Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity

Toxicology and Applied Pharmacology

Volumn 138, Issue 2, 1996, Pages 211-218

  Yoo, Hwan Soo ^a   Norred, William P ^a   Showker, Jency ^a   Riley, Ronald T ^a  

^a RUSSELL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 CHLOROALANINE; FUMONISIN B1; SPHINGANINE; SPHINGOLIPID;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN; CONTROLLED STUDY; CYTOTOXICITY; KIDNEY CELL; NONHUMAN; SWINE;

ANIMALIA; SPHINGIODEA; SUS SCROFA;

EID: 0030175768     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0119     Document Type: Article

References (36)

1. Bell, R. M., Hannun, Y. A., and Merrill, A. H., Jr. (1993). Advances in Lipid Research: Sphingolipids and Their Metabolites, Vols. 25-26. Academic Press, Orlando, FL.
2. Gaver, R. C., and Sweeley, C. C. (1965). Methods for methanolysis of sphingolipids and direct determination of long-chain bases by gas chromatography. J. Am. Oil Chem. Soc. 42, 294-298.
3. Hanada, K., Nishijima, M., and Akamatsu, Y. (1990). A temperature-sensitive mammalian cell mutant with thermolabile serine palmitoyltransferase for the sphingolipid biosynthesis. J. Biol. Chem. 265, 22137-22142.
4. Hanada, K., Nishijima, M., Kiso, M., Hasegawa, A., Fujita, S., Ogawa, T., and Akamatsu, Y. (1992). Sphingolipids are essential for the growth of Chinese hamster ovary cells. J. Biol. Chem. 267, 23527-23522.
5. Hannun, Y. A., Merrill, A. H, Jr., and Bell, R. M. (1991). Use of sphingosine as an inhibitor of protein kinase C. Methods Enzymol. 201, 316-328.
6. Harel, R., and Futerman, A. H. (1993). Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons. J. Biol. Chem. 268, 14476-14481.
7. Huang, C., Dickman, M., Henderson, G., and Jones, C. (1995). Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen. Cancer Res. 55, 1655-1659.
8. Jayadev, S., Liu, B., Bielawska, A. E., Lee, J. Y., Nazaire, F., Pushkareva, M. Y., Obeid, L. M. and Hannun, Y. A. (1995). Role for ceramide in cell cycle arrest. J. Biol. Chem. 270, 2047-2052.
9. Lambeth, J. D., Burnham, D. N., and Tyagi, S. R. (1988). Sphinganine effects on chemoattractant-induced diacylglycerol generation, calcium fluxes, superoxide production, and on cell viability in the human neutrophil. J. Biol. Chem. 263, 3818-3822.
10. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with folin phenol reagent. J. Biol. Chem. 193, 265-275.
11. Medlock, K. A., and Merrill, A. H., Jr. (1988). Inhibition of serine palmitoyltransferase in vitro and long-chain base biosynthesis in intact Chinese hamster ovary cells by β-chloroalanine. Biochemistry 27, 7079-7084.
12. Merrill, A. H., Jr. (1991). Cell regulation by sphingosine and more complex sphingolipids. J. Bioenerg. Biomembr. 23, 83-104.
13. Merrill, A. H., Jr., and Jones, D. D. (1990). An update of the enzymology and regulation of sphingomyelin metabolism. Biochim. Biophys. Acta 1044, 1-12.
14. 1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J. Biol. Chem. 268, 27299-27306.
15. Merrill, A. H., Jr., Wang, E., Gilchrist, D. G., and Riley, R. T. (1993b). Fumonisins and other inhibitors of de novo sphingolipid biosynthesis. Adv. Lipid Res. 26, 215-234.
16. Merrill, A. H., Jr., Wang, E., Mullins, R. E., Jamison, W. C., Nimkar, S., and Liotta, D. C. (1988). Quantitation of free sphingosine in liver by high performance liquid chromatography. Anal. Biochem. 171, 373-381.
17. Merrill, A. H., Jr., Wang, E., Schroeder, J. J., Smith, E. R., Yoo, H.-S., and Riley, R. T. (1995). Disruption of sphingolipid metabolism in the toxicity and carcinogenicity of fumonisins. In Molecular Approaches to Food Safety Issues Involving Toxic Microorganisms (M. Eklund, J. Richard, and K. Mise, Eds), pp. 429-443. Alaken Press, Fort Coffins, CO.
18. Nimkar, S., Menaldino, D., Merrill, A. H., Jr., and Liotta, D. (1988). A stereoselective synthesis of sphingosine, a protein kinase C inhibitor. Tetrahedron Lett. 29, 3037-3040.
19. Norred, W. P., and Voss, K. A. (1994). Toxicity and role of fumonisin in animal diseases and human esophageal cancer. J. Food Prot. 57, 522-527.
20. Obeid, L. M., Linardic, C. M., Karolak, L. A., and Hannun, Y. A. (1993). Programmed cell death induced by ceramide. Science 259, 1769-1771.
21. Radin, N. S. (1994). Glucosylceramide in the nervous system - A mini review. Neurochem. Res. 19, 533-540.
22. 1 alters sphingolipid metabolism and disrupts the barrier function of endothelial cells in culture. Toxicol. Appl. Pharmacol. 133, 343-348.
23. + by cyclopiazonic acid-treated renal epithelial cells. J. Toxicol. Environ. Health 15, 779-788.
24. Riley, R. T., Voss, K. A., Yoo, H.-S., Gelderblom, W. C. A., and Merrill, A. H., Jr. (1994a). Mechanism of fumonisin toxicity and carcinogenesis. J. Food Prot. 57, 638-645.
25. Riley, R. T., Wang, E., and Merrill, A. H., Jr. (1994b). Liquid chromatography of sphinganine and sphingosine: Use of sphinganine to sphingosine ratio as a biomarker for consumption of fumonisins. J. Assoc. Off. Anal. Chem. Int. 11, 533-540.
26. Rother, J., van Echten, G., Schwarzmann, G., and Sandhoff, K. (1992). Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells. Biochem. Biophys. Res. Commun. 189, 14-20.
27. SAS Institute Inc. (1985). SAS/STAT Guide for Personal Computers. SAS Institute, Cary, NC.
28. 1. J. Biol. Chem. 269, 3475-3481.
29. Smith, E. R., and Merrill, A. H., Jr. (1995). Differential roles of de novo sphingolipid biosynthesis and turnover in the "burst" of free sphingosine and sphinganine, and their 1-phosphates and n-acyl-derivatives, that occurs upon changing the medium of cells in culture. J. Biol. Chem. 270, 18749-18758.
30. Spiegel, S., Olivera, A., and Carlson, R. O. (1993). The role of sphingosine in cell growth regulation and transmembrane signaling. Adv. Lipid Res. 25, 105-129.
31. Stevens, V. L., Nimkar, S., Jamison, W. C., Liotta, D. C., and Merrill, A. H., Jr. (1990). Characteristics of the growth inhibition and cytotoxicity of long-chain (sphingoid) bases for Chinese hamster ovary cells: Evidence for an involvement of protein kinase C. Biochim. Biophys. Acta 1051, 37-45.
32. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T., and Merrill, A. H., Jr. (1991). Inhibition of sphingolipidbiosynthesis by fumonisins: Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266, 14486-14490.
33. 1 cells. Toxicol. Appl. Pharmacol. 114, 9-15.
34. 1. Toxicol. in Vitro 10, 77-84.
35. Zhang, H., Buckley, N. E., Gibson, K., and Spiegel, S. (1990). Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway. J. Biol. Chem. 265, 76-81.
36. Zhang, H., Desai, N. N., Olivera, A., Seki, T., Booker, G., and Spiegel, S. (1991). Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell. Biol. 114, 155-167.