Sphingosine generation, cytochrome c release, and activation of caspase-7 in doxorubicin-induced apoptosis of MCF7 breast adenocarcinoma cells

Cell Death and Differentiation

Volumn 8, Issue 2, 2001, Pages 162-171

  Cuvillier, O ^a,b   Nava, V E ^a   Murthy, S K ^a   Edsall, L C ^c   Levade, T ^b   Milstien, S ^c   Spiegel, S ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^b CHU RANGUEIL   (France)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Apoptosis; Caspases; Cytochrome c; Doxorubicin; Sphingosine

Indexed keywords

1,4 BENZOQUINONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACYLSPHINGOSINE DEACYLASE; ANTHRACYCLINE DERIVATIVE; ANTIBIOTIC AGENT; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; CASPASE 3; CASPASE 7; CERAMIDE; COUMARIN DERIVATIVE; CYTOCHROME C; CYTOKINE; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); DOXORUBICIN; ENZYME INHIBITOR; FAS LIGAND; FUMONISIN B1; MEMBRANE PROTEIN; MYCOTOXIN; OXYGEN RADICAL; PROTEIN BCL 2; PROTEIN BCL X; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE; SPHINGOSINE ACYLTRANSFERASE; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; APICAL MEMBRANE; APOPTOSIS; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL STRAIN MCF 7; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEDIATOR RELEASE; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; BREAST NEOPLASMS; CASPASE 7; CASPASES; CYTOCHROME C GROUP; DOXORUBICIN; ENZYME ACTIVATION; FEMALE; HUMANS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; SPHINGOSINE;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035090339     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400793     Document Type: Article

References (66)

1. A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin
2. Ceramide in the eukaryotic stress response
3. Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
4. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
5. Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells
6. The protein kinase C activators phorbol esters and phosphatidylserine inhibit neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
7. Serine protease inhibitors block neutral sphingomyelinase activation, ceramide generation, and apoptosis triggered by daunorubicin
8. Alteration of the daunorubicin-triggered sphingomyelin-ceramide pathway and apoptosis in MDR cells: Influence of drug transport abnormalities
9. Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: Implication in drug-induced ceramide generation and apoptosis
10. L-carnitine prevents doxorubicin-induced apoptosis of cardiac myocytes: Role of inhibition of ceramide generation
11. Doxorubicin induces slow ceramide accumulation and late apoptosis in cultured adult rat ventricular myocytes
12. A possible role of sphingosine in induction of apoptosis by tumor necrosis factor-alpha in human neutrophils
13. Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death
14. In vitro and in vivo induction of apoptosis by sphingosine and N,N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells
15. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines
16. Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide
17. Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells
18. Induction of apoptosis and potentiation of ceramide-mediated cytotoxicity by sphingoid bases in human myeloid leukemia cells
19. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells
20. 1,25-Dihydroxyvitamin D3 enhances the susceptibility of breast cancer cells to doxorubicin-induced oxidative damage
21. Changing J774A. 1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases
22. Differential roles of de novo sphingolipid biosynthesis and turnover in the 'burst' of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in culture
23. Induction of apoptosis by sphingosine in human leukemic HL-60 cells: A possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation
24. Sphingosine induces apoptosis in androgen-independent human prostatic carcinoma DU-145 cells by suppression of bcl-X(L) gene expression
25. Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ
26. (1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase
27. Bcl-2 interrupts the ceramide-mediated pathway of cell death
28. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA
29. prlCE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2
30. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-α: CrmA and Bcl-2 target distinct components in the apoptotic pathway
31. Apoptosis of lung cancer cells caused by some anti-cancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2
32. Molecular ordering of apoptosis induced by anticancer drugs in neuroblastoma cells
33. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis
34. BCL-2 expression does not not correlate with patient outcome in pediatric acute myelogenous leukemia
35. Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor
36. Caspase structure, proteolytic substrates, and function during apoptotic cell death
37. L functions downstream of caspase-8 to inhibit Fas- and Tumor Necrosis Factor Receptor 1-induced apoptosis of MCF7 breast carcinoma Cells
38. Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells
39. Cell-specific induction of apoptosis by microinjection of cytochrome c
40. L acts downstream of caspase-8 activation by the CD95 death-inducing signaling complex
41. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
42. Apafl and the apoptotic machinery
43. Serial killers: Ordering caspase activation events in apoptosis
44. Biochemical pathways of caspase activation during apoptosis
45. Caspase-3 is the primary activator of apoptotic DNA fragmentation via DNA fragmentation factor-45/inhibitor of caspase-activated DNase inactivation
46. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9- dependent manner
47. Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts
48. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis
49. Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells
50. Activation of the CD-95 (APO-1/Fas) pathway in drug- and γ-irradiation-induced apoptosis of brain tumor cells
51. Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis
52. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
53. Accumulation of glucosylceramides in multidrug-resistant cancer cells
54. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
55. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisenser reverses adriamycin resistance
56. Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833
57. Sphingomyelin potentiates chemotherapy of human cancer xenografts
58. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C
59. A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin
60. Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
61. Sphingosine kinase from Swiss 3T3 fibroblasts: A convenient assay for the measurement of intracellular levels of free sphingoid bases
62. Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation
63. Inorganic and organic phosphate measurements in the nanomolar range
64. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
65. 3
66. Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas- and ceramide-mediated apoptosis in Jurkat T lymphocytes