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Volumn 53, Issue 4, 2009, Pages 467-478

Mycotoxins and the kidney: Modes of action for renal tumor formation by ochratoxin A in rodents

Author keywords

Carcinogenicity Kidney Mycotoxins Nephrotoxicity Ochratoxin A

Indexed keywords

DNA; MYCOTOXIN; OCHRATOXIN;

EID: 65749089980     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200800149     Document Type: Review
Times cited : (71)

References (95)
  • 2
    • 0035755403 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of fumonisin B1 (cas no. 116355-83-0) in F344/N rats and B6C3F1 mice (feed studies)
    • NTP
    • NTP, Toxicology and carcinogenesis studies of fumonisin B1 (cas no. 116355-83-0) in F344/N rats and B6C3F1 mice (feed studies), Natl. Toxicol. Program Tech. Rep. Ser. 2001, 1-352.
    • (2001) Natl. Toxicol Program Tech. Rep. Ser. , pp. 1-352
  • 3
    • 0013519855 scopus 로고
    • Toxicology and carcinogenesis studies of ochratoxin A (cas no. 303-47-9) in F344/N Rats (Gavage Studies)
    • NTP
    • NTP, Toxicology and carcinogenesis studies of ochratoxin A (cas no. 303-47-9) in F344/N Rats (Gavage Studies), Natl. Toxicol. Program Tech. Rep. Ser. 1989, 358, 1-142.
    • (1989) Natl. Toxicol. Program Tech. Rep. Ser. , vol.358 , pp. 1-142
  • 4
    • 0026619924 scopus 로고
    • Renal lesions induced by ochratoxin A exposure in the F344 rat
    • Boorman, G. A., McDonald, M. R., Imoto, S., Persing, R., Renal lesions induced by ochratoxin A exposure in the F344 rat, Toxicol. Pathol. 1992, 20, 236-245.
    • (1992) Toxicol. Pathol. , vol.20 , pp. 236-245
    • Boorman, G.A.1    McDonald, M.R.2    Imoto, S.3    Persing, R.4
  • 5
    • 0034949595 scopus 로고    scopus 로고
    • Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor
    • Hard, G. C., Howard, P. C., Kovatch, R. M., Bucci, T. J., Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor, Toxicol. Pathol. 2001, 29, 379 - 386.
    • (2001) Toxicol. Pathol. , vol.29 , pp. 379-386
    • Hard, G.C.1    Howard, P.C.2    Kovatch, R.M.3    Bucci, T.J.4
  • 6
    • 0012799927 scopus 로고    scopus 로고
    • Safety evaluation of certain mycotoxins in food. Fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
    • JECFA
    • JECFA, Safety evaluation of certain mycotoxins in food. Fifty-sixth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), WHO Food Additives Series 2001, 47, 281-415.
    • (2001) WHO Food Additives Series , vol.47 , pp. 281-415
  • 7
    • 1842617483 scopus 로고    scopus 로고
    • Chemically induced renal tubule tumors in the laboratory rat and mouse: Review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information
    • Lock, E. A., Hard, G. C., Chemically induced renal tubule tumors in the laboratory rat and mouse: Review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information, Crit. Rev. Toxicol. 2004, 34, 211-299.
    • (2004) Crit. Rev. Toxicol. , vol.34 , pp. 211-299
    • Lock, E.A.1    Hard, G.C.2
  • 8
    • 0027818392 scopus 로고
    • Estrogen carcinogenesis in the hamster kidney: Role of cytotoxicity and cell proliferation
    • Li, J. J., Gonzalez, A., Banerjee, S., Banerjee, S. K., Li, S. A., Estrogen carcinogenesis in the hamster kidney: Role of cytotoxicity and cell proliferation, Environ. Health Perspect. 1993, 101 (Suppl. 5), 259 - 264.
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 5 , pp. 259-264
    • Li, J.J.1    Gonzalez, A.2    Banerjee, S.3    Banerjee, S.K.4    Li, S.A.5
  • 9
    • 0025102726 scopus 로고
    • The role of damage and proliferation in renal carcinogenesis
    • Stevens, J. L., Jones, T. W., The role of damage and proliferation in renal carcinogenesis, Toxicol. Lett. 1990, 53, 121 - 126.
    • (1990) Toxicol. Lett. , vol.53 , pp. 121-126
    • Stevens, J.L.1    Jones, T.W.2
  • 10
    • 0037387724 scopus 로고    scopus 로고
    • Alpha 2u-globulin nephropathy and carcinogenicity following exposure to decalin (decahydronaphthalene) in F344/N rats
    • Dill, J. A., Lee, K. M., Renne, R. A., Miller, R. A., et al., Alpha 2u-globulin nephropathy and carcinogenicity following exposure to decalin (decahydronaphthalene) in F344/N rats, Toxicol. Sci. 2003, 72, 223 - 234.
    • (2003) Toxicol. Sci. , vol.72 , pp. 223-234
    • Dill, J.A.1    Lee, K.M.2    Renne, R.A.3    Miller, R.A.4
  • 11
    • 33745212267 scopus 로고    scopus 로고
    • Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichloro-vinyl)-L-cysteine in vitro
    • Mally, A., Walker, C. L., Everitt, J. I., Dekant, W., Vamvakas, S., Analysis of renal cell transformation following exposure to trichloroethene in vivo and its metabolite S-(dichloro-vinyl)-L-cysteine in vitro, Toxicology 2006, 224, 108-118.
    • (2006) Toxicology , vol.224 , pp. 108-118
    • Mally, A.1    Walker, C.L.2    Everitt, J.I.3    Dekant, W.4    Vamvakas, S.5
  • 12
    • 0031427713 scopus 로고    scopus 로고
    • Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glu-tathion-S-yl)hydroquinone
    • Peters, M. M., Jones, T. W., Monks, T. J., Lau, S. S., Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-(tris-glu-tathion-S-yl)hydroquinone, Carcinogenesis 1997, 18, 2393 - 2401.
    • (1997) Carcinogenesis , vol.18 , pp. 2393-2401
    • Peters, M.M.1    Jones, T.W.2    Monks, T.J.3    Lau, S.S.4
  • 13
    • 77957174850 scopus 로고
    • Acute hepatotoxic and nephrotoxic effects of chloroform in male F-344 rats and female B6C3F1 mice
    • Larson, J. L., Wolf, D. C., Butterworth, B. E., Acute hepatotoxic and nephrotoxic effects of chloroform in male F-344 rats and female B6C3F1 mice, Fundam. Appl. Toxicol. 1993, 20, 302-315.
    • (1993) Fundam. Appl. Toxicol. , vol.20 , pp. 302-315
    • Larson, J.L.1    Wolf, D.C.2    Butterworth, B.E.3
  • 14
    • 0030972416 scopus 로고    scopus 로고
    • Methyl tert-butyl ether causes alpha2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats
    • Prescott-Mathews, J. S., Wolf, D. C., Wong, B. A., Borghoff, S. J., Methyl tert-butyl ether causes alpha2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats, Toxicol. Appl. Pharmacol. 1997, 143, 301-314.
    • (1997) Toxicol. Appl. Pharmacol. , vol.143 , pp. 301-314
    • Prescott-Mathews, J.S.1    Wolf, D.C.2    Wong, B.A.3    Borghoff, S.J.4
  • 15
    • 0031922836 scopus 로고    scopus 로고
    • Oxidative DNA damage and cell proliferation in kidneys of male and female rats during 13-weeks exposure to potassium bromate (KBrO3)
    • Umemura, T., Takagi, A., Sai, K., Hasegawa, R., Kurokawa, Y., Oxidative DNA damage and cell proliferation in kidneys of male and female rats during 13-weeks exposure to potassium bromate (KBrO3), Arch. Toxicol. 1998, 72, 264 - 269.
    • (1998) Arch. Toxicol. , vol.72 , pp. 264-269
    • Umemura, T.1    Takagi, A.2    Sai, K.3    Hasegawa, R.4    Kurokawa, Y.5
  • 16
    • 2942606042 scopus 로고    scopus 로고
    • Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective
    • Bolt, H. M., Foth, H., Hengstler, J. G., Degen, G. H., Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective, Toxicol. Lett. 2004, 151, 29-41.
    • (2004) Toxicol. Lett. , vol.151 , pp. 29-41
    • Bolt, H.M.1    Foth, H.2    Hengstler, J.G.3    Degen, G.H.4
  • 17
    • 4444381773 scopus 로고    scopus 로고
    • Human carcinogenic risk evaluation, part II: Contributions of the EUROTOX specialty section for carcinogenesis
    • Bolt, H. M., Degen, G. H., Human carcinogenic risk evaluation, part II: Contributions of the EUROTOX specialty section for carcinogenesis, Toxicol. Sci. 2004, 81, 3-6.
    • (2004) Toxicol. Sci. , vol.81 , pp. 3-6
    • Bolt, H.M.1    Degen, G.H.2
  • 18
    • 0017090690 scopus 로고
    • Experimental porcine nephropathy: Changes of renal function and structure perorally induced by crystalline ochratoxin A
    • Krogh, P., Elling, F., Gyrd-Hansen, N., Hald, B., et al., Experimental porcine nephropathy: Changes of renal function and structure perorally induced by crystalline ochratoxin A, Acta Pathol. Microbiol. Scand. A 1976, 84, 429-434.
    • (1976) Acta Pathol. Microbiol. Scand. A , vol.84 , pp. 429-434
    • Krogh, P.1    Elling, F.2    Gyrd-Hansen, N.3    Hald, B.4
  • 19
    • 0018779242 scopus 로고
    • Porcine nephropathy induced by long-term ingestion of ochratoxin A
    • Krogh, P., Elling, F., Friis, C., Hald, B., et al., Porcine nephropathy induced by long-term ingestion of ochratoxin A, Vet. Pathol. 1979, 16, 466 - 475.
    • (1979) Vet. Pathol. , vol.16 , pp. 466-475
    • Krogh, P.1    Elling, F.2    Friis, C.3    Hald, B.4
  • 21
    • 23844438306 scopus 로고    scopus 로고
    • Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats
    • Mally, A., Volkel, W., Amberg, A., Kurz, M., et al. Functional, biochemical, and pathological effects of repeated oral administration of ochratoxin A to rats, Chem. Res. Toxicol. 2005, 18, 1242 - 1252.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1242-1252
    • Mally, A.1    Volkel, W.2    Amberg, A.3    Kurz, M.4
  • 22
    • 0033009878 scopus 로고    scopus 로고
    • Karyomegaly of tubular cells as early stage marker of the nephrotoxicity induced by ochratoxin A in rats
    • Maaroufi, K., Zakhama, A., Baudrimont, I., Achour, A., et al., Karyomegaly of tubular cells as early stage marker of the nephrotoxicity induced by ochratoxin A in rats, Hum. Exp. Toxicol. 1999, 18, 410 - 415.
    • (1999) Hum. Exp. Toxicol. , vol.18 , pp. 410-415
    • Maaroufi, K.1    Zakhama, A.2    Baudrimont, I.3    Achour, A.4
  • 23
    • 34447551596 scopus 로고    scopus 로고
    • Ochratoxin a: 13-Week oral toxicity and cell proliferation in male f344/n rats
    • Rached, E., Hard, G. C., Blumbach, K., Weber, K., et al., Ochratoxin a: 13-Week oral toxicity and cell proliferation in male F344/N rats, Toxicol. Sci. 2007, 97, 288-298.
    • (2007) Toxicol. Sci. , vol.97 , pp. 288-298
    • Rached, E.1    Hard, G.C.2    Blumbach, K.3    Weber, K.4
  • 24
    • 34547549854 scopus 로고    scopus 로고
    • Aristolochic acid and the etiology of endemic (Balkan) nephropathy
    • Grollman, A. P., Shibutani, S., Moriya, M., Miller, F., et al., Aristolochic acid and the etiology of endemic (Balkan) nephropathy, Proc. Natl. Acad. Sci. USA 2007, 104, 12129 - 12134.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 12129-12134
    • Grollman, A.P.1    Shibutani, S.2    Moriya, M.3    Miller, F.4
  • 25
    • 36148933380 scopus 로고    scopus 로고
    • Aristolochic acid mutagenesis: Molecular clues to the aetiology of balkan endemic nephropathy-associated urothelial cancer
    • Arlt, V. M., Stiborova, M., vom Brocke, J., Simoes, M. L., et al., Aristolochic acid mutagenesis: Molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer, Carcinogenesis 2007, 28, 2253-2261.
    • (2007) Carcinogenesis , vol.28 , pp. 2253-2261
    • Arlt, V.M.1    Stiborova, M.2    vom Brocke, J.3    Simoes, M.L.4
  • 26
    • 35948966844 scopus 로고    scopus 로고
    • Role of environmental toxins in endemic (Balkan) nephropathy
    • October 2006, Zagreb, Croatia
    • Grollman, A. P., Jelakovic, B., Role of environmental toxins in endemic (Balkan) nephropathy. October 2006, Zagreb, Croatia, J. Am. Soc. Nephrol. 2007, 18, 2817-2823.
    • J. Am. Soc. Nephrol. , vol.2007 , Issue.18 , pp. 2817-2823
    • Grollman, A.P.1    Jelakovic, B.2
  • 27
    • 0141671914 scopus 로고    scopus 로고
    • Toxicokinetics of the mycotoxin ochratoxin A in F 344 rats after oral administration
    • Zepnik, H., Volkel, W., Dekant, W., Toxicokinetics of the mycotoxin ochratoxin A in F 344 rats after oral administration, Toxicol. Appl. Pharmacol. 2003, 192, 36-44.
    • (2003) Toxicol. Appl. Pharmacol. , vol.192 , pp. 36-44
    • Zepnik, H.1    Volkel, W.2    Dekant, W.3
  • 28
    • 0035147426 scopus 로고    scopus 로고
    • Ochratoxin A-induced tumor formation: Is there a role of reactive ochratoxin a metabolites?
    • Zepnik, H., Pahler, A., Schauer, U., Dekant, W., Ochratoxin A-induced tumor formation: Is there a role of reactive ochratoxin A metabolites? Toxicol. Sci. 2001, 59, 59-67.
    • (2001) Toxicol. Sci. , vol.59 , pp. 59-67
    • Zepnik, H.1    Pahler, A.2    Schauer, U.3    Dekant, W.4
  • 29
    • 0034802670 scopus 로고    scopus 로고
    • Electrochemical oxidation of ochratoxin A: Correlation with 4-chlorophenol
    • Calcutt, M. W., Gillman, I. G., Noftle, R. E., Manderville, R.A., Electrochemical oxidation of ochratoxin A: Correlation with 4-chlorophenol, Chem. Res. Toxicol. 2001, 14, 1266-1272.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1266-1272
    • Calcutt, M.W.1    Gillman, I.G.2    Noftle, R.E.3    Manderville, R.A.4
  • 30
    • 0037414317 scopus 로고    scopus 로고
    • Ochratoxin a forms a carbon-bonded c8-deoxyguanosine nucleoside adduct: Implications for c8 reactivity by a phenolic radical
    • Dai, J., Wright, M. W., Manderville, R. A., Ochratoxin a forms a carbon-bonded c8-deoxyguanosine nucleoside adduct: Implications for c8 reactivity by a phenolic radical, J.Am. Chem. Soc. 2003, 125, 3716 - 3717.
    • (2003) J.Am. Chem. Soc. , vol.125 , pp. 3716-3717
    • Dai, J.1    Wright, M.W.2    Manderville, R.A.3
  • 31
    • 0013215589 scopus 로고    scopus 로고
    • Detection and characterization of a glutathione conjugate of ochratoxin A
    • Dai, J., Park, G., Wright, M. W., Adams, M., et al., Detection and characterization of a glutathione conjugate of ochratoxin A, Chem. Res. Toxicol. 2002, 15, 1581 - 1588.
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 1581-1588
    • Dai, J.1    Park, G.2    Wright, M.W.3    Adams, M.4
  • 32
    • 0038470827 scopus 로고    scopus 로고
    • Effects of the mycotoxin ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system
    • Follmann, W., Lucas, S., Effects of the mycotoxin ochratoxin A in a bacterial and a mammalian in vitro mutagenicity test system, Arch. Toxicol. 2003, 77, 298-304.
    • (2003) Arch. Toxicol. , vol.77 , pp. 298-304
    • Follmann, W.1    Lucas, S.2
  • 33
    • 0025937573 scopus 로고
    • Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102
    • Wurgler, F. E., Friederich, U., Schlatter, J., Lack of mutagenicity of ochratoxin A and B, citrinin, patulin and cnestine in Salmonella typhimurium TA102, Mutat. Res. 1991, 261, 209-216.
    • (1991) Mutat. Res. , vol.261 , pp. 209-216
    • Wurgler, F.E.1    Friederich, U.2    Schlatter, J.3
  • 34
    • 0018071942 scopus 로고
    • Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins
    • Wehner, F. C., Thiel, P. G., van Rensburg, S. J., Demasius, I.P., Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins, Mutat. Res. 1978, 58, 193-203.
    • (1978) Mutat. Res. , vol.58 , pp. 193-203
    • Wehner, F.C.1    Thiel, P.G.2    van Rensburg, S.J.3    Demasius, I.P.4
  • 35
    • 0022373951 scopus 로고
    • Evaluation of ochratoxin A for mutagenicity in a battery of bacterial and mammalian cell assays
    • Bendele, A. M., Neal, S. B., Oberly, T. J., Thompson, C. Z., et al., Evaluation of ochratoxin A for mutagenicity in a battery of bacterial and mammalian cell assays, Food Chem. Toxicol. 1985, 23, 911-918.
    • (1985) Food Chem. Toxicol. , vol.23 , pp. 911-918
    • Bendele, A.M.1    Neal, S.B.2    Oberly, T.J.3    Thompson, C.Z.4
  • 36
    • 0032699716 scopus 로고    scopus 로고
    • Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes
    • Obrecht-Pflumio, S., Chassat, T., Dirheimer, G., Marzin, D., Genotoxicity of ochratoxin A by Salmonella mutagenicity test after bioactivation by mouse kidney microsomes, Mutat. Res. 1999, 446, 95-102.
    • (1999) Mutat. Res. , vol.446 , pp. 95-102
    • Obrecht-Pflumio, S.1    Chassat, T.2    Dirheimer, G.3    Marzin, D.4
  • 37
    • 0026271907 scopus 로고
    • Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation
    • Hennig, A., Fink-Gremmels, J., Leistner, L., Mutagenicity and effects of ochratoxin A on the frequency of sister chromatid exchange after metabolic activation, IARC Sci. Publ. 1991, 255-260.
    • (1991) IARC Sci. Publ. , pp. 255-260
    • Hennig, A.1    Fink-Gremmels, J.2    Leistner, L.3
  • 38
    • 0003827150 scopus 로고    scopus 로고
    • Greim, H. (Ed.), Senatskommission zur Pr fung gesundheitlicher Arbeits-stoffe der Deutschen Forschungsgemeinschaft, Wiley-VCH, 37. Lieferung 2003, in German
    • Greim, H. (Ed.), Gesundheitliche Arbeitsstoffe - Toxikologisch-arbeitsmedizinische Begr ndung von MAK-Werten, Senatskommission zur Pr fung gesundheitlicher Arbeits-stoffe der Deutschen Forschungsgemeinschaft, Wiley-VCH, 37. Lieferung 2003, in German.
    • Gesundheitliche Arbeitsstoffe - Toxikologisch-arbeitsmedizinische Begr ndung von MAK-Werten
  • 39
    • 0030925538 scopus 로고    scopus 로고
    • Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures
    • Degen, G. H., Gerber, M. M., Obrecht-Pflumio, S., Dirheimer, G., Induction of micronuclei with ochratoxin A in ovine seminal vesicle cell cultures, Arch. Toxicol. 1997, 71, 365-371.
    • (1997) Arch. Toxicol. , vol.71 , pp. 365-371
    • Degen, G.H.1    Gerber, M.M.2    Obrecht-Pflumio, S.3    Dirheimer, G.4
  • 40
    • 0036283028 scopus 로고    scopus 로고
    • Genotoxic effects of ochratoxin A in human-derived hepatoma (HepG2) cells
    • Ehrlich, V., Darroudi, F., Uhl, M., Steinkellner, H., et al., Genotoxic effects of ochratoxin A in human-derived hepatoma (HepG2) cells, Food Chem. Toxicol. 2002, 40, 1085 - 1090.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 1085-1090
    • Ehrlich, V.1    Darroudi, F.2    Uhl, M.3    Steinkellner, H.4
  • 41
    • 0345466411 scopus 로고    scopus 로고
    • Induction of genotoxic effects and modulation of the intracellular calcium level in syrian hamster embryo (SHE) fibroblasts caused by ochratoxin A
    • Dopp, E., Muller, J., Hahnel, C., Schiffmann, D., Induction of genotoxic effects and modulation of the intracellular calcium level in syrian hamster embryo (SHE) fibroblasts caused by ochratoxin A, Food Chem. Toxicol. 1999, 37, 713-721.
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 713-721
    • Dopp, E.1    Muller, J.2    Hahnel, C.3    Schiffmann, D.4
  • 42
    • 0035717799 scopus 로고    scopus 로고
    • Detection of ochratoxin A-induced DNA damage in MDCK cells by alkaline single cell gel electrophoresis (comet assay)
    • Lebrun, S., Follmann, W., Detection of ochratoxin A-induced DNA damage in MDCK cells by alkaline single cell gel electrophoresis (comet assay), Arch. Toxicol. 2002, 75, 734 - 741.
    • (2002) Arch. Toxicol. , vol.75 , pp. 734-741
    • Lebrun, S.1    Follmann, W.2
  • 43
    • 0028936253 scopus 로고
    • Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha
    • Follmann, W., Hillebrand, I. E., Creppy, E. E., Bolt, H. M., Sister chromatid exchange frequency in cultured isolated porcine urinary bladder epithelial cells (PUBEC) treated with ochratoxin A and alpha, Arch. Toxicol. 1995, 69, 280 - 286.
    • (1995) Arch. Toxicol. , vol.69 , pp. 280-286
    • Follmann, W.1    Hillebrand, I.E.2    Creppy, E.E.3    Bolt, H.M.4
  • 44
    • 47049113238 scopus 로고    scopus 로고
    • In vitro cytogenetic results supporting a DNA nonreactive mechanism for ochratoxin A, potentially relevant for its carcinogenicity
    • in press, DOI: 10.1021/tx800029f
    • Mosesso, P., Cinelli, S., Pinero, J., Bellacima, R., Pepe, G., In vitro cytogenetic results supporting a DNA nonreactive mechanism for ochratoxin A, potentially relevant for its carcinogenicity, Chem. Res. Toxicol. 2008, in press, DOI: 10.1021/tx800029f.
    • (2008) Chem. Res. Toxicol.
    • Mosesso, P.1    Cinelli, S.2    Pinero, J.3    Bellacima, R.4    Pepe, G.5
  • 45
    • 22544479430 scopus 로고    scopus 로고
    • Perspective: Ochratoxin a is not a genotoxic carcinogen
    • Turesky, R. J., Perspective: Ochratoxin A is not a genotoxic carcinogen, Chem. Res. Toxicol. 2005, 18, 1082 - 1090.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1082-1090
    • Turesky, R.J.1
  • 46
    • 22544454436 scopus 로고    scopus 로고
    • A case for the genotoxicity of ochratoxin A by bioactivation and covalent DNA adduction
    • Manderville, R. A., A case for the genotoxicity of ochratoxin A by bioactivation and covalent DNA adduction, Chem. Res. Toxicol. 2005, 18, 1091 - 1097.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1091-1097
    • Manderville, R.A.1
  • 47
    • 33645469269 scopus 로고    scopus 로고
    • DNA adduct formation by ochratoxin A: Review of the available evidence
    • Mally, A., Dekant, W., DNA adduct formation by ochratoxin A: Review of the available evidence, Food Addit. Contam. 2005, 22, 65-74.
    • (2005) Food Addit. Contam. , vol.22 , pp. 65-74
    • Mally, A.1    Dekant, W.2
  • 48
    • 0027504933 scopus 로고
    • Differential DNA adduct formation and disappearance in three mouse tissues after treatment with the mycotoxin ochratoxin A
    • Pfohl-Leszkowicz, A., Grosse, Y., Kane, A., Creppy, E. E., Dirheimer, G., Differential DNA adduct formation and disappearance in three mouse tissues after treatment with the mycotoxin ochratoxin A, Mutat. Res. 1993, 289, 265 - 273.
    • (1993) Mutat. Res. , vol.289 , pp. 265-273
    • Pfohl-Leszkowicz, A.1    Grosse, Y.2    Kane, A.3    Creppy, E.E.4    Dirheimer, G.5
  • 51
    • 0035148577 scopus 로고    scopus 로고
    • Metabolism of ochratoxin A: Absence of formation of genotoxic derivatives by human and rat enzymes
    • Gautier, J., Richoz, J., Welti, D. H., Markovic, J., et al., Metabolism of ochratoxin A: Absence of formation of genotoxic derivatives by human and rat enzymes, Chem. Res. Toxicol. 2001, 14, 34-45.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 34-45
    • Gautier, J.1    Richoz, J.2    Welti, D.H.3    Markovic, J.4
  • 52
    • 0037070059 scopus 로고    scopus 로고
    • Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes
    • Gross-Steinmeyer, K., Weymann, J., Hege, H. G., Metzler, M., Metabolism and lack of DNA reactivity of the mycotoxin ochratoxin a in cultured rat and human primary hepatocytes, J. Agric. Food Chem. 2002, 50, 938-945.
    • (2002) J. Agric. Food Chem. , vol.50 , pp. 938-945
    • Gross-Steinmeyer, K.1    Weymann, J.2    Hege, H.G.3    Metzler, M.4
  • 53
    • 1342310580 scopus 로고    scopus 로고
    • Ochratoxin A: Lack of formation of covalent dna adducts
    • Mally, A., Zepnik, H., Wanek, P., Eder, E., et al., Ochratoxin A: Lack of formation of covalent DNA adducts, Chem. Res. Toxicol. 2004, 17, 234 - 242.
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 234-242
    • Mally, A.1    Zepnik, H.2    Wanek, P.3    Eder, E.4
  • 54
    • 4644268330 scopus 로고    scopus 로고
    • Evidence for covalent DNA adduction by ochratoxin A following chronic exposure to rat and subacute exposure to pig
    • Faucet, V., Pfohl-Leszkowicz, A., Dai, J., Castegnaro, M., Manderville, R. A., Evidence for covalent DNA adduction by ochratoxin A following chronic exposure to rat and subacute exposure to pig, Chem. Res. Toxicol. 2004, 17, 1289 - 1296.
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 1289-1296
    • Faucet, V.1    Pfohl-Leszkowicz, A.2    Dai, J.3    Castegnaro, M.4    Manderville, R.A.5
  • 55
    • 48649097150 scopus 로고    scopus 로고
    • Absence of 29-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LC-MS/MS
    • Delatour, T., Mally, A., Richoz, J., Özden, S., et al., Absence of 29-deoxyguanosine-carbon 8-bound ochratoxin A adduct in rat kidney DNA monitored by isotope dilution LC-MS/MS, Mol. Nutr. Food Res. 2008, 52, 472-482.
    • (2008) Mol. Nutr. Food Res. , vol.52 , pp. 472-482
    • Delatour, T.1    Mally, A.2    Richoz, J.3    Özden, S.4
  • 56
    • 22544466793 scopus 로고    scopus 로고
    • Ochratoxin A causes DNA damage and cytogenetic effects but no DNA adducts in rats
    • Mally, A., Pepe, G., Ravoori, S., Fiore, M., et al., Ochratoxin A causes DNA damage and cytogenetic effects but no DNA adducts in rats, Chem. Res. Toxicol. 2005, 18, 1253-1261.
    • (2005) Chem. Res. Toxicol. , vol.18 , pp. 1253-1261
    • Mally, A.1    Pepe, G.2    Ravoori, S.3    Fiore, M.4
  • 57
    • 34547632542 scopus 로고    scopus 로고
    • Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress
    • Palma, N., Cinelli, S., Sapora, O., Wilson, S. H., Dogliotti, E., Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress, Chem. Res. Toxicol. 2007, 20, 1031 - 1037.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1031-1037
    • Palma, N.1    Cinelli, S.2    Sapora, O.3    Wilson, S.H.4    Dogliotti, E.5
  • 58
    • 33847112240 scopus 로고    scopus 로고
    • Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food, EFSA-Q-2005-154
    • EFSA
    • EFSA, Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to ochratoxin A in food, EFSA-Q-2005-154, EFSA J. 2006, 365, 1-56.
    • (2006) EFSA J. , vol.365 , pp. 1-56
  • 60
    • 29344435537 scopus 로고    scopus 로고
    • Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats
    • Kamp, H. G., Eisenbrand, G., Janzowski, C., Kiossev, J. et al., Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats, Mol. Nutr. Food Res. 2005, 49, 1160-1167.
    • (2005) Mol. Nutr. Food Res. , vol.49 , pp. 1160-1167
    • Kamp, H.G.1    Eisenbrand, G.2    Janzowski, C.3    Kiossev, J.4
  • 61
    • 0035873971 scopus 로고    scopus 로고
    • Oxidative damage and stress response from ochratoxin a exposure in rats
    • Gautier, J. C., Holzhaeuser, D., Markovic, J., Gremaud, E., et al., Oxidative damage and stress response from ochratoxin a exposure in rats, Free Radic. Biol. Med. 2001, 30, 1089 - 1098.
    • (2001) Free Radic. Biol. Med. , vol.30 , pp. 1089-1098
    • Gautier, J.C.1    Holzhaeuser, D.2    Markovic, J.3    Gremaud, E.4
  • 62
    • 33646233435 scopus 로고    scopus 로고
    • Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats
    • Domijan, A. M., Zeljezic, D., Kopjar, N., Peraica, M., Standard and Fpg-modified comet assay in kidney cells of ochratoxin A- and fumonisin B(1)-treated rats, Toxicology 2006, 222, 53-59.
    • (2006) Toxicology , vol.222 , pp. 53-59
    • Domijan, A.M.1    Zeljezic, D.2    Kopjar, N.3    Peraica, M.4
  • 63
    • 28944449329 scopus 로고    scopus 로고
    • Metabolism-mediated Ochratoxin A genotoxicity in the single-cell gel electrophoresis (Comet) assay
    • Simarro Doorten, Y., Nijmeijer, S., de Nijs-Tjon, L., Fink-Gremmels, J., Metabolism-mediated Ochratoxin A genotoxicity in the single-cell gel electrophoresis (Comet) assay, Food Chem. Toxicol. 2006, 44, 261-270.
    • (2006) Food Chem. Toxicol. , vol.44 , pp. 261-270
    • Simarro Doorten, Y.1    Nijmeijer, S.2    De Nijs-Tjon, L.3    Fink-Gremmels, J.4
  • 64
    • 33846061830 scopus 로고    scopus 로고
    • Oxidative DNA damage induced by Ochratoxin A in the HK-2 human kidney cell line: Evidence of the relationship with cytotoxicity
    • Arbillaga, L., Azqueta, A., Ezpeleta, O., Lopez de Cerain, A., Oxidative DNA damage induced by Ochratoxin A in the HK-2 human kidney cell line: Evidence of the relationship with cytotoxicity, Mutagenesis 2007, 22, 35-42.
    • (2007) Mutagenesis , vol.22 , pp. 35-42
    • Arbillaga, L.1    Azqueta, A.2    Ezpeleta, O.3    Lopez de Cerain, A.4
  • 65
    • 10044237965 scopus 로고    scopus 로고
    • Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells
    • Kamp, H. G., Eisenbrand, G., Schlatter, J., Wurth, K., Janzowski, C., Ochratoxin A: Induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells, Toxicology 2005, 206, 413 - 425.
    • (2005) Toxicology , vol.206 , pp. 413-425
    • Kamp, H.G.1    Eisenbrand, G.2    Schlatter, J.3    Wurth, K.4    Janzowski, C.5    Ochratoxin, A.6
  • 66
    • 45049088780 scopus 로고    scopus 로고
    • Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration
    • Arbillaga, L., Vettorazzi, A., Gil, A. G., Joost, H. M., et al., Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration, Toxicol. Appl. Pharmacol. 2008, 230, 197 - 207.
    • (2008) Toxicol. Appl. Pharmacol. , vol.230 , pp. 197-207
    • Arbillaga, L.1    Vettorazzi, A.2    Gil, A.G.3    Joost, H.M.4
  • 68
    • 33847321653 scopus 로고    scopus 로고
    • Reduction in antioxidant defences may contribute to ochratoxin A toxicity and carcinogenicity
    • Cavin, C., Delatour, T., Marin-Kuan, M., Holzhauser, D., et al., Reduction in antioxidant defences may contribute to ochratoxin A toxicity and carcinogenicity, Toxicol. Sci. 2007, 96, 30-39.
    • (2007) Toxicol. Sci. , vol.96 , pp. 30-39
    • Cavin, C.1    Delatour, T.2    Marin-Kuan, M.3    Holzhauser, D.4
  • 69
    • 29544433884 scopus 로고    scopus 로고
    • A Toxicogenomics approach to identify new Plausible Epigenetic Mechanisms of Ochratoxin A Carcinogenicity in Rat
    • Marin-Kuan, M., Nestler, S., Verguet, C., Bezencon, C., et al., A Toxicogenomics approach to identify new Plausible Epigenetic Mechanisms of Ochratoxin A Carcinogenicity in Rat, Toxicol. Sci. 2006, 89, 120 - 134.
    • (2006) Toxicol. Sci. , vol.89 , pp. 120-134
    • Marin-Kuan, M.1    Nestler, S.2    Verguet, C.3    Bezencon, C.4
  • 70
    • 0032586788 scopus 로고    scopus 로고
    • The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats
    • Rasonyi, T., Schlatter, J., Dietrich, D. R., The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats, Toxicol. Lett. 1999, 104, 83-92.
    • (1999) Toxicol. Lett. , vol.104 , pp. 83-92
    • Rasonyi, T.1    Schlatter, J.2    Dietrich, D.R.3
  • 71
    • 65749092996 scopus 로고    scopus 로고
    • Gender disparity in early ochratoxin A mediated renal toxicity
    • Stemmer, K., Dietrich, D., Gender disparity in early ochratoxin A mediated renal toxicity, Toxicologist 2008, 102, 21.
    • (2008) Toxicologist , vol.102 , pp. 21
    • Stemmer, K.1    Dietrich, D.2
  • 72
    • 0029583799 scopus 로고
    • Role of active cell death (apoptosis) in multi-stage carcinogenesis
    • Schulte-Hermann, R., Bursch, W., Grasl-Kraupp, B., Torok, L., et al., Role of active cell death (apoptosis) in multi-stage carcinogenesis, Toxicol. Lett. 1995, 82-83, 143-148.
    • (1995) Toxicol. Lett. , vol.82-83 , pp. 143-148
    • Schulte-Hermann, R.1    Bursch, W.2    Grasl-Kraupp, B.3
  • 73
    • 0028208243 scopus 로고
    • Suppression of liver cell apoptosis in vitro by the nongenotoxic hepatocarcinogen and peroxisome proliferator nafenopin
    • Bayly, A. C., Roberts, R. A., Dive, C., Suppression of liver cell apoptosis in vitro by the nongenotoxic hepatocarcinogen and peroxisome proliferator nafenopin, J. Cell Biol. 1994, 125, 197-203.
    • (1994) J. Cell Biol. , vol.125 , pp. 197-203
    • Bayly, A.C.1    Roberts, R.A.2    Dive, C.3
  • 74
    • 0029878895 scopus 로고    scopus 로고
    • Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor beta 1
    • Worner, W., Schrenk, D., Influence of liver tumor promoters on apoptosis in rat hepatocytes induced by 2-acetylaminofluorene, ultraviolet light, or transforming growth factor beta 1, Cancer Res. 1996, 56, 1272-1278.
    • (1996) Cancer Res. , vol.56 , pp. 1272-1278
    • Worner, W.1    Schrenk, D.2
  • 75
    • 0032435561 scopus 로고    scopus 로고
    • Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexylphlathate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB)
    • James, N. H., Soames, A. R., Roberts, R. A., Suppression of hepatocyte apoptosis and induction of DNA synthesis by the rat and mouse hepatocarcinogen diethylhexylphlathate (DEHP) and the mouse hepatocarcinogen 1,4-dichlorobenzene (DCB), Arch. Toxicol. 1998, 72, 784-790.
    • (1998) Arch. Toxicol. , vol.72 , pp. 784-790
    • James, N.H.1    Soames, A.R.2    Roberts, R.A.3
  • 76
    • 0034045754 scopus 로고    scopus 로고
    • Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations
    • Gekle, M., Schwerdt, G., Freudinger, R., Mildenberger, S., et al., Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations, J. Pharmacol. Exp. Ther. 2000, 293, 837-844.
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 837-844
    • Gekle, M.1    Schwerdt, G.2    Freudinger, R.3    Mildenberger, S.4
  • 77
    • 15744381934 scopus 로고    scopus 로고
    • Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2
    • Sauvant, C., Holzinger, H., Gekle, M., Proximal tubular toxicity of ochratoxin A is amplified by simultaneous inhibition of the extracellular signal-regulated kinases 1/2, J. Pharmacol. Exp. Ther. 2005, 313, 234-241.
    • (2005) J. Pharmacol. Exp. Ther. , vol.313 , pp. 234-241
    • Sauvant, C.1    Holzinger, H.2    Gekle, M.3
  • 78
    • 0031473318 scopus 로고    scopus 로고
    • Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation
    • Schramek, H., Wilflingseder, D., Pollack, V., Freudinger, R. et al., Ochratoxin A-induced stimulation of extracellular signal-regulated kinases 1/2 is associated with Madin-Darby canine kidney-C7 cell dedifferentiation, J. Pharmacol. Exp. Ther. 1997, 283, 1460-1468.
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , pp. 1460-1468
    • Schramek, H.1    Wilflingseder, D.2    Pollack, V.3    Freudinger, R.4
  • 80
    • 33646541705 scopus 로고    scopus 로고
    • Ochratoxin A alters cell adhesion and gap junction intercellular communication in MDCK cells
    • Mally, A., Decker, M., Bekteshi, M., Dekant, W., Ochratoxin A alters cell adhesion and gap junction intercellular communication in MDCK cells, Toxicology 2006, 223, 15-25.
    • (2006) Toxicology , vol.223 , pp. 15-25
    • Mally, A.1    Decker, M.2    Bekteshi, M.3    Dekant, W.4
  • 81
    • 0034768453 scopus 로고    scopus 로고
    • Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line
    • Horvath, A., Upham, B. L., Ganev, V., Trosko, J. E., Determination of the epigenetic effects of ochratoxin in a human kidney and a rat liver epithelial cell line, Toxicon 2002, 40, 273 - 282.
    • (2002) Toxicon , vol.40 , pp. 273-282
    • Horvath, A.1    Upham, B.L.2    Ganev, V.3    Trosko, J.E.4
  • 82
    • 0346639211 scopus 로고    scopus 로고
    • Apoptosis and oxidative stress induced by ochratoxin A in rat kidney
    • Petrik, J., Zanic-Grubisic, T., Barisic, K., Pepeljnjak, S., et al., Apoptosis and oxidative stress induced by ochratoxin A in rat kidney, Arch. Toxicol. 2003, 77, 685-693.
    • (2003) Arch. Toxicol. , vol.77 , pp. 685-693
    • Petrik, J.1    Zanic-Grubisic, T.2    Barisic, K.3    Pepeljnjak, S.4
  • 83
    • 12444345857 scopus 로고    scopus 로고
    • The nephrotoxinochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells
    • Sauvant, C., Holzinger, H., Gekle, M., The nephrotoxinochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells, Cell Physiol. Biochem. 2005, 15, 125-134.
    • (2005) Cell Physiol. Biochem. , vol.15 , pp. 125-134
    • Sauvant, C.1    Holzinger, H.2    Gekle, M.3
  • 84
    • 33745614599 scopus 로고    scopus 로고
    • Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics?
    • Rached, E., Pfeiffer, E., Dekant, W., Mally, A., Ochratoxin A: Apoptosis and aberrant exit from mitosis due to perturbation of microtubule dynamics? Toxicol. Sci. 2006, 92, 78-86.
    • (2006) Toxicol. Sci. , vol.92 , pp. 78-86
    • Rached, E.1    Pfeiffer, E.2    Dekant, W.3    Mally, A.4    Ochratoxin, A.5
  • 85
    • 34848837597 scopus 로고    scopus 로고
    • MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma
    • Marin-Kuan, M., Nestler, S., Verguet, C., Bezencon, C., et al., MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma, Toxicol. Appl. Pharmacol. 2007, 224, 174-181.
    • (2007) Toxicol. Appl. Pharmacol. , vol.224 , pp. 174-181
    • Marin-Kuan, M.1    Nestler, S.2    Verguet, C.3    Bezencon, C.4
  • 86
    • 0034769180 scopus 로고    scopus 로고
    • Species-, sex and cell type-specific effects of ochratoxin A and B
    • O'Brien, E., Heussner, A. H., Dietrich, D. R., Species-, sex and cell type-specific effects of ochratoxin A and B, Toxicol. Sci. 2001, 63, 256-264.
    • (2001) Toxicol. Sci. , vol.63 , pp. 256-264
    • O'brien, E.1    Heussner, A.H.2    Dietrich, D.R.3
  • 87
    • 0037834732 scopus 로고    scopus 로고
    • A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: Expression profiling in vivo and in vitro employing cdna microarrays
    • Luhe, A., Hildebrand, H., Bach, U., Dingermann, T., Ahr, H. J., A new approach to studying ochratoxin A (OTA)-induced nephrotoxicity: Expression profiling in vivo and in vitro employing cDNA microarrays, Toxicol. Sci. 2003, 73, 315-328.
    • (2003) Toxicol. Sci. , vol.73 , pp. 315-328
    • Luhe, A.1    Hildebrand, H.2    Bach, U.3    Dingermann, T.4    Ahr, H.J.5
  • 88
    • 33947718284 scopus 로고    scopus 로고
    • In vitro gene expression data supporting a DNA nonreactive genotoxic mechanism for ochratoxin A
    • Arbillaga, L., Azqueta, A., van Delft, J. H., Lopez de Cerain, A., In vitro gene expression data supporting a DNA nonreactive genotoxic mechanism for ochratoxin A, Toxicol. Appl. Pharmacol. 2007, 220, 216-224.
    • (2007) Toxicol. Appl. Pharmacol. , vol.220 , pp. 216-224
    • Arbillaga, L.1    Azqueta, A.2    van Delft, J.H.3    Lopez de Cerain, A.4
  • 89
    • 2142825650 scopus 로고    scopus 로고
    • Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins
    • Hu, T., Gibson, D. P., Carr, G. J., Torontali, S. M., et al., Identification of a gene expression profile that discriminates indirect-acting genotoxins from direct-acting genotoxins, Mutat. Res. 2004, 549, 5-27.
    • (2004) Mutat. Res. , vol.549 , pp. 5-27
    • Hu, T.1    Gibson, D.P.2    Carr, G.J.3    Torontali, S.M.4
  • 90
    • 33847321653 scopus 로고    scopus 로고
    • Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity
    • Cavin, C., Delatour, T., Marin-Kuan, M., Holzhauser, D., et al., Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity, Toxicol. Sci. 2007, 96, 30-39.
    • (2007) Toxicol. Sci. , vol.96 , pp. 30-39
    • Cavin, C.1    Delatour, T.2    Marin-Kuan, M.3    Holzhauser, D.4
  • 91
    • 34249277438 scopus 로고    scopus 로고
    • Carcinogen-specific gene expression profiles in shortterm treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis
    • Stemmer, K., Ellinger-Ziegelbauer, H., Ahr, H. J., Dietrich, D. R., Carcinogen-specific gene expression profiles in shortterm treated Eker and wild-type rats indicative of pathways involved in renal tumorigenesis, Cancer Res. 2007, 67, 4052-4068.
    • (2007) Cancer Res. , vol.67 , pp. 4052-4068
    • Stemmer, K.1    Ellinger-Ziegelbauer, H.2    Ahr, H.J.3    Dietrich, D.R.4
  • 92
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., Weinberg, R. A., The hallmarks of cancer, Cell 2000, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 93
    • 65749091117 scopus 로고    scopus 로고
    • Aberrant expression of key regulators of mitosis and chromosome segregation in rat kidney following exposure to ochratoxin A
    • Adler, M., Miller, K., Rached, E., Dekant, W., Mally, A., Aberrant expression of key regulators of mitosis and chromosome segregation in rat kidney following exposure to ochratoxin A, Toxicologist 2008, 102, 108.
    • (2008) Toxicologist , vol.102 , pp. 108
    • Adler, M.1    Miller, K.2    Rached, E.3    Dekant, W.4    Mally, A.5
  • 94
    • 33746508429 scopus 로고    scopus 로고
    • Mitotic kinases: The key to dulication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis
    • Li, J. J., Li, S. A., Mitotic kinases: The key to dulication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis, Pharmacol. Ther. 2006, 111, 974-984.
    • (2006) Pharmacol. Ther. , vol.111 , pp. 974-984
    • Li, J.J.1    Li, S.A.2
  • 95
    • 34447094967 scopus 로고    scopus 로고
    • A census of mitotic cancer genes: New insights into tumor cell biology and cancer therapy
    • Perez de Castro, I., de Carcer, G., Malumbres, M., A census of mitotic cancer genes: New insights into tumor cell biology and cancer therapy, Carcinogenesis 2007, 28, 899-912.
    • (2007) Carcinogenesis , vol.28 , pp. 899-912
    • Perez de Castro, I.1    de Carcer, G.2    Malumbres, M.3


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