-
1
-
-
40749150603
-
Acute lymphoblastic leukaemia
-
Pui CH, Robison LL, Look AT (2008) Acute lymphoblastic leukaemia. Lancet 371:1030-1043.
-
(2008)
Lancet
, vol.371
, pp. 1030-1043
-
-
Pui, C.H.1
Robison, L.L.2
Look, A.T.3
-
2
-
-
34147224008
-
Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
-
DOI 10.1038/nature05690, PII NATURE05690
-
Mullighan CG, et al. (2007) Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446:758-764. (Pubitemid 46582031)
-
(2007)
Nature
, vol.446
, Issue.7137
, pp. 758-764
-
-
Mullighan, C.G.1
Goorha, S.2
Radtke, I.3
Miller, C.B.4
Coustan-Smith, E.5
Dalton, J.D.6
Girtman, K.7
Mathew, S.8
Ma, J.9
Pounds, S.B.10
Su, X.11
Pui, C.-H.12
Relling, M.V.13
Evans, W.E.14
Shurtleff, S.A.15
Downing, J.R.16
-
3
-
-
43049139905
-
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros
-
DOI 10.1038/nature06866, PII NATURE06866
-
Mullighan CG, et al. (2008) BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 453:110-114. (Pubitemid 351630327)
-
(2008)
Nature
, vol.453
, Issue.7191
, pp. 110-114
-
-
Mullighan, C.G.1
Miller, C.B.2
Radtke, I.3
Phillips, L.A.4
Dalton, J.5
Ma, J.6
White, D.7
Hughes, T.P.8
Le Beau, M.M.9
Pui, C.-H.10
Relling, M.V.11
Shurtleff, S.A.12
Downing, J.R.13
-
4
-
-
58749109707
-
Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia
-
Mullighan CG, et al. (2009) Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 360:470-480.
-
(2009)
N Engl J Med
, vol.360
, pp. 470-480
-
-
Mullighan, C.G.1
-
5
-
-
0032482394
-
Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy
-
DOI 10.1056/NEJM199806043382304
-
Nachman JB, et al. (1998) Augmented post-induction therapy for children with high-risk acute lymphoblastic leukemia and a slow response to initial therapy. N Engl J Med 338:1663-1671. (Pubitemid 28267911)
-
(1998)
New England Journal of Medicine
, vol.338
, Issue.23
, pp. 1663-1671
-
-
Nachman, J.B.1
Sather, H.N.2
Sensel, M.G.3
Trigg, M.E.4
Cherlow, J.M.5
Lukens, J.N.6
Wolff, L.7
Uckun, F.M.8
Gaynon, P.S.9
-
6
-
-
47049093795
-
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: A Children's Oncology Group study
-
Borowitz MJ, et al. (2008) Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: A Children's Oncology Group study. Blood 111:5477-5485.
-
(2008)
Blood
, vol.111
, pp. 5477-5485
-
-
Borowitz, M.J.1
-
8
-
-
0035959746
-
Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation
-
DOI 10.1038/sj.onc.1204834
-
Xie S, et al. (2001) Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation. Oncogene 20:6188-6195. (Pubitemid 32964431)
-
(2001)
Oncogene
, vol.20
, Issue.43
, pp. 6188-6195
-
-
Xie, S.1
Wang, Y.2
Liu, J.3
Sun, T.4
Wilson, M.B.5
Smithgall, T.E.6
Arlinghaus, R.B.7
-
9
-
-
52949089050
-
JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies
-
Vainchenker W, Dusa A, Constantinescu SN (2008) JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies. Semin Cell Dev Biol 19:385-393.
-
(2008)
Semin Cell Dev Biol
, vol.19
, pp. 385-393
-
-
Vainchenker, W.1
Dusa, A.2
Constantinescu, S.N.3
-
10
-
-
54349086521
-
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome
-
Bercovich D, et al. (2008) Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet 372:1484-1492.
-
(2008)
Lancet
, vol.372
, pp. 1484-1492
-
-
Bercovich, D.1
-
11
-
-
60249086789
-
A specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
-
Kearney L, et al. (2008) A specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia. Blood 113:646-648.
-
(2008)
Blood
, vol.113
, pp. 646-648
-
-
Kearney, L.1
-
12
-
-
42249091014
-
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia
-
DOI 10.1084/jem.20072182
-
Flex E, et al. (2008) Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. J Exp Med 205:751-758. (Pubitemid 351549874)
-
(2008)
Journal of Experimental Medicine
, vol.205
, Issue.4
, pp. 751-758
-
-
Flex, E.1
Petrangeli, V.2
Stella, L.3
Chiaretti, S.4
Hornakova, T.5
Knoops, L.6
Ariola, C.7
Fodale, V.8
Clappier, E.9
Paoloni, F.10
Martinelli, S.11
Fragale, A.12
Sanchez, M.13
Tavolaro, S.14
Messina, M.15
Cazzaniga, G.16
Camera, A.17
Pizzolo, G.18
Tornesello, A.19
Vignetti, M.20
Battistini, A.21
Cave, H.22
Gelb, B.D.23
Renauld, J.-C.24
Biondi, A.25
Constantinescu, S.N.26
Foa, R.27
Tartaglia, M.28
more..
-
13
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
DOI 10.1038/nature03546
-
James C, et al. (2005) A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434:1144-1148. (Pubitemid 40663494)
-
(2005)
Nature
, vol.434
, Issue.7037
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.-P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
14
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
DOI 10.1056/NEJMoa051113
-
Kralovics R, et al. (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N Engl J Med 352:1779-1790. (Pubitemid 40570926)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.-S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
15
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
DOI 10.1016/j.ccr.2005.03.023
-
Levine RL, et al. (2005) Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7:387-397. (Pubitemid 40544655)
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.P.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
Adelsperger, J.11
Koo, S.12
Lee, J.C.13
Gabriel, S.14
Mercher, T.15
D'Andrea, A.16
Frohling, S.17
Dohner, K.18
Marynen, P.19
Vandenberghe, P.20
Mesa, R.A.21
Tefferi, A.22
Griffin, J.D.23
Eck, M.J.24
Sellers, W.R.25
Meyerson, M.26
Golub, T.R.27
Lee, S.J.28
Gilliland, D.G.29
more..
-
16
-
-
20144363192
-
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders
-
DOI 10.1016/S0140-6736(05)71142-9
-
Baxter EJ, et al. (2005) Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders. Lancet 365:1054-1061. (Pubitemid 40386783)
-
(2005)
Lancet
, vol.365
, Issue.9464
, pp. 1054-1061
-
-
Baxter, E.J.1
Scott, L.M.2
Campbell, P.J.3
East, C.4
Fourouclas, N.5
Swanton, S.6
Vassiliou, G.S.7
Bench, A.J.8
Boyd, E.M.9
Curtin, N.10
Scott, M.A.11
Erber, W.N.12
Avis, T.13
Barthorpe, A.14
Bignell, G.15
Blow, M.16
Brackenbury, L.17
Buck, G.18
Clegg, S.19
Clements, J.20
Cole, J.21
Davies, H.22
Edkins, S.23
Gray, K.24
Gorton, M.25
O'Meara, S.26
Halliday, K.27
Harrison, R.28
Haynes, W.29
Hills, K.30
Hunter, C.31
Jones, D.32
Kosmidou, V.33
Laman, R.34
Lugg, R.35
Parker, A.36
Perry, J.37
Petty, R.38
Small, A.39
Solomon, H.40
Stephens, P.41
Stephens, Y.42
Stevens, C.43
Smith, R.44
Tarpey, P.45
Tofts, C.46
Varian, J.47
West, S.48
Widaa, S.49
Bamford, S.50
Butler, A.51
Dawson, E.52
Dicks, E.53
Edwards, K.54
Forbes, S.55
Greenman, C.56
Hinton, J.57
Menzies, A.58
Raine, K.59
Shepherd, R.60
Teague, J.61
Yates, A.62
Wooster, R.63
Futreal, A.64
Stratton, M.65
Green, A.R.66
more..
-
18
-
-
0037033012
-
The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction
-
DOI 10.1074/jbc.M205156200
-
Saharinen P, Silvennoinen O (2002) The pseudokinase domain is required for suppression of basal activity of Jak2 and Jak3 tyrosine kinases and for cytokine-inducible activation of signal transduction. J Biol Chem 277:47954-47963. (Pubitemid 36159324)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.49
, pp. 47954-47963
-
-
Saharinen, P.1
Silvennoinen, O.2
-
19
-
-
0029665852
-
Crystal structure of the p27(Kip1) cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
-
DOI 10.1038/382325a0
-
Russo AA, et al. (1996) Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382:325-331. (Pubitemid 26260452)
-
(1996)
Nature
, vol.382
, Issue.6589
, pp. 325-331
-
-
Russo, A.A.1
Jeffrey, P.D.2
Patten, A.K.3
Massague, J.4
Pavletich, N.P.5
-
20
-
-
0032541623
-
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16(INK4a)
-
DOI 10.1038/26155
-
Russo AA, et al. (1998) Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a. Nature 395:237-243. (Pubitemid 28447541)
-
(1998)
Nature
, vol.395
, Issue.6699
, pp. 237-243
-
-
Russo, A.A.1
Tong, L.2
Lee, J.-O.3
Jeffrey, P.D.4
Pavletich, N.P.5
-
21
-
-
0032541640
-
Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19(INK4d)
-
DOI 10.1038/26164
-
Brotherton DH, et al. (1998) Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d. Nature 395:244-250. (Pubitemid 28447542)
-
(1998)
Nature
, vol.395
, Issue.6699
, pp. 244-250
-
-
Brotherton, D.H.1
Dhanaraj, V.2
Wick, S.3
Brizuela, L.4
Domaille, P.J.5
Volyanik, E.6
Xu, X.7
Parisini, E.8
Smith, B.O.9
Archer, S.J.10
Serrano, M.11
Brenner, S.L.12
Blundell, T.L.13
Laue, E.D.14
-
22
-
-
30144436273
-
The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
-
DOI 10.1182/blood-2005-06-2413
-
Lucet IS, et al. (2006) The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood 107:176-183. (Pubitemid 43053540)
-
(2006)
Blood
, vol.107
, Issue.1
, pp. 176-183
-
-
Lucet, I.S.1
Fantino, E.2
Styles, M.3
Bamert, R.4
Patel, O.5
Broughton, S.E.6
Walter, M.7
Burns, C.J.8
Treutlein, H.9
Wilks, A.F.10
Rossjohn, J.11
-
23
-
-
34548240698
-
Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders
-
DOI 10.1038/nrc2210, PII NRC2210
-
Levine RL, Pardanani A, Tefferi A, Gilliland DG (2007) Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat Rev Cancer 7:673-683. (Pubitemid 47327415)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.9
, pp. 673-683
-
-
Levine, R.L.1
Pardanani, A.2
Tefferi, A.3
Gilliland, D.G.4
-
24
-
-
55249095625
-
Myeloproliferative disorders
-
Levine RL, Gilliland DG (2008) Myeloproliferative disorders. Blood 112:2190-2198.
-
(2008)
Blood
, vol.112
, pp. 2190-2198
-
-
Levine, R.L.1
Gilliland, D.G.2
-
25
-
-
0032839892
-
Identification of newly diagnosed children with acute lymphocytic leukemia at high risk for relapse
-
Shuster JJ, et al. (1999) Identification of newly diagnosed children with acute lymphocytic leukemia at high risk for relapse. Cancer Res Ther Control 9:101-107. (Pubitemid 29408333)
-
(1999)
Cancer Research Therapy and Control
, vol.9
, Issue.1-2
, pp. 101-107
-
-
Shuster, J.J.1
Camitta, B.M.2
Pullen, J.3
Borowitz, M.J.4
Carroll, A.J.5
Thomas Look, A.6
Mahoney, D.H.7
Mahmoud, H.8
Lauer, S.J.9
Land, V.J.10
-
26
-
-
40749093314
-
Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity
-
Funakoshi-Tago M, et al. (2008) Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity. Mol Cell Biol 28:1792-1801.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 1792-1801
-
-
Funakoshi-Tago, M.1
-
27
-
-
52949129499
-
Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
-
Kotecha N, et al. (2008) Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell 14:335-343.
-
(2008)
Cancer Cell
, vol.14
, pp. 335-343
-
-
Kotecha, N.1
-
28
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
DOI 10.1073/pnas.0506580102
-
Subramanian A, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102:15545-15550. (Pubitemid 41528093)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.43
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
29
-
-
19044399684
-
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling
-
DOI 10.1016/S1535-6108(02)00032-6
-
Yeoh EJ, et al. (2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1:133-143. (Pubitemid 41039160)
-
(2002)
Cancer Cell
, vol.1
, Issue.2
, pp. 133-143
-
-
Yeoh, E.-J.1
Ross, M.E.2
Shurtleff, S.A.3
Williams, W.K.4
Patel, D.5
Mahfouz, R.6
Behm, F.G.7
Raimondi, S.C.8
Relling, M.V.9
Patel, A.10
Cheng, C.11
Campana, D.12
Wilkins, D.13
Zhou, X.14
Li, J.15
Liu, H.16
Pui, C.-H.17
Evans, W.E.18
Naeve, C.19
Wong, L.20
Downing, J.R.21
more..
-
30
-
-
0141993002
-
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
-
DOI 10.1182/blood-2003-01-0338
-
Ross ME, et al. (2003) Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 102:2951-2959. (Pubitemid 37248870)
-
(2003)
Blood
, vol.102
, Issue.8
, pp. 2951-2959
-
-
Ross, M.E.1
Zhou, X.2
Song, G.3
Shurtleff, S.A.4
Girtman, K.5
Williams, W.K.6
Liu, H.-C.7
Mahfouz, R.8
Raimondi, S.C.9
Lenny, N.10
Patel, A.11
Downing, J.R.12
-
31
-
-
0000120995
-
A class of K-sample tests for comparing the cumulative incidence of a competing risk
-
Gray RJ (1988) A class of K-sample tests for comparing the cumulative incidence of a competing risk. Ann Stat 16:1141-1154.
-
(1988)
Ann Stat
, vol.16
, pp. 1141-1154
-
-
Gray, R.J.1
-
32
-
-
0013886333
-
Evaluation of survival data and two new rank order statistics arising in its consideration
-
Mantel N (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170.
-
(1966)
Cancer Chemother Rep
, vol.50
, pp. 163-170
-
-
Mantel, N.1
-
33
-
-
1542532754
-
A proportional hazards model for the subdistribution of a competing risk
-
Fine JP, Gray RJ (1999) A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 94:496-509
-
(1999)
J Am Stat Assoc
, vol.94
, pp. 496-509
-
-
Fine, J.P.1
Gray, R.J.2
|