Fumonisin B 1 and the kidney: Modes of action for renal tumor formation by fumonisin B 1 in rodents

Food and Chemical Toxicology

Volumn 50, Issue 10, 2012, Pages 3833-3846

  Müller, Stephanie ^a   Dekant, Wolfgang ^a   Mally, Angela ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Carcinogenicity; Food contaminant; Fumonisin B 1; Kidney; Mycotoxins; Nephrotoxicity

Indexed keywords

FUMONISIN B1; MYCOTOXIN; SPHINGOLIPID; FUMONISIN;

ARTICLE; CARCINOGENICITY; CELL FUNCTION; CHEMICAL CARCINOGENESIS; ENVIRONMENTAL EXPOSURE; HUMAN; KIDNEY TUMOR; LIPID METABOLISM; RODENT; TOXIN STRUCTURE; ANIMAL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; FOOD CONTAMINATION; RAT; REVIEW;

RATTUS; RODENTIA; ZEA MAYS;

ANIMALS; FOOD CONTAMINATION; FUMONISINS; HUMANS; KIDNEY NEOPLASMS; RATS;

EID: 84865446410     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.06.053     Document Type: Article

References (141)

1. Abado-Becognee K., Mobio T.A., Ennamany R., Fleurat-Lessard F., Shier W.T., Badria F., Creppy E.E. Cytotoxicity of fumonisin B1: implication of lipid peroxidation and inhibition of protein and DNA syntheses. Arch. Toxicol. 1998, 72:233-236.
2. Abel S., Gelderblom W.C. Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo. Toxicology 1998, 131:121-131.
3. Alvarez S.E., Milstien S., Spiegel S. Autocrine and paracrine roles of sphingosine-1-phosphate. Trends Endocrinol. Metab. 2007, 18:300-307.
4. Aranda M., Perez-Alzola L.P., Ellahuene M.F., Sepulveda C. Assessment of in vitro mutagenicity in Salmonella and in vivo genotoxicity in mice of the mycotoxin fumonisin B1. Mutagenesis 2000, 15:469-471.
5. Atroshi F., Rizzo A., Biese I., Veijalainen P., Saloniemi H., Sankari S., Andersson K. Fumonisin B1-induced DNA damage in rat liver and spleen: effects of pretreatment with coenzyme Q10, l-carnitine, alpha-tocopherol, and selenium. Pharmacol. Res. 1999, 40:459-467.
6. Bartke N., Hannun Y.A. Bioactive sphingolipids: metabolism and function. J. Lipid Res. 2009, 50(Suppl.):S91-S96.
7. Berdyshev E.V., Gorshkova I., Skobeleva A., Bittman R., Lu X., Dudek S.M., Mirzapoiazova T., Garcia J.G., Natarajan V. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J. Biol. Chem. 2009, 284:5467-5477.
8. Blasi F., Carmeliet P. UPAR: a versatile signalling orchestrator. Nat. Rev. Mol. Cell Biol. 2002, 3:932-943.
9. Bondy G., Suzuki C., Barker M., Armstrong C., Fernie S., Hierlihy L., Rowsell P., Mueller R. Toxicity of fumonisin B1 administered intraperitoneally to male Sprague-Dawley rats. Food Chem. Toxicol. 1995, 33:653-665.
10. Boorman G.A., McDonald M.R., Imoto S., Persing R. Renal lesions induced by ochratoxin A exposure in the F344 rat. Toxicol. Pathol. 1992, 20:236-245.
11. Brady R.O., Koval G.J. The enzymatic synthesis of sphingosine. J. Biol. Chem. 1958, 233:26-31.
12. Bryan L., Paugh B.S., Kapitonov D., Wilczynska K.M., Alvarez S.M., Singh S.K., Milstien S., Spiegel S., Kordula T. Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness. Mol. Cancer Res. 2008, 6:1469-1477.
13. Bu S., Yamanaka M., Pei H., Bielawska A., Bielawski J., Hannun Y.A., Obeid L., Trojanowska M. Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. FASEB J. 2006, 20:184-186.
14. Carman G.M., Han G.S. Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis. J. Biol. Chem. 2009, 284:2593-2597.
15. Ciacci-Zanella J.R., Merrill A.H., Wang E., Jones C. Characterization of cell-cycle arrest by fumonisin B1 in CV-1 cells. Food Chem. Toxicol. 1998, 36:791-804.
16. Croucher D.R., Saunders D.N., Lobov S., Ranson M. Revisiting the biological roles of PAI2 (SERPINB2) in cancer. Nat. Rev. Cancer 2008, 8:535-545.
17. Cuvillier O., Pirianov G., Kleuser B., Vanek P.G., Coso O.A., Gutkind S., Spiegel S. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 1996, 381:800-803.
18. Cuvillier O., Nava V.E., Murthy S.K., Edsall L.C., Levade T., Milstien S., Spiegel S. Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells. Cell Death Differ. 2001, 8:162-171.
19. Desai K., Sullards M.C., Allegood J., Wang E., Schmelz E.M., Hartl M., Humpf H.-U., Liotta D.C., Peng Q., Merrill A.H. Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis. Biochim. Biophys. Acta 2002, 1585:188-192.
20. Domijan A., Zeljezic D., Peraica M., Kovacevic G., Gregorovic G., Krstanac Z., Horvatin K., Kalafatic M. Early toxic effects of fumonisin B1 in rat liver. Hum. Exp. Toxicol. 2008, 27:895-900.
21. Domijan A.M., Zeljezic D., Kopjar N., Peraica M. Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B1-treated rats. Toxicology 2006, 222:53-59.
22. Domijan A.M., Peraica M., Vrdoljak A.L., Radic B., Zlender V., Fuchs R. The involvement of oxidative stress in ochratoxin A and fumonisin B1 toxicity in rats. Mol. Nutr. Food Res. 2007, 51:1147-1151.
23. Domijan A.M., Zeljezic D., Milic M., Peraica M. Fumonisin B(1): oxidative status and DNA damage in rats. Toxicology 2007, 232:163-169.
24. Dragan Y.P., Bidlack W.R., Cohen S.M., Goldsworthy T.L., Hard G.C., Howard P.C., Riley R.T., Voss K.A. Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B1 as an example. Toxicol. Sci. 2001, 61:6-17.
25. Dutton M. The African Fusarium/maize disease. Mycotoxin Res. 2009, 25:29-39.
26. Ehrlich V., Darroudi F., Uhl M., Steinkellner H., Zsivkovits M., Knasmueller S. Fumonisin B(1) is genotoxic in human derived hepatoma (HepG2) cells. Mutagenesis 2002, 17:257-260.
27. Galvano F., Russo A., Cardile V., Galvano G., Vanella A., Renis M. DNA damage in human fibroblasts exposed to fumonisin B(1). Food Chem. Toxicol. 2002, 40:25-31.
28. Galvano F., Campisi A., Russo A., Galvano G., Palumbo M., Renis M., Barcellona M.L., Perez-Polo J.R., Vanella A. DNA damage in astrocytes exposed to fumonisin B1. Neurochem. Res. 2002, 27:345-351.
29. Gelderblom W.C., Jaskiewicz K., Marasas W.F., Thiel P.G., Horak R.M., Vleggaar R., Kriek N.P. Fumonisins-novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl. Environ. Microbiol. 1988, 54:1806-1811.
30. Gelderblom W.C., Kriek N.P., Marasas W.F., Thiel P.G. Toxicity and carcinogenicity of the Fusarium moniliforme metabolite, fumonisin B1, in rats. Carcinogenesis 1991, 12:1247-1251.
31. Gelderblom W.C., Snyman S.D. Mutagenicity of potentially carcinogenic mycotoxins produced by Fusarium moniliforme. Mycotoxin Res. 1991, 7:46-52.
32. Gelderblom W.C., Semple E., Marasas W.F., Farber E. The cancer-initiating potential of the fumonisin B mycotoxins. Carcinogenesis 1992, 13:433-437.
33. Gelderblom W.C., Snyman S.D., Lebepe-Mazur S., van der Westhuizen L., Kriek N.P., Marasas W.F. The cancer-promoting potential of fumonisin B1 in rat liver using diethylnitrosamine as a cancer initiator. Cancer Lett. 1996, 109:101-108.
34. Gelderblom W.C., Smuts C.M., Abel S., Snyman S.D., Van der Westhuizen L., Huber W.W., Swanevelder S. Effect of fumonisin B1 on the levels and fatty acid composition of selected lipids in rat liver in vivo. Food Chem. Toxicol. 1997, 35:647-656.
35. Gelderblom W.C., Lebepe-Mazur S., Snijman P.W., Abel S., Swanevelder S., Kriek N.P., Marasas W.F. Toxicological effects in rats chronically fed low dietary levels of fumonisin B(1). Toxicology 2001, 161:39-51.
36. Gelderblom W.C., Abel S., Smuts C.M., Marnewick J., Marasas W.F., Lemmer E.R., Ramljak D. Fumonisin-induced hepatocarcinogenesis: mechanisms related to cancer initiation and promotion. Environ. Health Perspect. 2001, 109(Suppl 2):291-300.
37. Goldsworthy T.L., Conolly R.B., Fransson-Steen R. Apoptosis and cancer risk assessment. Mutat. Res. 1996, 365:71-90.
38. Gopee N.V., He Q., Sharma R.P. Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-kB and tumor necrosis factor alpha in LLC-PK1 cells. Chem. Biol. Interact. 2003, 146:131-145.
39. Gopee N.V., Sharma R.P. Selective and transient activation of protein kinase C alpha by fumonisin B1, a ceramide synthase inhibitor mycotoxin, in cultured porcine renal cells. Life Sci. 2004, 74:1541-1559.
40. Hait N.C., Oskeritzian C.A., Paugh S.W., Milstien S., Spiegel S. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim. Biophys. Acta 2006, 1758:2016-2026.
41. Hannun Y.A., Loomis C.R., Merrill A.H., Bell R.M. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 1986, 261:12604-12609.
42. Hannun Y.A., Obeid L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 2008, 9:139-150.
43. Hard G.C., Howard P.C., Kovatch R.M., Bucci T.J. Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor. Toxicol. Pathol. 2001, 29:379-386.
44. Harrison L.R., Colvin B.M., Greene J.T., Newman L.E., Cole J.R. Pulmonary edema and hydrothorax in swine produced by fumonisin B1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest. 1990, 2:217-221.
45. He Q., Riley R.T., Sharma R.P. Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. Toxicol. Appl. Pharmacol. 2001, 174:69-77.
46. He, Q., Riley, R.T., Sharma, R.P., 2002. Pharmacological antagonism of fumonisin B1 cytotoxicity in porcine renal epithelial cells (LLC-PK1): a model for reducing fumonisin-induced nephrotoxicity in vivo. Pharmacol. Toxicol. (Oxford, United Kingdom) 90, 268-277.
47. He Q., Suzuki H., Sharma R.P. S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver. J. Appl. Toxicol. 2006, 26:509-516.
48. Howard P.C., Eppley R.M., Stack M.E., Warbritton A., Voss K.A., Lorentzen R.J., Kovach R.M., Bucci T.J. Fumonisin b1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice. Environ. Health Perspect. 2001, 109(Suppl. 2):277-282.
49. Howard P.C., Warbritton A., Voss K.A., Lorentzen R.J., Thurman J.D., Kovach R.M., Bucci T.J. Compensatory regeneration as a mechanism for renal tubule carcinogenesis of fumonisin B1 in the F344/N/Nctr BR rat. Environ. Health Perspect. Suppl. 2001, 109:309-314.
50. Hu W., Xu R., Zhang G., Jin J., Szulc Z.M., Bielawski J., Hannun Y.A., Obeid L.M., Mao C. Golgi fragmentation is associated with ceramide-induced cellular effects. Mol. Biol. Cell 2005, 16:1555-1567.
51. Humpf H.U., Schmelz E.M., Meredith F.I., Vesper H., Vales T.R., Wang E., Menaldino D.S., Liotta D.C., Merrill A.H. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor. J. Biol. Chem. 1998, 273:19060-19064.
52. Humphreys S.H., Carrington C., Bolger M. A quantitative risk assessment for fumonisins B1 and B2 in US corn. Food Addit. Contam. 2001, 18:211-220.
53. JECFA, 2001. Safety evaluation of certain mycotoxins in food. Fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). WHO Food Additives Series 47, 103-279.
54. Jones C., Ciacci-Zanella J.R., Zhang Y., Henderson G., Dickman M. Analysis of fumonisin B1-induced apoptosis. Environ. Health Perspect. Suppl. 2001, 109:315-320.
55. Kagedal K., Zhao M., Svensson I., Brunk U.T. Sphingosine-induced apoptosis is dependent on lysosomal proteases. Biochem. J. 2001, 359:335-343.
56. Katsuma S., Hada Y., Ueda T., Shiojima S., Hirasawa A., Tanoue A., Takagaki K., Ohgi T., Yano J., Tsujimoto G. Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. Genes Cells 2002, 7:1217-1230.
57. Kellerman T.S., Marasas W.F., Thiel P.G., Gelderblom W.C., Cawood M., Coetzer J.A. Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1. Onderstepoort J. Vet. Res. 1990, 57:269-275.
58. Kimura T., Watanabe T., Sato K., Kon J., Tomura H., Tamama K., Kuwabara A., Kanda T., Kobayashi I., Ohta H., Ui M., Okajima F. Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. Biochem. J. 2000, 348(Pt. 1):71-76.
59. Klaric M.S., Pepeljnjak S., Domijan A.-M., Petrik J. Lipid peroxidation and glutathione levels in porcine kidney PK15 cells after individual and combined treatment with fumonisin B1, beauvericin and ochratoxin A. Basic Clin. Pharmacol. Toxicol. 2007, 100:157-164.
60. Klaric M.S., Rumora L., Ljubanovic D., Pepeljnjak S. Cytotoxicity and apoptosis induced by fumonisin B(1), beauvericin and ochratoxin A in porcine kidney PK15 cells: effects of individual and combined treatment. Arch. Toxicol. 2008, 82:247-255.
61. Knasmueller S., Bresgen N., Kassie F., Mersch-Sundermann V., Gelderblom W., Zoehrer E., Eckl P.M. Genotoxic effects of three Fusarium mycotoxins, fumonisin B1, moniliformin and vomitoxin in bacteria and in primary cultures of rat hepatocytes. Mutat. Res., Genet. Toxicol. Environ. Mutagen. 1997, 391:39-48.
62. Kohno M., Momoi M., Oo M.L., Paik J.H., Lee Y.M., Venkataraman K., Ai Y., Ristimaki A.P., Fyrst H., Sano H., Rosenberg D., Saba J.D., Proia R.L., Hla T. Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. Mol. Cell. Biol. 2006, 26:7211-7223.
63. Kouadio J.H., Dano S.D., Moukha S., Mobio T.A., Creppy E.E. Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells. Toxicon 2007, 49:306-317.
64. Liu Y.Y., Han T.Y., Giuliano A.E., Cabot M.C. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J. 2001, 15:719-730.
65. Lock E.A., Hard G.C. Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information. Crit. Rev. Toxicol. 2004, 34:211-299.
66. Mally A., Dekant W. Mycotoxins and the kidney: modes of action for renal tumor formation by ochratoxin A in rodents. Mol. Nutr. Food Res. 2009, 53:467-478.
67. Mao C., Obeid L.M. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim. Biophys. Acta 2008, 1781:424-434.
68. Marasas W.F., Kellerman T.S., Gelderblom W.C., Coetzer J.A., Thiel P.G., van der Lugt J.J. Leukoencephalomalacia in a horse induced by fumonisin B1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res. 1988, 55:197-203.
69. Marasas W.F. Fumonisins: history, world-wide occurrence and impact. Adv. Exp. Med. Biol. 1996, 392:1-17.
70. Marasas W.F. Discovery and occurrence of the fumonisins: a historical perspective. Environ. Health Perspect. 2001, 109(Suppl 2):239-243.
71. Marasas W.F., Riley R.T., Hendricks K.A., Stevens V.L., Sadler T.W., Gelineau-van Waes J., Missmer S.A., Cabrera J., Torres O., Gelderblom W.C., Allegood J., Martinez C., Maddox J., Miller J.D., Starr L., Sullards M.C., Roman A.V., Voss K.A., Wang E., Merrill A.H. Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. J. Nutr. 2004, 134:711-716.
72. Marin D.E., Taranu I., Pascale F., Lionide A., Burlacu R., Bailly J.D., Oswald I.P. Sex-related differences in the immune response of weanling piglets exposed to low doses of fumonisin extract. Br. J. Nutr. 2006, 95:1185-1192.
73. Martinez-Larranaga M.R., Anadon A., Diaz M.J., Fernandez-Cruz M.L., Martinez M.A., Frejo M.T., Martinez M., Fernandez R., Anton R.M., Morales M.E., Tafur M. Toxicokinetics and oral bioavailability of fumonisin B1. Vet. Hum. Toxicol. 1999, 41:357-362.
74. Meca G., Fernandez-Franzon M., Ritieni A., Font G., Ruiz M.J., Manes J. Formation of fumonisin B(1)-glucose reaction product, in vitro cytotoxicity, and lipid peroxidation on kidney cells. J. Agric. Food Chem. 2010, 58:1359-1365.
75. Merrill A.H., van Echten G., Wang E., Sandhoff K. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J. Biol. Chem. 1993, 268:27299-27306.
76. Merrill A.H., Morgan E.T., Nikolova-Karakashian M., Stewart J. Sphingomyelin hydrolysis and regulation of the expression of the gene for cytochrome P450. Biochem. Soc. Trans. 1999, 27:383-387.
77. Merrill A.H., Sullards M.C., Wang E., Voss K.A., Riley R.T. Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins. Environ. Health Perspect. 2001, 109(Suppl. 2):283-289.
78. Meyer zu Heringdorf D., Jakobs K.H. Lysophospholipid receptors: signalling, pharmacology and regulation by lysophospholipid metabolism. Biochim. Biophys. Acta 2007, 1768:923-940.
79. Milstien S., Spiegel S. Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics. Cancer Cell 2006, 9:148-150.
80. Min J.K., Yoo H.S., Lee E.Y., Lee W.J., Lee Y.M. Simultaneous quantitative analysis of sphingoid base 1-phosphates in biological samples by o-phthalaldehyde precolumn derivatization after dephosphorylation with alkaline phosphatase. Anal. Biochem. 2002, 303:167-175.
81. Mobio T.A., Baudrimont I., Sanni A., Shier T.W., Saboureau D., Dano S.D., Ueno Y., Steyn P.S., Creppy E.E. Prevention by vitamin E of DNA fragmentation and apoptosis induced by fumonisin B1 in C6 glioma cells. Arch. Toxicol. 2000, 74:112-119.
82. Mobio T.A., Tavan E., Baudrimont I., Anane R., Carratu M.-R., Sanni A., Gbeassor M.F., Shier T.W., Narbonne J.-F., Creppy E.E. Comparative study of the toxic effects of fumonisin B1 in rat C6 glioma cells and p53-null mouse embryo fibroblasts. Toxicology 2003, 183:65-75.
83. Norred W.P., Plattner R.D., Vesonder R.F., Bacon C.W., Voss K.A. Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes. Food Chem. Toxicol. 1992, 30:233-237.
84. NTP, 1989. Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies). Natl. Toxicol. Program Tech. Rep. Ser. 358, 1-142.
85. NTP, 2001. Toxicology and Carcinogenesis Studies of Fumonisin B1 (CAS No. 116355-83-0) in F344/N Rats and B6C3F1 mice (Feed Studies). Natl. Toxicol. Program Tech. Rep. Ser. 1-352.
86. Ogretmen B., Hannun Y.A. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev. Cancer 2004, 4:604-616.
87. Ohanian J., Ohanian V. Sphingolipids in mammalian cell signalling. Cell. Mol. Life Sci. 2001, 58:2053-2068.
88. Pacella-Norman R., Urban M.I., Sitas F., Carrara H., Sur R., Hale M., Ruff P., Patel M., Newton R., Bull D., Beral V. Risk factors for oesophageal, lung, oral and laryngeal cancers in black South Africans. Br. J. Cancer 2002, 86:1751-1756.
89. Pelagalli A., Belisario M.A., Squillacioti C., Morte R.D., d'Angelo D., Tafuri S., Lucisano A., Staiano N. The mycotoxin fumonisin B1 inhibits integrin-mediated cell-matrix adhesion. Biochimie 1999, 81:1003-1008.
90. Perry D.K., Hand W.L., Edmondson D.E., Lambeth J.D. Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors. J. Immunol. 1992, 149:2749-2758.
91. Pruett S.T., Bushnev A., Hagedorn K., Adiga M., Haynes C.A., Sullards M.C., Liotta D.C., Merrill A.H. Thematic Review Series: Sphingolipids. Biodiversity of sphingoid bases (" sphingosines" ) and related amino alcohols. J. Lipid Res. 2008, 49:1621-1639.
92. Qiu M., Liu X. Determination of sphinganine, sphingosine and Sa/So ratio in urine of humans exposed to dietary fumonisin B1. Food Addit. Contam. 2001, 18:263-269.
93. Rheeder J.P., Marasas W.F.O., Thiel P.G., Sydenham E.W., Shephard G.S., Van Schalkwyk D.J. Fusarium moniliforme and fumonisins in maize in relation to human eosophageal cancer in Transkei. Phytopathology 1992, 82:353-357.
94. Riley R.T., An N.H., Showker J.L., Yoo H.S., Norred W.P., Chamberlain W.J., Wang E., Merrill A.H., Motelin G., Beasley V.R., et al. Alteration of tissue and serum sphinganine to sphingosine ratio: an early biomarker of exposure to fumonisin-containing feeds in pigs. Toxicol. Appl. Pharmacol. 1993, 118:105-112.
95. Riley R.T., Hinton D.M., Chamberlain W.J., Bacon C.W., Wang E., Merrill A.H., Voss K.A. Dietary fumonisin B1 induces disruption of sphingolipid metabolism in Sprague-Dawley rats: a new mechanism of nephrotoxicity. J. Nutr. 1994, 124:594-603.
96. Riley R.T., Enongene E., Voss K.A., Norred W.P., Meredith F.I., Sharma R.P., Spitsbergen J., Williams D.E., Carlson D.B., Merrill A.H. Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ. Health Perspect. Suppl. 2001, 109:301-308.
97. Riley, R.T., Voss, K.A., 2006. Differential sensitivity of rat kidney and liver to fumonisin toxicity: organ specific differences in toxin accumulation and sphingoid base metabolism. Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, September 10-14, 2006, AGFD-120.
98. Rotter B.A., Thompson B.K., Prelusky D.B., Trenholm H.L., Stewart B., Miller J.D., Savard M.E. Response of growing swine to dietary exposure to pure fumonisin B1 during an eight-week period: growth and clinical parameters. Nat. Toxins 1996, 4:42-50.
99. Rumora, L., Kovacic, S., Rozgaj, R., Cepelak, I., Pepeljnjak, S., Zanic Grubisic, T., 2002. Cytotoxic and genotoxic effects of fumonisin B1 on rabbit kidney RK13 cell line. Arch. Toxicol. 76, 55-61.
100. Rumora L., Domijan A.-M., Grubisic T.Z., Peraica M. Mycotoxin fumonisin B1 alters cellular redox balance and signalling pathways in rat liver and kidney. Toxicology 2007, 242:31-38.
101. Santana P., Pena L.A., Haimovitz-Friedman A., Martin S., Green D., McLoughlin M., Cordon-Cardo C., Schuchman E.H., Fuks Z., Kolesnick R. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 1996, 86:189-199.
102. Schmelz E.M., Dombrink-Kurtzman M.A., Roberts P.C., Kozutsumi Y., Kawasaki T., Merrill A.H. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases. Toxicol. Appl. Pharmacol. 1998, 148:252-260.
103. Schmelz E.M., Roberts P.C., Kustin E.M., Lemonnier L.A., Sullards M.C., Dillehay D.L., Merrill A.H. Modulation of intracellular beta-catenin localization and intestinal tumorigenesis in vivo and in vitro by sphingolipids. Cancer Res. 2001, 61:6723-6729.
104. Schulte-Hermann, R., Bursch, W., Marian, B., Grasl-Kraupp, B., 1999. Active cell death (apoptosis) and cellular proliferation as indicators of exposure to carcinogens. IARC Sci. Publ. 273-285.
105. Seefelder W., Humpf H.U., Schwerdt G., Freudinger R., Gekle M. Induction of apoptosis in cultured human proximal tubule cells by fumonisins and fumonisin metabolites. Toxicol. Appl. Pharmacol. 2003, 192:146-153.
106. Seiferlein M., Humpf H.-U., Voss K.A., Sullards M.C., Allegood J.C., Wang E., Merrill A.H. Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. Mol. Nutr. Food Res. 2007, 51:1120-1130.
107. Sharma N., He Q., Sharma R.P. Sphingosine kinase activity confers resistance to apoptosis by fumonisin B1 in human embryonic kidney (HEK-293) cells. Chem. Biol. Interact. 2004, 151:33-42.
108. Shayman J.A. Sphingolipids. Kidney Int. 2000, 58:11-26.
109. Shephard G.S., Thiel P.G., Sydenham E.W., Vleggaar R., Alberts J.F. Determination of the mycotoxin fumonisin B1 and identification of its partially hydrolysed metabolites in the faeces of non-human primates. Food Chem. Toxicol. 1994, 32:23-29.
110. Shephard G.S., Thiel P.G., Sydenham E.W., Savard M.E. Fate of a single dose of 14C-labelled fumonisin B1 in vervet monkeys. Nat. Toxins 1995, 3:145-150.
111. Shephard G.S., Marasas W.F., Leggott N.L., Yazdanpanah H., Rahimian H., Safavi N. Natural occurrence of fumonisins in corn from Iran. J. Agric. Food Chem. 2000, 48:1860-1864.
112. Shephard G.S., Marasas W.F., Burger H.M., Somdyala N.I., Rheeder J.P., Van der Westhuizen L., Gatyeni P., Van Schalkwyk D.J. Exposure assessment for fumonisins in the former Transkei region of South Africa. Food Addit. Contam. 2007, 24:621-629.
113. Smith E.R., Merrill A.H. Differential roles of de novo sphingolipid biosynthesis and turnover in the " burst" of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture. J. Biol. Chem. 1995, 270:18749-18758.
114. Smith E.R., Merrill A.H., Obeid L.M., Hannun Y.A. Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 2000, 312:361-373.
115. Solomon J.C., Sharma K., Wei L.X., Fujita T., Shi Y.F. A novel role for sphingolipid intermediates in activation-induced cell death in T cells. Cell Death Differ. 2003, 10:193-202.
116. Spiegel S., Milstien S. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 2003, 4:397-407.
117. Spotti M., Maas R.F., de Nijs C.M., Fink-Gremmels J. Effect of fumonisin B(1) on rat hepatic P450 system. Environ. Toxicol. Pharmacol. 2000, 8:197-204.
118. Stockmann-Juvala H., Mikkola J., Naarala J., Loikkanen J., Elovaara E., Savolainen K. Oxidative stress induced by fumonisin B1 in continuous human and rodent neural cell cultures. Free Radic. Res. 2004, 38:933-942.
119. Sugimoto N., Takuwa N., Okamoto H., Sakurada S., Takuwa Y. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol. Cell. Biol. 2003, 23:1534-1545.
120. Sun G., Wang S., Hu X., Su J., Huang T., Yu J., Tang L., Gao W., Wang J.S. Fumonisin B1 contamination of home-grown corn in high-risk areas for esophageal and liver cancer in China. Food Addit. Contam. 2007, 24:181-185.
121. Sydenham E.W., Thiel P.G., Marasas W.F.O., Shephard G.S., Van Schalkwyk D.J., Koch K.R. Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of the Transkei, Southern Africa. J. Agric. Food Chem. 1990, 38:1900-1903.
122. Taha T.A., Argraves K.M., Obeid L.M. Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy. Biochim. Biophys. Acta 2004, 1682:48-55.
123. Taha T.A., Mullen T.D., Obeid L.M. A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death. Biochim. Biophys. Acta 2006, 1758:2027-2036.
124. Tamama K., Kon J., Sato K., Tomura H., Kuwabara A., Kimura T., Kanda T., Ohta H., Ui M., Kobayashi I., Okajima F. Extracellular mechanism through the Edg family of receptors might be responsible for sphingosine-1-phosphate-induced regulation of DNA synthesis and migration of rat aortic smooth-muscle cells. Biochem. J. 2001, 353:139-146.
125. Tani M., Sano T., Ito M., Igarashi Y. Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. J. Lipid Res. 2005, 46:2458-2467.
126. Tolleson W.H., Dooley K.L., Sheldon W.G., Thurman J.D., Bucci T.J., Howard P.C. The mycotoxin fumonisin induces apoptosis in cultured human cells and in livers and kidneys of rats. Adv. Exp. Med. Biol. 1996, 392:237-250.
127. Tolleson W.H., Couch L.H., Melchior W.B., Jenkins G.R., Muskhelishvili M., Muskhelishvili L., McGarrity L.J., Domon O., Morris S.M., Howard P.C. Fumonisin B1 induces apoptosis in cultured human keratinocytes through sphinganine accumulation and ceramide depletion. Int. J. Oncol. 1999, 14:833-843.
128. Torres O.A., Palencia E., Lopez de Pratdesaba L., Grajeda R., Fuentes M., Speer M.C., Merrill A.H., O'Donnell K., Bacon C.W., Glenn A.E., Riley R.T. Estimated fumonisin exposure in Guatemala is greatest in consumers of lowland maize. J. Nutr. 2007, 137:2723-2729.
129. Turner P.C., Nikiema P., Wild C.P. Fumonisin contamination of food: progress in development of biomarkers to better assess human health risks. Mutat. Res., Genet. Toxicol. Environ. Mutagen. 1999, 443:81-93.
130. Visentin B., Vekich J.A., Sibbald B.J., Cavalli A.L., Moreno K.M., Matteo R.G., Garland W.A., Lu Y., Yu S., Hall H.S., Kundra V., Mills G.B., Sabbadini R.A. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 2006, 9:225-238.
131. Voss K.A., Chamberlain W.J., Bacon C.W., Norred W.P. A preliminary investigation on renal and hepatic toxicity in rats fed purified fumonisin B1. Nat. Toxins 1993, 1:222-228.
132. Voss K.A., Chamberlain W.J., Bacon C.W., Herbert R.A., Walters D.B., Norred W.P. Subchronic feeding study of the mycotoxin fumonisin B1 in B6C3F1 mice and Fischer 344 rats. Fundam. Appl. Toxicol. 1995, 24:102-110.
133. Voss K.A., Riley R.T., Snook M.E., Waes J.G. Reproductive and sphingolipid metabolic effects of fumonisin B(1) and its alkaline hydrolysis product in LM/Bc mice: hydrolyzed fumonisin B(1) did not cause neural tube defects. Toxicol. Sci. 2009, 112:459-467.
134. Wang E., Norred W.P., Bacon C.W., Riley R.T., Merrill A.H. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 1991, 266:14486-14490.
135. Wang E., Ross P.F., Wilson T.M., Riley R.T., Merrill A.H. Increases in serum sphingosine and sphinganine and decreases in complex sphingolipids in ponies given feed containing fumonisins, mycotoxins produced by Fusarium moniliforme. J. Nutr. 1992, 122:1706-1716.
136. Wu W.T., Chen C.N., Lin C.I., Chen J.H., Lee H. Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. Endocrinology 2005, 146:3387-3400.
137. Yang C.S. Research on esophageal cancer in China: a review. Cancer Res. 1980, 40:2633-2644.
138. Yoo H.S., Norred W.P., Showker J., Riley R.T. Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. Toxicol. Appl. Pharmacol. 1996, 138:211-218.
139. Yoshizawa T., Yamashita A., Luo Y. Fumonisin occurrence in corn from high- and low-risk areas for human esophageal cancer in China. Appl. Environ. Microbiol. 1994, 60:1626-1629.
140. Zimmer I., Usleber E., Klaffke H., Weber R., Majerus P., Otteneder H., Gareis M., Dietrich R., Märtlbauer E. Fumonisin intake of the German consumer. Mycotoxin Res. 2008, 24:40-52.
141. Zitomer N.C., Mitchell T., Voss K.A., Bondy G.S., Pruett S.T., Garnier-Amblard E.C., Liebeskind L.S., Park H., Wang E., Sullards M.C., Merrill A.H., Riley R.T. Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals. J. Biol. Chem. 2009, 284:4786-4795.