FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells

Journal of Biological Chemistry

Volumn 284, Issue 9, 2009, Pages 5467-5477

  Berdyshev, Evgeny V ^a   Gorshkova, Irina ^a   Skobeleva, Anastasia ^a   Bittman, Robert ^b   Lu, Xuequan ^b   Dudek, Steven M ^a   Mirzapoiazova, Tamara ^a   Garcia, Joe G N ^a   Natarajan, Viswanathan ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR LEVELS; CERAMIDE; CERAMIDE SYNTHASE; CERAMIDES; ENZYMATIC ASSAY; FUMONISIN B1; HUMAN LUNG; IN-CELL; IN-VITRO; KINETIC STUDY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MYRIOCIN; PULMONARY ARTERY ENDOTHELIAL CELLS; PULSE-LABELING; SERINE PALMITOYLTRANSFERASE; SMALL INTERFERING RNA; SPHINGOLIPID; SPHINGOLIPIDS; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATES; SPHINGOSINE KINASE; STABLE ISOTOPES; SYNTHASES; SYNTHETIC ANALOGS; THERAPEUTIC APPLICATION; UP-REGULATION;

AMIDES; AMINO ACIDS; BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; BLOOD VESSEL PROSTHESES; CELL MEMBRANES; CHROMATOGRAPHIC ANALYSIS; ENZYMES; LIPIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MODULATION; NUCLEIC ACIDS; RNA; SELF ASSEMBLY; SIGNALING;

ENDOTHELIAL CELLS;

CERAMIDE; DIHYDROCERAMIDE; DIHYDROSPHINGOSINE 1 PHOSPHATE; FINGOLIMOD; FUMONISIN B1; SERINE; SMALL INTERFERING RNA; SPHINGANINE; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE ACYLTRANSFERASE; SPHINGOSINE KINASE 1; SPHINGOSINE KINASE 2; UNCLASSIFIED DRUG; DIHYDROCERAMIDE DESATURASE; DIHYDROSPHINGOSINE 1-PHOSPHATE; DRUG DERIVATIVE; IMMUNOSUPPRESSIVE AGENT; LYSOPHOSPHOLIPID; MESSENGER RNA; OXIDOREDUCTASE; PHOSPHOTRANSFERASE; PROPANEDIOL DERIVATIVE; SERINE PALMITOYLTRANSFERASE; SPHINGOSINE 1-PHOSPHATE; SPHINGOSINE KINASE;

ARTERY ENDOTHELIUM; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYMATIC ASSAY; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; LIPOGENESIS; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PULMONARY ARTERY; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; UPREGULATION; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; LUNG; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM;

CELLS, CULTURED; CERAMIDES; CHROMATOGRAPHY, LIQUID; ENDOTHELIUM, VASCULAR; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LUNG; LYSOPHOSPHOLIPIDS; OXIDOREDUCTASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROPYLENE GLYCOLS; PULMONARY ARTERY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SERINE C-PALMITOYLTRANSFERASE; SPHINGOSINE; TANDEM MASS SPECTROMETRY; UP-REGULATION;

EID: 65549109859     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805186200     Document Type: Article

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