메뉴 건너뛰기




Volumn 115, Issue 17, 2010, Pages 3570-3579

The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4

Author keywords

[No Author keywords available]

Indexed keywords

AF4 MIXED LINEAGE LEUKEMIA FUSION PROTEIN; MIXED LINEAGE LEUKEMIA AF4 FUSION PROTEIN; ONCOPROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; MLL PROTEIN, MOUSE; MLLT2H PROTEIN, MOUSE; NUCLEAR PROTEIN;

EID: 77951749557     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-06-229542     Document Type: Article
Times cited : (125)

References (39)
  • 3
    • 0025910286 scopus 로고
    • Oncogenic conversion of transcription factors by chromosomal translocations
    • Cleary ML. Oncogenic conversion of transcription factors by chromosomal translocations. Cell. 1991;66(4):619-622. (Pubitemid 121001698)
    • (1991) Cell , vol.66 , Issue.4 , pp. 619-622
    • Cleary, M.L.1
  • 4
    • 0025984266 scopus 로고
    • Translocations, master genes, and differences between the origins of acute and chronic leukemias
    • Rabbitts TH. Translocations, master genes, and differences between the origins of acute and chronic leukemias. Cell. 1991;67(4):641-644.
    • (1991) Cell , vol.67 , Issue.4 , pp. 641-644
    • Rabbitts, T.H.1
  • 5
    • 0027970838 scopus 로고
    • Chromosomal translocations in human cancer
    • Rabbitts TH. Chromosomal translocations in human cancer. Nature. 1994;372:143-149.
    • (1994) Nature , vol.372 , pp. 143-149
    • Rabbitts, T.H.1
  • 6
    • 68749120703 scopus 로고    scopus 로고
    • New insights into the MLL recombinome of acute leukemias
    • Meyer C, Kowarz E, Hofmann J, et al. New insights into the MLL recombinome of acute leukemias. Leukemia. 2009;23(8):1490-1499.
    • (2009) Leukemia , vol.23 , Issue.8 , pp. 1490-1499
    • Meyer, C.1    Kowarz, E.2    Hofmann, J.3
  • 7
    • 34249651279 scopus 로고    scopus 로고
    • Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele
    • Kowarz E, Burmeister T, Lo Nigro L, et al. Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele. Leukemia. 2007;21(6):1232-1328.
    • (2007) Leukemia , vol.21 , Issue.6 , pp. 1232-1328
    • Kowarz, E.1    Burmeister, T.2    Lo Nigro, L.3
  • 9
    • 0030791974 scopus 로고    scopus 로고
    • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
    • DOI 10.1093/emboj/16.14.4226
    • Lavau C, Szilvassy SJ, Slany R, Cleary ML. Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J. 1997;16(14):4226-4237. (Pubitemid 27298175)
    • (1997) EMBO Journal , vol.16 , Issue.14 , pp. 4226-4237
    • Lavau, C.1    Szilvassy, S.J.2    Slany, R.3    Cleary, M.L.4
  • 10
    • 0031972784 scopus 로고    scopus 로고
    • The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX
    • Slany RK, Lavau C, Cleary ML. The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNAbinding motifs of HRX. Mol Cell Biol. 1998;18(1):122-129. (Pubitemid 28021024)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.1 , pp. 122-129
    • Slany, R.K.1    Lavau, C.2    Cleary, M.L.3
  • 11
    • 0034548830 scopus 로고    scopus 로고
    • A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL
    • DiMartino JF, Miller T, Ayton PM, et al. A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood. 2000;96(12):3887-3893.
    • (2000) Blood , vol.96 , Issue.12 , pp. 3887-3893
    • DiMartino, J.F.1    Miller, T.2    Ayton, P.M.3
  • 12
    • 0034718552 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
    • Lavau C, Luo RT, Du C, Thirman MJ. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. Proc Natl Acad Sci U SA. 2000;97(20):10984-10989.
    • (2000) Proc Natl Acad Sci U SA , vol.97 , Issue.20 , pp. 10984-10989
    • Lavau, C.1    Luo, R.T.2    Du, C.3    Thirman, M.J.4
  • 13
    • 0042872887 scopus 로고    scopus 로고
    • MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    • DOI 10.1016/S1535-6108(03)00019-9
    • So CW, Karsunky H, Passegué E, Cozzio A, Weissman IL, Cleary ML. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell. 2003;3(2):161-171. (Pubitemid 37443388)
    • (2003) Cancer Cell , vol.3 , Issue.2 , pp. 161-171
    • So, C.W.1    Karsunky, H.2    Passegue, E.3    Cozzio, A.4    Weissman, I.L.5    Cleary, M.L.6
  • 15
    • 0037427073 scopus 로고    scopus 로고
    • The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21)
    • DOI 10.1038/sj.onc.1206042
    • Strehl S, Borkhardt A, Slany R, Fuchs UE, König M, Haas OA. The human LASP1 gene is fused to MLL in an acute myeloid leukemia with t(11;17)(q23;q21). Oncogene. 2003;22(1):157-160. (Pubitemid 36152894)
    • (2003) Oncogene , vol.22 , Issue.1 , pp. 157-160
    • Strehl, S.1    Borkhardt, A.2    Slany, R.3    Fuchs, U.E.4    Konig, M.5    Haas, O.A.6
  • 16
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    • Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev. 2003;17(18):2298-2307.
    • (2003) Genes Dev , vol.17 , Issue.18 , pp. 2298-2307
    • Ayton, P.M.1    Cleary, M.L.2
  • 18
    • 0037093081 scopus 로고    scopus 로고
    • The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10
    • DiMartino JF, Ayton PM, Chen EH, Naftzger CC, Young BD, Cleary ML. The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood. 2002;99(10):3780-3785.
    • (2002) Blood , vol.99 , Issue.10 , pp. 3780-3785
    • DiMartino, J.F.1    Ayton, P.M.2    Chen, E.H.3    Naftzger, C.C.4    Young, B.D.5    Cleary, M.L.6
  • 20
    • 0042885909 scopus 로고    scopus 로고
    • Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
    • DOI 10.1016/S1535-6108(03)00188-0
    • So CW, Lin M, Ayton PM, Chen EH, Cleary ML. Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell. 2003;4:99-110. (Pubitemid 37040826)
    • (2003) Cancer Cell , vol.4 , Issue.2 , pp. 99-110
    • So, C.W.1    Lin, M.2    Ayton, P.M.3    Chen, E.H.4    Cleary, M.L.5
  • 21
    • 2342484341 scopus 로고    scopus 로고
    • The small oligomerization domain of gephyrin converts MLL to an oncogene
    • DOI 10.1182/blood-2003-11-3817
    • Eguchi M, Eguchi-Ishimae M, Greaves M. The small oligomerization domain of gephyrin converts MLL to an oncogene. Blood. 2004;103(10):3876-3882. (Pubitemid 38596308)
    • (2004) Blood , vol.103 , Issue.10 , pp. 3876-3882
    • Eguchi, M.1    Eguchi-Ishimae, M.2    Greaves, M.3
  • 22
    • 33745941911 scopus 로고    scopus 로고
    • Amurine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy
    • DOI 10.1182/blood-2005-08-3498
    • Chen W, Li Q, Hudson WA, Kumar A, Kirchhof N, Kersey JH. A murine MLL·AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. Blood. 2006;108(2):669-677. (Pubitemid 44061369)
    • (2006) Blood , vol.108 , Issue.2 , pp. 669-677
    • Chen, W.1    Li, Q.2    Hudson, W.A.3    Kumar, A.4    Kirchhof, N.5    Kersey, J.H.6
  • 23
    • 33745103352 scopus 로고    scopus 로고
    • A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology
    • DOI 10.1038/sj.onc.1209636, PII 1209636
    • Metzler M, Forster A, Pannell R, et al. A conditional model of MLL·AF4 B-cell tumourigenesis using invertor technology. Oncogene. 2006;25(22):3093-3103. (Pubitemid 43881551)
    • (2006) Oncogene , vol.25 , Issue.22 , pp. 3093-3103
    • Metzler, M.1    Forster, A.2    Pannell, R.3    Arends, M.J.4    Daser, A.5    Lobato, M.N.6    Rabbitts, T.H.7
  • 24
    • 54549083228 scopus 로고    scopus 로고
    • H3K79 methylation profiles define murine and human MLL·AF4 leukemias
    • Krivtsov AV, Feng Z, Lemieux ME, et al. H3K79 methylation profiles define murine and human MLL·AF4 leukemias. Cancer Cell. 2008;14(5):355-368.
    • (2008) Cancer Cell , vol.14 , Issue.5 , pp. 355-368
    • Krivtsov, A.V.1    Feng, Z.2    Lemieux, M.E.3
  • 25
    • 2942631425 scopus 로고    scopus 로고
    • Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein
    • DOI 10.1038/sj.leu.2403321
    • Caslini C, Serna A, Rossi V, Introna M, Biondi A. Modulation of cell cycle by graded expression of MLL·AF4 fusion oncoprotein. Leukemia. 2004;18(6):1064-1071. (Pubitemid 38786964)
    • (2004) Leukemia , vol.18 , Issue.6 , pp. 1064-1071
    • Caslini, C.1    Serna, A.2    Rossi, V.3    Introna, M.4    Biondi, A.5
  • 26
    • 34249104594 scopus 로고    scopus 로고
    • Combined effects of the two reciprocal t(4;11) fusion proteins MLL·AF4 and AF4·MLL confer resistance to apoptosis, cell cycling capacity and growth transformation
    • DOI 10.1038/sj.onc.1210125, PII 1210125
    • Gaussmann A,Wenger T, Eberle I, et al. Combined effects of the two reciprocal t(4;11) fusion proteins MLL·AF4 and AF4·MLL confer resistance to apoptosis, cell cycling capacity and growth transformation. Oncogene. 2007;26(23):3352-3363. (Pubitemid 46788884)
    • (2007) Oncogene , vol.26 , Issue.23 , pp. 3352-3363
    • Gaussmann, A.1    Wenger, T.2    Eberle, I.3    Bursen, A.4    Bracharz, S.5    Herr, I.6    Dingermann, T.7    Marschalek, R.8
  • 27
    • 4344663459 scopus 로고    scopus 로고
    • Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: Indication for t(4;11) pathobiology?
    • DOI 10.1038/sj.onc.1207837
    • Bursen A, Moritz S, Gaussmann A, Dingermann T, Marschalek R. Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? Oncogene. 2004;23(37):6237-6249. (Pubitemid 39215294)
    • (2004) Oncogene , vol.23 , Issue.37 , pp. 6237-6249
    • Bursen, A.1    Moritz, S.2    Gaussmann, A.3    Moritz, S.4    Dingermann, T.5    Marschalek, R.6
  • 30
    • 0029034494 scopus 로고
    • Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11)
    • Marschalek R, Greil J, Löchner K, et al. Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11). Brit J Haematol. 1995;90(2):308-320.
    • (1995) Brit J Haematol , vol.90 , Issue.2 , pp. 308-320
    • Marschalek, R.1    Greil, J.2    Löchner, K.3
  • 32
    • 84870532154 scopus 로고    scopus 로고
    • National Center for Biotechnology Information. Gene Expression Omnibus (GEO). http://www.ncbi.nlm.nih.gov/geo.
    • Gene Expression Omnibus (GEO)
  • 33
    • 70349964642 scopus 로고    scopus 로고
    • Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients
    • Trentin L, Giordan M, Dingerman T, et al. Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients. Eur J Haematol. 2009;83(5):406-419.
    • (2009) Eur J Haematol , vol.83 , Issue.5 , pp. 406-419
    • Trentin, L.1    Giordan, M.2    Dingerman, T.3
  • 34
    • 77950966577 scopus 로고    scopus 로고
    • Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants
    • Stam RW, Schneider P, Hagelstein JA, et al. Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants. Blood. 2010;115(14):2835-2844.
    • (2010) Blood , vol.115 , Issue.14 , pp. 2835-2844
    • Stam, R.W.1    Schneider, P.2    Hagelstein, J.A.3
  • 38
    • 20444417108 scopus 로고    scopus 로고
    • WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
    • DOI 10.1016/j.cell.2005.03.036, PII S0092867405003557
    • Wysocka J, Swigut T, Milne TA, et al. WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell. 2005;121(6): 859-872. (Pubitemid 40806418)
    • (2005) Cell , vol.121 , Issue.6 , pp. 859-872
    • Wysocka, J.1    Swigut, T.2    Milne, T.A.3    Dou, Y.4    Zhang, X.5    Burlingame, A.L.6    Roeder, R.G.7    Brivanlou, A.H.8    Allis, C.D.9
  • 39
    • 33846522525 scopus 로고    scopus 로고
    • The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
    • DOI 10.1093/hmg/ddl444
    • Bitoun E, Oliver PL, Davies KE. The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum Mol Genet. 2007;16(1):92-106. (Pubitemid 46152547)
    • (2007) Human Molecular Genetics , vol.16 , Issue.1 , pp. 92-106
    • Bitoun, E.1    Oliver, P.L.2    Davies, K.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.