Early hematopoietic lineage restrictions directed by Ikaros

Nature Immunology

Volumn 7, Issue 4, 2006, Pages 382-391

  Yoshida, Toshimi ^a   Yao Ming Ng, Samuel ^a   Zuniga Pflucker, Juan Carlos ^b   Georgopoulos, Katia ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; ERYTHROPOIETIN RECEPTOR; FLT3 LIGAND; IKAROS PROTEIN; PROTEIN ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL SELECTION; CELL SEPARATION; CONTROLLED STUDY; ERYTHROCYTE; FLOW CYTOMETRY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LYMPHOID CELL; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; CROSSES, GENETIC; GREEN FLUORESCENT PROTEINS; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; IKAROS TRANSCRIPTION FACTOR; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; MYELOID CELLS; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 33645109285     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1314     Document Type: Article

References (43)

1. Morrison, S.J., Uchida, N. & Weissman, I.L. The biology of hematopoetic stem cells. Annu. Rev. Cell Dev. Biol. 11, 35-71 (1995).
2. Kondo, M. et al. Biology of hematopoietic stem cells and progenitors: implications for clinical application. Annu. Rev. Immunol. 21, 759-806 (2003).
3. Lemischka, I.R. Clonal, in vivo behavior of the totipotent hematopoietic stem cell. Semin. Immunol. 3, 349-355 (1991).
4. Kondo, M., Weissman, I.L. & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661-672 (1997).
5. Akashi, K., Traver, D., Miyamato, T. & Weissman, I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000).
6. Spangrude, G.J., Heimfeld, S. & Weissman, I.L. Purification and characterization of mouse hematopoietic stem cells. Science 241, 58-62 (1988).
7. Morrison, SJ. & Weissman, I.L. The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1, 661-673 (1994).
8. Weissman, I.L., Anderson, D.J. & Gage, F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu. Rev. Cell Dev. Biol. 17, 387-403 (2001).
9. + stem cell compartment is accompanied by loss of self-renewal capacity. Immunity 15, 659-669 (2001).
10. Christensen, J.L. & Weissman, I.L. Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells. Proc. Natl. Acad. Sci. USA 98, 14541-14546 (2001).
11. Osawa, M., Hanada, K., Hamada, H. & Nakauchi, H. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hemnatopoetic stem cell. Science 273, 242-245 (1996).
12. - short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients. Blood 105, 2717-2723 (2005).
13. Igarashi, H., Gregory, S.C., Yokota, T., Sakaguchi, N. & Kincade, P.W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 17, 117-130 (2002).
14. Allman, D. et al. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4, 168-174 (2003).
15. Schwarz, B.A. & Bhandoola, A. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5, 953-960 (2004).
16. + lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121, 295-306 (2005).
17. Lessard, J., Faubert, A. & Sauvageau, G. Genetic programs regulating HSC specification, maintenance and expansion. Oncogene 23, 7199-7209 (2004).
18. Busslinger, M. Transcriptional control of early B cell development. Annu. Rev. Immunol. 22, 55-79 (2004).
19. Rothenberg, E.V. & Taghon, T. Molecular genetics of T cell development. Annu. Rev. Immunol. 23, 601-649 (2005).
20. Friedman, A.D. Transcriptional regulation of granulocyte and monocyte development. Oncogene 21, 3377-3390 (2002).
21. Cantor, A.B. & Orkin, S.H. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21, 3368-3376 (2002).
22. Georgopoulos, K., Moore, D.D. & Derfler, B. Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. Science 258, 808-812 (1992).
23. Georgopoulos, K. et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell 79, 143-156 (1994).
24. Wang, J.H. et al. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity 5, 537-549 (1996).
25. Winandy, S., Wu, P. & Georgopoulos, K. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma. Cell 83, 289-299 (1995).
26. Hahm, K. et al. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol. Cell. Biol. 14, 7111-7123 (1994).
27. Nichogiannopoulou, A., Trevisan, M., Neben, S., Friedrich, C. & Georgopoulos, K. Defects in hemopoietic stem cell activity in Ikaros mutant mice. J. Exo. Med. 190, 1201-1214 (1999).
28. Mackarehtschian, K. et al. Targeted disruption of the flk2lflt3 gene leads to deficiencies in primitive hematopoietic progenitors. Immunity 3, 147-161 (1995).
29. Sitnicka, E. et al. Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool, Immunity 17, 463-472 (2002).
30. Kim, J. et al. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity 10, 345-355 (1999).
31. O'Neill, D.W. et al. An Ikaros-containing chromatin-remodeling complex in adult-type erythroid cells. Mol. Cell. Biol. 20, 7572-7582 (2000).
32. Harker, N. et al. The CD8α gene locus is regulated by the Ikaros family of proteins. Mol. Cell 10, 1403-1415 (2002).
33. Kaufmann, C. et al. A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis. EMBO J. 22, 2211-2223 (2003).
34. Miyamoto, T. et al. Myeloid or lymphoid promiscuity as a critical step in hematopoetic lineage commitment. Dev. Cell 3, 137-147 (2002).
35. Akashi, K. et al. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 101, 383-389 (2003).
36. Metcalf, D., Johnson, G.R. & Mandel, T.E. Colony formation in agar by multipotential hemopoietic cells. J. Cell, Physiol. 98, 401-420 (1979).
37. Nakahata, T. & Ogawa, M. Clonal origin of murine hemopoietic colonies with apparent restriction to granuclocyte-macrophage-megakaryocyte (GMM) differentiation. J. Cell. Physiol. 111, 239-246 (1982).
38. Schmitt, T.M. & Zuniga-Pflucker, J.C. Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17, 749-756 (2002).
39. Phillips, R.L. et al. The genetic program of hematopoietic stem cells. Science 288, 1635-1640 (2000).
40. D'Amico, A. & Wu, L. The early progenitors of mouse dendritic cells and plasmacytoid predendritic cells are within the bone marrow hemopoietic precursors expressing Flt3. J. Exo. Med. 198, 293-303 (2003).
41. + lymphoid-restricted bone marrow cells with T precursor potential. Nat. Immunol. 4, 866-873 (2003).
42. Terszowski, G. et aL Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit (CFU-E). Blood 105, 1937-1945 (2005).
43. Lopez, R.A., Schoetz, S., DeAngelis, K., O'Neill, D. & Bank, A. Multiple hematopoetic defects and delayed globin switching in Ikaros null mice. Proc. Natl. Acad. Sci. USA 99, 602-607 (2002).