Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor α homodimers

Journal of Biological Chemistry

Volumn 284, Issue 11, 2009, Pages 6773-6781

  Hornakova, Tekla ^a   Staerk, Judith ^a   Royer, Yohan ^a   Flex, Elisabetta ^b   Tartaglia, Marco ^b   Constantinescu, Stefan N ^a   Knoops, Laurent ^a,c   Renauld, Jean Christophe ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; CO-EXPRESSION; CO-IMMUNOPRECIPITATION EXPERIMENTS; CYTOKINE RECEPTOR; DOMINANT NEGATIVE; ECTOPIC EXPRESSIONS; HEK293 CELLS; HETERODIMERIZATION; HOMODIMERIZATION; HOMODIMERS; IN STATS; JANUS KINASE; RECEPTOR COMPLEX; WILD TYPES;

AMINO ACIDS; COBALT COMPOUNDS; DIMERIZATION;

CHEMICAL ACTIVATION;

HIGH MOBILITY GROUP B1 PROTEIN; HOMODIMER; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 9 RECEPTOR; INTERLEUKIN 9 RECEPTOR ALPHA; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 3; MUTANT PROTEIN; STAT PROTEIN; UNCLASSIFIED DRUG; IL2RB PROTEIN, HUMAN; IL2RB PROTEIN, MOUSE; IL9R PROTEIN, HUMAN; IL9R PROTEIN, MOUSE; JAK1 PROTEIN, HUMAN; JAK1 PROTEIN, MOUSE; JAK3 PROTEIN, HUMAN; JAK3 PROTEIN, MOUSE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE MUTATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; DIMERIZATION; GENETICS; METABOLISM; MISSENSE MUTATION; MOUSE; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE, TUMOR; DIMERIZATION; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; JANUS KINASE 1; JANUS KINASE 3; MICE; MUTATION, MISSENSE; PHOSPHORYLATION; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, INTERLEUKIN-9; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS;

EID: 65449160177     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807531200     Document Type: Article

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