Pharmacological inhibition of BLT1 diminishes early abdominal aneurysm formation

Atherosclerosis

Volumn 210, Issue 1, 2010, Pages 107-113

  Kristo, Fjoralba ^a,b   Hardy, Gregory J ^a,b   Anderson, Thomas J T ^a,b   Sinha, Sumita ^a,b   Ahluwalia, Neil ^a,b   Lin, Alexander Y ^a,b   Passeri, Jonathan ^a,b   Scherrer Crosbie, Marielle ^a,b   Gerszten, Robert E ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Abdominal aortic aneurysm; Angiotensin II; BLT1

Indexed keywords

1 [3 (4 BIPHENYLYLMETHYL) 4 HYDROXYCHROMAN 7 YL]CYCLOPENTANECARBOXYLIC ACID; ANGIOTENSIN II; CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR; GELATINASE A; LEUKOTRIENE B4; STROMAL CELL DERIVED FACTOR 1;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ATHEROSCLEROSIS; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; DOSE RESPONSE; INCIDENCE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN CELL; VASODILATATION;

ANGIOTENSIN II; ANIMALS; AORTA; AORTIC ANEURYSM, ABDOMINAL; BENZOPYRANS; CARBOXYLIC ACIDS; CHEMOTAXIS; DISEASE PROGRESSION; IMMUNOHISTOCHEMISTRY; LEUKOTRIENE B4; MALE; MICE;

EID: 77952424069     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2009.11.031     Document Type: Article

References (28)

1. Spanbroek R., Grabner R., Lotzer K., et al. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci USA 2003, 100:1238-1243.
2. De Caterina R., Mazzone A., Giannessi D., et al. Leukotriene B4 production in human atherosclerotic plaques. Biomed Biochim Acta 1988, 47:S182-S185.
3. Qiu H., Gabrielsen A., Agardh H.E., et al. Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci USA 2006, 103:8161-8166.
4. Dwyer J.H., Allayee H., Dwyer K.M., et al. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N Engl J Med 2004, 350:29-37.
5. Helgadottir A., Manolescu A., Helgason A., et al. A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction. Nat Genet 2006, 38:68-74.
6. Helgadottir A., Manolescu A., Thorleifsson G., et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet 2004, 36:233-239.
7. Heller E.A., Liu E., Tager A.M., et al. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation 2005, 112:578-586.
8. Back M., Bu D.X., Branstrom R., Sheikine Y., Yan Z.Q., Hansson G.K. Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. Proc Natl Acad Sci USA 2005, 102:17501-17506.
9. Watanabe S., Yamasaki A., Hashimoto K., et al. Expression of functional leukotriene B(4) receptors on human airway smooth muscle cells. J Allergy Clin Immunol 2009, 124:59-65. e1-3.
10. Yokomizo T., Kato K., Terawaki K., Izumi T., Shimizu T. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med 2000, 192:421-432.
11. Tager A.M., Luster A.D. BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot Essent Fatty Acids 2003, 69:123-134.
12. Subbarao K., Jala V.R., Mathis S., et al. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler Thromb Vasc Biol 2004, 24:369-375.
13. Ahluwalia N., Lin A.Y., Tager A.M., et al. Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol 2007, 179:691-697.
14. Daugherty A., Manning M.W., Cassis L.A. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 2000, 105:1605-1612.
15. Thompson R.W., Geraghty P.J., Lee J.K. Abdominal aortic aneurysms: basic mechanisms and clinical implications. Curr Probl Surg 2002, 39:110-230.
16. Zhao L., Moos M.P., Grabner R., et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004, 10:966-973.
17. Cao R.Y., Adams M.A., Habenicht A.J., Funk C.D. Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice. Prostaglandins Other Lipid Mediat 2007, 84:34-42.
18. Showell H.J., Breslow R., Conklyn M.J., Hingorani G.P., Koch K. Characterization of the pharmacological profile of the potent LTB4 antagonist CP-105,696 on murine LTB4 receptors in vitro. Br J Pharmacol 1996, 117:1127-1132.
19. Aiello R.J., Bourassa P.A., Lindsey S., Weng W., Freeman A., Showell H.J. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol 2002, 22:443-449.
20. Barisione C., Charnigo R., Howatt D.A., Moorleghen J.J., Rateri D.L., Daugherty A. Rapid dilation of the abdominal aorta during infusion of angiotensin II detected by noninvasive high-frequency ultrasonography. J Vasc Surg 2006, 44:372-376.
21. Martin-McNulty B., Vincelette J., Vergona R., Sullivan M.E., Wang Y.X. Noninvasive measurement of abdominal aortic aneurysms in intact mice by a high-frequency ultrasound imaging system. Ultrasound Med Biol 2005, 31:745-749.
22. King V.L., Lin A.Y., Kristo F., et al. Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation 2009, 119:426-435.
23. Liston T.E., Conklyn M.J., Houser J., et al. Pharmacokinetics and pharmacodynamics of the leukotriene B4 receptor antagonist CP-105,696 in man following single oral administration. Br J Clin Pharmacol 1998, 45:115-121.
24. Saraff K., Babamusta F., Cassis L.A., Daugherty A. Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II-infused, apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2003, 23:1621-1626.
25. Levy B.D., De Sanctis G.T., Devchand P.R., et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med 2002, 8:1018-1023.
26. Yoshimura K., Aoki H., Ikeda Y., Furutani A., Hamano K., Matsuzaki M. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase in mice. Ann N Y Acad Sci 2006, 1085:74-81.
27. Yoshimura K., Aoki H., Ikeda Y., et al. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med 2005, 11:1330-1338.
28. Babamusta F., Rateri D.L., Moorleghen J.J., Howatt D.A., Li X.A., Daugherty A. Angiotensin II infusion induces site-specific intra-laminar hemorrhage in macrophage colony-stimulating factor-deficient mice. Atherosclerosis 2006, 186:282-290.