Leukotriene B4 triggers release of the cathelicidin LL-37 from human neutrophils: Novel lipid-peptide interactions in innate immune responses

FASEB Journal

Volumn 21, Issue 11, 2007, Pages 2897-2905

  Wan, Min ^a   Sabirsh, Alan ^a   Wetterholm, Anders ^a   Agerberth, Birgitta ^a   Haeggström, Jesper Z ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Inflammation; Phagocytosis

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; LEUKOTRIENE B4; PHOSPHOPROTEIN PHOSPHATASE 1; ANTIMICROBIAL CATIONIC PEPTIDE; ANTIMICROBIAL PEPTIDE LL-37; CATHELICIDIN ANTIMICROBIAL PEPTIDE; LEUKOTRIENE B4 RECEPTOR; LTB4R PROTEIN, HUMAN; LTB4R2 PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IMMUNE RESPONSE; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOLOGY; METABOLISM; WESTERN BLOTTING;

ESCHERICHIA COLI;

ANTIMICROBIAL CATIONIC PEPTIDES; BLOTTING, WESTERN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; HUMANS; LEUKOTRIENE B4; NEUTROPHILS; PHAGOCYTOSIS; PHOSPHOPROTEIN PHOSPHATASE; RECEPTORS, LEUKOTRIENE B4;

EID: 34548476951     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7974com     Document Type: Article

References (45)

1. Funk, C. D. (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294, 1871-1875
2. 4 that mediates chemotaxis. Nature 387, 620-624
3. 4 receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192, 421-432
4. 4 to humans. J. Infect. Dis. 189, 2001-2009
5. Serezani, C. H., Aronoff, D. M., Jancar, S., Mancuso, P., and Peters-Golden, M. (2005) Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood 106, 1067-1075
6. 4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat. Immunol. 4, 965-973
7. Zasloff, M. (2002) Antimicrobial peptides of multicellular organisms. Nature 415, 389-395
8. Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., and Gallo, R. L. (2001) Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 414, 454-457
9. Chromek, M., Slamova, Z., Bergman, P., Kovacs, L., Podracka, L., Ehren, I., Hokfelt, T., Gudmundsson, G. H., Gallo, R. L., Agerberth, B., and Brauner, A. (2006) The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat. Med. 12, 636-641
10. De Yang, B., Chen, Q., Schmidt, A. P., Anderson, G. M., Wang, J. M., Wooters, J., Oppenheim, J. J., and Chertov, O. (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J. Exp. Med. 192, 1069-1074
11. Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schroder, J. M., Wang, J. M., Howard, O. M., and Oppenheim, J. J. (1999) Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286, 525-528
12. Koczulla, R., von Degenfeld, G., Kupatt, C., Krotz, F., Zahler, S., Gloe, T., Issbrucker, K., Unterberger, P., Zaiou, M., Lebherz, C., et al. (2003) An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J. Clin. Invest. 111, 1665-1672
13. Sorensen, O. E., Follin, P., Johnsen, A. H., Calafat, J., Tjabringa, G. S., Hiemstra, P. S., and Borregaard, N. (2001) Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3. Blood 97, 3951-3959
14. Varoga, D., Pufe, T., Mentlein, R., Kohrs, S., Grohmann, S., Tillmann, B., Hassenpflug, J., and Paulsen, F. (2005) Expression and regulation of antimicrobial peptides in articular joints. Ann. Anat. 187, 499-508
15. Edfeldt, K., Agerberth, B., Rottenberg, M. E., Gudmundsson, G. H., Wang, X. B., Mandal, K., Xu, Q., and Yan, Z. Q. (2006) Involvement of the antimicrobial peptide LL-37 in human atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 26, 1551-1557
16. Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., and Leung, D. Y. (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347, 1151-1160
17. Yoshio, H., Tollin, M., Gudmundsson, G. H., Lagercrantz, H., Jornvall, H., Marchini, G., and Agerberth, B. (2003) Antimicrobial polypeptides of human vernix caseosa and amniotic fluid: implications for newborn innate defense. Pediatr. Res. 53, 211-216
18. Csernok, E., Ludemann, J., Gross, W. L., and Bainton, D. F. (1990) Ultrastructural localization of proteinase 3, the target antigen of anti-cytoplasmic antibodies circulating in Wegener's granulomatosis. Am. J. Pathol. 137, 1113-1120
19. Mocsai, A., Jakus, Z., Vantus, T., Berton, G., Lowell, C. A., and Ligeti, E. (2000) Kinase pathways in chemoattractant-induced degranulation of neutrophils: the role of p38 mitogen-activated protein kinase activated by Src family kinases. J. Immunol. 164, 4321-4331
20. 4 receptor, BLT2. J. Biol. Chem. 276, 12454-12459
21. 4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes. J. Biol. Chem. 280, 24816-24823
22. Woods, J. W., Evans, J. F., Ethier, D., Scott, S., Vickers, P. J., Hearn, L., Heibein, J. A., Charleson, S., and Singer, I. I. (1993) 5-lipoxygenase and 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leukocytes. J. Exp. Med. 178, 1935-1946
23. Borregaard, N. (1997) Development of neutrophil granule diversity. Ann. N. Y. Acad. Sci. 832, 62-68
24. Mocsai, A., Ligeti, E., Lowell, C. A., and Berton, G. (1999) Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck. J. Immunol. 162, 1120-1126
25. Hanke, J. H., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A., and Connelly, P. A. (1996) Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J. Biol. Chem. 271, 695-701
26. 4 is a complete secretagogue in human neutrophils: a kinetic analysis. Biochem. Biophys. Res. Commun. 107, 1006-1012
27. 4 and its ω-oxidized metabolites. FEBS Lett. 136, 141-144
28. 4 - a stereospecific stimulator for release of lysosomal enzymes from neutrophils. FEBS Lett. 130, 146-148
29. 4 to receptors on human polymorphonuclear leukocytes. J. Immunol. 129, 1600-1604
30. 4. Identification of a subset of high affinity receptors that transduce the chemotactic response. J. Exp. Med. 159, 1027-1041
31. Rouzer, C. A., and Kargman, S. (1988) Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187. J. Biol. Chem. 263, 10980-10988
32. Wong, A., Cook, M. N., Foley, J. J., Sarau, H. M., Marshall, P., and Hwang, S. M. (1991) Influx of extracellular calcium is required for the membrane translocation of 5-lipoxygenase and leukotriene synthesis. Biochemistry 30, 9346-9354
33. Malaviya, R., and Jakschik, B. A. (1993) Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation. J. Biol. Chem. 268, 4939-4944
34. Werz, O., Burkert, E., Samuelsson, B., Radmark, O., and Steinhilber, D. (2002) Activation of 5-lipoxygenase by cell stress is calcium independent in human polymorphonuclear leukocytes. Blood 99, 1044-1052
35. DiPersio, J. F., Billing, P., Williams, R., and Gasson, J. C. (1988) Human granulocyte-macrophage colony-stimulating factor and other cytokines prime human neutrophils for enhanced arachidonic acid release and leukotriene B4 synthesis. J. Immunol. 140, 4315-4322
36. 4 in chemotactic peptide-stimulated human neutrophils. FASEB J. 12, 1521-1531
37. Scott, M. G., Vreugdenhil, A. C., Buurman, W. A., Hancock, R. E., and Gold, M. R. (2000) Cutting edge: cationic antimicrobial peptides block the binding of lipopolysaccharide (LPS) to LPS binding protein. J. Immunol. 164, 549-553
38. Raqib, R., Sarker, P., Bergman, P., Ara, G., Lindh, M., Sack, D. A., Nasirul Islam, K. M., Gudmundsson, G. H., Andersson, J., and Agerberth, B. (2006) Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc. Natl. Acad. Sci. U. S. A. 103, 9178-9183
39. Zasloff, M. (2002) Innate immunity, antimicrobial peptides, and protection of the oral cavity. Lancet 360, 1116-1117
40. Bailie, M. B., Standiford, T. J., Laichalk, L. L., Coffey, M. J., Strieter, R., and Peters-Golden, M. (1996) Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J. Immunol. 157, 5221-5224
41. 4 hydrolase-deficient mice. J. Immunol. 163, 6810-6819
42. 4 receptor BLT1 mediates early effector T cell recruitment. Nat. Immunol. 4, 982-990
43. 4 is required for inflammatory arthritis. J. Exp. Med. 203, 837-842
44. 4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc. Natl. Acad. Sci. U. S. A. 103, 8161-8166
45. Funk, C. D. (2005) Leukotriene modifiers as potential therapeutics for cardiovascular disease. Nat. Rev. Drug. Discov. 4, 664-672