L-leucine availability regulates phosphatidylinositol 3-kinase, p70 s6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: Evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L-leucine-induced up-regulation of System A amino acid transport

Biochemical Journal

Volumn 350, Issue 2, 2000, Pages 361-368

  Peyrollier, K ^a   Hajduch, E ^a   Blair, A S ^a   Hyde, R ^a   Hundal, H S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

4E BP1; Branched chain amino acid; Insulin; PKB Akt; Protein synthesis

Indexed keywords

CARRIER PROTEIN; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LEUCINE; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; RAPAMYCIN; REGULATOR PROTEIN; S6 KINASE; SYSTEM A AMINO ACID TRANSPORTER; UNCLASSIFIED DRUG; WORTMANNIN;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACIDS; ANDROSTADIENES; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASES; IMMUNOBLOTTING; LEUCINE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MUSCLES; PHOSPHOPROTEINS; PRECIPITIN TESTS; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES; SIGNAL TRANSDUCTION; SIROLIMUS; TIME FACTORS; UP-REGULATION;

EID: 0034283186     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3500361     Document Type: Article

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