Wide diversity of PAX5 alterations in B-ALL: A Groupe Francophone de Cytogénétique Hématologique study

Blood

Volumn 115, Issue 15, 2010, Pages 3089-3097

  Coyaud, Etienne ^a,b   Struski, Stephanie ^c   Prade, Nais ^a   Familiades, Julien ^a,b   Eichner, Ruth ^a,b   Quelen, Cathy ^a,b   Bousquet, Marina ^a,b   Mugneret, Francine ^d   Talmant, Pascaline ^e   Pages, Marie Pierre ^f   Lefebvre, Christine ^g   Penther, Dominique ^h   Lippert, Eric ⁱ   Nadal, Nathalie ^j   Taviaux, Sylvie ^k   Poppe, Bruce ^l   Luquet, Isabelle ^m   Baranger, Laurence ⁿ   Eclache, Virginie ^o   Radford, Isabelle ^p   Barin, Carole ^q   Mozziconacci, Marie Joëlle ^r   Lafage Pochitaloff, Marina ^s   Antoine Poirel, Hélène ^t   Charrin, Christiane ^f   Perot, Christine ^u   Terre, Christine ^v   Brousset, Pierre ^c   Dastugue, Nicole ^c   Broccardo, Cyril ^a   more..

^a CHU PURPAN   (France)

^b France   (France)

^c TOULOUSE UNIVERSITY HOSPITAL   (France)

^d HÔPITAL DU BOCAGE   (France)

^e NANTES UNIVERSITY HOSPITAL   (France)

^f HOSPICES CIVILS DE LYON   (France)

^g GRENOBLE UNIVERSITY HOSPITAL   (France)

^h Centre de Lutte Contre le Cancer Henri Becquerel   (France)

ⁱ BORDEAUX UNIVERSITY HOSPITAL   (France)

^j HÔPITAL NORD   (France)

^k MONTPELLIER UNIVERSITY HOSPITAL   (France)

^l GHENT UNIVERSITY HOSPITAL   (Belgium)

^m REIMS UNIVERSITY HOSPITAL   (France)

ⁿ ANGERS UNIVERSITY HOSPITAL   (France)

^o AVICENNE HOSPITAL   (France)

^p HÔPITAL NECKER ENFANTS MALADES   (France)

^q CHU BRETONNEAU   (France)

^r INSTITUT PAOLI CALMETTES   (France)

^s TIMONE HOSPITAL   (France)

^t CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^u HÔPITAL SAINT ANTOINE   (France)

^v CENTRE HOSPITALIER DE VERSAILLES   (France)

more..

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; TRANSCRIPTION FACTOR PAX5;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER CELL; CHILD; CHROMOSOME 9P; CHROMOSOME ABERRATION; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; FEMALE; FUSION GENE; GENE AMPLIFICATION; GENE DELETION; GENE FUSION; GENE MUTATION; GENE REARRANGEMENT; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HYPOTHESIS; INFANT; KARYOTYPE; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 77951083709     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-07-234229     Document Type: Article

References (24)

1. Armstrong SA, Look AT. Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol. 2005;23(26):6306-6315. (Pubitemid 46218840)
2. Mullighan CG, Goorha S, Radtke I, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007;446(7137):758-764. (Pubitemid 46582031)
3. Familiades J, Bousquet M, Lafage-Pochitaloff M, et al. PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study. Leukemia. 2009;23(11):1989-1998.
4. Nutt SL, Heavey B, Rolink AG, Busslinger M. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature. 1999;401(6753):556- 562. (Pubitemid 129517063)
5. Cobaleda C, Jochum W, Busslinger M. Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature. 2007;449(7161):473-477. (Pubitemid 47509547)
6. Delogu A, Schebesta A, Sun Q, Aschenbrenner K, Perlot T, Busslinger M. Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. Immunity. 2006;24(3):269-281.
7. Schebesta A, McManus S, Salvagiotto G, Delogu A, Busslinger GA, Busslinger M. Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity. 2007;27(1):49-63. (Pubitemid 47096800)
8. Cazzaniga G, Daniotti M, Tosi S, et al. The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case. Cancer Res. 2001;61(12):4666-4670. (Pubitemid 32691872)
9. Nebral K, Denk D, Attarbaschi A, et al. Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia. Leukemia. 2009;23(1):134-143.
10. An Q, Wright SL, Konn ZJ, et al. Variable breakpoints target PAX5 in patients with dicentric chromosomes: a model for the basis of unbalanced translocations in cancer. Proc Natl Acad Sci U S A. 2008;105(44):17050-17054.
11. Bousquet M, Broccardo C, Quelen C, et al. A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5. Blood. 2007;109(8):3417-3423. (Pubitemid 46572531)
12. Heerema NA, Sather HN, Sensel MG, et al. Association of chromosome arm 9p abnormalities with adverse risk in childhood acute lymphoblastic leukemia: a report from the Children's Cancer Group. Blood. 1999;94(5):1537-1544. (Pubitemid 29411302)
13. Bene MC, Castoldi G, Knapp W, et al. Proposals for the immunological classification of acute leukemias: European Group for the Immunological Characterization of Leukemias (EGIL). Leukemia. 1995;9(10):1783-1786.
14. Shaffer L, Tommerup N. An International System for Human Cytogenetic Nomenclature. Basel, Switzerland: Karger; 2005;1-130.
15. Polidoros AN, Pasentsis K, Tsaftaris AS. Rolling circle amplification-RACE: a method for simultaneous isolation of 5′ and 3′ cDNA ends from amplified cDNA templates. Biotechniques. 2006;41(1):35-36. (Pubitemid 46534899)
16. Dörfler P, Busslinger M. C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8. EMBO J. 1996;15(8):1971-1982. (Pubitemid 26119230)
17. Fazio G, Palmi C, Rolink A, Biondi A, Cazzaniga G. PAX5/TEL acts as a transcriptional repressor causing down-modulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells. Cancer Res. 2008;68(1):181-189. (Pubitemid 351380119)
18. Kawamata N, Ogawa S, Zimmermann M, et al. Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray. Proc Natl Acad Sci U S A. 2008;105(33):11921-11926.
19. Hörlein AJ, Naar AM, Heinzel T, et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor corepressor. Nature. 1995;377(6548):397-404.
20. Davis RJ, Shen W, Sandler YI, Heanue TA, Mardon G. Characterization of mouse Dach2, a homologue of Drosophila dachshund. Mech Dev. 2001;102(1):169-179. (Pubitemid 32273595)
21. Gilles F, Goy A, Remache Y, Manova K, Zelenetz AD. Cloning and characterization of a Golgin-related gene from the large-scale polymorphism linked to the PML gene. Genomics. 2000;70(3):364-374. (Pubitemid 32095435)
22. Miller CB, Mullighan CG, Su X, et al. Pax5 haplo-insufficiency cooperates with BCR-ABL1 to induce acute lymphoblastic leukemia [Abstract]. Blood (ASH Annual Meeting Abstracts). 2008;112:Abstract 293.
23. Heerema NA, Raimondi SC, Anderson JR, et al. Specific extra chromosomes occur in a modal number dependent pattern in pediatric acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2007;46(7):684-693.
24. Strefford JC, Worley H, Barber K, et al. Genome complexity in acute lymphoblastic leukemia is revealed by array-based comparative genomic hybridization. Oncogene. 2007;26(29):4306-4318. (Pubitemid 46975791)