Serum leptin concentration in moderate and severe obesity: Relationship with clinical, anthropometric and metabolic factors

International Journal of Obesity

Volumn 23, Issue 10, 1999, Pages 1066-1073

  Liuzzi, A ^a   Savia, G ^a   Tagliaferri, M ^a   Lucantoni, R ^a   Berselli, M E ^a   Petroni, M L ^a   De Medici, C ^b   Viberti, G C ^c  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b Ospedale San Giuseppe   (Italy)

^c GUY S HOSPITAL   (United Kingdom)

Author keywords

Cardiovascular risk factors; Fat distribution; Leptin; Obesity

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; TRIACYLGLYCEROL; URIC ACID;

ADULT; ANTHROPOMETRY; ARTICLE; BLOOD LEVEL; BODY COMPOSITION; BODY FAT; BODY MASS; CALORIC INTAKE; CALORIMETRY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; CONTROL; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; IMPEDANCE; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLISM; OBESITY; PRIORITY JOURNAL; SEX DIFFERENCE; TISSUE DISTRIBUTION; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

EID: 0032853754     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0801036     Document Type: Article

References (44)

1. 1 Zhang Y, Proenca R, Maffei M, Barone M, Leopoid L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
2. 2 Bray GA, York DA. Leptin and clinical medicine - a new piece in the puzzle of obesity. J Clin Endocrinol Metab 1997; 82: 2771-2776.
3. 3 Rosenbaum M, Leibel R, Hirsch J. Obesity. N Engl J Med 1997; 337: 396-407.
4. 4 Auwerx J, Staels B. Leptin. Lancet 1998; 351: 737-742.
5. 5 Campfield LA, Smith JF, Burn P. OB protein: a hormonal controller of central neural network mediating behavioral, metabolic and neuroendocrine responses. Endocrinol Metab 1997; 4: 81-102.
6. 6 Ostlund RE, Yang JW, Klein S, Gingerich R. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 1996; 81: 3909-3913.
7. 7 Havel PJ, Kasim-Karakas S, Mueller W, Johnson PR, Gingerich RL, Stern JS. Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effect of dietary fat content and sustained weight loss. J Clin Endocrinol Metab 1996; 81: 4406-4413.
8. 8 Sumner AE, Falkner B, Kushner H, Considine RV. Relationship of leptin concentrations to gender, menopause, age, diabetes, and fat mass in African Americans. Obes Res 1998; 6: 128-133.
9. 9 Lonnqvist F, Wennlund A, Arner P. Relationship between circulating leptin and peripheral fat distribution in obese subjects. Int J Obes 1997; 21: 255-260.
10. 10 Chapman IM, Wittert GA, Norman RJ. Circulating leptin concentrations in polycystic ovary syndrome-relation to anthropometric and metabolic parameters. Clin Endocrinol 1997; 46: 175-181.
11. 11 Saad MF, Damani S, Gingerich R, Riad-Gabriel MG, Khan A, Boyadjian R, Jinagouda SD, el-Tawil K, Rude RK, Kamdar V. Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 1997; 82: 579-584.
12. 12 Niskanen LK, Haffner SM, Karhunen LJ, Turpeinen AK, Miettinen H, Uusitupa MIJ. Serum leptin in obesity is related to gender and body fat topography but does not predict successful weight loss. Eur J Endocrinol 1997; 137: 61-67.
13. 13 Piccoli A, Brunani A, Savia G, Pillon L, Favaro E, Berselli ME, Cavagnini F. Discriminating between body fat and fluid changes in the obese adult using bioimpedance vector analysis. Int J Obes 1998; 22: 97-104.
14. 14 Lukaski HC, Bolonchuck WW. Estimation of body fluid volumes using tetrapolar bioelectrical impedance measurements. Aviat Space Environ Med 1988; 59: 1163-1169.
15. 15 Lukaski HC, Bolonchuck WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol 1986; 60: 1327-1332.
16. 16 Valdez R, Seidell J, Ahn Yi, Weiss KM. A new index of abdominal adiposity as indicator of risk for cardiovascular disease. A cross population study. Int J Obes 1993; 17: 77-82.
17. 17 Matthews D, Hosher J, Rudenski A, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment. Insulin resistance and beta cell function from fasting plasma and insulin concentration in man. Diabetologia 1985; 28: 412-419.
18. 18 Rosenbaum M, Nicolson M, Hirsch J, Heynsfield SB, Gallagher D, Chu F, Leibel RL. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996; 81: 324-327.
19. 19 Klein S, Coppack SW, Mohamed-Ali V, Landt M. Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 1996; 45: 984-987.
20. 20 Cinti S, Frederich RC, Zingaretti MC, De Matteis R, Flier JS, Lowell BB. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology 1997; 138: 797-804.
21. 21 Montague CT, Prins JB, Sanders L, Digby JE, O'Rahilly S. Depot-and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 1997; 46: 342-347.
22. 22 Lefebvre AM, Laville M, Vega, N Riou JP, van Gaal L, Auvwerx J, Vidal H. Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes 1998; 47: 98-103.
23. 23 Van Harmelen V, Reynisdottir S, Eriksson P, Thorne A, Hoffstedt E, Lonnqvist F, Amer P. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998; 47: 913-917.
24. 24 Takahashi M, Funahashi T, Shimomura I, Miyaoka K, Matsuzawa Y. Plasma leptin concentrations and body fat distribution. Horm Metab Res 1996; 28: 751-752.
25. 25 Haffner SM, Gingerich R, Miettinen H, Stern MP. Leptin concentration in relation to adiposity and regional adiposity. Int J Obes 1996; 20: 904-908.
26. 26 Bennett FI, McFarlane-Anderson N, Wilks R, Luke A, Cooper RS, Forrester TE. Leptin concentration in women is influenced by regional distribution of adipose tissue. Am J Clin Nutr 1997; 66: 1340-1344.
27. 27 Taylor RW, Goulding A. Plasma leptin in relation to regional body fat in older New Zealand women. An N Z J Med 1998; 28: 316-321.
28. 28 Scarpace PJ, Matheny M, Pollock BH, Tumer N. Leptin increases uncoupling protein expression and energy expenditure. Am J Physiol 1997; 36: E226-E230.
29. 29 Toth MJ, Gottlieb S, Fisher ML, Ryan AS, Nicklas BJ, Poehlman ET. Plasma leptin concentrations and energy expenditure in heart failure patients. Metabolism 1997; 46: 450-453.
30. 30 Farooqui IS, Jebb S, Cook G, Cheetham CH, Lawrence E, Prentice A, Hughes IA, McCamish M, O'Rahilly S. Treatment of congenital leptin deficiency in man. Presentation at the 8th International Congress on Obesity. Paris, 1998.
31. 31 Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908.
32. 32 Roberts SB, Nichoison M, Staten M, Dallal GE, Sawaya AL, Heyman MB, Fuss P, Greenberg AS. Relationship between circulating leptin and energy expenditure in adult men and women aged 18 years to 81 years. Obes Res 1997; 5: 459-463.
33. 33 Rosenbaum M, Nicolson M, Hirsch J, Murphy E, Chu F, Leibel RL. Effects of weight change on plasma leptin concentrations and energy expenditure. J Clin Endocrinol Metab 1997; 82: 3647-3654.
34. 34 Niskanen L, Haffner S, Karhunen LJ, Turpeinen AK, Miettinen H, Uusitupa MIJ. Serum leptin in relation to resting energy expenditure and fuel metabolism in obese subjects. Int J Obes 1997; 21: 309-313.
35. 35 Larsson H, Elmstahl S, Berglund G, Ahren B. Evidence for leptin regulation of food intake in humans. J Clin Endocrinol Metab 1998; 83: 4382-4385.
36. 36 Black AE, Goldberg GR, Jebb SA, Livingstone MB, Cole TJ, Prentice AM. Critical evaluation of energy intake data using fundamental principles of energy physiology: 2. Evaluating the results of published surveys. Eur J Clin Nutr 1991; 45: 583-589.
37. 37 Lafay L, Basdevant A, Charles MA, Vray M, Balkau B, Borys JM, Eschwege E, Romon M. Determinants and nature of dietary unserreporting in a free living population: the Fleurbaix Laventie Villesante (FLVS) study. Int J Obes 1997; 21: 567-573.
38. 38 Breifel RR, Sempos CT, McDowell MA, Chien S, Alaimo K. Dietary methods research in the third National Health and Nutrition Examination Survey: underreporting of energy intake. Am J Clin Nutr 1997; 65: 1203S-1209S.
39. 39 Kim-Motoyama H, Yamaguchi T, Katakura T, Myura M, Ohashi Y, Yazaki I, Kadawaki T. Serum leptin levels are associated with hyperinsulinemia independent of body mass index but not with visceral obesity. Biochem Biophys Res Commun 1997; 239: 340-344.
40. 40 Popovic V, Micic D, Danjanovic S, Zoric S, Djurovic M, Obradovic S, Petakov M, Dieguez C, Casanueva F. Serum leptin and insulin concentrations in patients with insulinoma before and after surgery. Eur J Endocrinol 1997; 138: 86-88.
41. 41 Havel PJ, Uriu-Harc JY, Liu T, Stanhope KL, Stern JS, Keen CL, Ahren B. Marked and rapid decrease of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am J Physiol 1998; 274: R1482-R1491.
42. 42 Patel BK, Koenig JK, Kaplan LM, Hooi SC. Increase in plasma leptin and Lep mRNA concentrations by food intake is dependent on insulin. Metabolism 1998; 47: 603-607.
43. 43 Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997; 138: 3395-3401.
44. 44 Barzilai N, Wang J, Massilon D, Vuguin P, Hawkins M, Rossetti L. Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 1997; 100: 3105-3110.