메뉴 건너뛰기




Volumn 116, Issue 6, 2010, Pages 962-970

Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)

(22)  Hirose, Kinuko a   Inukai, Takeshi a   Kikuchi, Jiro b   Furukawa, Yusuke b   Ikawa, Tomokatsu c   Kawamoto, Hiroshi c   Oram, S Helen d   Göttgens, Berthold d   Kiyokawa, Nobutaka e   Miyagawa, Yoshitaka e   Okita, Hajime e   Akahane, Koshi a   Zhang, Xiaochun a   Kuroda, Itaru a   Honna, Hiroko a   Kagami, Keiko a   Goi, Kumiko a   Kurosawa, Hidemitsu f   Look, A Thomas g   Matsui, Hirotaka h   more..


Author keywords

[No Author keywords available]

Indexed keywords


EID: 77956528501     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-09-244673     Document Type: Article
Times cited : (32)

References (45)
  • 1
    • 0027970838 scopus 로고
    • Chromosomal translocations in human cancer
    • Rabbitts TH. Chromosomal translocations in human cancer. Nature. 1994;372(6502):143-149.
    • (1994) Nature , vol.372 , Issue.6502 , pp. 143-149
    • Rabbitts, T.H.1
  • 2
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • DOI 10.1126/science.278.5340.1059
    • Look AT. Oncogenic transcription factors in the human acute leukemias. Science. 1997;278(5340):1059-1064. (Pubitemid 27517875)
    • (1997) Science , vol.278 , Issue.5340 , pp. 1059-1064
    • Look, A.T.1
  • 4
    • 0025933456 scopus 로고
    • TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11)
    • Royer-Pokora B, Loos U, Ludwig WD. TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11). Oncogene. 1991;6(10):1887-1893. (Pubitemid 21924023)
    • (1991) Oncogene , vol.6 , Issue.10 , pp. 1887-1893
    • Royer-Pokora, B.1    Loos, U.2    Ludwig, W.-D.3
  • 5
    • 0027973545 scopus 로고
    • Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
    • Wadman I, Li J, Bash RO, et al. Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia. EMBO J. 1994;13(20):4831-4839. (Pubitemid 24319365)
    • (1994) EMBO Journal , vol.13 , Issue.20 , pp. 4831-4839
    • Wadman, I.1    Li, J.2    Bash, R.O.3    Forster, A.4    Osada, H.5    Rabbitts, T.H.6    Baer, R.7
  • 6
    • 0030999645 scopus 로고    scopus 로고
    • The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
    • DOI 10.1093/emboj/16.11.3145
    • Wadman IA, Osada H, Grutz GG, et al. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J. 1997;16(11):3145-3157. (Pubitemid 27234954)
    • (1997) EMBO Journal , vol.16 , Issue.11 , pp. 3145-3157
    • Wadman, I.A.1    Osada, H.2    Grutz, G.G.3    Agulnick, A.D.4    Westphal, H.5    Forster, A.6    Rabbitts, T.H.7
  • 7
    • 0029906061 scopus 로고    scopus 로고
    • Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins
    • DOI 10.1038/384270a0
    • Agulnick AD, Taira M, Breen JJ, Tanaka T, Dawid IB, Westphal H. Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996;384(6606):270-272. (Pubitemid 26396977)
    • (1996) Nature , vol.384 , Issue.6606 , pp. 270-272
    • Agulnick, A.D.1    Taira, M.2    Breen, J.J.3    Tanaka, T.4    Dawid, I.B.5    Westphal, H.6
  • 8
    • 0032541488 scopus 로고    scopus 로고
    • The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells
    • DOI 10.1093/emboj/17.16.4594
    • Grütz GG, Bucher K, Lavenir I, Larson T, Larson R, Rabbitts TH. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. EMBO J. 1998;17(16):4594-4605. (Pubitemid 28377160)
    • (1998) EMBO Journal , vol.17 , Issue.16 , pp. 4594-4605
    • Grutz, G.G.1    Bucher, K.2    Lavenir, I.3    Larson, T.4    Larson, R.5    Rabbitts, T.H.6
  • 9
    • 0028278325 scopus 로고
    • The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development
    • Warren AJ, Colledge WH, Carlton MB, Evans MJ, Smith AJ, Rabbitts TH. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994;78(1):45-57.
    • (1994) Cell , vol.78 , Issue.1 , pp. 45-57
    • Warren, A.J.1    Colledge, W.H.2    Carlton, M.B.3    Evans, M.J.4    Smith, A.J.5    Rabbitts, T.H.6
  • 12
    • 0037438387 scopus 로고    scopus 로고
    • Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
    • Akashi K, He X, Chen J, Iwasaki H, Niu C, Steenhard B, Zhang J, Haug J, Li L. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood. 2003;101(2):383-389.
    • (2003) Blood , vol.101 , Issue.2 , pp. 383-389
    • Akashi, K.1    He, X.2    Chen, J.3    Iwasaki, H.4    Niu, C.5    Steenhard, B.6    Zhang, J.7    Haug, J.8    Li, L.9
  • 13
    • 0034598746 scopus 로고    scopus 로고
    • Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
    • Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403(6769):503-511.
    • (2000) Nature , vol.403 , Issue.6769 , pp. 503-511
    • Alizadeh, A.A.1    Eisen, M.B.2    Davis, R.E.3
  • 14
    • 2342587416 scopus 로고    scopus 로고
    • Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes
    • Lossos IS, Czerwinski DK, Alizadeh AA, et al. Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. N Engl J Med. 2004;350(18):1828-1837.
    • (2004) N Engl J Med , vol.350 , Issue.18 , pp. 1828-1837
    • Lossos, I.S.1    Czerwinski, D.K.2    Alizadeh, A.A.3
  • 16
    • 0344197969 scopus 로고    scopus 로고
    • The LMO2 T-Cell Oncogene Is Activated via Chromosomal Translocations or Retroviral Insertion during Gene Therapy but Has No Mandatory Role in Normal T-Cell Development
    • DOI 10.1128/MCB.23.24.9003-9013.2003
    • McCormack MP, Forster A, Drynan L, Pannell R, Rabbitts TH. The LMO2 T-cell oncogene is activated via chromosomal translocations or retroviral insertion during gene therapy but has no mandatory role in normal T-cell development. Mol Cell Biol. 2003;23(24):9003-9013. (Pubitemid 37499791)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.24 , pp. 9003-9013
    • McCormack, M.P.1    Forster, A.2    Drynan, L.3    Pannell, R.4    Rabbitts, T.H.5
  • 17
    • 0026446264 scopus 로고
    • T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes
    • Fisch P, Boehm T, Lavenir I, et al. T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes. Oncogene. 1992;7(12):2389-2397.
    • (1992) Oncogene , vol.7 , Issue.12 , pp. 2389-2397
    • Fisch, P.1    Boehm, T.2    Lavenir, I.3
  • 19
    • 0029113214 scopus 로고
    • The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice
    • Larson RC, Osada H, Larson TA, Lavenir I, Rabbitts TH. The oncogenic LIM protein Rbtn2 causes thymic developmental aberrations that precede malignancy in transgenic mice. Oncogene. 1995;11(5):853-862.
    • (1995) Oncogene , vol.11 , Issue.5 , pp. 853-862
    • Larson, R.C.1    Osada, H.2    Larson, T.A.3    Lavenir, I.4    Rabbitts, T.H.5
  • 20
    • 0028892254 scopus 로고
    • Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- Lymphocytes in the thymus and T-cell tumors in transgenic mice
    • Neale GA, Rehg JE, Goorha RM. Ectopic expression of rhombotin-2 causes selective expansion of CD4-CD8- lymphocytes in the thymus and T-cell tumors in transgenic mice. Blood. 1995;86(8):3060-3071.
    • (1995) Blood , vol.86 , Issue.8 , pp. 3060-3071
    • Neale, G.A.1    Rehg, J.E.2    Goorha, R.M.3
  • 21
    • 0142084745 scopus 로고    scopus 로고
    • LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
    • Hacein-Bey-Abina S, Von Kalle C, Schmidt M, et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science. 2003;302(5644):415-419.
    • (2003) Science , vol.302 , Issue.5644 , pp. 415-419
    • Hacein-Bey-Abina, S.1    Von Kalle, C.2    Schmidt, M.3
  • 22
    • 1342289322 scopus 로고    scopus 로고
    • Activation of the T-Cell Oncogene LMO2 after Gene Therapy for X-Linked Severe Combined Immunodeficiency
    • DOI 10.1056/NEJMra032207
    • McCormack MP, Rabbitts TH. Activation of the T-cell oncogene LMO2 after gene therapy for X-linked severe combined immunodeficiency. N Engl J Med. 2004;350(9):913-922. (Pubitemid 38252539)
    • (2004) New England Journal of Medicine , vol.350 , Issue.9 , pp. 913-922
    • McCormack, M.P.1    Rabbitts, T.H.2
  • 23
    • 0028969344 scopus 로고
    • The TTG-2/RBTN2 T cell oncogene encodes two alternative transcripts from two promoters: The distal promoter is removed by most 11p13 translocations in acute T cell leukaemia's (T-ALL)
    • Royer-Pokora B, Rogers M, Zhu TH, Schneider S, Loos U, Bolitz U. The TTG-2/RBTN2 T cell oncogene encodes two alternative transcripts from two promoters: the distal promoter is removed by most 11p13 translocations in acute T cell leukaemia's (T-ALL). Oncogene. 1995;10(7):1353-1360.
    • (1995) Oncogene , vol.10 , Issue.7 , pp. 1353-1360
    • Royer-Pokora, B.1    Rogers, M.2    Zhu, T.H.3    Schneider, S.4    Loos, U.5    Bolitz, U.6
  • 24
    • 27144469889 scopus 로고    scopus 로고
    • Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells
    • DOI 10.1182/blood-2004-12-4755
    • Landry JR, Kinston S, Knezevic K, Donaldson IJ, Green AR, Gottgens B. Fli1, Elf1, and Ets1 regulate the proximal promoter of the LMO2 gene in endothelial cells. Blood. 2005;106(8):2680-2687. (Pubitemid 41510740)
    • (2005) Blood , vol.106 , Issue.8 , pp. 2680-2687
    • Landry, J.-R.1    Kinston, S.2    Knezevic, K.3    Donaldson, I.J.4    Green, A.R.5    Gottgens, B.6
  • 25
    • 0038115240 scopus 로고    scopus 로고
    • A PAR domain transcription factor is involved in the expression from a hematopoietic-specific promoter for the human LMO2 gene
    • Crable SC, Anderson KP. A PAR domain transcription factor is involved in the expression from a hematopoietic-specific promoter for the human LMO2 gene. Blood. 2003;101(12):4757-4764. (Pubitemid 36857732)
    • (2003) Blood , vol.101 , Issue.12 , pp. 4757-4764
    • Crable, S.C.1    Anderson, K.P.2
  • 26
    • 0026744416 scopus 로고
    • Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia
    • Inaba T, Roberts WM, Shapiro LH, et al. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. Science. 1992;257(5069):531-534.
    • (1992) Science , vol.257 , Issue.5069 , pp. 531-534
    • Inaba, T.1    Roberts, W.M.2    Shapiro, L.H.3
  • 27
    • 0026761786 scopus 로고
    • Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia
    • Hunger SP, Ohyashiki K, Toyama K, Cleary ML. Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. Genes Dev. 1992;6(9):1608-1620.
    • (1992) Genes Dev , vol.6 , Issue.9 , pp. 1608-1620
    • Hunger, S.P.1    Ohyashiki, K.2    Toyama, K.3    Cleary, M.L.4
  • 28
    • 0025319528 scopus 로고
    • DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally
    • DOI 10.1016/0092-8674(90)90808-R
    • Mueller CR, Maire P, Schibler U. DBP, a liver-enriched transcriptional activator, is expressed late in ontogeny and its tissue specificity is determined posttranscriptionally. Cell. 1990;61(2):279-291. (Pubitemid 20149359)
    • (1990) Cell , vol.61 , Issue.2 , pp. 279-291
    • Mueller, C.R.1    Maire, P.2    Schibler, U.3
  • 29
    • 0026091281 scopus 로고
    • TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins
    • Drolet D, Scully K, Simmons D, et al. TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 1991;5(10):1739-1753. (Pubitemid 21905871)
    • (1991) Genes and Development , vol.5 , Issue.10 , pp. 1739-1753
    • Drolet, D.W.1    Scully, K.M.2    Simmons, D.M.3    Wegner, M.4    Chu, K.5    Swanson, L.W.6    Rosenfeld, M.G.7
  • 30
    • 0028997689 scopus 로고
    • E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF
    • Yoshihara T, Inaba T, Shapiro LH, Kato JY, Look AT. E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF. Mol Cell Biol. 1995;15(6):3247-3255.
    • (1995) Mol Cell Biol , vol.15 , Issue.6 , pp. 3247-3255
    • Yoshihara, T.1    Inaba, T.2    Shapiro, L.H.3    Kato, J.Y.4    Look, A.T.5
  • 31
    • 0031029142 scopus 로고    scopus 로고
    • Cell transformation mediated by homodimeric E2A-HLF transcription factors
    • Inukai T, Inaba T, Yoshihara T, Look AT. Cell transformation mediated by homodimeric E2A-HLF transcription factors. Mol Cell Biol. 1997;17(3):1417-1424. (Pubitemid 27097370)
    • (1997) Molecular and Cellular Biology , vol.17 , Issue.3 , pp. 1417-1424
    • Inukai, T.1    Inaba, T.2    Yoshihara, T.3    Look, A.T.4
  • 33
    • 0031656237 scopus 로고    scopus 로고
    • The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF
    • Inukai T, Inaba T, Ikushima S, Look AT. The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF. Mol Cell Biol. 1998;18(10):6035-6043. (Pubitemid 28450554)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.10 , pp. 6035-6043
    • Inukai, T.1    Inaba, T.2    Ikushima, S.3    Look, A.T.4
  • 35
    • 0344348920 scopus 로고    scopus 로고
    • Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice
    • Smith KS, Rhee JW, Naumovski L, Cleary ML. Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic mice. Mol Cell Biol. 1999;19(6):4443-4451. (Pubitemid 29242018)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.6 , pp. 4443-4451
    • Smith, K.S.1    Rhee, J.W.2    Naumovski, L.3    Cleary, M.L.4
  • 36
    • 0033135718 scopus 로고    scopus 로고
    • Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia
    • Honda H, Inaba T, Suzuki T, et al. Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia. Blood. 1999;93(9):2780-2790. (Pubitemid 29200767)
    • (1999) Blood , vol.93 , Issue.9 , pp. 2780-2790
    • Honda, H.1    Inaba, T.2    Suzuki, T.3    Oda, H.4    Ebihara, Y.5    Tsuiji, K.6    Nakahata, T.7    Ishikawa, T.8    Yazaki, Y.9    Hirai, H.10
  • 38
    • 0028144968 scopus 로고
    • DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF
    • Hunger SP, Brown R, Cleary ML. DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF. Mol Cell Biol. 1994;14(9):5986-5996. (Pubitemid 24264427)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.9 , pp. 5986-5996
    • Hunger, S.P.1    Brown, R.2    Cleary, M.L.3
  • 42
    • 35348854322 scopus 로고    scopus 로고
    • E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1
    • DOI 10.1634/stemcells.2007-0207
    • Kikuchi J, Shimizu R, Wada T, et al. E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1. Stem Cells. 2007;25(10):2439-2447. (Pubitemid 47582736)
    • (2007) Stem Cells , vol.25 , Issue.10 , pp. 2439-2447
    • Kikuchi, J.1    Shimizu, R.2    Wada, T.3    Ando, H.4    Nakamura, M.5    Ozawa, K.6    Furukawa, Y.7
  • 44
    • 33751168051 scopus 로고    scopus 로고
    • The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia
    • Van Vlierberghe P, van Grotel M, Beverloo HB, et al. The cryptic chromosomal deletion del(11)(p12p13) as a new activation mechanism of LMO2 in pediatric T-cell acute lymphoblastic leukemia. Blood. 2006;108(10):3520-3529.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3520-3529
    • Van Vlierberghe, P.1    Van Grotel, M.2    Beverloo, H.B.3
  • 45
    • 33846479947 scopus 로고    scopus 로고
    • Hypercalcemia in childhood acute lymphoblastic leukemia: Frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19
    • Inukai T, Hirose K, Inaba T, Kurosawa H, et al. Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19. Leukemia. 2007;21(2):288-296.
    • (2007) Leukemia , vol.21 , Issue.2 , pp. 288-296
    • Inukai, T.1    Hirose, K.2    Inaba, T.3    Kurosawa, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.