Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia

Science

Volumn 322, Issue 5906, 2008, Pages 1377-1380

  Mullighan, Charles G ^a   Phillips, Letha A ^a   Su, Xiaoping ^a   Ma, Jing ^a   Miller, Christopher B ^a   Shurtleff, Sheila A ^a   Downing, James R ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

BLOOD SYSTEM DISORDER; CLONE; CYTOLOGY; GENETIC ANALYSIS;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER RELAPSE; CHILD; CHILDHOOD LEUKEMIA; CLONE; COPY NUMBER ABNORMALITY; DNA SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN GENOME; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; TREATMENT RESPONSE;

B-LYMPHOCYTES; CELL CYCLE; CHILD; CYCLIN-DEPENDENT KINASE INHIBITOR P15; GENE DELETION; GENE DOSAGE; GENES, P16; GENOME, HUMAN; GENOMICS; HUMANS; LOSS OF HETEROZYGOSITY; LYMPHOPOIESIS; METABOLIC NETWORKS AND PATHWAYS; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS C-ETS; RECURRENCE; REPRESSOR PROTEINS;

EID: 57149118627     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1164266     Document Type: Article

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29. We thank R. Ashmun and the St. Jude Flow Cytometry and Cell Sorting Shared Resource for flow sorting of leukemia samples, the St. Jude Clinical Applications Core Technology Laboratory for performing SNP arrays, L. Kiedrowski for lesion mapping and backtracking assays, and J. Stokes for assistance with artwork. Supported by the American Lebanese Syrian Associated Charities of St. Jude Children's Research Hospital and by the National Health and Medical Research Council of Australia (C.G.M.). Primary SNP array data are available from the authors upon request. J.R.D. has participated in gene expression profiling research sponsored by Roche. C.G.M. and J.R.D. have filed a patent application related to this work.