메뉴 건너뛰기




Volumn 43, Issue 9, 2012, Pages 1347-1362

Advances in the molecular pathobiology of B-lymphoblastic leukemia

Author keywords

B cell development; B lymphoblastic leukemia; Clonal evolution; Genomic; Molecular pathology

Indexed keywords

BREAKPOINT CLUSTER REGION PROTEIN; CD15 ANTIGEN; CD19 ANTIGEN; CD200 ANTIGEN; CD22 ANTIGEN; CD33 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA NUCLEOTIDYLEXOTRANSFERASE; ERYTHROPOIETIN RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 7 RECEPTOR ALPHA; JANUS KINASE; MICRORNA; MICRORNA 125B1; MICROSOMAL AMINOPEPTIDASE; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN KINASE SYK; PROTEIN KINASE TYK2; PROTEIN MCL 1; RETICULIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PBX1; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84864284051     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.02.004     Document Type: Article
Times cited : (56)

References (132)
  • 1
    • 0033759812 scopus 로고    scopus 로고
    • Precursor B-cell lymphoblastic lymphoma: A predominantly extranodal tumor with low propensity for leukemic involvement
    • P. Lin, D. Jones, and D.M. Dorfman Precursor B-cell lymphoblastic lymphoma: a predominantly extranodal tumor with low propensity for leukemic involvement Am J Surg Pathol 24 2000 1480 1490
    • (2000) Am J Surg Pathol , vol.24 , pp. 1480-1490
    • Lin, P.1    Jones, D.2    Dorfman, D.M.3
  • 3
    • 0141675132 scopus 로고    scopus 로고
    • The biology and therapy of adult acute lymphoblastic leukemia
    • DOI 10.1002/cncr.11664
    • S. Faderl, S. Jeha, and H.M. Kantarjian The biology and therapy of adult acute lymphoblastic leukemia Cancer 98 2003 1337 1354 (Pubitemid 37151487)
    • (2003) Cancer , vol.98 , Issue.7 , pp. 1337-1354
    • Faderl, S.1    Jeha, S.2    Kantarjian, H.M.3
  • 4
    • 0024818985 scopus 로고
    • Bone marrow fibrosis in childhood acute lymphoblastic leukaemia
    • J.P. Wallis, and M.M. Reid Bone marrow fibrosis in childhood acute lymphoblastic leukaemia J Clin Pathol 42 1989 1253 1254 (Pubitemid 20035909)
    • (1989) Journal of Clinical Pathology , vol.42 , Issue.12 , pp. 1253-1254
    • Wallis, J.P.1    Reid, M.M.2
  • 6
    • 0030995678 scopus 로고    scopus 로고
    • Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A Pediatric Oncology Group study
    • M.J. Borowitz, J. Shuster, and A.J. Carroll Prognostic significance of fluorescence intensity of surface marker expression in childhood B-precursor acute lymphoblastic leukemia. A Pediatric Oncology Group Study Blood 89 1997 3960 3966 (Pubitemid 27220939)
    • (1997) Blood , vol.89 , Issue.11 , pp. 3960-3966
    • Borowitz, M.J.1    Shuster, J.2    Carroll, A.J.3    Nash, M.4    Look, A.T.5    Camitta, B.6    Mahoney, D.7    Lauer, S.J.8    Pullen, D.J.9
  • 7
    • 67650594764 scopus 로고    scopus 로고
    • Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia
    • D.A. Thomas, S. O'Brien, and J.L. Jorgensen Prognostic significance of CD20 expression in adults with de novo precursor B-lineage acute lymphoblastic leukemia Blood 113 2009 6330 6337
    • (2009) Blood , vol.113 , pp. 6330-6337
    • Thomas, D.A.1    O'Brien, S.2    Jorgensen, J.L.3
  • 8
    • 0022647730 scopus 로고
    • Lineage promiscuity in hemopoietic differentiation and leukemia
    • M.F. Greaves, L.C. Chan, and A.J. Furley Lineage promiscuity in hemopoietic differentiation and leukemia Blood 67 1986 1 11 (Pubitemid 16167003)
    • (1986) Blood , vol.67 , Issue.1 , pp. 1-11
    • Greaves, M.F.1    Chan, L.C.2    Furley, A.J.W.3
  • 12
    • 1642311876 scopus 로고    scopus 로고
    • Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent
    • DOI 10.1016/S1074-7613(04)00049-4, PII S1074761304000494
    • T. Ikawa, H. Kawamoto, and L.Y. Wright Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent Immunity 20 2004 349 360 (Pubitemid 38388236)
    • (2004) Immunity , vol.20 , Issue.3 , pp. 349-360
    • Ikawa, T.1    Kawamoto, H.2    Wright, L.Y.T.3    Murre, C.4
  • 13
    • 18644373047 scopus 로고    scopus 로고
    • PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    • DOI 10.1084/jem.20050075
    • A. Dakic, D. Metcalf, and L. Di Rago PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis J Exp Med 201 2005 1487 1502 (Pubitemid 40664092)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.9 , pp. 1487-1502
    • Dakic, A.1    Metcalf, D.2    Di Rago, L.3    Mifsud, S.4    Wu, L.5    Nutt, S.L.6
  • 14
    • 33645109285 scopus 로고    scopus 로고
    • Early hematopoietic lineage restrictions directed by Ikaros
    • T. Yoshida, S.Y. Ng, and J.C. Zuniga-Pflucker Early hematopoietic lineage restrictions directed by Ikaros Nat Immunol 7 2006 382 391
    • (2006) Nat Immunol , vol.7 , pp. 382-391
    • Yoshida, T.1    Ng, S.Y.2    Zuniga-Pflucker, J.C.3
  • 15
    • 0034717335 scopus 로고    scopus 로고
    • Regulation of B lymphocyte and macrophage development by graded expression of PU.1
    • R.P. DeKoter, and H. Singh Regulation of B lymphocyte and macrophage development by graded expression of PU.1 Science 288 2000 1439 1441
    • (2000) Science , vol.288 , pp. 1439-1441
    • Dekoter, R.P.1    Singh, H.2
  • 17
    • 47849118209 scopus 로고    scopus 로고
    • Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros
    • D. Reynaud, I.A. Demarco, and K.L. Reddy Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros Nat Immunol 9 2008 927 936
    • (2008) Nat Immunol , vol.9 , pp. 927-936
    • Reynaud, D.1    Demarco, I.A.2    Reddy, K.L.3
  • 18
    • 0028148938 scopus 로고
    • The helix-loop-helix gene E2A is required for B cell formation
    • DOI 10.1016/0092-8674(94)90076-0
    • Y. Zhuang, P. Soriano, and H. Weintraub The helix-loop-helix gene E2A is required for B cell formation Cell 79 1994 875 884 (Pubitemid 24371977)
    • (1994) Cell , vol.79 , Issue.5 , pp. 875-884
    • Zhuang, Y.1    Soriano, P.2    Weintraub, H.3
  • 19
    • 44649186791 scopus 로고    scopus 로고
    • Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
    • K. Kwon, C. Hutter, and Q. Sun Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development Immunity 28 2008 751 762
    • (2008) Immunity , vol.28 , pp. 751-762
    • Kwon, K.1    Hutter, C.2    Sun, Q.3
  • 20
    • 34848853915 scopus 로고    scopus 로고
    • Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors
    • DOI 10.1038/nature06159, PII NATURE06159
    • C. Cobaleda, W. Jochum, and M. Busslinger Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors Nature 449 2007 473 477 (Pubitemid 47509547)
    • (2007) Nature , vol.449 , Issue.7161 , pp. 473-477
    • Cobaleda, C.1    Jochum, W.2    Busslinger, M.3
  • 21
    • 38449102306 scopus 로고    scopus 로고
    • Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
    • J.M. Pongubala, D.L. Northrup, and D.W. Lancki Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5 Nat Immunol 9 2008 203 215
    • (2008) Nat Immunol , vol.9 , pp. 203-215
    • Pongubala, J.M.1    Northrup, D.L.2    Lancki, D.W.3
  • 22
    • 70350596826 scopus 로고    scopus 로고
    • A robust and highly efficient immune cell reprogramming system
    • L.H. Bussmann, A. Schubert, and T.P. Vu Manh A robust and highly efficient immune cell reprogramming system Cell Stem Cell 5 2009 554 566
    • (2009) Cell Stem Cell , vol.5 , pp. 554-566
    • Bussmann, L.H.1    Schubert, A.2    Vu Manh, T.P.3
  • 24
    • 18244386710 scopus 로고    scopus 로고
    • IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
    • DOI 10.1084/jem.20050158
    • K. Kikuchi, A.Y. Lai, and C.L. Hsu IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF J Exp Med 201 2005 1197 1203 (Pubitemid 40629064)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.8 , pp. 1197-1203
    • Kikuchi, K.1    Lai, A.Y.2    Hsu, C.-L.3    Kondo, M.4
  • 25
    • 41149149301 scopus 로고    scopus 로고
    • Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B
    • DOI 10.1101/gad.1643908
    • L. Hennighausen, and G.W. Robinson Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B Genes Dev 22 2008 711 721 (Pubitemid 351439101)
    • (2008) Genes and Development , vol.22 , Issue.6 , pp. 711-721
    • Hennighausen, L.1    Robinson, G.W.2
  • 26
    • 0042469392 scopus 로고    scopus 로고
    • EBF-regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells
    • DOI 10.1002/eji.200323974
    • S. Hirokawa, H. Sato, and I. Kato EBF-regulating Pax5 transcription is enhanced by STAT5 in the early stage of B cells Eur J Immunol 33 2003 1824 1829 (Pubitemid 37120853)
    • (2003) European Journal of Immunology , vol.33 , Issue.7 , pp. 1824-1829
    • Hirokawa, S.1    Sato, H.2    Kato, I.3    Kudo, A.4
  • 27
    • 17144422917 scopus 로고    scopus 로고
    • Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors
    • DOI 10.1084/jem.20042393
    • S. Dias, H. Silva Jr., and A. Cumano Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors J Exp Med 201 2005 971 979 (Pubitemid 40524466)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.6 , pp. 971-979
    • Dias, S.1    Silva Jr., H.2    Cumano, A.3    Vieira, P.4
  • 28
    • 75649093758 scopus 로고    scopus 로고
    • Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    • S. Malin, S. McManus, and C. Cobaleda Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development Nat Immunol 11 2010 171 179
    • (2010) Nat Immunol , vol.11 , pp. 171-179
    • Malin, S.1    McManus, S.2    Cobaleda, C.3
  • 29
    • 0032402316 scopus 로고    scopus 로고
    • Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression
    • A.J. Marshall, H.E. Fleming, and G.E. Wu Modulation of the IL-7 dose-response threshold during pro-B cell differentiation is dependent on pre-B cell receptor expression J Immunol 161 1998 6038 6045 (Pubitemid 28535973)
    • (1998) Journal of Immunology , vol.161 , Issue.11 , pp. 6038-6045
    • Marshall, A.J.1    Fleming, H.E.2    Wu, G.E.3    Paige, C.J.4
  • 30
    • 0034748389 scopus 로고    scopus 로고
    • Pre-B cell receptor signaling mediates selective response to IL-7 at the Pro-B to Pre-B cell transition via an ERK/MAP kinase-dependent pathway
    • DOI 10.1016/S1074-7613(01)00216-3
    • H.E. Fleming, and C.J. Paige Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway Immunity 15 2001 521 531 (Pubitemid 33016438)
    • (2001) Immunity , vol.15 , Issue.4 , pp. 521-531
    • Fleming, H.E.1    Paige, C.J.2
  • 31
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene
    • D. Kitamura, J. Roes, and R. Kuhn A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene Nature 350 1991 423 426 (Pubitemid 21912244)
    • (1991) Nature , vol.350 , Issue.6317 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kuhn, R.3    Rajewsky, K.4
  • 33
    • 0028889302 scopus 로고
    • Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
    • M. Turner, P.J. Mee, and P.S. Costello Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk Nature 378 1995 298 302
    • (1995) Nature , vol.378 , pp. 298-302
    • Turner, M.1    Mee, P.J.2    Costello, P.S.3
  • 36
    • 80052922387 scopus 로고    scopus 로고
    • Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group
    • J. Zhang, C.G. Mullighan, and R.C. Harvey Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group Blood 118 2011 3080 3087
    • (2011) Blood , vol.118 , pp. 3080-3087
    • Zhang, J.1    Mullighan, C.G.2    Harvey, R.C.3
  • 37
    • 0025137176 scopus 로고
    • A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
    • M.P. Kamps, C. Murre, and X.H. Sun A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL Cell 60 1990 547 555
    • (1990) Cell , vol.60 , pp. 547-555
    • Kamps, M.P.1    Murre, C.2    Sun, X.H.3
  • 38
    • 0141922983 scopus 로고    scopus 로고
    • Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1
    • DOI 10.1016/S1097-2765(03)00277-6
    • K.S. Smith, S.K. Chanda, and M. Lingbeek Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1 Mol Cell 12 2003 393 400 (Pubitemid 37238926)
    • (2003) Molecular Cell , vol.12 , Issue.2 , pp. 393-400
    • Smith, K.S.1    Chanda, S.K.2    Lingbeek, M.3    Ross, D.T.4    Botstein, D.5    Van Lohuizen, M.6    Cleary, M.L.7
  • 40
    • 79751529186 scopus 로고    scopus 로고
    • The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors
    • J. de Boer, J. Yeung, and J. Ellu The E2A-HLF oncogenic fusion protein acts through Lmo2 and Bcl-2 to immortalize hematopoietic progenitors Leukemia 25 2011 321 330
    • (2011) Leukemia , vol.25 , pp. 321-330
    • De Boer, J.1    Yeung, J.2    Ellu, J.3
  • 41
    • 77956528501 scopus 로고    scopus 로고
    • Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)
    • K. Hirose, T. Inukai, and J. Kikuchi Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19) Blood 116 2010 962 970
    • (2010) Blood , vol.116 , pp. 962-970
    • Hirose, K.1    Inukai, T.2    Kikuchi, J.3
  • 42
    • 77952305440 scopus 로고    scopus 로고
    • Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: Results from the UK Medical Research Council ALL97/99 randomised trial
    • A.V. Moorman, H.M. Ensor, and S.M. Richards Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97/99 randomised trial Lancet Oncol 11 2010 429 438
    • (2010) Lancet Oncol , vol.11 , pp. 429-438
    • Moorman, A.V.1    Ensor, H.M.2    Richards, S.M.3
  • 43
    • 0033987718 scopus 로고    scopus 로고
    • Reversibility of acute B-cell leukaemia induced by BCR-ABL1
    • DOI 10.1038/71691
    • C.S. Huettner, P. Zhang, and R.A. Van Etten Reversibility of acute B-cell leukaemia induced by BCR-ABL1 Nat Genet 24 2000 57 60 (Pubitemid 30041421)
    • (2000) Nature Genetics , vol.24 , Issue.1 , pp. 57-60
    • Huettner, C.S.1    Zhang, P.2    Van Etten, R.A.3    Tenen, D.G.4
  • 45
    • 0031034526 scopus 로고    scopus 로고
    • Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA
    • DOI 10.1046/j.1365-2141.1997.d01-2053.x
    • L.M. Secker-Walker, H.G. Prentice, and J. Durrant Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA. MRC Adult Leukaemia Working Party Br J Haematol 96 1997 601 610 (Pubitemid 27087248)
    • (1997) British Journal of Haematology , vol.96 , Issue.3 , pp. 601-610
    • Secker-Walker, L.M.1    Prentice, H.G.2    Durrant, J.3    Richards, S.4    Hall, E.5    Harrison, G.6
  • 47
    • 75649092322 scopus 로고    scopus 로고
    • A population-based cytogenetic study of adults with acute lymphoblastic leukemia
    • A.V. Moorman, L. Chilton, and J. Wilkinson A population-based cytogenetic study of adults with acute lymphoblastic leukemia Blood 115 2010 206 214
    • (2010) Blood , vol.115 , pp. 206-214
    • Moorman, A.V.1    Chilton, L.2    Wilkinson, J.3
  • 48
    • 68749120703 scopus 로고    scopus 로고
    • New insights to the MLL recombinome of acute leukemias
    • C. Meyer, E. Kowarz, and J. Hofmann New insights to the MLL recombinome of acute leukemias Leukemia 23 2009 1490 1499
    • (2009) Leukemia , vol.23 , pp. 1490-1499
    • Meyer, C.1    Kowarz, E.2    Hofmann, J.3
  • 49
    • 33745941911 scopus 로고    scopus 로고
    • Amurine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy
    • DOI 10.1182/blood-2005-08-3498
    • W. Chen, Q. Li, and W.A. Hudson A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy Blood 108 2006 669 677 (Pubitemid 44061369)
    • (2006) Blood , vol.108 , Issue.2 , pp. 669-677
    • Chen, W.1    Li, Q.2    Hudson, W.A.3    Kumar, A.4    Kirchhof, N.5    Kersey, J.H.6
  • 51
    • 79955958417 scopus 로고    scopus 로고
    • + cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia
    • + cells enhances the hematopoietic repopulating cell function and clonogenic potential but is not sufficient to initiate leukemia Blood 117 2011 4746 4758
    • (2011) Blood , vol.117 , pp. 4746-4758
    • Montes, R.1    Ayllon, V.2    Gutierrez-Aranda, I.3
  • 52
    • 77951749557 scopus 로고    scopus 로고
    • The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4
    • A. Bursen, K. Schwabe, and B. Ruster The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4 Blood 115 2010 3570 3579
    • (2010) Blood , vol.115 , pp. 3570-3579
    • Bursen, A.1    Schwabe, K.2    Ruster, B.3
  • 55
    • 84864283262 scopus 로고    scopus 로고
    • B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: Is it therapy-related?
    • [Epub ahead of print]
    • G. Tang, Z. Zuo, and D.A. Thomas B-acute lymphoblastic leukemia occurring in patients with a history of prior malignancies: is it therapy-related? Haematologica 2011 [Epub ahead of print]
    • (2011) Haematologica
    • Tang, G.1    Zuo, Z.2    Thomas, D.A.3
  • 56
    • 0031034526 scopus 로고    scopus 로고
    • Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA
    • DOI 10.1046/j.1365-2141.1997.d01-2053.x
    • L.M. Secker-Walker, and H.G. Prentice Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukemia on MRC trial UKALL XA Br J Haematol 96 1997 601 610 (Pubitemid 27087248)
    • (1997) British Journal of Haematology , vol.96 , Issue.3 , pp. 601-610
    • Secker-Walker, L.M.1    Prentice, H.G.2    Durrant, J.3    Richards, S.4    Hall, E.5    Harrison, G.6
  • 61
    • 58749109707 scopus 로고    scopus 로고
    • Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
    • C.G. Mullighan, X. Su, and J. Zhang Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia N Engl J Med 360 2009 470 480
    • (2009) N Engl J Med , vol.360 , pp. 470-480
    • Mullighan, C.G.1    Su, X.2    Zhang, J.3
  • 62
    • 38349183668 scopus 로고    scopus 로고
    • Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
    • D. Hong, R. Gupta, and P. Ancliff Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia Science 319 2008 336 339
    • (2008) Science , vol.319 , pp. 336-339
    • Hong, D.1    Gupta, R.2    Ancliff, P.3
  • 67
    • 79959510774 scopus 로고    scopus 로고
    • Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia
    • V. Rand, H. Parker, and L.J. Russell Genomic characterization implicates iAMP21 as a likely primary genetic event in childhood B-cell precursor acute lymphoblastic leukemia Blood 117 2011 6848 6855
    • (2011) Blood , vol.117 , pp. 6848-6855
    • Rand, V.1    Parker, H.2    Russell, L.J.3
  • 70
    • 77949910163 scopus 로고    scopus 로고
    • Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: Rare clinical curios or potent genetic drivers?
    • M.J. Dyer, T. Akasaka, and M. Capasso Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers? Blood 115 2010 1490 1499
    • (2010) Blood , vol.115 , pp. 1490-1499
    • Dyer, M.J.1    Akasaka, T.2    Capasso, M.3
  • 72
    • 57649219316 scopus 로고    scopus 로고
    • B-cell precursor t(8;14)(q11;q32)-positive acute lymphoblastic leukemia in children is strongly associated with Down syndrome or with a concomitant Philadelphia chromosome
    • C. Lundin, J. Heldrup, and T. Ahlgren B-cell precursor t(8;14)(q11;q32)-positive acute lymphoblastic leukemia in children is strongly associated with Down syndrome or with a concomitant Philadelphia chromosome Eur J Haematol 82 2009 46 53
    • (2009) Eur J Haematol , vol.82 , pp. 46-53
    • Lundin, C.1    Heldrup, J.2    Ahlgren, T.3
  • 73
    • 38049126095 scopus 로고    scopus 로고
    • T(6;14)(p22;q32): A new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
    • L.J. Russell, T. Akasaka, and A. Majid t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) Blood 111 2008 387 391
    • (2008) Blood , vol.111 , pp. 387-391
    • Russell, L.J.1    Akasaka, T.2    Majid, A.3
  • 74
    • 62549141516 scopus 로고    scopus 로고
    • A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin
    • L.J. Russell, D.G. De Castro, and M. Griffiths A novel translocation, t(14;19)(q32;p13), involving IGH@ and the cytokine receptor for erythropoietin Leukemia 23 2009 614 617
    • (2009) Leukemia , vol.23 , pp. 614-617
    • Russell, L.J.1    De Castro, D.G.2    Griffiths, M.3
  • 75
    • 0024353369 scopus 로고
    • The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene
    • J.C. Grimaldi, and T.C. Meeker The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene Blood 73 1989 2081 2085 (Pubitemid 19179537)
    • (1989) Blood , vol.73 , Issue.8 , pp. 2081-2085
    • Grimaldi, J.C.1    Meeker, T.C.2
  • 76
    • 27644442420 scopus 로고    scopus 로고
    • Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia [9]
    • DOI 10.1038/sj.leu.2403938, PII 2403938
    • T. Sonoki, E. Iwanaga, and H. Mitsuya Insertion of microRNA-125b-1, a human homologue of lin-4, into a rearranged immunoglobulin heavy chain gene locus in a patient with precursor B-cell acute lymphoblastic leukemia Leukemia 19 2005 2009 2010 (Pubitemid 41554016)
    • (2005) Leukemia , vol.19 , Issue.11 , pp. 2009-2010
    • Sonoki, T.1    Iwanaga, E.2    Mitsuya, H.3    Asou, N.4
  • 77
    • 77954658856 scopus 로고    scopus 로고
    • A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia
    • E. Chapiro, L.J. Russell, and S. Struski A new recurrent translocation t(11;14)(q24;q32) involving IGH@ and miR-125b-1 in B-cell progenitor acute lymphoblastic leukemia Leukemia 24 2010 1362 1364
    • (2010) Leukemia , vol.24 , pp. 1362-1364
    • Chapiro, E.1    Russell, L.J.2    Struski, S.3
  • 78
    • 0028001362 scopus 로고
    • The Ikaros gene is required for the development of all lymphoid lineages
    • DOI 10.1016/0092-8674(94)90407-3
    • K. Georgopoulos, M. Bigby, and J.H. Wang The Ikaros gene is required for the development of all lymphoid lineages Cell 79 1994 143 156 (Pubitemid 24309520)
    • (1994) Cell , vol.79 , Issue.1 , pp. 143-156
    • Georgopoulos, K.1    Bigby, M.2    Wang, J.-H.3    Molnar, A.4    Wu, P.5    Winandy, S.6    Sharpe, A.7
  • 79
    • 0028866897 scopus 로고
    • A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
    • S. Winandy, P. Wu, and K. Georgopoulos A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma Cell 83 1995 289 299
    • (1995) Cell , vol.83 , pp. 289-299
    • Winandy, S.1    Wu, P.2    Georgopoulos, K.3
  • 80
    • 77954609243 scopus 로고    scopus 로고
    • Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia
    • C. Virely, S. Moulin, and C. Cobaleda Haploinsufficiency of the IKZF1 (IKAROS) tumor suppressor gene cooperates with BCR-ABL in a transgenic model of acute lymphoblastic leukemia Leukemia 24 2010 1200 1204
    • (2010) Leukemia , vol.24 , pp. 1200-1204
    • Virely, C.1    Moulin, S.2    Cobaleda, C.3
  • 82
    • 0032761116 scopus 로고    scopus 로고
    • Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia
    • L. Sun, P.A. Goodman, and C.M. Wood Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia J Clin Oncol 17 1999 3753 3766
    • (1999) J Clin Oncol , vol.17 , pp. 3753-3766
    • Sun, L.1    Goodman, P.A.2    Wood, C.M.3
  • 84
    • 0036045383 scopus 로고    scopus 로고
    • Non-DNA-binding Ikaros isoform gene expressed in adult B-precursor acute lymphoblastic leukemia
    • K. Nishii, N. Katayama, and H. Miwa Non-DNA-binding Ikaros isoform gene expressed in adult B-precursor acute lymphoblastic leukemia Leukemia 16 2002 1285 1292
    • (2002) Leukemia , vol.16 , pp. 1285-1292
    • Nishii, K.1    Katayama, N.2    Miwa, H.3
  • 86
    • 70349242044 scopus 로고    scopus 로고
    • Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: On behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)
    • I. Iacobucci, C.T. Storlazzi, and D. Cilloni Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP) Blood 114 2009 2159 2167
    • (2009) Blood , vol.114 , pp. 2159-2167
    • Iacobucci, I.1    Storlazzi, C.T.2    Cilloni, D.3
  • 88
    • 81555205127 scopus 로고    scopus 로고
    • Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia
    • G. Cazzaniga, F.W. van Delft, and L. Lo Nigro Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia Blood 118 2011 5559 5564
    • (2011) Blood , vol.118 , pp. 5559-5564
    • Cazzaniga, G.1    Van Delft, F.W.2    Lo Nigro, L.3
  • 89
    • 70450255241 scopus 로고    scopus 로고
    • PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: A GRAALL study
    • J. Familiades, M. Bousquet, and M. Lafage-Pochitaloff PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study Leukemia 23 2009 1989 1998
    • (2009) Leukemia , vol.23 , pp. 1989-1998
    • Familiades, J.1    Bousquet, M.2    Lafage-Pochitaloff, M.3
  • 90
    • 77951083709 scopus 로고    scopus 로고
    • Wide diversity of PAX5 alterations in B-ALL: A Groupe Francophone de Cytogenetique Hematologique study
    • E. Coyaud, S. Struski, and N. Prade Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study Blood 115 2010 3089 3097
    • (2010) Blood , vol.115 , pp. 3089-3097
    • Coyaud, E.1    Struski, S.2    Prade, N.3
  • 91
    • 58249118804 scopus 로고    scopus 로고
    • Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia
    • K. Nebral, D. Denk, and A. Attarbaschi Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia Leukemia 23 2009 134 143
    • (2009) Leukemia , vol.23 , pp. 134-143
    • Nebral, K.1    Denk, D.2    Attarbaschi, A.3
  • 92
    • 34147176683 scopus 로고    scopus 로고
    • A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5
    • DOI 10.1182/blood-2006-05-025221
    • M. Bousquet, C. Broccardo, and C. Quelen A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5 Blood 109 2007 3417 3423 (Pubitemid 46572531)
    • (2007) Blood , vol.109 , Issue.8 , pp. 3417-3423
    • Bousquet, M.1    Broccardo, C.2    Quelen, C.3    Meggetto, F.4    Kuhlein, E.5    Delsol, G.6    Dastugue, N.7    Brousset, P.8
  • 93
    • 38349177862 scopus 로고    scopus 로고
    • Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray
    • N. Kawamata, S. Ogawa, and M. Zimmermann Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray Blood 111 2008 776 784
    • (2008) Blood , vol.111 , pp. 776-784
    • Kawamata, N.1    Ogawa, S.2    Zimmermann, M.3
  • 94
    • 59449093453 scopus 로고    scopus 로고
    • A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups
    • S. Sulong, A.V. Moorman, and J.A. Irving A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups Blood 113 2009 100 107
    • (2009) Blood , vol.113 , pp. 100-107
    • Sulong, S.1    Moorman, A.V.2    Irving, J.A.3
  • 96
    • 70349876858 scopus 로고    scopus 로고
    • Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: A comparative deletion and hypermethylation study
    • M. Kim, S.H. Yim, and N.S. Cho Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study Cancer Genet Cytogenet 195 2009 59 65
    • (2009) Cancer Genet Cytogenet , vol.195 , pp. 59-65
    • Kim, M.1    Yim, S.H.2    Cho, N.S.3
  • 97
    • 54349086521 scopus 로고    scopus 로고
    • Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
    • D. Bercovich, I. Ganmore, and L.M. Scott Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome Lancet 372 2008 1484 1492
    • (2008) Lancet , vol.372 , pp. 1484-1492
    • Bercovich, D.1    Ganmore, I.2    Scott, L.M.3
  • 98
    • 60249086789 scopus 로고    scopus 로고
    • Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
    • L. Kearney, D. Gonzalez De Castro, and J. Yeung Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia Blood 113 2009 646 648
    • (2009) Blood , vol.113 , pp. 646-648
    • Kearney, L.1    Gonzalez De Castro, D.2    Yeung, J.3
  • 100
    • 67249146555 scopus 로고    scopus 로고
    • JAK mutations in high-risk childhood acute lymphoblastic leukemia
    • C.G. Mullighan, J. Zhang, and R.C. Harvey JAK mutations in high-risk childhood acute lymphoblastic leukemia Proc Natl Acad Sci U S A 106 2009 9414 9418
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9414-9418
    • Mullighan, C.G.1    Zhang, J.2    Harvey, R.C.3
  • 101
    • 65449160177 scopus 로고    scopus 로고
    • Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers
    • T. Hornakova, J. Staerk, and Y. Royer Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers J Biol Chem 284 2009 6773 6781
    • (2009) J Biol Chem , vol.284 , pp. 6773-6781
    • Hornakova, T.1    Staerk, J.2    Royer, Y.3
  • 102
    • 0034232353 scopus 로고    scopus 로고
    • Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
    • A. Pandey, K. Ozaki, and H. Baumann Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin Nat Immunol 1 2000 59 64
    • (2000) Nat Immunol , vol.1 , pp. 59-64
    • Pandey, A.1    Ozaki, K.2    Baumann, H.3
  • 103
    • 70350519430 scopus 로고    scopus 로고
    • Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia
    • L.J. Russell, M. Capasso, and I. Vater Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia Blood 114 2009 2688 2698
    • (2009) Blood , vol.114 , pp. 2688-2698
    • Russell, L.J.1    Capasso, M.2    Vater, I.3
  • 104
    • 70350680415 scopus 로고    scopus 로고
    • Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia
    • C.G. Mullighan, J.R. Collins-Underwood, and L.A. Phillips Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia Nat Genet 41 2009 1243 1246
    • (2009) Nat Genet , vol.41 , pp. 1243-1246
    • Mullighan, C.G.1    Collins-Underwood, J.R.2    Phillips, L.A.3
  • 105
    • 77649214639 scopus 로고    scopus 로고
    • Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: A report from the International BFM Study Group
    • L. Hertzberg, E. Vendramini, and I. Ganmore Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group Blood 115 2010 1006 1017
    • (2010) Blood , vol.115 , pp. 1006-1017
    • Hertzberg, L.1    Vendramini, E.2    Ganmore, I.3
  • 106
    • 76249096219 scopus 로고    scopus 로고
    • Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia
    • A. Yoda, Y. Yoda, and S. Chiaretti Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia Proc Natl Acad Sci U S A 107 2010 252 257
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 252-257
    • Yoda, A.1    Yoda, Y.2    Chiaretti, S.3
  • 107
    • 77949425065 scopus 로고    scopus 로고
    • Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia
    • E. Chapiro, L. Russell, and E. Lainey Activating mutation in the TSLPR gene in B-cell precursor lymphoblastic leukemia Leukemia 24 2010 642 645
    • (2010) Leukemia , vol.24 , pp. 642-645
    • Chapiro, E.1    Russell, L.2    Lainey, E.3
  • 108
    • 79956108320 scopus 로고    scopus 로고
    • Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias
    • C. Shochat, N. Tal, and O.R. Bandapalli Gain-of-function mutations in interleukin-7 receptor-alpha (IL7R) in childhood acute lymphoblastic leukemias J Exp Med 208 2011 901 908
    • (2011) J Exp Med , vol.208 , pp. 901-908
    • Shochat, C.1    Tal, N.2    Bandapalli, O.R.3
  • 109
    • 64349101658 scopus 로고    scopus 로고
    • MicroRNA-125b is a novel negative regulator of p53
    • M.T. Le, C. Teh, and N. Shyh-Chang MicroRNA-125b is a novel negative regulator of p53 Genes Dev 23 2009 862 876
    • (2009) Genes Dev , vol.23 , pp. 862-876
    • Le, M.T.1    Teh, C.2    Shyh-Chang, N.3
  • 111
    • 79955716719 scopus 로고    scopus 로고
    • MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia
    • D. Schotte, R.X. De Menezes, and F.A. Moqadam MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia Haematologica 96 2011 703 711
    • (2011) Haematologica , vol.96 , pp. 703-711
    • Schotte, D.1    De Menezes, R.X.2    Moqadam, F.A.3
  • 112
    • 80052458509 scopus 로고    scopus 로고
    • Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia
    • D. Schotte, F.A. Moqadam, and E.A. Lange-Turenhout Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia Leukemia 25 2011 1389 1399
    • (2011) Leukemia , vol.25 , pp. 1389-1399
    • Schotte, D.1    Moqadam, F.A.2    Lange-Turenhout, E.A.3
  • 114
    • 69249240343 scopus 로고    scopus 로고
    • Discordance of MLL-rearranged (MLL-R) infant acute lymphoblastic leukemia in monozygotic twins with spontaneous clearance of preleukemic clone in unaffected twin
    • M.K. Chuk, E. McIntyre, and D. Small Discordance of MLL-rearranged (MLL-R) infant acute lymphoblastic leukemia in monozygotic twins with spontaneous clearance of preleukemic clone in unaffected twin Blood 113 2009 6691 6694
    • (2009) Blood , vol.113 , pp. 6691-6694
    • Chuk, M.K.1    McIntyre, E.2    Small, D.3
  • 115
    • 77951751194 scopus 로고    scopus 로고
    • Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
    • C.M. Bateman, S.M. Colman, and T. Chaplin Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia Blood 115 2010 3553 3558
    • (2010) Blood , vol.115 , pp. 3553-3558
    • Bateman, C.M.1    Colman, S.M.2    Chaplin, T.3
  • 116
    • 78751644099 scopus 로고    scopus 로고
    • Genetic variegation of clonal architecture and propagating cells in leukaemia
    • K. Anderson, C. Lutz, and F.W. van Delft Genetic variegation of clonal architecture and propagating cells in leukaemia Nature 469 2011 356 361
    • (2011) Nature , vol.469 , pp. 356-361
    • Anderson, K.1    Lutz, C.2    Van Delft, F.W.3
  • 117
    • 78751661556 scopus 로고    scopus 로고
    • Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells
    • F. Notta, C.G. Mullighan, and J.C. Wang Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells Nature 469 2011 362 367
    • (2011) Nature , vol.469 , pp. 362-367
    • Notta, F.1    Mullighan, C.G.2    Wang, J.C.3
  • 118
    • 77952485949 scopus 로고    scopus 로고
    • Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: Presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations
    • J. Davidsson, K. Paulsson, and D. Lindgren Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations Leukemia 24 2010 924 931
    • (2010) Leukemia , vol.24 , pp. 924-931
    • Davidsson, J.1    Paulsson, K.2    Lindgren, D.3
  • 122
    • 47049093795 scopus 로고    scopus 로고
    • Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: A Children's Oncology Group study
    • M.J. Borowitz, M. Devidas, and S.P. Hunger Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study Blood 111 2008 5477 5485
    • (2008) Blood , vol.111 , pp. 5477-5485
    • Borowitz, M.J.1    Devidas, M.2    Hunger, S.P.3
  • 123
    • 66149141393 scopus 로고    scopus 로고
    • Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL)
    • R. Bassan, O. Spinelli, and E. Oldani Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL) Blood 113 2009 4153 4162
    • (2009) Blood , vol.113 , pp. 4153-4162
    • Bassan, R.1    Spinelli, O.2    Oldani, E.3
  • 124
    • 70449721037 scopus 로고    scopus 로고
    • Aberrant underexpression of CD81 in precursor B-cell acute lymphoblastic leukemia: Utility in detection of minimal residual disease by flow cytometry
    • T. Muzzafar, L.J. Medeiros, and S.A. Wang Aberrant underexpression of CD81 in precursor B-cell acute lymphoblastic leukemia: utility in detection of minimal residual disease by flow cytometry Am J Clin Pathol 132 2009 692 698
    • (2009) Am J Clin Pathol , vol.132 , pp. 692-698
    • Muzzafar, T.1    Medeiros, L.J.2    Wang, S.A.3
  • 125
    • 79959450187 scopus 로고    scopus 로고
    • New markers for minimal residual disease detection in acute lymphoblastic leukemia
    • E. Coustan-Smith, G. Song, and C. Clark New markers for minimal residual disease detection in acute lymphoblastic leukemia Blood 117 2011 6267 6276
    • (2011) Blood , vol.117 , pp. 6267-6276
    • Coustan-Smith, E.1    Song, G.2    Clark, C.3
  • 126
    • 70449719091 scopus 로고    scopus 로고
    • IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: A GIMEMA AL WP report
    • G. Martinelli, I. Iacobucci, and C.T. Storlazzi IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report J Clin Oncol 27 2009 5202 5207
    • (2009) J Clin Oncol , vol.27 , pp. 5202-5207
    • Martinelli, G.1    Iacobucci, I.2    Storlazzi, C.T.3
  • 127
    • 78649742010 scopus 로고    scopus 로고
    • Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: Correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
    • R.C. Harvey, C.G. Mullighan, and X. Wang Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome Blood 116 2010 4874 4884
    • (2010) Blood , vol.116 , pp. 4874-4884
    • Harvey, R.C.1    Mullighan, C.G.2    Wang, X.3
  • 128
    • 58749097408 scopus 로고    scopus 로고
    • A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: A genome-wide classification study
    • M.L. Den Boer, M. van Slegtenhorst, and R.X. De Menezes A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study Lancet Oncol 10 2009 125 134
    • (2009) Lancet Oncol , vol.10 , pp. 125-134
    • Den Boer, M.L.1    Van Slegtenhorst, M.2    De Menezes, R.X.3
  • 129
    • 77949879862 scopus 로고    scopus 로고
    • Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia
    • H. Kang, I.M. Chen, and C.S. Wilson Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia Blood 115 2010 1394 1405
    • (2010) Blood , vol.115 , pp. 1394-1405
    • Kang, H.1    Chen, I.M.2    Wilson, C.S.3
  • 130
    • 78049468425 scopus 로고    scopus 로고
    • A pathway-based gene signature correlates with therapeutic response in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia
    • Z. Zuo, D. Jones, and H. Yao A pathway-based gene signature correlates with therapeutic response in adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia Mod Pathol 23 2010 1524 1534
    • (2010) Mod Pathol , vol.23 , pp. 1524-1534
    • Zuo, Z.1    Jones, D.2    Yao, H.3
  • 132
    • 77957191745 scopus 로고    scopus 로고
    • First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
    • F. Ravandi, S. O'Brien, and D. Thomas First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia Blood 116 2010 2070 2077
    • (2010) Blood , vol.116 , pp. 2070-2077
    • Ravandi, F.1    O'Brien, S.2    Thomas, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.