Activation of innate immunity by the leukotriene B 4 inhibits EBV induced B-cell transformation in cord-blood derived mononuclear cultures

Immunology Letters

Volumn 116, Issue 2, 2008, Pages 174-177

  Klein, Eva ^a   Liu, Anquan ^a   Claesson, Hans Erik ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cord blood mononuclear cells; Epstein Barr virus; Leukotriene B4

Indexed keywords

LEUKOTRIENE B4; LEUKOTRIENE B4 RECEPTOR ANTAGONIST;

ARTICLE; CELL FUNCTION; CELL POPULATION; CELL PROLIFERATION; CELL TRANSFORMATION; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; EPSTEIN BARR VIRUS; HUMAN; IN VITRO STUDY; INNATE IMMUNITY; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD;

B-LYMPHOCYTES; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; FETAL BLOOD; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNITY, NATURAL; LEUKOTRIENE B4; T-LYMPHOCYTES, CYTOTOXIC;

EID: 40149107407     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2007.12.006     Document Type: Article

References (22)

1. Claesson H.E., Odlander B., and Jakobsson P.J. Leukotriene B4 in the immune system. Int J Immunopharmacol 14 (1992) 441-449
2. Claesson H.E., and Dahlén S.E. Asthma and leukotrienes: antileukotrienes as novel antiasthmatic drugs. J Intern Med 245 (1999) 205-227
3. Tager A.M., and Luster A.D. BLT1 and BLT2: the leukotriene B(4) receptors. Prostaglandins Leukot Essent Fatty Acids 69 (2003) 123-134
4. Peres C.M., Aronoff D.M., Serezani C.M., Flamand N., Faccioli L.H., and Peters-Golden M. Specific leukotriene receptors couple to distinct G proteins to effect stimulation of alveolar macrophage host defense functions. J Immunol 179 (2007) 5454-5461
5. Flamand N., Mancuso P., Serezani C.H., and Brock T.G. Leukotrienes: mediators that been typecast as villains. Cell Mol 64 (2007) 2657-2670
6. Henle W., and Henle G. The Epstein-Barr virus (1979), Springer, Berlin p. 297-320
7. Williams H., and Crawford D.H. Epstein-Barr virus: the impact of scientific advances on clinical practice. Blood 107 (2006) 862-869
8. Hadinoto V., Shapiro M., Greenough T.C., Sullivan J.L., Luzuriaga K., and Thorley-Lawson D.A. On the dynamics of acute EBV infection. Blood 111 (2008) 1420-1427
9. Hislop A.D., Taylor G.S., Sauce D., and Rickinson A.B. Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Ann Rev Immunol 25 (2007) 587-617
10. Liu A., Klein G., Bandobashi K., Klein E., and Nagy N. SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK. Immunol Lett 80 (2002) 181-188
11. Liu A., Arbiser H., Holmgren A., Klein G., and Klein E. PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cell activated by the monocyte products IL-15 and IL-12. Blood 105 (2005) 1606-1613
12. Tsukagoshi S., Hashimoto Y., Fujii G., Kobayashi H., Nomoto K., and Orita K. Krestin (PSK) Cancer Treat Rev 11 (1984) 31-55
13. Pekkari K., and Holmgren A. Truncated thioredoxin: physiological functions and mechanism. Antioxid Redox Signal 6 (2004) 53-61
14. Fehniger T.A., and Caligiuri M.A. Interleukin 15: biology and relevance to human disease. Blood 97 (2001) 14-32
15. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 3 (2003) 133-146
16. Liu A, Holmgren A, Klein G, Klein E. The role of NK cells in the immunological recognition of EBV infected B cells in cord blood mononuclear cell cultures. J Leukocyte Biol; submitted for publication.
17. 4 activated T cells which inhibit B cell proliferation in EBV infected cord blood derived mononuclear cultures. Blood 111 (2008) 2693-2703
18. Okamura H., Tsutsui H., Kashiwamura S., Yoshimoto T., and Nakanishi K. Interleukin-18: a novel cytokine that augments both innate and acquired immunity. Adv Immunol 70 (1998) 281-312
19. Gosselin J., Borgeat P., and Flamand. Leukotriene B4 protects latently infected mice against murine cytomegalovirus reactivation following allogeneic transplantation. J Immunol 174 (2005) 1587-1593
20. Bailie M.B., Standiford T.J., Laichalk L.L., Coffey M.J., Strieter R., and Peters-Golden M. Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J Immunol 157 (1996) 5221-5224
21. Corsi M.M., Ruscica M., Passoni D., Scarmozzino M.G., and Gulletta E. High Th1-type cytokine serum levels in patients with infectious mononucleosis. Acta Virol 48 (2004) 263-266
22. Rubin P., and Mollison K.W. Pharmacotherapy of diseases mediated by 5-lipoxygenase pathway eicosanoids. Prostaglandins Other Lipid Mediat 83 (2007) 188-197