Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1585, Issue 2-3, 2002, Pages 188-192

  Desai, Kena ^a   Sullards, M Cameron ^a   Allegood, Jeremy ^a   Wang, Elaine ^a   Schmelz, Eva M ^b   Hartl, Michaela ^c   Humpf, Hans Ulrich ^c   Liotta, D C ^d   Peng, Qiong ^a   Merrill Jr , Alfred H ^a  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d EMORY UNIVERSITY   (United States)

Author keywords

Aminopentol; Apoptosis; Carcinogenesis; Ceramide synthase; Fumonisin; Sphinganine; Sphinganine 1 phosphate; Toxicity

Indexed keywords

FUMONISIN; MYCOTOXIN; N ACETYLSPHINGOSINE; N,N DIMETHYLSPHINGOSINE; SPHINGANINE; SPHINGOSINE; SPHINGOSINE ACYLTRANSFERASE; SPHINGOSINE DERIVATIVE; UNCLASSIFIED DRUG;

APOPTOSIS; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; LIPOGENESIS; METABOLISM; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALS; APOPTOSIS; CARBOXYLIC ACIDS; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; ENZYME INHIBITORS; FUMONISINS; GLYCOSPHINGOLIPIDS; HUMANS; LIVER NEOPLASMS; OXIDOREDUCTASES; SPHINGOLIPIDS; SPHINGOSINE; ZEA MAYS;

SPHINGIODEA; TETRAGASTRIS BALSAMIFERA;

EID: 0037203347     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(02)00340-2     Document Type: Review

References (37)

1. Marasas W.F.O. Environ. Health Perspect. 109(Suppl. 2):2001;239-243.
2. Sydenham E.W., Shepard G.S., Theil P.G., Marasas W.F.O. J. Agric. Food Chem. 40:1992;1352-1354.
3. Pittet A., Parisod V., Schellenberg M. J. Agric. Food Chem. 40:1992;1352-1354.
4. Haschek W.M., Gumprecht L.A., Smith G., Tumbleson M.E., Constable P.D. Environ. Health Perspect. 109(Suppl. 2):2001;251-257.
5. Merrill A.H. Jr., Sullards M.C., Wang E., Voss K.A., Riley R.T. Environ. Health Perspect. 109(Suppl. 2):2001;283-289.
6. Riley R.T., Enongene E., Voss K.A., Norred W.P., Meredith F.I., Sharme R.P., Spitsbergen J., Williams D.E., Carlson D.B., Merrill A.H. Jr. Environ. Health Perspect. 109(Suppl. 2):2001;301-308.
7. Bose R., Verheij M., Haimovitz-Friedman A., Scotto K., Fuks Z., Kolesnick R. Cell. 82:1995;405-414.
8. Schroeder J.J., Crane H.M., Xia J., Liotta D.C., Merrill A.H. Jr. J. Biol. Chem. 269:1994;3475-3481.
9. Merrill A.H. Jr., van Echten G., Wang E., Sandhoff K. J. Biol. Chem. 268:1993;27299-27306.
10. Humpf H.U., Schmelz E.M., Meredith F.I., Vesper H., Vales T.R., Menaldino D.S., Liotta D.C., Merrill A.H. Jr. J. Biol. Chem. 273:1998;19060-19064.
11. Ciacci-Zanella J.R. Jr., Merrill A.H. Jr., Wang E., Jones C. Food Chem. Toxicol. 36:1998;791-804.
12. Zhang Y., Dickman M.B., Jones C. J. Biol. Chem. 274:1999;12367-12371.
13. Schmelz E.M., Dombrink-Kurtzman M.A., Roberts P.C., Kozutsumi Y., Kawasaki T., Merrill A.H. Jr. Toxicol. Appl. Pharmacol. 148:1998;252-260.
14. Smith E.R., Jones P.L., Boss J.M., Merrill A.H. Jr. J. Biol. Chem. 272:1997;5640-5646.
15. Jones C., Ciacci-Zanella J.R., Zhang Y., Henderson G., Dickman M. Environ. Health Perspect. 109(Suppl. 2):2001;315-320.
16. Ramasamy S., Wang E., Hennig B., Merrill A.H. Jr. Toxicol. Appl. Pharmacol. 133:1995;343-348.
17. Wattenberg E.V., Badria F.A., Shier W.T. Biochem. Biophys. Res. Commun. 227:1996;622-627.
18. Pinelli E., Poux N., Garren L., Pipy B., Castegnaro M., Miller D.J., Pfohl-Leszkowicz A. Carcinogenesis. 20:1999;1683-1688.
19. Wang E., Ross P.F., Wilson T.M., Riley R.T., Merrill A.H. Jr. J. Nutr. 122:1992;1706-1716.
20. Riley R.T., An N.H., Showker J.L., Yoo H.S., Norred W.P., Chamberlain W.J., Wang E., Merrill A.H. Jr., Motelin G., Beasley V.R., Hascheck W.M. Toxicol. Appl. Pharmacol. 118:1993;105-112.
21. Gelderblom W.C.A., Abel S., Smuts C.M., Marnewick J., Marasas W.F.O. Environ. Health Perspect. 109(Suppl. 2):2001;291-300.
22. Howard P.C., Warbritton A., Voss K.A., Lorentzen R.J., Thurman J.D., Kovach R.M., Bucci T.J. Environ. Health Perspect. 109(Suppl. 2):2001;309-314.
23. Gelderblom W.C.A., Kriek N.P.J., Marasas W.F.O., Thiel P.G. Carcinogen. 12:1991;1247-1251.
24. Natl. Toxicol. Program Tech. Rep. Ser. (496):2001;1-352.
25. Norred W.P., Plattner R.D., Chamberlain W.J. Nat. Toxins. 1:1993;246-341.
26. Sullards M.C., Merrill A.H. Jr. Sci. Signal Transduct. Knowl. Environ. (67):January 30, 2001;PL1 http://www.stke.sciencemag.org.
27. Smith E.R., Merrill A.H. Jr. J. Biol. Chem. 270:1995;18749-18758.
28. Gennero I., Fauvel J., Nie'to M., Cariven C., Gaits F., Briand-Me'sange F., Chap H., Salles J.P. J. Biol. Chem. 277:2002;12724-12734.
29. Barbour S., Edidin M., Felding-Habermann B., Taylor-Norton J., Radin N.S., Fenderson B.A. J. Cell. Physiol. 150:1992;610-619.
30. Stevens V.L., Tang J. J. Biol. Chem. 272:1997;18020-18025.
31. Naslavsky N., Shmeeda H., Friedlander G., Yanai A., Futerman A.H., Barenholz Y., Taraboulos A. J. Biol. Chem. 274:1999;20763-20771.
32. Merrill A.H. Jr., Schmelz E.M., Dillehay D.L., Spiegel S., Shayman J.A., Schroeder J.J., Riley R.T., Voss K.A., Wang E. Toxicol. Appl. Pharmacol. 142:1997;208-225.
33. Voss K.A., Bacon C.W., Meredith F.I., Norred W.P. Food. Chem. Toxicol. 34:1996;623-632.
34. Hendrich S., Miller K.A., Wilson T.M., Murphy P.A. J. Agric. Food Chem. 41:1993;1649-1654.
35. Sharma R.P., Bhandari N., Riley R.T., Voss K.A., Meredith F.I. Toxicology. 143:2000;183-194.
36. Sharma R.P., Bhandari N., He Q., Riley R.T., Voss K.A. Toxicology. 159:2001;69-79.
37. Venkataraman K., Riebeling C., Bodennec J., Riezman H., Allegood J.C., Sullards M.C., Merrill A.H. Jr., Futerman A.H. J. Biol. Chem. 277:2002;35642-35649.