메뉴 건너뛰기




Volumn 49, Issue 3, 2007, Pages 306-317

Effects of combinations of Fusarium mycotoxins on the inhibition of macromolecular synthesis, malondialdehyde levels, DNA methylation and fragmentation, and viability in Caco-2 cells

Author keywords

Cell viability; Cellular macromolecules synthesis; DNA fragmentation; Fusarium toxins; Human intestinal Caco 2 cells; Interactive effects

Indexed keywords

5 METHYLCYTOSINE; ESTRADIOL; FUMONISIN B1; MALONALDEHYDE; MYCOTOXIN; NEUTRAL RED; VOMITOXIN; ZEARALENONE;

EID: 33846616733     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2006.09.029     Document Type: Article
Times cited : (165)

References (63)
  • 2
    • 0032538806 scopus 로고    scopus 로고
    • Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo
    • Abel S., and Gelderblom W.C. Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo. Toxicology 131 (1998) 121-131
    • (1998) Toxicology , vol.131 , pp. 121-131
    • Abel, S.1    Gelderblom, W.C.2
  • 3
    • 0032468368 scopus 로고    scopus 로고
    • Effects of Fusarium moniliforme culture extracts and fumonisin B1 on DNA, RNA and protein synthesis by baby hamster kidney cells
    • Abeywickrama K., Bean GA., and Kennedy KA. Effects of Fusarium moniliforme culture extracts and fumonisin B1 on DNA, RNA and protein synthesis by baby hamster kidney cells. Mycopathologia 143 (1998) 59-63
    • (1998) Mycopathologia , vol.143 , pp. 59-63
    • Abeywickrama, K.1    Bean, GA.2    Kennedy, KA.3
  • 4
    • 0142219463 scopus 로고    scopus 로고
    • DNA fragmentation, apoptosis and cell cycle arrest induced by zearalenone in cultured DOK, Vero and Caco-2 cells: prevention by Vitamin E
    • Abid-Essefi S., Baudrimont I., Hassen W., Ouanes Z., Mobio T.A., Anane R., Creppy E.E., and Bacha H. DNA fragmentation, apoptosis and cell cycle arrest induced by zearalenone in cultured DOK, Vero and Caco-2 cells: prevention by Vitamin E. Toxicology 192 (2003) 237-248
    • (2003) Toxicology , vol.192 , pp. 237-248
    • Abid-Essefi, S.1    Baudrimont, I.2    Hassen, W.3    Ouanes, Z.4    Mobio, T.A.5    Anane, R.6    Creppy, E.E.7    Bacha, H.8
  • 5
    • 2342480564 scopus 로고    scopus 로고
    • Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone
    • Abid-Essefi S., Ouanes Z., Hassen W., Baudrimont I., Creppy E.E., and Bacha H. Cytotoxicity, inhibition of DNA and protein syntheses and oxidative damage in cultured cells exposed to zearalenone. Toxicol. In Vitro 18 (2004) 467-474
    • (2004) Toxicol. In Vitro , vol.18 , pp. 467-474
    • Abid-Essefi, S.1    Ouanes, Z.2    Hassen, W.3    Baudrimont, I.4    Creppy, E.E.5    Bacha, H.6
  • 7
    • 0034103286 scopus 로고    scopus 로고
    • The effect of combinations of Fusarium mycotoxins (deoxynivalenol, zearalenon and fumonisin B1) on growth of brewing yeasts
    • Boeira L.S., Bryce J.H., Stewart G.G., and Flannigan B. The effect of combinations of Fusarium mycotoxins (deoxynivalenol, zearalenon and fumonisin B1) on growth of brewing yeasts. J. Appl. Microbiol. 88 (2000) 388-403
    • (2000) J. Appl. Microbiol. , vol.88 , pp. 388-403
    • Boeira, L.S.1    Bryce, J.H.2    Stewart, G.G.3    Flannigan, B.4
  • 8
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 11
    • 0031588774 scopus 로고    scopus 로고
    • Tyrosine prevents capsaicin-induced protein synthesis inhibition in cultured cells
    • Cochereau C., Sanchez D., and Creppy E.E. Tyrosine prevents capsaicin-induced protein synthesis inhibition in cultured cells. Toxicology 117 (1997) 133-139
    • (1997) Toxicology , vol.117 , pp. 133-139
    • Cochereau, C.1    Sanchez, D.2    Creppy, E.E.3
  • 12
    • 0027567737 scopus 로고
    • Biological action of mycotoxins
    • Coulombe R.A. Biological action of mycotoxins. J. Dairy Sci. 76 (1993) 880-891
    • (1993) J. Dairy Sci. , vol.76 , pp. 880-891
    • Coulombe, R.A.1
  • 13
    • 0037186863 scopus 로고    scopus 로고
    • Update of survey, regulation and toxic effects of mycotoxins in Europe
    • Creppy E.E. Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 127 (2002) 19-28
    • (2002) Toxicol. Lett. , vol.127 , pp. 19-28
    • Creppy, E.E.1
  • 14
    • 3543069308 scopus 로고    scopus 로고
    • Synergistic effects of Fumonisin B1 and Ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity?
    • Creppy E.E., Chiarappa P., Baudrimont I., Borracci P., Moukha S., and Carratù M.R. Synergistic effects of Fumonisin B1 and Ochratoxin A: are in vitro cytotoxicity data predictive of in vivo acute toxicity?. Toxicology 201 (2004) 115-123
    • (2004) Toxicology , vol.201 , pp. 115-123
    • Creppy, E.E.1    Chiarappa, P.2    Baudrimont, I.3    Borracci, P.4    Moukha, S.5    Carratù, M.R.6
  • 15
    • 0346668196 scopus 로고    scopus 로고
    • The occurrence of mycotoxins in key commodities in Bangladesh: surveillance results from 1993 to 1995
    • Dawlatana M., Coker R.D., Nagler M.J., Wild C.P., Hassan M.S., and Bluden G. The occurrence of mycotoxins in key commodities in Bangladesh: surveillance results from 1993 to 1995. J. Nat. Toxins 11 (2002) 379-386
    • (2002) J. Nat. Toxins , vol.11 , pp. 379-386
    • Dawlatana, M.1    Coker, R.D.2    Nagler, M.J.3    Wild, C.P.4    Hassan, M.S.5    Bluden, G.6
  • 16
    • 0028986148 scopus 로고
    • Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases
    • El Ghissassi F., Barbin A., Nair J., and Bartsch H. Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases. Chem. Res. Toxicol. 8 (1995) 278-283
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 278-283
    • El Ghissassi, F.1    Barbin, A.2    Nair, J.3    Bartsch, H.4
  • 19
    • 33846618407 scopus 로고    scopus 로고
    • Eriksen, G.S., Alexander, J., 1998. In: Nordic Council of Ministers, TemaNord (Eds.), Fusarium Toxins in Cereals-A Risk Assessment, vol. 502, Copenhagen, pp. 45-58.
  • 20
    • 0003130095 scopus 로고
    • Statistics for toxicologists
    • Hayes A.W. (Ed), Raven Press, New York
    • Gad S.C., and Neil C.S. Statistics for toxicologists. In: Hayes A.W. (Ed). Principles and Methods of Toxicology (1982), Raven Press, New York 273
    • (1982) Principles and Methods of Toxicology , pp. 273
    • Gad, S.C.1    Neil, C.S.2
  • 24
  • 26
    • 0344199409 scopus 로고    scopus 로고
    • Cytotoxicity and genotoxic effects of Zearalenone: Prevention by Vitamin E
    • Ghedira-chekir L., Maaroufi K., Creppy E.E., and Bacha H. Cytotoxicity and genotoxic effects of Zearalenone: Prevention by Vitamin E. J. Toxicol. 18 (1999) 355-368
    • (1999) J. Toxicol. , vol.18 , pp. 355-368
    • Ghedira-chekir, L.1    Maaroufi, K.2    Creppy, E.E.3    Bacha, H.4
  • 27
    • 0032465818 scopus 로고    scopus 로고
    • Statistically designed experiments to screen chemical mixtures for possible interactions
    • Groten J.P., Tajima O., Feron V.J., and Schoen E.D. Statistically designed experiments to screen chemical mixtures for possible interactions. Environ. Health Perspect. 106 (1998) 1361-1365
    • (1998) Environ. Health Perspect. , vol.106 , pp. 1361-1365
    • Groten, J.P.1    Tajima, O.2    Feron, V.J.3    Schoen, E.D.4
  • 28
    • 0037416726 scopus 로고    scopus 로고
    • Zearalenone induces male germ cell apoptosis in rats
    • Kim I.H., Son H.Y., Cho S.W., Ha C.S., and Kang B.H. Zearalenone induces male germ cell apoptosis in rats. Toxicol. Lett. 138 (2003) 185-192
    • (2003) Toxicol. Lett. , vol.138 , pp. 185-192
    • Kim, I.H.1    Son, H.Y.2    Cho, S.W.3    Ha, C.S.4    Kang, B.H.5
  • 29
    • 23944513331 scopus 로고    scopus 로고
    • Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2
    • Kouadio J.H., Mobio T.A., Baudrimont I., Moukha S., Dano S.D., and Creppy E.E. Comparative study of cytotoxicity and oxidative stress induced by deoxynivalenol, zearalenone or fumonisin B1 in human intestinal cell line Caco-2. Toxicology 213 (2005) 56-65
    • (2005) Toxicology , vol.213 , pp. 56-65
    • Kouadio, J.H.1    Mobio, T.A.2    Baudrimont, I.3    Moukha, S.4    Dano, S.D.5    Creppy, E.E.6
  • 30
    • 0031227822 scopus 로고    scopus 로고
    • Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and T-2 toxin or deoxynivalenol in broiler chicks
    • Kubena L.F., Edrington T.S., Harvey R.B., Buckley S.A., Phillips T.D., Rottinghaus G.E., and Casper H.H. Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and T-2 toxin or deoxynivalenol in broiler chicks. Poult. Sci. 76 (1997) 1239-1247
    • (1997) Poult. Sci. , vol.76 , pp. 1239-1247
    • Kubena, L.F.1    Edrington, T.S.2    Harvey, R.B.3    Buckley, S.A.4    Phillips, T.D.5    Rottinghaus, G.E.6    Casper, H.H.7
  • 32
    • 27644509568 scopus 로고    scopus 로고
    • Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor
    • Le Drean G., Auffret M., Batina P., Arnold F., Sibiril Y., Arzur D., and Parent-Massin D. Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor. Toxicol. In Vitro 19 (2005) 1015-1024
    • (2005) Toxicol. In Vitro , vol.19 , pp. 1015-1024
    • Le Drean, G.1    Auffret, M.2    Batina, P.3    Arnold, F.4    Sibiril, Y.5    Arzur, D.6    Parent-Massin, D.7
  • 33
    • 0033371598 scopus 로고    scopus 로고
    • Mycotoxins (trichothecenes, zearalenone and fumonisins) in cereals associated with human red-mold intoxications stored since 1989 and 1991 in China
    • Li F.Q., Luo X.Y., and Yoshizawa T. Mycotoxins (trichothecenes, zearalenone and fumonisins) in cereals associated with human red-mold intoxications stored since 1989 and 1991 in China. Nat. Toxins 7 (1999) 93-97
    • (1999) Nat. Toxins , vol.7 , pp. 93-97
    • Li, F.Q.1    Luo, X.Y.2    Yoshizawa, T.3
  • 35
    • 0031973970 scopus 로고    scopus 로고
    • 5-Methyldeoxycytosine as a biological marker of DNA damage induced by okadaïc acid in Vero cells
    • Matias W.G., and Creppy E.E. 5-Methyldeoxycytosine as a biological marker of DNA damage induced by okadaïc acid in Vero cells. Environ. Toxicol. Water Qual. 13 (1998) 83-87
    • (1998) Environ. Toxicol. Water Qual. , vol.13 , pp. 83-87
    • Matias, W.G.1    Creppy, E.E.2
  • 36
    • 0242573229 scopus 로고    scopus 로고
    • Toxicity and apoptosis induced by the mycotoxins nivalenol, Deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line
    • Minervini F., Fornelli F., and Flynn KM. Toxicity and apoptosis induced by the mycotoxins nivalenol, Deoxynivalenol and fumonisin B1 in a human erythroleukemia cell line. Toxicol. In Vitro 18 (2004) 21-28
    • (2004) Toxicol. In Vitro , vol.18 , pp. 21-28
    • Minervini, F.1    Fornelli, F.2    Flynn, KM.3
  • 40
    • 0024431109 scopus 로고
    • Drug-induced DNA hypermethylation and drug resistance in human tumors
    • Nyce J. Drug-induced DNA hypermethylation and drug resistance in human tumors. Cancer Res. 49 (1989) 5829-5836
    • (1989) Cancer Res. , vol.49 , pp. 5829-5836
    • Nyce, J.1
  • 41
    • 33846599032 scopus 로고    scopus 로고
    • NTP, National Toxicology Program USA, 1982. Technical report on the carcinogenesis bioassay of zearalenone (CAS No. 17924-92-4) in F 344/N rats and B6C3F1 mice (Feed Study). Research Triangle Park, NC NIH. Publ. no. 83-1791.
  • 42
    • 0038433245 scopus 로고    scopus 로고
    • Induction of micronuclei by zearalenone in Vero monkey kidney cells and in bone marrow cells of mice: protective effect of vitamin E
    • Ouanes Z., Abid S., Ayed I., Anane R., Mobio T., Creppy E.E., and Bacha H. Induction of micronuclei by zearalenone in Vero monkey kidney cells and in bone marrow cells of mice: protective effect of vitamin E. Mutat. Res. 538 (2003) 63-70
    • (2003) Mutat. Res. , vol.538 , pp. 63-70
    • Ouanes, Z.1    Abid, S.2    Ayed, I.3    Anane, R.4    Mobio, T.5    Creppy, E.E.6    Bacha, H.7
  • 43
    • 12344305164 scopus 로고    scopus 로고
    • Zearalenone induces chromosome aberrations in mouse bone marrow: preventive effect of 17beta-estradiol, progesterone and Vitamin E
    • Ouanes Z., Ayed-Boussema I., Baati T., Creppy E.E., and Bacha H. Zearalenone induces chromosome aberrations in mouse bone marrow: preventive effect of 17beta-estradiol, progesterone and Vitamin E. Mutat. Res. 565 (2005) 139-149
    • (2005) Mutat. Res. , vol.565 , pp. 139-149
    • Ouanes, Z.1    Ayed-Boussema, I.2    Baati, T.3    Creppy, E.E.4    Bacha, H.5
  • 44
    • 0028839564 scopus 로고
    • Genotoxicity of zearalenone, an oestrogenic mycotoxin: DNA adducts formation in female mouse tissues
    • Pfohl-Leszkowicz A., Chekir-Ghedira L., and Bacha H. Genotoxicity of zearalenone, an oestrogenic mycotoxin: DNA adducts formation in female mouse tissues. Carcinogenesis 16 (1995) 2315-2320
    • (1995) Carcinogenesis , vol.16 , pp. 2315-2320
    • Pfohl-Leszkowicz, A.1    Chekir-Ghedira, L.2    Bacha, H.3
  • 45
    • 0027661837 scopus 로고
    • Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine Perspective
    • Price W.D., Lovell R.A., and McChesney D.G. Naturally occurring toxins in feedstuffs: Center for Veterinary Medicine Perspective. J. Anim. Sci. 71 (1993) 2556-2562
    • (1993) J. Anim. Sci. , vol.71 , pp. 2556-2562
    • Price, W.D.1    Lovell, R.A.2    McChesney, D.G.3
  • 46
    • 0021168535 scopus 로고
    • DNA methylation patterns. Formation and function
    • Razin A., and Szyf M. DNA methylation patterns. Formation and function. Biochim. Biophys. Acta 782 (1984) 331-342
    • (1984) Biochim. Biophys. Acta , vol.782 , pp. 331-342
    • Razin, A.1    Szyf, M.2
  • 47
    • 0037960367 scopus 로고    scopus 로고
    • Sphingoid bases as possible diagnostic parameters
    • Ribar S., Mesaric M., and Sedic M. Sphingoid bases as possible diagnostic parameters. Croat. Med. J. 44 (2003) 165-170
    • (2003) Croat. Med. J. , vol.44 , pp. 165-170
    • Ribar, S.1    Mesaric, M.2    Sedic, M.3
  • 49
  • 51
    • 0034982739 scopus 로고    scopus 로고
    • Structure-activity relationships for human oestrogenic activity in zearalenone mycotoxins
    • Shier W.T., Shier A.C., Xie X., and Mirocha C.J. Structure-activity relationships for human oestrogenic activity in zearalenone mycotoxins. Toxicon 39 (2001) 1435-1438
    • (2001) Toxicon , vol.39 , pp. 1435-1438
    • Shier, W.T.1    Shier, A.C.2    Xie, X.3    Mirocha, C.J.4
  • 52
    • 0033553563 scopus 로고    scopus 로고
    • Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis
    • Shifrin V.I., and Anderson P. Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis. J. Biol. Chem. 274 (1999) 13985-13992
    • (1999) J. Biol. Chem. , vol.274 , pp. 13985-13992
    • Shifrin, V.I.1    Anderson, P.2
  • 53
    • 4444242105 scopus 로고    scopus 로고
    • Combined toxic effects of mycotoxins
    • Speijers G.J., and Speijers M.H. Combined toxic effects of mycotoxins. Toxicol. Lett. 153 (2004) 91-98
    • (2004) Toxicol. Lett. , vol.153 , pp. 91-98
    • Speijers, G.J.1    Speijers, M.H.2
  • 54
    • 0035902615 scopus 로고    scopus 로고
    • Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination
    • Sutton M.D., and Walker G.C. Managing DNA polymerases: coordinating DNA replication, DNA repair, and DNA recombination. Proc. Natl. Acad. Sci. USA 98 (2001) 8342-8349
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8342-8349
    • Sutton, M.D.1    Walker, G.C.2
  • 55
    • 0036225888 scopus 로고    scopus 로고
    • Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions
    • Tajima O., Schoen E.D., Feron V.J., and Groten J.P. Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions. Food Chem. Toxicol. 40 (2002) 685-695
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 685-695
    • Tajima, O.1    Schoen, E.D.2    Feron, V.J.3    Groten, J.P.4
  • 56
    • 0020696276 scopus 로고
    • Genotoxicity of Fusarium mycotoxins (nivalenol, fusarenon-X, T-2 toxin, and zearalenone) in Chinese hamster V79-E cells in vitro
    • Thust R., Kneist S., and Huhne V. Genotoxicity of Fusarium mycotoxins (nivalenol, fusarenon-X, T-2 toxin, and zearalenone) in Chinese hamster V79-E cells in vitro. Arch. Geschwulstforsch. 53 (1983) 9-15
    • (1983) Arch. Geschwulstforsch. , vol.53 , pp. 9-15
    • Thust, R.1    Kneist, S.2    Huhne, V.3
  • 57
    • 0038002236 scopus 로고    scopus 로고
    • Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing
    • Tost J., Dunker J., and Gut I.G. Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing. Biotechniques 35 (2003) 152-156
    • (2003) Biotechniques , vol.35 , pp. 152-156
    • Tost, J.1    Dunker, J.2    Gut, I.G.3
  • 58
    • 0030000466 scopus 로고    scopus 로고
    • Subchronic toxic effects of Fusarium moniliforme and fumonisin B1 in rats and mice
    • Voss K.A., Riley R.T., Bacon C.W., Chamberlain W.J., and Norred W.P. Subchronic toxic effects of Fusarium moniliforme and fumonisin B1 in rats and mice. Nat. Toxins 4 (1996) 16-23
    • (1996) Nat. Toxins , vol.4 , pp. 16-23
    • Voss, K.A.1    Riley, R.T.2    Bacon, C.W.3    Chamberlain, W.J.4    Norred, W.P.5
  • 59
    • 0031825272 scopus 로고    scopus 로고
    • In vivo effects of fumonisin B1-producing and fumonisin B1-nonproducing Fusarium moniliforme isolates are similar: fumonisins B2 and B3 cause hepato- and nephrotoxicity in rats
    • Voss K.A., Plattner R.D., Riley R.T., Meredith F.I., and Norred W.P. In vivo effects of fumonisin B1-producing and fumonisin B1-nonproducing Fusarium moniliforme isolates are similar: fumonisins B2 and B3 cause hepato- and nephrotoxicity in rats. Mycopathologia 141 (1998) 45-58
    • (1998) Mycopathologia , vol.141 , pp. 45-58
    • Voss, K.A.1    Plattner, R.D.2    Riley, R.T.3    Meredith, F.I.4    Norred, W.P.5
  • 60
    • 0029867051 scopus 로고    scopus 로고
    • Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells
    • Wang W., Jones C., Ciacci-Zanella J., Holt T., Gilchrist D.G., and Dickman M.B. Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells. Proc. Natl. Acad. Sci. USA 93 (1996) 3461-3465
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3461-3465
    • Wang, W.1    Jones, C.2    Ciacci-Zanella, J.3    Holt, T.4    Gilchrist, D.G.5    Dickman, M.B.6
  • 61
    • 0020697086 scopus 로고
    • Inhibition of DNA methylation by chemical carcigenogens in vitro
    • Wilson V.L., and Jones P.A. Inhibition of DNA methylation by chemical carcigenogens in vitro. Cell 32 (1983) 239-246
    • (1983) Cell , vol.32 , pp. 239-246
    • Wilson, V.L.1    Jones, P.A.2
  • 63
    • 24044504416 scopus 로고    scopus 로고
    • Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol
    • Zhou H.R., Islam Z., and Pestka J.J. Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol. Toxicol. Sci. 87 (2005) 113-122
    • (2005) Toxicol. Sci. , vol.87 , pp. 113-122
    • Zhou, H.R.1    Islam, Z.2    Pestka, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.