Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia

Cancer Research

Volumn 60, Issue 15, 2000, Pages 4062-4065

  Nakase, K ^a   Ishimaru, F ^a   Avitahl, N ^a   Dansako, H ^a   Matsuo, K ^a   Fujii, K ^a   Sezaki, N ^a   Nakayama, H ^a   Yano, T ^a   Fukuda, S ^a   Imajoh, K ^a   Takeuchi, M ^a   Miyata, A ^a   Hara, M ^a   Yasukawa, M ^a   Takahashi, I ^a   Taguchi, H ^a   Matsue, K ^a   Nakao, S ^a   Niho, Y ^a   Takenaka, K ^a   Shinagawa, K ^a   Ikeda, K ^a   Niiya, K ^a   Harada, M ^a   more..

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; B CELL LEUKEMIA; BONE MARROW EXAMINATION; CANCER GENETICS; CLINICAL ARTICLE; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMOGENESIS; MALE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ADOLESCENT; ADULT; ALTERNATIVE SPLICING; BONE MARROW CELLS; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION; GENES, DOMINANT; HUMANS; IKAROS TRANSCRIPTION FACTOR; LEUKEMIA, B-CELL, ACUTE; MALE; MIDDLE AGED; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; ZINC FINGERS;

EID: 0033870658     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. The Ikaros gene is required for the development of all lymphoid lineages
2. A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma
3. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation
4. The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse
5. Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development
6. Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation
7. Aiolos regulates B cell activation and maturation to effector state
8. Human Aiolos, an Ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping
9. Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin
10. Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors
11. Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia
12. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia
13. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia
14. Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia
15. The type 2 CD10/neutral endopeptidase 24.11 promoter: Functional characterization and tissue-specific regulation by CBF/ NF-Y isoforms
16. Molecular genetic survey of five Japanese families with high-molecular-weight kininogen deficiency
17. Ikaros sets thresholds for T cell activation and regulates chromosome propagation
18. Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes
19. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylases complex by the acute myeloid leukemia fusion partner ETO
20. The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein