Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites

Molecular Nutrition and Food Research

Volumn 51, Issue 9, 2007, Pages 1120-1130

  Seiferlein, Michaela ^a,d   Humpf, Hans Ulrich ^a,c   Voss, Kenneth A ^b   Sullards, M Cameron ^c   Allegood, Jeremy C ^c   Wang, Elaine ^c   Merrill Jr , Alfred H ^c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b RUSSELL RESEARCH CENTER   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d BASF SE   (Germany)

Author keywords

Ceramide synthase; Cytotoxic; HPLC MS; Hydrolyzed fumonisins; N Acyl metabolites

Indexed keywords

ANIMALIA; FUSARIUM; GIBBERELLA MONILIFORMIS; RATTUS;

DIHYDROCERAMIDE DESATURASE; ENZYME INHIBITOR; FUMONISIN; FUMONISIN B1; FUMONISIN B2; OXIDOREDUCTASE; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL; ARTICLE; CELL DEATH; CELL STRAIN HT29; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; LIVER MICROSOME; MALE; METABOLISM; RAT; SPRAGUE DAWLEY RAT;

ACYLATION; ANIMALS; CELL DEATH; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; FUMONISINS; HT29 CELLS; HUMANS; HYDROLYSIS; MALE; MICROSOMES, LIVER; OXIDOREDUCTASES; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 34948900878     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200700118     Document Type: Article

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