dwyer, J.H. et al. Arachidonate 5-Lipoxygenase Promoter Genotype, Dietary Arachidonic Acid, and Atherosclerosis. N. Engl. J. Med. 350, 29-37 (2004).
    • (2004) N. Engl. J. Med. , vol.350 , pp. 29-37
    • Dwyer, J.H.1
  • 31
    • 0036124634 scopus 로고    scopus 로고
    • Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice
    • Aiello, R.J. et al. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler. Thromb. Vasc. Biol. 22, 443-449 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol. , vol.22 , pp. 443-449
    • Aiello, R.J.1
  • 32
    • 0141819194 scopus 로고    scopus 로고
    • The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
    • Gretarsdottir, S. et al. The gene encoding phosphodiesterase 4D confers risk of ischemic stroke. Nat. Genet. 35, 131-138 (2003).
    • (2003) Nat. Genet. , vol.35 , pp. 131-138
    • Gretarsdottir, S.1
  • 33
    • 18244401151 scopus 로고    scopus 로고
    • Localization of a susceptibility gene for common forms of stroke to 5q12
    • Gretarsdottir, S. et al. Localization of a susceptibility gene for common forms of stroke to 5q12. Am. J. Hum. Genet. 70, 593-603 (2002).
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 593-603
    • Gretarsdottir, S.1
  • 34
    • 18244401676 scopus 로고    scopus 로고
    • Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31
    • Gudmundsson, G. et al. Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31. Am. J. Hum. Genet. 70, 586-592 (2002).
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 586-592
    • Gudmundsson, G.1
  • 36
    • 0030728925 scopus 로고    scopus 로고
    • Allele-sharing models: LOD scores and accurate linkage tests
    • Kong, A. & Cox, N.J. Allele-sharing models: LOD scores and accurate linkage tests. Am. J. Hum. Genet. 61, 1179-1188 (1997).
    • (1997) Am. J. Hum. Genet. , vol.61 , pp. 1179-1188
    • Kong, A.1    Cox, N.J.2
  • 37
    • 0034098774 scopus 로고    scopus 로고
    • Allegro, a new computer program for multipoint linkage analysis
    • Gudbjartsson, D.F., Jonasson, K., Frigge, M.L. & Kong, A. Allegro, a new computer program for multipoint linkage analysis. Nat. Genet. 25, 12-13 (2000).
    • (2000) Nat. Genet. , vol.25 , pp. 12-13
    • Gudbjartsson, D.F.1    Jonasson, K.2    Frigge, M.L.3    Kong, A.4
  • 38
    • 18544381909 scopus 로고    scopus 로고
    • A high-resolution recombination map of the human genome
    • Kong, A. et al. A high-resolution recombination map of the human genome. Nat. Genet. 31, 241-247 (2002).
    • (2002) Nat. Genet. , vol.31 , pp. 241-247
    • Kong, A.1
  • 39
    • 0028301661 scopus 로고
    • A class of tests for linkage using affected pedigree members
    • Whittemore, A.S. & Halpern, J. A class of tests for linkage using affected pedigree members. Biometrics 50, 118-127 (1994).
    • (1994) Biometrics , vol.50 , pp. 118-127
    • Whittemore, A.S.1    Halpern, J.2
  • 40
    • 0029886532 scopus 로고    scopus 로고
    • Parametric and nonparametric linkage analysis: A unified multipoint approach
    • Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. & Lander, E.S. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 58, 1347-1363 (1996).
    • (1996) Am. J. Hum. Genet. , vol.58 , pp. 1347-1363
    • Kruglyak, L.1    Daly, M.J.2    Reeve-Daly, M.P.3    Lander, E.S.4
  • 42
    • 0002629270 scopus 로고
    • Maximum likelihood from incomplete data via the EM algorithm
    • Dempster, A., Laird, N.M. & Rubin, D.B. Maximum likelihood from incomplete data via the EM algorithm. J. R. Stat. Soc. B39, 1-38 (1977).
    • (1977) J. R. Stat. Soc. B , vol.39 , pp. 1-38
    • Dempster, A.1    Laird, N.M.2    Rubin, D.B.3
  • 43
    • 0026494911 scopus 로고
    • A haplotype-based 'haplotype relative risk' approach to detecting allelic associations
    • Terwilliger, J.D. & Ott, J. A haplotype-based 'haplotype relative risk' approach to detecting allelic associations. Hum. Hered. 42, 337-346 (1992).
    • (1992) Hum. Hered. , vol.42 , pp. 337-346
    • Terwilliger, J.D.1    Ott, J.2
  • 44
    • 0023235253 scopus 로고
    • Haplotype relative risks: An easy reliable way to construct a proper control sample for risk calculations
    • Falk, C.T. & Rubinstein, P. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann. Hum. Genet. 51 Pt 3, 227-233 (1987).
    • (1987) Ann. Hum. Genet. , vol.51 , Issue.PART 3 , pp. 227-233
    • Falk, C.T.1    Rubinstein, P.2
  • 45
    • 0000356980 scopus 로고
    • The interaction of selection and linkage. ii. Optimum models
    • Lewontin, R.C. The interaction of selection and linkage. ii. Optimum models. Genetics 50, 757-782 (1964).
    • (1964) Genetics , vol.50 , pp. 757-782
    • Lewontin, R.C.1
  • 46
    • 0014357408 scopus 로고
    • The effects of inbreeding at loci with heterozygote advantage
    • Hill, W.G. & Robertson, A. The effects of inbreeding at loci with heterozygote advantage. Genetics 60, 615-628 (1968).
    • (1968) Genetics , vol.60 , pp. 615-628
    • Hill, W.G.1    Robertson, A.2
  • 47
    • 0030885877 scopus 로고    scopus 로고
    • Fluorescence energy transfer detection as a homogeneous DNA diagnostic method
    • Chen. X., Zehnbauer, B., Gnirke, A. & Kwok, P.Y. Fluorescence energy transfer detection as a homogeneous DNA diagnostic method. Proc. Natl. Acad. Sci. USA 94, 10756-10761 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10756-10761
    • Chen, X.1    Zehnbauer, B.2    Gnirke, A.3    Kwok, P.Y.4
  • 48
    • 0031978177 scopus 로고    scopus 로고
    • Distribution of tissue plasminogen activator insertion/deletion polymorphism in myocardial infarction and control subjects
    • Steeds, R., Adams, M., Smith, P., Channer, K. & Samani, N.J. Distribution of tissue plasminogen activator insertion/deletion polymorphism in myocardial infarction and control subjects. Thromb. Haemost. 79, 980-984 (1998).
    • (1998) Thromb. Haemost. , vol.79 , pp. 980-984
    • Steeds, R.1    Adams, M.2    Smith, P.3    Channer, K.4    Samani, N.J.5
  • 50
    • 0018354308 scopus 로고
    • Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature
    • Nomenclature and criteria for diagnosis of ischemic heart disease. Report of the Joint International Society and Federation of Cardiology/World Health Organization task force on standardization of clinical nomenclature. Circulation 59, 607-609 (1979).
    • (1979) Circulation , vol.59 , pp. 607-609


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.