A Robust and Highly Efficient Immune Cell Reprogramming System

Cell Stem Cell

Volumn 5, Issue 5, 2009, Pages 554-566

  Bussmann, Lars H ^a   Schubert, Alexis ^a   Vu Manh, Thien Phong ^a   De Andres, Luisa ^a   Desbordes, Sabrina C ^a,b   Parra, Maribel ^a   Zimmermann, Timo ^a   Rapino, Francesca ^a   Rodriguez Ubreva, Javier ^b   Ballestar, Esteban ^b   Graf, Thomas ^a,c  

^a CENTRE FOR GENOMIC REGULATION CRG   (Spain)

^b BELLVITGE BIOMEDICAL RESEARCH INSTITUTE IDIBELL   (Spain)

^c INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

STEMCELL

Indexed keywords

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL MIGRATION; CELL ORGANELLE; CELL STRUCTURE; CHROMATIN; DOWN REGULATION; GENETIC TRANSCRIPTION; IMMUNOCOMPETENT CELL; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGOCYTOSIS; PRIORITY JOURNAL; TRANSGENE; UPREGULATION;

ANIMALS; ANTIGENS, DIFFERENTIATION; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE, TRANSFORMED; CELL MOVEMENT; CELL TRANSDIFFERENTIATION; DNA-BINDING PROTEINS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INFLAMMATION MEDIATORS; MACROPHAGES; MICE; PRECURSOR CELLS, B-LYMPHOID; RECOMBINANT FUSION PROTEINS; TRANSCRIPTIONAL ACTIVATION; TRANSDUCTION, GENETIC;

EID: 70350596826     PISSN: 19345909     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stem.2009.10.004     Document Type: Article

References (42)

1. Alessandrini A., Pierce J.H., Baltimore D., and Desiderio S.V. Continuing rearrangement of immunoglobulin and T-cell receptor genes in a Ha-ras-transformed lymphoid progenitor cell line. Proc. Natl. Acad. Sci. USA 84 (1987) 1799-1803
2. Brady G., Boggan L., Bowie A., and O'Neill L.A. Schlafen-1 causes a cell cycle arrest by inhibiting induction of cyclin D1. J. Biol. Chem. 280 (2005) 30723-30734
3. Busslinger M. Transcriptional control of early B cell development. Annu. Rev. Immunol. 22 (2004) 55-79
4. Cai D.H., Wang D., Keefer J., Yeamans C., Hensley K., and Friedman A.D. C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1. Oncogene 27 (2008) 2772-2779
5. Cooper C., Henderson A., Artandi S., Avitahl N., and Calame K. Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators. Nucleic Acids Res. 23 (1995) 4371-4377
6. Davis R.L., Weintraub H., and Lassar A.B. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51 (1987) 987-1000
7. DeKoter R.P., and Singh H. Regulation of B lymphocyte and macrophage development by graded expression of PU.1. Science 288 (2000) 1439-1441
8. Dengler H.S., Baracho G.V., Omori S.A., Bruckner S., Arden K.C., Castrillon D.H., DePinho R.A., and Rickert R.C. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat. Immunol. 9 (2008) 1388-1398
9. Faust N., Huber M.C., Sippel A.E., and Bonifer C. Different macrophage populations develop from embryonic/fetal and adult hematopoietic tissues. Exp. Hematol. 25 (1997) 432-444
10. Feng R., Desbordes S.C., Xie H., Tillo E.S., Pixley F., Stanley E.R., and Graf T. PU.1 and C/EBPalpha/beta convert fibroblasts into macrophage-like cells. Proc. Natl. Acad. Sci. USA 105 (2008) 6057-6062
11. Friedman A.D. Transcriptional control of granulocyte and monocyte development. Oncogene 26 (2007) 6816-6828
12. Gordon S., and Taylor P.R. Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5 (2005) 953-964
13. Hanna J., Markoulaki S., Schorderet P., Carey B.W., Beard C., Wernig M., Creyghton M.P., Steine E.J., Cassady J.P., Foreman R., et al. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 133 (2008) 250-264
14. Heasman S.J., and Ridley A.J. Mammalian Rho GTPases: New insights into their functions from in vivo studies. Nat. Rev. Mol. Cell Biol. 9 (2008) 690-701
15. Heins N., Malatesta P., Cecconi F., Nakafuku M., Tucker K.L., Hack M.A., Chapouton P., Barde Y.A., and Gotz M. Glial cells generate neurons: The role of the transcription factor Pax6. Nat. Neurosci. 5 (2002) 308-315
16. Horb M.E., Shen C.N., Tosh D., and Slack J.M. Experimental conversion of liver to pancreas. Curr. Biol. 13 (2003) 105-115
17. Irizarry R.A., Bolstad B.M., Collin F., Cope L.M., Hobbs B., and Speed T.P. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res. 31 (2003) e15
18. Kulessa H., Frampton J., and Graf T. GATA-1 reprograms avian myelomonocytic cell lines into eosinophils, thromboblasts, and erythroblasts. Genes Dev. 9 (1995) 1250-1262
19. Laiosa C.V., Stadtfeld M., and Graf T. Determinants of lymphoid-myeloid lineage diversification. Annu. Rev. Immunol. 24 (2006) 705-738
20. Laiosa C.V., Stadtfeld M., Xie H., de Andres-Aguayo L., and Graf T. Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 25 (2006) 731-744
21. Laslo P., Spooner C.J., Warmflash A., Lancki D.W., Lee H.J., Sciammas R., Gantner B.N., Dinner A.R., and Singh H. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 126 (2006) 755-766
22. Lim J.P., Wang J.T., Kerr M.C., Teasdale R.D., and Gleeson P.A. A role for SNX5 in the regulation of macropinocytosis. BMC Cell Biol. 9 (2008) 58
23. Mikkelsen T.S., Hanna J., Zhang X., Ku M., Wernig M., Schorderet P., Bernstein B.E., Jaenisch R., Lander E.S., and Meissner A. Dissecting direct reprogramming through integrative genomic analysis. Nature 454 (2008) 49-55
24. Niwa H., Toyooka Y., Shimosato D., Strumpf D., Takahashi K., Yagi R., and Rossant J. Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123 (2005) 917-929
25. Parada L.A., McQueen P.G., and Misteli T. Tissue-specific spatial organization of genomes. Genome Biol. 5 (2004) R44
26. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29 (2001) e45
27. Porse B.T., Pedersen T.A., Xu X., Lindberg B., Wewer U.M., Friis-Hansen L., and Nerlov C. E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell 107 (2001) 247-258
28. Pridans C., Holmes M.L., Polli M., Wettenhall J.M., Dakic A., Corcoran L.M., Smyth G.K., and Nutt S.L. Identification of Pax5 target genes in early B cell differentiation. J. Immunol. 180 (2008) 1719-1728
29. Sahai E., and Marshall C.J. RHO-GTPases and cancer. Nat. Rev. Cancer 2 (2002) 133-142
30. Schebesta A., McManus S., Salvagiotto G., Delogu A., Busslinger G.A., and Busslinger M. Transcription factor Pax5 activates the chromatin of key genes involved in B cell signaling, adhesion, migration, and immune function. Immunity 27 (2007) 49-63
31. Shen C.N., Horb M.E., Slack J.M., and Tosh D. Transdifferentiation of pancreas to liver. Mech. Dev. 120 (2003) 107-116
32. Stadtfeld M., Maherali N., Breault D.T., and Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2 (2008) 230-240
33. Takahashi K., and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126 (2006) 663-676
34. Thomas M.D., Kremer C.S., Ravichandran K.S., Rajewsky K., and Bender T.P. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity 23 (2005) 275-286
35. Wang H., and Morse III H.C. IRF8 regulates myeloid and B lymphoid lineage diversification. Immunol. Res. 43 (2008) 109-117
36. Wang W., Wang X., Ward A.C., Touw I.P., and Friedman A.D. C/EBPalpha and G-CSF receptor signals cooperate to induce the myeloperoxidase and neutrophil elastase genes. Leukemia 15 (2001) 779-786
37. Weigelt K., Moehle C., Stempfl T., Weber B., and Langmann T. An integrated workflow for analysis of ChIP-chip data. Biotechniques 45 (2008) 131-132, 134, 136 passim
38. Weigelt K., Lichtinger M., Rehli M., and Langmann T. Transcriptomic profiling identifies a PU.1 regulatory network in macrophages. Biochem. Biophys. Res. Commun. 380 (2009) 308-312
39. Weintraub H., Tapscott S.J., Davis R.L., Thayer M.J., Adam M.A., Lassar A.B., and Miller A.D. Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast cell lines by forced expression of MyoD. Proc. Natl. Acad. Sci. USA 86 (1989) 5434-5438
40. Wernig M., Lengner C.J., Hanna J., Lodato M.A., Steine E., Foreman R., Staerk J., Markoulaki S., and Jaenisch R. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat. Biotechnol. 26 (2008) 916-924
41. Xie H., Ye M., Feng R., and Graf T. Stepwise reprogramming of B cells into macrophages. Cell 117 (2004) 663-676
42. Zhou Q., Brown J., Kanarek A., Rajagopal J., and Melton D.A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 455 (2008) 627-632