Fumonisin B1-induced apoptosis is associated with delayed inhibition of protein kinase C, nuclear factor-κB and tumor necrosis factor α in LLC-PK1 cells

Chemico-Biological Interactions

Volumn 146, Issue 2, 2003, Pages 131-145

  Gopee, Neera V ^a,b   He, Quanren ^a   Sharma, Raghubir P ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Apoptosis; Caspase 3; Fumonisin B1; Nuclear factor kappa B; Phorbol 12 myristate 13 acetate; Protein kinase C; Tumor necrosis factor

Indexed keywords

FUMONISIN B1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA; CARCINOGEN; CASPASE; CASPASE 3; ENZYME INHIBITOR; FUMONISIN; ISOENZYME; MESSENGER RNA; MYCOTOXIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL GROWTH; CELL STRAIN; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; ANIMAL; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; EPITHELIUM CELL; GENETICS; KIDNEY; METABOLISM; PATHOLOGY; PROTEIN SYNTHESIS; SWINE;

SUIDAE;

ANIMALS; APOPTOSIS; CARCINOGENS, ENVIRONMENTAL; CASPASE 3; CASPASES; CELL LINE; CELL MEMBRANE; CELL NUCLEUS; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPITHELIAL CELLS; FUMONISINS; ISOENZYMES; KIDNEY; MYCOTOXINS; NF-KAPPA B; PROTEIN BIOSYNTHESIS; PROTEIN KINASE C; RNA, MESSENGER; SWINE; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0142187112     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(03)00102-9     Document Type: Article

References (57)

1. 3 content of commercial unprocessed maize imported into South Africa from Argentina and the USA during 1992. Food Addit. Contam. 15:1998;676-680.
2. 1 isolated from Fusarium moniliforme. Onderstepoort J. Vet. Res. 55:1988;197-203.
3. 1, a toxic metabolite of Fusarium moniliforme. J. Vet. Diagn. Invest. 2:1990;217-221.
4. 1 carcinogenicity in a two-year feeding study using F344 rats and B6C3F1 mice. Environ. Health Perspect. 109:(Suppl 2):2001;277-282.
5. Sydenham E.W., Thiel P.G., Marasas W.F.O., Shephard G.S., van Schalkwyk D.J., Koch K.R. Natural occurrence of some Fusarium mycotoxins in corn from low and high esophageal cancer prevalence areas of Transkei. South Africa. J.Agric.Food Chem. 38:2000;1900-1903.
6. Wang E., Norred W.P., Bacon C.W., Riley R.T., Merrill A.H. Jr. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266:1991;14486-14490.
7. Norred W.P., Bacon C.W., Riley R.T., Voss K.A., Meredith F.I. Screening of fungal species for fumonisin production and fumonisin-like disruption of sphingolipid biosynthesis. Mycopathologia. 146:1999;91-98.
8. Riley R.T., Voss K.A., Norred W.P., Sharma R.P., Wang E., Merrill A.H. Fumonisins: mechanism of mycotoxicity. Rev. Med. Vet. 149:1998;617-626.
9. 1 toxicity. J. Pharmacol. Exp. Ther. 285:1998;317-324.
10. Sharma R.P., Bhandari N., Riley R.T., Voss K.A., Meredith F.I. Tolerance to fumonisin toxicity in a mouse strain lacking the P75 tumor necrosis factor receptor. Toxicology. 143:2000;183-194.
11. Sharma R.P., Bhandari N., Tsunoda M., Riley R.T., Voss K.A. Fumonisin hepatotoxicity is reduced in mice carrying the human tumour necrosis factor α transgene. Arch. Toxicol. 74:2000;238-248.
12. Sharma R.P., Bhandari N., He Q., Riley R.T., Voss K.A. Decreased fumonisin hepatotoxicity in mice with a targeted deletion of tumor necrosis factor receptor 1. Toxicology. 159:2001;69-79.
13. Lee J.Y., Hannun Y.A., Obeid L.M. Functional dichotomy of protein kinase C (PKC) in tumor necrosis factor-α (TNF-α) signal transduction in L929 cells. Translocation and inactivation of PKC by TNF-α J. Biol. Chem. 275:2000;29290-29298.
14. Mellor H., Parker P.J. The extended protein kinase C superfamily. Biochem. J. 332:1998;281-292.
15. Pontremoli S., Melloni E., Sparatore B., Michetti M., Salamino F., Horecker B.L. Isozymes of protein kinase C in human neutrophils and their modification by two endogenous proteinases. J. Biol. Chem. 265:1990;706-712.
16. Kontny E., Kurowska M., Szczepanska K., Maslinski W. Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes. J. Leukoc. Biol. 67:2000;249-258.
17. Kang J.L., Pack I.S., Hong S.M., Lee H.S., Castranova V. Silica induces nuclear factor-kappa B activation through tyrosine phosphorylation of I kappa B-alpha in RAW264.7 macrophages. Toxicol. Appl. Pharmacol. 169:2000;59-65.
18. Barnes P.J., Karin M. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1997;1066-1071.
19. Aggarwal B.B., Natarajan K. Tumor necrosis factors: developments during the last decade. Eur. Cytokine Netw. 7:1996;93-124.
20. Wang C.Y., Mayo M.W., Korneluk R.G., Goeddel D.V., Baldwin A.S. Jr. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science. 281:1998;1680-1683.
21. Riley R.T., Enongene E., Voss K.A., Norred W.P., Meredith F.I., Sharma R.P., Spitsbergen J., Williams D.E., Carlson D.B., Merrill A.H. Jr. Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis. Environ. Health Perspect. 109:(Suppl. 2):2001;301-308.
22. 1 in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells. Carcinogenesis. 17:1996;239-249.
23. 1 in rats and mice. Nat. Toxins. 4:1996;16-23.
24. 1. J. Comp. Pathol. 117:1997;371-381.
25. Koriyama H., Kouchi Z., Umeda T., Saido T.C., Momoi T., Ishiura S., Suzuki K. Proteolytic activation of protein kinase C delta and epsilon by caspase-3 in U937 cells during chemotherapeutic agent-induced apoptosis. Cell Signal. 11:1999;831-838.
26. Au J.L., Panchal N., Li D., Gan Y. Apoptosis: a new pharmacodynamic endpoint. Pharm. Res. 14:1997;1659-1671.
27. Hannun Y.A., Loomis C.R., Merrill A.H. Jr, Bell R.M. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J. Biol. Chem. 261:1986;12604-12609.
28. Hannun Y.A., Bell R.M. Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses. Science. 235:1987;670-674.
29. Huang C., Dickman M., Henderson G., Jones C. Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen. Cancer Res. 55:1995;1655-1659.
30. 1 induces protein kinase C translocation via direct interaction with diacylglycerol binding site. Toxicol. Appl. Pharmacol. 141:1996;178-184.
31. He Q., Riley R.T., Sharma R.P. Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition. Toxicol. Appl. Pharmacol. 174:2001;69-77.
32. Yoo H.S., Norred W.P., Showker J., Riley R.T. Elevated sphingoid bases and complex sphingolipid depletion as contributing factors in fumonisin-induced cytotoxicity. Toxicol. Appl. Pharmacol. 138:1996;211-218.
33. 1 renal epithelial cells via a sphinganine- and calmodulin-dependent pathway. Toxicol. Appl. Pharmacol. 176:2001;118-126.
34. 1 cells. Toxicol. Sci. 66:(S-1):2002;7.
35. 1 cytotoxicity. Toxicology. 187:2003;239-250.
36. 1-treated porcine renal epithelial cells is mediated via activation of protein kinase C-α and nuclear factor-κB. Toxicol. Sci. 72:(S-1):2003;254.
37. Smith E.R., Jones P.L., Boss J.M., Merrill A.H. Jr. Changing J774A.1 cells to new medium perturbs multiple signaling pathways, including the modulation of protein kinase C by endogenous sphingoid bases. J. Biol. Chem. 272:1997;5640-5646.
38. 1 renal epithelia. Kidney Int. 58:2000;1004-1015.
39. 2 receptor coupled to NF-κB. Am. J. Physiol. Renal Physiol. 278:2000;F270-F278.
40. 2+, phospholipid-dependent protein kinase associated with plasma membrane. Nature. 301:1983;621-623.
41. 1 cells. Toxicol. Appl. Pharmacol. 114:1992;9-15.
42. 2 and Alternaria alternata f. sp. lycopersici toxin (AAL) in cultured mammalian cells. Mycopathologia. 116:1991;97-104.
43. 1. Neurochem. Res. 27:2002;345-351.
44. 1 on cell death in cultured cells: the significance of the elevated sphinganine. Arch. Pharm. Res. 24:2001;136-143.
45. Huwiler A., Fabbro D., Pfeilschifter J. Differential recovery of protein kinase C-alpha and -epsilon isozymes after long-term phorbol ester treatment in rat renal mesangial cells. Biochem. Biophys. Res. Commun. 180:1991;1422-1428.
46. Huwiler A., Fabbro D., Stabel S., Pfeilschifter J. Immunocharacterization of delta- and zeta-isoenzymes of protein kinase C in rat renal mesangial cells. FEBS Lett. 300:1992;259-262.
47. Schnaper H.W. Signal transduction through protein kinase C. Pediatr. Nephrol. 14:2000;254-258.
48. Reyland M.E., Anderson S.M., Matassa A.A., Barzen K.A., Quissell D.O. Protein kinase C delta is essential for etoposide-induced apoptosis in salivary gland acinar cells. J. Biol. Chem. 274:1999;19115-19123.
49. Chmura S.J., Nodzenski E., Weichselbaum R.R., Quintans J. Protein kinase C inhibition induces apoptosis and ceramide production through activation of a neutral sphingomyelinase. Cancer Res. 56:1996;2711-2714.
50. Suga K., Sugimoto I., Ito H., Hashimoto E. Down-regulation of protein kinase C-alpha detected in human colorectal cancer. Biochem. Mol. Biol. Int. 44:1998;523-528.
51. Scaglione-Sewell B., Abraham C., Bissonnette M., Skarosi S.F., Hart J., Davidson N.O., Wali R.K., Davis B.H., Sitrin M., Brasitus T.A. Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. Cancer Res. 58:1998;1074-1081.
52. Merrill A.H. Jr, Hannun Y.A., Bell R.M. Introduction: sphingolipids and their metabolites in cell regulation. Adv. Lipid Res. 25:1993;1-24.
53. Clemens M.J., Trayner I., Menaya J. The role of protein kinase C isoenzymes in the regulation of cell proliferation and differentiation. J. Cell Sci. 103:(Pt 4):1992;881-887.
54. Baron C.L., Malhotra V. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science. 295:2002;325-328.
55. Mege J.L., Sanguedolce M.V., Jacob T., Bongrand P., Capo C., Myssiakine E.B., Barot-Ciorbaru R. Nocardia fractions, NLD and NWSM, induce tumor necrosis factor-alpha secretion in human monocytes: role of protein kinase C. Eur. J. Immunol. 23:1993;1582-1587.
56. Kontny E., Ziolkowska M., Ryzewska A., Maslinski W. Protein kinase c-dependent pathway is critical for the production of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Cytokine. 11:1999;839-848.
57. Siflinger-Birnboim A., Johnson A. Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 284:2003;L435-451.