Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase: Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor

Journal of Biological Chemistry

Volumn 273, Issue 30, 1998, Pages 19060-19064

  Humpf, Hans Ulrich ^a   Schmelz, Eva Maria ^b   Meredith, Filmore I ^c   Vesper, Hubert ^b   Vales, Teresa R ^b   Wang, Elaine ^b   Menaldino, David S ^b   Liotta, Dennis C ^b   Merrill Jr , Alfred H ^b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c AGRICULTURAL RESEARCH SERVICE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXYSPHINGANINE; CERAMIDE SYNTHASE; DECANE; ENZYME INHIBITOR; FUMONISIN B1; MYCOTOXIN; N PALMITOYLAMINOPENTOL; SPHINGANINE; SYNTHETASE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; ENZYME INHIBITION; FUSARIUM MONILIFORME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; ISOMER; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACYLATION; CARBOXYLIC ACIDS; FUMONISINS; HUMANS; HYDROLYSIS; KINETICS; MYCOTOXINS; OXIDOREDUCTASES; PALMITIC ACID; SPHINGOSINE;

EID: 0032563093     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.30.19060     Document Type: Article

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